6-hydroxyindoramin has been researched along with debrisoquin in 1 studies
*Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. [MeSH]
*Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. [MeSH]
| Studies (6-hydroxyindoramin) | Trials (6-hydroxyindoramin) | Recent Studies (post-2010) (6-hydroxyindoramin) | Studies (debrisoquin) | Trials (debrisoquin) | Recent Studies (post-2010) (debrisoquin) |
|---|---|---|---|---|---|
| 6 | 0 | 0 | 890 | 89 | 17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Franklin, RA; Pierce, DM; Smith, SE | 1 |
1 other study(ies) available for 6-hydroxyindoramin and debrisoquin
| Article | Year |
|---|---|
The pharmacokinetics of indoramin and 6-hydroxyindoramin in poor and extensive hydroxylators of debrisoquine.
Topics: Adult; Blood Pressure; Debrisoquin; Female; Heart Rate; Humans; Hydroxylation; Indoles; Indoramin; Isoquinolines; Male; Phenotype; Polymorphism, Genetic | 1987 |