6-ethylguanine has been researched along with guanine in 82 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (56.10) | 18.7374 |
| 1990's | 30 (36.59) | 18.2507 |
| 2000's | 5 (6.10) | 29.6817 |
| 2010's | 1 (1.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balog, B; Pegg, AE | 1 |
| Craig, AW; Curtin, NJ; Margison, GP; Snell, K | 1 |
| Roelen, HL; Sriram, M; van Boom, JH; van der Marel, GA; Wang, AH | 2 |
| Goldmacher, VS | 1 |
| Bronstein, SM; Skopek, TR; Swenberg, JA | 1 |
| Bronstein, SM; Hooth, MJ; Skopek, TR; Swenberg, JA | 1 |
| Asai, A; Handa, H; Huh, NH; Kuroki, T; Moriyama, C; Rajewsky, MF; Satoh, MS | 1 |
| Ambatzi, P; Bousiotou, V; Davaris, G; Haritopoulos, G; Kyrtopoulos, SA; Pangalis, G; Souliotis, VL | 1 |
| Katakura, R; Mashiyama, S; Sasaki, T; Suzuki, J; Takahashi, K; Yoshimoto, T | 1 |
| Anderson, MW; Darden, TA; Foley, CK; Glickman, BW; Pedersen, LG | 1 |
| Eberle, G; Huh, NH; Nehls, P; Rajewsky, MF; Thomale, J | 1 |
| Abbondandolo, A; Bonatti, S; Cercignani, G; De Ferrari, M; Ipata, PL; Rocco, M; Tozzi, MG; Viaggi, S | 1 |
| Den Engelse, L; Scherer, E; Van Den Berg, T; Vermeulen, E; Winterwerp, HH | 1 |
| Kyrtopoulos, SA; Souliotis, VL | 1 |
| Cawkwell, L; Georgiadis, P; Margison, GP; Patel, D; Potter, PM; Swann, PF; Wilkinson, MC | 1 |
| Kalnik, MW; Li, BF; Patel, DJ; Swann, PF | 1 |
| Basu, AK; Connors, TD; Dogliotti, E; Ellison, KS; Essigmann, JM | 1 |
| Rajewsky, MF; Samson, L; Thomale, J | 1 |
| Horie, Y; Huh, NH; Kuroki, T; Rajewsky, MF; Satoh, MS; Thomale, J | 1 |
| Bailey, GS; Dashwood, RH; Fong, AT; Hendricks, JD; Lee, BC; Van Winkle, S | 1 |
| Bailey, GS; Dashwood, RH; Fong, AT; Hendricks, JD; Van Winkle, S | 1 |
| Burns, PA; Glickman, BW; Gordon, AJ; Kunsmann, K | 1 |
| Graves, RJ; Li, BF; Swann, PF | 1 |
| Abbondandolo, A; Bonatti, S; De Ferrari, M; Pisano, V | 1 |
| Berger, J; Nehls, P; Rajewsky, MF; Spiess, E; Weber, E | 1 |
| Huh, N; Kuroki, T; Rajewsky, MF; Satoh, MS | 1 |
| Huh, NH; Rajewsky, MF | 1 |
| Anderson, MW; Darden, TA; Deerfield, DW; Hoel, DG; Pedersen, LG | 1 |
| Barbason, H; Brumioul, D; Lemaître, M; Verly, WG | 1 |
| Bresil, H; Lu, LY; Lu, SX; Montesano, R; Xiao, GL | 1 |
| Kalnik, M; Li, BF; Patel, DJ; Swann, PF | 1 |
| Fong, AT; Rasmussen, RE | 2 |
| Kleihues, P; von Hofe, E | 1 |
| Ehling, UH; Mohn, GR; Neuhäuser-Klaus, A; van Zeeland, AA | 1 |
| Saffhill, R | 1 |
| Huh, N; Rajewsky, MF | 1 |
| Nehls, P; Rajewsky, MF | 1 |
| Becker, RA; Shank, RC | 1 |
| Goth, R; Rajewsky, MF | 1 |
| Lemaître, M; Verly, WG | 1 |
| Lehmann, AR; Müller, R; Rajewsky, MF; Teo, IA | 1 |
| Verly, WG | 1 |
| Guttenplan, JB | 1 |
| Cao, EH; Delihas, NC; Setlow, RB | 1 |
| Renard, A; Verly, WG | 2 |
| Ludlum, DB; Mehta, JR; Renard, A; Verly, WG | 2 |
| Müller, R; Rajewsky, MF | 1 |
| Lindahl, T; Sedgwick, B | 1 |
| Lemaître, M; Renard, A; Verly, WG | 1 |
| Chang, MJ; Hart, RW; Koestner, A | 1 |
| Drosdziok, W; Müller, R; Rajewsky, MF | 1 |
| Jansen, JG; Mohn, GR; Tates, AD; van Teijlingen, CM; van Zeeland, AA; Vrieling, H | 1 |
| Dragan, YP; Hully, JR; Mass, MJ; Nakamura, J; Pitot, HC; Swenberg, JA | 1 |
| Buschfort, C; Müller, MR; Rajewsky, MF; Seeber, S; Seiler, F; Thomale, J | 1 |
| Hughes, SH; Moschel, RC; Pauly, GT | 1 |
| Gao, YG; Sriram, M; Wang, AH; Yang, D | 1 |
| Cerutti, P; Pourzand, C | 1 |
| Li, BF; Liem, LK; Lim, A | 1 |
| Hochleitner, K; Rajewsky, MF; Thomale, J | 1 |
| Bishop, RE; Dolan, ME; Dunn, LL; Moschel, RC; Pauly, GT | 1 |
| Bishop, RE; Moschel, RC; Pauly, GT | 1 |
| Bender, K; Federwisch, M; Loggen, U; Nehls, P; Rajewsky, MF | 1 |
| Cunningham, JM; Delaney, CA; Di Matteo, M; Dunger, A; Green, IC; Green, MH | 1 |
| Emura, M; Kamino, K; Mohr, U; Rajewsky, MF; Seiler, F; Thomale, J | 1 |
| Ali, N; Gebhardt, R; Iatropoulos, MJ; Peterson, LA; Rivenson, A; Schulz, C; Wang, CX; Williams, GM | 1 |
| Baan, RA; Berends, F; Hochleitner, K; Lohman, PH; Luiten-Schuite, A; Mientjes, EJ; Rajewsky, MF; Thomale, J; van Delft, JH | 1 |
| Gerson, SL; Liu, L; Markowitz, S | 1 |
| Baan, RA; Berends, F; Bergmans, A; Borsboom, Y; Lohman, PH; Luiten-Schuite, A; Mientjes, EJ; van Delft, JH; van der Wolf, E | 1 |
| Engelbergs, J; Galhoff, A; Rajewsky, MF; Thomale, J | 1 |
| Emura, M; Kamino, K; Mohr, U; Seiler, F; Thomale, J | 1 |
| Buschfort, C; Lensing, C; Müller, MR; Rajewsky, MF; Seeber, S; Thomale, J | 1 |
| Engelbergs, J; Rajewsky, MF; Schweer, T; Thomale, J | 1 |
| Abbondandolo, A; Bonatti, S; Pigullo, S; Simili, M | 1 |
| Den Engelse, L; Heyting, C; Huigen, A | 1 |
| Moschel, RC; Pauly, GT | 1 |
| Abbruzzese, JL; Chang, P; Firozi, PF; Jiao, L; Lai, D; Li, D | 1 |
| Bartleman, AP; Kirkland, JB; Kostecki, LM; Linford, G; Lizotte, M; Thomas, M; Toxopeus, L | 1 |
| Katanić, J; Matić, S; Mihailović, V; Mladenović, M; Solujić, S; Stanić, S; Stanković, N | 1 |
2 review(s) available for 6-ethylguanine and guanine
| Article | Year |
|---|---|
Enzymology of repair of DNA adducts produced by N-nitroso compounds.
Topics: Alkylation; Animals; Base Sequence; Cells, Cultured; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Nitroso Compounds | 1984 |
Crystal and solution structures of d(CGC[e6G]AATTCGCG)-drug complexes reveal conformational polymorphism of O6-ethyl-guanine:cytosine base pair.
Topics: Base Composition; Base Sequence; Crystallization; Cytosine; DNA; Guanine; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Sequence Data; Nucleic Acid Conformation; Pharmaceutical Preparations | 1994 |
80 other study(ies) available for 6-ethylguanine and guanine
| Article | Year |
|---|---|
Formation and subsequent excision of O6-ethylguanine from DNA of rat liver following administration of diethylnitrosamine.
Topics: Alkylation; Animals; Diethylnitrosamine; DNA; Female; Guanine; In Vitro Techniques; Liver; Nitrosamines; Rats; Time Factors | 1979 |
Effect of chronic N,N-diethylnitrosamine on the excision of O6-ethylguanine from rat liver DNA.
Topics: Adenine; Alkylation; Animals; Diethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Male; Nitrosamines; Rats | 1979 |
Structural consequences of a carcinogenic alkylation lesion on DNA: effect of O6-ethylguanine on the molecular structure of the d(CGC[e6G]AATTCGCG)-netropsin complex.
Topics: Alkylation; Base Composition; Base Sequence; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallization; DNA; Guanine; Hydrogen Bonding; Molecular Sequence Data; Molecular Structure; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; X-Ray Diffraction | 1992 |
Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342.
Topics: Base Composition; Base Sequence; Benzimidazoles; Bisbenzimidazole; DNA; Fluorescent Dyes; Guanine; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation | 1992 |
Re: S. M. Bronstein et al. Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells. Cancer Res., 52: 2008-2011, 1992.
Topics: Cells, Cultured; DNA Repair; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine | 1992 |
Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.
Topics: B-Lymphocytes; Cell Line; DNA Repair; Ethylnitrosourea; Guanine; Humans; Kinetics; Methyltransferases; Models, Biological; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidine Dimers; Substrate Specificity; Thymine; Time Factors | 1992 |
Modulation of ethylnitrosourea-induced toxicity and mutagenicity in human cells by O6-benzylguanine.
Topics: Alkylation; Cell Line, Transformed; Cell Survival; DNA Repair; Ethylnitrosourea; Guanine; Humans; Lymphocytes; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1992 |
Monoclonal antibody-mediated solid-phase assay for mammalian O6-alkylguanine DNA alkyltransferase activity.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; DNA; Guanine; Immunoblotting; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tritium | 1991 |
Novel, sensitive assays for O6-alkylguanine and its repair and their application to studies of the molecular epidemiology of this lesion in human populations.
Topics: DNA Damage; DNA Repair; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1991 |
[Effect of X-rays combined with ACNU and O6-ethylguanine on rat subcutaneous gliomas].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Combined Modality Therapy; Glioma; Guanine; Male; Neoplasm Transplantation; Nimustine; Rats; Rats, Inbred Strains; Skin Neoplasms; Tumor Cells, Cultured | 1991 |
Theoretical and experimental measures of DNA helix stability and their relation to sequence specific repair of O6-ethylguanine lesions.
Topics: Base Sequence; DNA Damage; DNA Repair; DNA, Bacterial; Escherichia coli; Ethyl Methanesulfonate; Guanine; Kinetics; Molecular Sequence Data; Nucleic Acid Conformation; Thermodynamics | 1991 |
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea.
Topics: Animals; Carmustine; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; DNA; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1990 |
The role of nucleotide pool alkylation in the induction of numerical chromosome aberrations.
Topics: Adenosine Deaminase; Alkylation; Aneuploidy; Chromosome Aberrations; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Nucleotides; Purine-Nucleoside Phosphorylase | 1989 |
Immunocytochemical analysis of O6-alkylguanine shows tissue specific formation in and removal from esophageal and liver DNA in rats treated with methylbenzylnitrosamine, dimethylnitrosamine, diethylnitrosamine and ethylnitrosourea.
Topics: Animals; Carcinogens; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; DNA Repair; Esophagus; Ethylnitrosourea; Female; Guanine; Immunoenzyme Techniques; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Substrate Specificity | 1989 |
A novel, sensitive assay for O6-methyl- and O6-ethylguanine in DNA, based on repair by the enzyme O6-alkylguanine-DNA-alkyltransferase in competition with an oligonucleotide containing O6-methylguanine.
Topics: Animals; DNA; DNA Damage; DNA Repair; Escherichia coli; Guanine; In Vitro Techniques; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotides; Radioimmunoassay; Rats; Rats, Inbred Strains | 1989 |
Purification of the E. coli ogt gene product to homogeneity and its rate of action on O6-methylguanine, O6-ethylguanine and O4-methylthymine in dodecadeoxyribonucleotides.
Topics: Alkylating Agents; Amino Acids; Chromatography, High Pressure Liquid; Deoxyribonucleotides; DNA Repair; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Genes, Bacterial; Guanine; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine | 1989 |
O6-ethylguanine carcinogenic lesions in DNA: an NMR study of O6etG.T pairing in dodecanucleotide duplexes.
Topics: Base Composition; Base Sequence; Carcinogens; DNA; Guanine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Thymine | 1989 |
Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.
Topics: Animals; Base Sequence; Cell Line; Chromosomes; DNA Repair; Genetic Vectors; Guanine; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Polymerase Chain Reaction; Transfection | 1989 |
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.
Topics: Alkylation; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Kinetics; Methylnitrosourea; Mutation; Thymine | 1988 |
Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanine.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; DNA Repair; Drug Resistance; Guanine; Methyltransferases; Nimustine; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1987 |
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Diethylnitrosamine; DNA; Flavonoids; Guanine; Indoles; Liver; Liver Neoplasms; Polychlorinated Biphenyls; Salmonidae; Trout | 1988 |
Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure.
Topics: Animals; Chromatography, High Pressure Liquid; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Trout; Water | 1988 |
Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli.
Topics: Base Sequence; DNA Repair; Escherichia coli; Ethylnitrosourea; Guanine; Methylnitronitrosoguanidine; Mutation; Thymine | 1988 |
Repair of synthetic oligonucleotides containing O6-methylguanine, O6-ethylguanine and O4-methylthymine, by O6-alkylguanine-DNA alkyltransferase.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Repair; Escherichia coli; Guanine; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine | 1987 |
Cytogenetic effects induced by alkylated guanine in mammalian cells.
Topics: Animals; Cell Line; Cell Nucleus; Chromosome Aberrations; Guanine; Humans; Lymphocytes; Mutagenicity Tests; Mutagens; Ploidies; Sulfuric Acid Esters | 1986 |
Distribution of O6-ethylguanine in DNA exposed to ethylnitrosourea in vitro as visualized by electron microscopy using a monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; DNA; DNA Damage; Ethylnitrosourea; Guanine; Microscopy, Electron; Rats; Software | 1988 |
Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo.
Topics: Animals; Brain; Cell Nucleus; DNA Repair; DNA, Mitochondrial; Ethylnitrosourea; Guanine; Kidney; Kinetics; Male; Mitochondria; Mitochondria, Liver; Rats; Rats, Inbred Strains; Thymidine | 1988 |
Enzymatic elimination of O6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell culture versus in vivo conditions.
Topics: Animals; Brain Neoplasms; DNA; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Rats; Tumor Cells, Cultured | 1988 |
A theoretical study of the effect of methylation or ethylation at O6-guanine in the structure and energy of DNA double strands.
Topics: Alkylation; Base Sequence; Chemical Phenomena; Chemistry, Physical; Computer Simulation; DNA; Guanine; Hydrogen Bonding; Methylation; Molecular Conformation; Structure-Activity Relationship; Thermodynamics | 1988 |
Action of phenobarbital given to rats together with diethylnitrosamine on the O6-ethylguanine content of liver DNA.
Topics: Animals; Diethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
[Effect of molybdenum Mo on the alkylation of DNA in the liver of rats treated with 14C-diethylnitrosamine].
Topics: Alkylation; Animals; Carbon Radioisotopes; Diethylnitrosamine; DNA; Guanine; Liver; Male; Molybdenum; Rats | 1987 |
Synthesis and structural studies by nuclear magnetic resonance of dodecadeoxynucleotides containing O6-methylguanine, O6-ethylguanine and O4-methylthymine.
Topics: Guanine; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Thymine | 1987 |
DNA ethylation in hamster tissues during subchronic diethylnitrosamine administration and in the hamster trachea after acute diethylnitrosamine administration.
Topics: Alkylation; Animals; Cricetinae; Diethylnitrosamine; DNA; Guanine; Liver; Lung; Male; Mesocricetus; Trachea; Tracheal Neoplasms | 1986 |
Comparative studies on hepatic DNA alkylation in rats by N-nitrosomethylethylamine and N-nitrosodimethylamine plus N-nitrosodiethylamine.
Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Male; Mathematics; Rats; Rats, Inbred F344 | 1986 |
Formation and accumulation of O6-ethylguanine in DNA of enriched populations of Clara cells, alveolar type II cells, and macrophages of hamsters exposed to diethylnitrosamine.
Topics: Alkylation; Animals; Cricetinae; Diethylnitrosamine; DNA; Guanine; Macrophages; Male; Mesocricetus; Pulmonary Alveoli | 1987 |
Quantitative comparison of genetic effects of ethylating agents on the basis of DNA adduct formation. Use of O6-ethylguanine as molecular dosimeter for extrapolation from cells in culture to the mouse.
Topics: Alkylating Agents; Animals; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; DNA; Environmental Exposure; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Lung; Methylnitronitrosoguanidine; Mice; Mutation; Structure-Activity Relationship; Sulfuric Acid Esters | 1985 |
The competitive miscoding of O6-methylguanine and O6-ethylguanine and the possible importance of cellular deoxynucleoside 5'-triphosphate pool sizes in mutagenesis and carcinogenesis.
Topics: Deoxyribonucleotides; DNA Polymerase I; DNA Replication; Guanine; Mutation; Templates, Genetic | 1986 |
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture.
Topics: Animals; Cells, Cultured; Clone Cells; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Neurons; Rats; Thymine | 1986 |
Differential formation of O6-ethylguanine in the DNA of rat brain chromatin fibers of different folding levels exposed to N-ethyl-N-nitrosourea in vitro.
Topics: Alkylation; Animals; Brain; Chromatin; DNA; Ethylnitrosourea; Guanine; In Vitro Techniques; Nitrosourea Compounds; Nucleosomes; Rats | 1985 |
Kinetics of formation and persistence of ethylguanines in DNA of rats and hamsters treated with diethylnitrosamine.
Topics: Alkylation; Animals; Cricetinae; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Kinetics; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mesocricetus; Nitrosamines; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.
Topics: Adenine; Alkylation; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Carcinogens; Cell Transformation, Neoplastic; Chromatography, Gel; DNA; DNA Replication; Guanine; Kinetics; Liver; Nitrosourea Compounds; Purine Nucleosides; Rats | 1974 |
[The same alkyl acceptor acts in the repair of DNA containing O6-methylguanine or O6-ethylguanine].
Topics: Alkylation; Animals; Chromatin; DNA Repair; Guanine; Liver; Nucleoproteins; Rats | 1984 |
Similar rate of O6-ethylguanine elimination from DNA in normal human fibroblast and xeroderma pigmentosum cell strains not transformed by SV40.
Topics: Cell Line; Cell Transformation, Neoplastic; DNA; Fibroblasts; Guanine; Humans; Kinetics; Reference Values; Simian virus 40; Skin; Xeroderma Pigmentosum | 1983 |
Chromatin and DNA repair after treatment with simple alkylating agents; relation to carcinogenesis.
Topics: Alkylating Agents; Alkylation; Animals; Chromatin; DNA Repair; Endonucleases; Guanine; Humans; Liver; Neoplasms; Rats | 1983 |
Mutagenesis and O6-ethylguanine levels in DNA from N-nitroso-N-ethylurea-treated Salmonella typhimurium: evidence for a high mutational efficiency of O6-ethylguanine.
Topics: DNA, Bacterial; Ethylnitrosourea; Guanine; Mutagenicity Tests; Mutagens; Mutation; Nitrosourea Compounds; Salmonella typhimurium | 1984 |
Repair of O6-ethylguanine DNA lesions in isolated cell nuclei. Presence of the activity in the chromatin proteins.
Topics: Animals; Cell Nucleus; Chemical Phenomena; Chemistry; Chromatin; Chromatography, Paper; Diethylnitrosamine; DNA Repair; Ethylnitrosourea; Guanine; Liver; Male; Rats; Rats, Inbred Strains | 1983 |
Properties of the chromatin repair activity against O6-ethylguanine lesions in DNA. Mechanism of the reaction.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Chromatin; DNA Repair; Guanine; Liver; Rats; Temperature; Thymus Gland | 1983 |
Elimination of O6-ethylguanine from the DNA of brain, liver, and other rat tissues exposed to ethylnitrosourea at different stages of prenatal development.
Topics: Animals; Brain; DNA; Ethylnitrosourea; Female; Fetus; Guanine; Kinetics; Liver; Male; Nitrosourea Compounds; Pregnancy; Rats | 1983 |
Repair of O6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein.
Topics: Animals; Chromatin; Cysteine; DNA; DNA Repair; Guanine; Liver; Peptide Fragments; Proteins; Rats | 1981 |
A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA.
Topics: Alkylating Agents; DNA Repair; Escherichia coli; Guanine; Mutagens; Mutation | 1982 |
A common chromatin factor involved in the repair of O6-methylguanine and O6-ethylguanine lesions in DNA.
Topics: Alkylation; Animals; Chromatin; DNA Repair; Guanine; Liver; Rats | 1982 |
Retention of promutagenic O6-ethylguanine in the DNA of various rat tissues following transplacental inoculation with ethylnitrosourea.
Topics: Alkylation; Animals; Brain; DNA; DNA Replication; Ethylnitrosourea; Female; Guanine; Kidney; Liver; Maternal-Fetal Exchange; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats | 1980 |
Enzymatic synthesis of double-stranded DNA containing radioactively labeled O(6)-ethylguanine as the only modified base.
Topics: DNA; DNA Polymerase I; DNA Replication; Guanine; Isotope Labeling; Kinetics | 1981 |
A chromatin factor in rat liver which destroys O6-ethylguanine in DNA.
Topics: Animals; Cattle; Chromatin; DNA; DNA Repair; Guanine; Liver; Nucleoproteins; Rats | 1980 |
Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea.
Topics: Adenine; Animals; Base Composition; Base Sequence; Carcinogens; DNA Adducts; DNA, Complementary; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Male; Molecular Sequence Data; Mutagenesis; Point Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred Lew; T-Lymphocytes; Thioguanine; Thymidine | 1995 |
Biochemical events during initiation of rat hepatocarcinogenesis.
Topics: Animals; Cell Division; Diethylnitrosamine; DNA; Glutathione Transferase; Guanine; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344 | 1994 |
Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.
Topics: Acute Disease; Carmustine; Cyclophosphamide; Cytarabine; DNA Repair; Doxorubicin; Drug Resistance; Ethylnitrosourea; Glutathione; Guanine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Lymphocytes; Treatment Outcome | 1994 |
Response of repair-competent and repair-deficient Escherichia coli to three O6-substituted guanines and involvement of methyl-directed mismatch repair in the processing of O6-methylguanine residues.
Topics: Base Sequence; Codon; DNA Repair; DNA Replication; Escherichia coli; Genes, Bacterial; Guanine; Methyltransferases; Models, Genetic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Plasmids | 1994 |
Mutagenesis of H-ras codons 11 and 12 in human fibroblasts by N-ethyl-N-nitrosourea.
Topics: Base Sequence; Codon; Ethylnitrosourea; Fibroblasts; Genes, ras; Guanine; Humans; Molecular Sequence Data; Point Mutation; Polymorphism, Restriction Fragment Length | 1993 |
Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA.
Topics: Animals; Bacterial Proteins; Base Sequence; DNA; DNA Repair; Escherichia coli; Escherichia coli Proteins; Guanine; Humans; Kinetics; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats; Substrate Specificity; Transcription Factors | 1994 |
Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat.
Topics: Alkylation; Animals; Carcinoma, Hepatocellular; Cell Line; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Gene Expression; Guanine; Liver Neoplasms; Mutagenesis; Rats; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
Topics: Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Codon; DNA Damage; DNA Repair; Genes, ras; Guanine; Methyltransferases; Molecular Sequence Data; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Transfection | 1993 |
O6-ethylguanine and O6-benzylguanine incorporated site-specifically in codon 12 of the rat H-ras gene induce semi-targeted as well as targeted mutations in Rat4 cells.
Topics: Animals; Base Sequence; Cell Line; Cell Line, Transformed; Clone Cells; Codon; DNA; Genes, ras; Guanine; Molecular Sequence Data; Mutation; Rats | 1996 |
Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context.
Topics: Base Sequence; DNA; DNA Repair; Guanine; Humans; Kinetics; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Recombinant Proteins; Sodium | 1996 |
Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability.
Topics: Alkylating Agents; Animals; Cyclic GMP; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose; Guanine; Insulin; Islets of Langerhans; Methyl Methanesulfonate; Methylnitrosourea; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 1995 |
Formation of O6-ethylguanine in spermatogonial DNA of adult Syrian golden hamster by intraperitoneal injection of diethylnitrosamine.
Topics: Animals; Biotransformation; Cricetinae; Diethylnitrosamine; DNA; DNA Adducts; Guanine; Injections, Intraperitoneal; Male; Mesocricetus; Spermatogonia | 1995 |
Diethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit some non-linearities.
Topics: Alkylating Agents; Alkylation; Animals; Cell Division; Diethylnitrosamine; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Guanine; Liver Neoplasms; Male; Rats; Rats, Inbred F344 | 1996 |
Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of lambda(lacZ) transgenic mice treated with N-ethyl-N-nitrosourea.
Topics: Animals; Bacteriophage lambda; Brain; DNA; DNA Repair; Ethylnitrosourea; Female; Genome; Guanine; Immunoblotting; Lac Operon; Liver; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Polymerase Chain Reaction; Sensitivity and Specificity | 1996 |
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
DNA adducts, mutant frequencies, and mutation spectra in various organs of lambda lacZ mice exposed to ethylating agents.
Topics: Animals; Bone Marrow; Brain; Diethylnitrosamine; DNA Adducts; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Guanine; Lac Operon; Liver; Mice; Mice, Transgenic; Mutagens | 1998 |
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Topics: Alkylation; Animals; Animals, Genetically Modified; DNA Adducts; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Transcription, Genetic | 1998 |
Formation and persistence of the miscoding DNA alkylation product O6-ethylguanine in male germ cells of the hamster.
Topics: Animals; Antibodies, Monoclonal; Carcinogens; Cricetinae; Diethylnitrosamine; DNA; DNA Adducts; DNA Damage; DNA Repair; Ethylnitrosourea; Fluorescent Antibody Technique, Indirect; Guanine; Male; Mesocricetus; Spermatogonia | 1997 |
DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Nucleus; Chlorambucil; Cyclophosphamide; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Ethylnitrosourea; Guanine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Prednisone; Vincristine | 1997 |
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Carcinogens; DNA; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutagens; Mutation; Rats | 2000 |
Induction of apoptosis and inhibition of signalling pathways by alkylated purines.
Topics: Adenine; Alkylation; Androstadienes; Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Line; Cricetinae; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Fibroblasts; G1 Phase; Genes, p53; Guanine; MAP Kinase Signaling System; Mutation; Phosphorylation; Purines; Resting Phase, Cell Cycle; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Repair of ethylnitrosourea-induced DNA damage in the newborn rat. I. Alkali-labile lesions and in situ breaks.
Topics: Adenine; Alkylating Agents; Animals; Animals, Newborn; Brain; DNA; DNA Damage; DNA Repair; Ethylnitrosourea; Female; Guanine; Hydrogen-Ion Concentration; Kidney; Liver; Lung; Male; Rats; Rats, Sprague-Dawley; Sodium Hydroxide | 1980 |
Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.
Topics: Base Pair Mismatch; Colonic Neoplasms; Escherichia coli; Genetic Vectors; Guanine; Humans; Kidney; Lac Operon; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Transfection | 2001 |
Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes.
Topics: Aged; DNA Repair Enzymes; Ethylnitrosourea; Female; Guanine; Humans; Lymphocytes; Male; Metabolic Detoxication, Phase II; Middle Aged; Polymorphism, Genetic; Xenobiotics | 2007 |
Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow.
Topics: Animals; Bone Marrow; Chromosomal Instability; Chromosome Aberrations; Comet Assay; DNA Adducts; DNA Repair; Ethylnitrosourea; Guanine; Male; Micronucleus Tests; Niacin; Rats; Rats, Long-Evans | 2007 |
Combining molecular docking and 3-D pharmacophore generation to enclose the in vivo antigenotoxic activity of naturally occurring aromatic compounds: myricetin, quercetin, rutin, and rosmarinic acid.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Binding Sites; Catalytic Domain; Cinnamates; Depsides; DNA Damage; Drosophila melanogaster; Ethyl Methanesulfonate; Flavonoids; Guanine; Male; Molecular Docking Simulation; Monte Carlo Method; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Quercetin; Rosmarinic Acid; Rutin; Thymine | 2013 |