Compounds > 6-ketoprostaglandin-f1-alpha

6-ketoprostaglandin-f1-alpha and 2-aminomethyl-4-t-butyl-6-iodophenol

6-ketoprostaglandin-f1-alpha has been researched along with 2-aminomethyl-4-t-butyl-6-iodophenol* in 1 studies

Other Studies

1 other study(ies) available for 6-ketoprostaglandin-f1-alpha and 2-aminomethyl-4-t-butyl-6-iodophenol

ArticleYear
Enhancement of endogenous prostaglandin I2 (prostacyclin) generation in vivo by a phenolic anti-inflammatory agent in the rabbit.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:1

    Angiotensin II (i.v.) increased the plasma level of 6-keto-PGF1 alpha from 241 +/- 60 pg/ml (n = 8) to 612 +/- 108 pg/ml (n = 8) in anesthetized rabbits, which was further significantly increased by pretreatment with a phenolic anti-inflammatory agent, MK-447, to 1007 +/- 218 pg/ml (n = 8). MK-447 alone did not affect the level. The level of thromboxane B2 was not affected by these treatments. These results suggest that MK-447 may selectively enhance the PGI2 level by acting as a tryptophan-like cofactor of PG endoperoxide synthase.

    Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butylated Hydroxytoluene; Epoprostenol; Indomethacin; Male; Rabbits; Thromboxane B2

1991