Page last updated: 2024-09-03

6-deoxyerythronolide b and erythromycin

6-deoxyerythronolide b has been researched along with erythromycin in 69 studies

Compound Research Comparison

Studies (6-deoxyerythronolide b)	Trials (6-deoxyerythronolide b)	Recent Studies (post-2010) (6-deoxyerythronolide b)	Studies (erythromycin)	Trials (erythromycin)	Recent Studies (post-2010) (erythromycin)
73	0	15	14,524	1,138	1,926

Protein Interaction Comparison

Protein	Taxonomy	erythromycin (IC50)
30S ribosomal protein S6	Escherichia coli K-12	1.156
30S ribosomal protein S7	Escherichia coli K-12	1.156
50S ribosomal protein L15	Escherichia coli K-12	1.156
Cytochrome P450 3A4	Homo sapiens (human)	1.045
50S ribosomal protein L10	Escherichia coli K-12	1.156
50S ribosomal protein L11	Escherichia coli K-12	1.156
50S ribosomal protein L7/L12	Escherichia coli K-12	1.156
50S ribosomal protein L19	Escherichia coli K-12	1.156
50S ribosomal protein L1	Escherichia coli K-12	1.156
50S ribosomal protein L20	Escherichia coli K-12	1.156
50S ribosomal protein L27	Escherichia coli K-12	1.156
50S ribosomal protein L28	Escherichia coli K-12	1.156
50S ribosomal protein L29	Escherichia coli K-12	1.156
50S ribosomal protein L31	Escherichia coli K-12	1.156
50S ribosomal protein L31 type B	Escherichia coli K-12	1.156
50S ribosomal protein L32	Escherichia coli K-12	1.156
50S ribosomal protein L33	Escherichia coli K-12	1.156
50S ribosomal protein L34	Escherichia coli K-12	1.156
50S ribosomal protein L35	Escherichia coli K-12	1.156
50S ribosomal protein L36	Escherichia coli K-12	1.156
30S ribosomal protein S10	Escherichia coli K-12	1.156
30S ribosomal protein S11	Escherichia coli K-12	1.156
30S ribosomal protein S12	Escherichia coli K-12	1.156
30S ribosomal protein S13	Escherichia coli K-12	1.156
30S ribosomal protein S16	Escherichia coli K-12	1.156
30S ribosomal protein S18	Escherichia coli K-12	1.156
30S ribosomal protein S19	Escherichia coli K-12	1.156
30S ribosomal protein S20	Escherichia coli K-12	1.156
30S ribosomal protein S2	Escherichia coli K-12	1.156
30S ribosomal protein S3	Escherichia coli K-12	1.156
30S ribosomal protein S4	Escherichia coli K-12	1.156
30S ribosomal protein S5	Escherichia coli K-12	1.156
30S ribosomal protein S8	Escherichia coli K-12	1.156
30S ribosomal protein S9	Escherichia coli K-12	1.156
50S ribosomal protein L13	Escherichia coli K-12	1.156
50S ribosomal protein L14	Escherichia coli K-12	1.156
50S ribosomal protein L16	Escherichia coli K-12	1.156
50S ribosomal protein L23	Escherichia coli K-12	1.156
30S ribosomal protein S15	Escherichia coli K-12	1.156
50S ribosomal protein L17	Escherichia coli K-12	1.156
50S ribosomal protein L21	Escherichia coli K-12	1.156
50S ribosomal protein L30	Escherichia coli K-12	1.156
50S ribosomal protein L6	Escherichia coli K-12	1.156
30S ribosomal protein S14	Escherichia coli K-12	1.156
30S ribosomal protein S17	Escherichia coli K-12	1.156
30S ribosomal protein S1	Escherichia coli K-12	1.156
50S ribosomal protein L18	Escherichia coli K-12	1.156
50S ribosomal protein L2	Escherichia coli K-12	1.156
50S ribosomal protein L3	Escherichia coli K-12	1.156
50S ribosomal protein L24	Escherichia coli K-12	1.156
50S ribosomal protein L4	Escherichia coli K-12	1.156
50S ribosomal protein L22	Escherichia coli K-12	1.156
50S ribosomal protein L5	Escherichia coli K-12	1.156
30S ribosomal protein S21	Escherichia coli K-12	1.156
50S ribosomal protein L25	Escherichia coli K-12	1.156
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	0.039
50S ribosomal protein L36 2	Escherichia coli K-12	1.156

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.90)	18.7374
1990's	16 (23.19)	18.2507
2000's	33 (47.83)	29.6817
2010's	17 (24.64)	24.3611
2020's	1 (1.45)	2.80

Authors

Authors	Studies
Donadio, S; Katz, L	1
Donadio, S; Katz, L; McAlpine, JB; Staver, MJ; Swanson, SJ	1
Hutchinson, CR; Shafiee, A	1
Corcoran, JW; Vygantas, AM	1
Cane, DE; Khosla, C; Luo, G; Pieper, R	1
Cupp-Vickery, JR; Poulos, TL	1
Cupp-Vickery, JR; Li, H; Poulos, TL	1
Kao, CM; Katz, L; Khosla, C	1
Cane, DE; Kao, CM; Khosla, C; Pieper, R	1
Cane, DE; Hutchinson, CR; Jacobsen, JR; Khosla, C	1
Goo, YM; Ju, J	1
Cane, DE; Chuck, JA; Huang, H; Jacobsen, JR; Khosla, C; McPherson, M	1
Cane, DE; Jacobsen, JR; Khosla, C	1
Cortés, J; Gaisser, S; Leadlay, PF; Rowe, CJ; Staunton, J	1
Cane, DE; Jacobsen, JR; Keatinge-Clay, AT; Khosla, C	1
Betlach, MC; Ziermann, R	1
Cane, DE; Fu, H; Khosla, C; Lau, J	1
Ashley, G; Hutchinson, CR; Santi, DV; Xue, Q	1
Blackaby, AP; Böhm, IU; Buss, AD; Cooper, DJ; Cortés, J; Dawson, MJ; Foster, G; Gaisser, S; Leadlay, PF; Rowe, CJ; Rudd, BA; Sidebottom, PJ; Staunton, J; Taylor, NL; Wilkinson, B	1
Ortiz De Montellano, PR; Tschirret-Guth, RA; Xiang, H	1
Admiraal, SJ; Cane, DE; Gramajo, H; Khosla, C; Pfeifer, BA	1
Ferber, D	1
Cane, DE; Khosla, C; Tsuji, SY	1
Han, O; Kim, C; Kim, H	1
Cane, DE; Gokhale, R; Khosla, C; Yin, Y	1
Ashley, G; Burlingame, M; Cadapan, L; Carney, J; Carreras, C; Frykman, S; Leaf, T; Licari, P; Ou, S; Patel, S; Woo, E; Zavala, S	1
Gauges, R; Lounnas, V; Lüdemann, SK; Wade, RC; Winn, PJ	1
Gaisser, S; Leadlay, PF; Lill, R; Méndez, C; Salas, J; Staunton, J	1
Hu, Z; Khosla, C; Licari, P; Pfeifer, B	1
Paterson, I; Temal-Laïb, T	1
Gates, P; Roddis, M; Roddis, Y; Staunton, J	1
Cane, DE; Khosla, C; Lu, H; Stroud, RM; Tsai, SC	1
Carney, JR; Dayem, LC; Kealey, JT; Kennedy, J; Murli, S	1
Ashley, G; Carney, JR; Chao, E; Hu, Z; Hutchinson, CR; Kealey, J; Khosla, C; Murli, S; Pfeifer, BA	1
Kealey, JT; Kennedy, J; Murli, S	1
Kealey, JT; Kennedy, J	1
Galazzo, J; Lau, J; Licari, P; Tran, C	1
Ashley, GW; Carney, JR	1
Hutchinson, CR; McDaniel, R; Murli, S; Piagentini, M	1
Ashley, GW; Dong, SD; Hu, Z; Kealey, JT; Kennedy, J; MacMillan, KS; Murli, S; Reeves, CD	1
Broadbelt, LJ; González-Lergier, J; Hatzimanikatis, V	1
Crimmins, MT; Slade, DJ	1
Desai, RP; Gramajo, H; Hu, Z; Katz, L; Ward, SL	1
Cane, DE; Chen, AY; Khosla, C; Schnarr, NA; Tang, Y	1
Boddy, CN; Sharma, KK	1
Boghigian, BA; Pfeifer, BA; Wang, Y	1
Pfeifer, BA; Wang, Y	1
Keatinge-Clay, A	1
Khosla, C	1
Boghigian, BA; Pfeifer, BA; Zhang, H	2
Boghigian, BA; Myint, M; Pfeifer, BA; Wu, J; Zhang, H; Zhang, S	1
Cane, DE; Chen, AY; Kapur, S; Khosla, C	1
Boghigian, B; Pfeifer, BA; Wang, Y; Zhang, H	1
Stang, EM; White, MC	1
Boghigian, BA; Myint, M; Pfeifer, BA; Wu, J	1
Cane, DE; Kapur, S; Khosla, C; Yuzawa, S	1
Boddy, CN; Horsman, M; Pinto, A; Wang, M	1
Fan, Q; He, Z; Huang, F; Shi, M; Wang, D; Wang, Y; Ye, B; Zhao, Z	1
Gao, X; Krische, MJ; Woo, SK	1
Dechert-Schmitt, AM; Gao, X; Itoh, T; Krische, MJ; Schmitt, DC	1
Chen, D; Duan, Y; Feng, J; Huang, L; Wu, J; Xu, Z; Zhang, Q; Zhu, X	1
Lv, HJ; Song, SJ; Wang, JF; Wang, Y; Xiong, ZQ; Yang, J	1
Amin, MA; Ashford, DA; El Gazayerly, ON; Fayed, B; Gregory, MA; Hashem, AM; Smith, MC	1
Fang, L; Kumpfmüller, J; Lalk, M; Methling, K; Pfeifer, BA; Schweder, T	1
Argyropoulos, P; Bergeret, F; Boddy, CN; Pardin, C; Pinto, A; Reimer, JM; Schmeing, TM	1
Meng, HL; Song, SJ; Wang, J; Wang, Y; Xiong, ZQ	1
Craik, CS; Hsu, J; Khosla, C; La Greca, F; Li, X; Mathews, II; Matsui, T; Sevillano, N	1
Brodsky, KL; Cogan, DP; Craik, CS; Guzman, KM; Khosla, C; Li, X; Mathews, II; Nguyen, KP; Sevillano, N; Soohoo, AM	1

Reviews

3 review(s) available for 6-deoxyerythronolide b and erythromycin

Article	Year
Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual review of biochemistry, 2007, Volume: 76 Topics: Amino Acid Sequence; Erythromycin; Isoenzymes; Models, Molecular; Molecular Sequence Data; Molecular Structure; Polyketide Synthases; Protein Conformation; Sequence Alignment; Substrate Specificity	2007
Structures and mechanisms of polyketide synthases. The Journal of organic chemistry, 2009, Sep-04, Volume: 74, Issue:17 Topics: Anthraquinones; Anti-Bacterial Agents; Bacteria; Catalysis; Erythromycin; Genetic Techniques; Models, Biological; Models, Chemical; Molecular Conformation; Molecular Structure; Polyketide Synthases	2009
Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition. Natural product reports, 2014, Volume: 31, Issue:4 Topics: Biological Products; Bridged Bicyclo Compounds, Heterocyclic; Bryostatins; Catalysis; Erythromycin; Humans; Hydrogenation; Macrolides; Molecular Structure; Polyketides; Rifamycins; Stereoisomerism	2014

Other Studies

66 other study(ies) available for 6-deoxyerythronolide b and erythromycin

Article	Year
Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. Gene, 1992, Feb-01, Volume: 111, Issue:1 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acyl Carrier Protein; Acyltransferases; Amino Acid Sequence; Animals; Biological Evolution; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Erythromycin; Esterases; Hydro-Lyases; Ketone Oxidoreductases; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Oxidoreductases; Saccharopolyspora; Sequence Alignment	1992
Modular organization of genes required for complex polyketide biosynthesis. Science (New York, N.Y.), 1991, May-03, Volume: 252, Issue:5006 Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; DNA, Bacterial; Erythromycin; Genes, Bacterial; Gram-Positive Bacteria; Hydroxylation; Models, Molecular; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Mutation; Nucleic Acid Hybridization; Repetitive Sequences, Nucleic Acid	1991
Macrolide antibiotic biosynthesis: isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus). Biochemistry, 1987, Sep-22, Volume: 26, Issue:19 Topics: Amino Acids; Anti-Bacterial Agents; Bacterial Proteins; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Epitopes; Erythromycin; Isoenzymes; Kinetics; Mixed Function Oxygenases; Molecular Weight; Spectrophotometry; Streptomyces	1987
Accumulation of 6-deoxyerythronolide B in a normal strain of Streptomyces erythreus and hydroxylation at carbon 6 of the erythranolide ring system by a soluble noninduced cell-free enzyme system. Biochemistry, 1982, Jan-19, Volume: 21, Issue:2 Topics: Cell-Free System; Cytochrome P-450 Enzyme System; Erythromycin; Fatty Acids; Hydroxylation; Lactones; Mixed Function Oxygenases; NADP; Streptomyces	1982
Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. Nature, 1995, Nov-16, Volume: 378, Issue:6554 Topics: Amino Acid Sequence; Cell-Free System; Erythromycin; Molecular Sequence Data; Multienzyme Complexes; Pyrones; Recombinant Proteins; Sequence Deletion; Streptomyces	1995
Structure of cytochrome P450eryF involved in erythromycin biosynthesis. Nature structural biology, 1995, Volume: 2, Issue:2 Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Camphor 5-Monooxygenase; Catalysis; Cytochrome P-450 Enzyme System; Erythromycin; Hydrogen Bonding; Hydroxylation; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Oxygen; Protein Binding; Protein Conformation; Protein Structure, Secondary; Sequence Alignment; Sequence Homology, Amino Acid	1995
Preliminary crystallographic analysis of an enzyme involved in erythromycin biosynthesis: cytochrome P450eryF. Proteins, 1994, Volume: 20, Issue:2 Topics: Amino Acid Sequence; Bacterial Proteins; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Erythromycin; Escherichia coli; Mixed Function Oxygenases; Molecular Sequence Data; Recombinant Proteins; Saccharopolyspora; Sequence Homology, Amino Acid	1994
Engineered biosynthesis of a complete macrolactone in a heterologous host. Science (New York, N.Y.), 1994, Jul-22, Volume: 265, Issue:5171 Topics: Acyl Coenzyme A; Base Sequence; Binding Sites; Cloning, Molecular; Drug Design; Erythromycin; Escherichia coli; Genes, Bacterial; Genetic Engineering; Genetic Vectors; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Mutation; Oleandomycin; Recombinant Proteins; Streptomyces; Structure-Activity Relationship	1994
Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase. Biochemistry, 1996, Sep-24, Volume: 35, Issue:38 Topics: Acyl Carrier Protein; Binding Sites; Dimerization; Electrophoresis, Polyacrylamide Gel; Erythromycin; Fatty Acid Synthases; Genetic Complementation Test; Molecular Structure; Multienzyme Complexes; Mutagenesis, Site-Directed; Protein Conformation; Streptomyces	1996
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science (New York, N.Y.), 1997, Jul-18, Volume: 277, Issue:5324 Topics: Amino Acid Substitution; Bacillus cereus; Binding Sites; Catalysis; Cyclization; Erythromycin; Microbial Sensitivity Tests; Multienzyme Complexes; Mutagenesis, Site-Directed; Saccharopolyspora; Streptomyces; Transformation, Genetic	1997
8-Deoxylankolide from a lankamycin producing Streptomyces spp. The Journal of antibiotics, 1997, Volume: 50, Issue:8 Topics: Anti-Bacterial Agents; Erythromycin; Microbial Sensitivity Tests; Streptomyces; Structure-Activity Relationship	1997
Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. Chemistry & biology, 1997, Volume: 4, Issue:10 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Catalysis; Erythromycin; Multienzyme Complexes; Peptide Chain Elongation, Translational; Protein Engineering; Protein Structure, Tertiary; Stereoisomerism; Substrate Specificity; Thiolester Hydrolases	1997
Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. Biochemistry, 1998, Apr-07, Volume: 37, Issue:14 Topics: Amino Acid Sequence; Erythromycin; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Multienzyme Complexes; Recombinant Proteins; Reference Standards	1998
Construction of new vectors for high-level expression in actinomycetes. Gene, 1998, Aug-17, Volume: 216, Issue:1 Topics: Actinomycetales; Anti-Bacterial Agents; DNA, Recombinant; Erythromycin; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Engineering; Genetic Vectors; Multienzyme Complexes; Plasmids; Recombinant Fusion Proteins; Saccharopolyspora; Thiolester Hydrolases	1998
Precursor-directed biosynthesis of 12-ethyl erythromycin. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:8 Topics: Anti-Bacterial Agents; Erythromycin; Multienzyme Complexes; Mutation; Saccharopolyspora; Streptomyces	1998
Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. BioTechniques, 1999, Volume: 26, Issue:1 Topics: DNA Methylation; DNA, Bacterial; Erythromycin; Genetic Engineering; Multienzyme Complexes; Plasmids; Recombinant Proteins; Streptomyces; Transformation, Genetic	1999
Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. Biochemistry, 1999, Feb-02, Volume: 38, Issue:5 Topics: Acyl Coenzyme A; Acyltransferases; Amino Acid Sequence; Erythromycin; Escherichia coli; Isoenzymes; Molecular Sequence Data; Multienzyme Complexes; Plasmids; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sirolimus; Stereoisomerism; Streptomyces; Substrate Specificity; Thiolester Hydrolases	1999
A multiplasmid approach to preparing large libraries of polyketides. Proceedings of the National Academy of Sciences of the United States of America, 1999, Oct-12, Volume: 96, Issue:21 Topics: Anti-Bacterial Agents; Combinatorial Chemistry Techniques; Drug Resistance, Microbial; Erythromycin; Genotype; Models, Chemical; Multienzyme Complexes; Mutagenesis, Insertional; Peptide Library; Plasmids; Polyenes; Recombinant Fusion Proteins; RNA, Messenger; Streptomyces	1999
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. Chemistry & biology, 2000, Volume: 7, Issue:2 Topics: Anti-Bacterial Agents; Erythromycin; Multienzyme Complexes; Multigene Family; Mutation; Peptide Chain Elongation, Translational; Protein Biosynthesis; Saccharopolyspora	2000
An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. The Journal of biological chemistry, 2000, Nov-17, Volume: 275, Issue:46 Topics: Amino Acid Substitution; Bacterial Proteins; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deuterium; Erythromycin; Hydrogen Peroxide; Hydroxylation; Kinetics; Ligands; Mixed Function Oxygenases; Molecular Structure; Mutation; Oxidants; Protein Binding; Saccharopolyspora; Spectrophotometry; Substrate Specificity; Testosterone; Threonine	2000
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science (New York, N.Y.), 2001, Mar-02, Volume: 291, Issue:5509 Topics: Acyl Coenzyme A; Bacterial Proteins; Cloning, Molecular; Erythromycin; Escherichia coli; Multienzyme Complexes; Promoter Regions, Genetic; Recombinant Fusion Proteins; Saccharopolyspora; Transferases (Other Substituted Phosphate Groups); Transformation, Bacterial	2001
Microbiology. Possible new route to polyketide synthesis. Science (New York, N.Y.), 2001, Mar-02, Volume: 291, Issue:5509 Topics: Acyl Coenzyme A; Bacillus subtilis; Erythromycin; Escherichia coli; Genetic Engineering; Multienzyme Complexes; Pantetheine; Patents as Topic; Protein Engineering; Recombinant Proteins; Saccharopolyspora	2001
Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. Biochemistry, 2001, Feb-27, Volume: 40, Issue:8 Topics: Amino Acid Sequence; Circular Dichroism; Cyclohexanones; Disaccharides; Erythromycin; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Peptide Fragments; Protein Engineering; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Thiolester Hydrolases	2001
The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:4 Topics: Bacterial Proteins; Chromatography, Gas; Cytochrome P-450 Enzyme System; Erythromycin; Hydrogen Peroxide; Hydroxylation; Indicators and Reagents; Kinetics; Mixed Function Oxygenases; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Serine; Spectrophotometry, Ultraviolet	2001
Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. Bioorganic & medicinal chemistry letters, 2001, Jun-18, Volume: 11, Issue:12 Topics: Bacteria; Catalytic Domain; Deuterium; Erythromycin; Gas Chromatography-Mass Spectrometry; Multienzyme Complexes; NADP; Oxidation-Reduction; Protein Structure, Tertiary; Substrate Specificity	2001
Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins. Journal of biotechnology, 2002, Jan-18, Volume: 92, Issue:3 Topics: Bioreactors; Biotechnology; Biotransformation; Culture Media; Erythromycin; Kinetics; Molecular Structure; Multienzyme Complexes; Mutation; Plasmids; Saccharopolyspora; Streptomyces	2002
Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. Proceedings of the National Academy of Sciences of the United States of America, 2002, Apr-16, Volume: 99, Issue:8 Topics: Arginine; Bacterial Proteins; Binding Sites; Camphor; Camphor 5-Monooxygenase; Carbon; Cytochrome P-450 Enzyme System; Erythromycin; Hydrogen Bonding; Kinetics; Ligands; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; NADPH-Ferrihemoprotein Reductase; Oxygen; Protein Binding; Software; Substrate Specificity; Thermodynamics; Time Factors	2002
Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. Molecular microbiology, 2002, Volume: 44, Issue:3 Topics: Bacterial Proteins; Erythromycin; Macrolides; Nuclear Magnetic Resonance, Biomolecular; Oleandomycin; Operon; Oxidation-Reduction; Recombinant Fusion Proteins; Rhamnose; Saccharopolyspora; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity	2002
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. Applied and environmental microbiology, 2002, Volume: 68, Issue:7 Topics: Erythromycin; Escherichia coli; Fermentation	2002
Toward the combinatorial synthesis of polyketide libraries: asymmetric aldol reactions with alpha-chiral aldehydes on solid support. Organic letters, 2002, Jul-25, Volume: 4, Issue:15 Topics: Acetals; Aldehydes; Alkanes; Carbamates; Chemistry, Pharmaceutical; Combinatorial Chemistry Techniques; Erythromycin; Ketones; Lactones; Polymers; Pyrones; Stereoisomerism	2002
Structural elucidation studies on 14- and 16-membered macrolide aglycones by accurate-mass electrospray sequential mass spectrometry. Journal of the American Society for Mass Spectrometry, 2002, Volume: 13, Issue:7 Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Erythromycin; Fermentation; Fourier Analysis; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Multienzyme Complexes; Spectrometry, Mass, Electrospray Ionization	2002
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry, 2002, Oct-22, Volume: 41, Issue:42 Topics: Amino Acid Motifs; Amino Acid Sequence; Anti-Bacterial Agents; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Dimerization; Erythromycin; Hydrogen-Ion Concentration; Macrolides; Molecular Sequence Data; Multienzyme Complexes; Protein Structure, Tertiary; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity; Thiolester Hydrolases	2002
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. Journal of industrial microbiology & biotechnology, 2003, Volume: 30, Issue:8 Topics: Acyl Coenzyme A; Carbon Isotopes; Chromosomes, Bacterial; Erythromycin; Escherichia coli; Gene Expression Regulation, Bacterial; Industrial Microbiology; Intramolecular Transferases; Molecular Biology; Multienzyme Complexes; Plasmids; Propionates	2003
A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. Microbiology (Reading, England), 2003, Volume: 149, Issue:Pt 8 Topics: Base Sequence; DNA, Bacterial; Erythromycin; Fatty Acid Synthases; Gene Expression; Genes, Bacterial; Models, Chemical; Multienzyme Complexes; Saccharopolyspora; Streptomyces; Substrate Specificity; Thiolester Hydrolases	2003
6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. Biochemistry, 2003, Dec-09, Volume: 42, Issue:48 Topics: Acetoacetates; Acyl Coenzyme A; Bacterial Proteins; Bacteriocins; Butyrates; DNA Glycosylases; DNA-Binding Proteins; Erythromycin; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genetic Engineering; Multienzyme Complexes; Peptides; Plasmids; Racemases and Epimerases	2003
Tools for metabolic engineering in Escherichia coli: inactivation of panD by a point mutation. Analytical biochemistry, 2004, Apr-01, Volume: 327, Issue:1 Topics: Acyl Coenzyme A; Amino Acid Substitution; beta-Alanine; Erythromycin; Escherichia coli; Escherichia coli Proteins; Glutamate Decarboxylase; Macrolides; Point Mutation; Protein Engineering	2004
Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. Journal of biotechnology, 2004, May-13, Volume: 110, Issue:1 Topics: Ammonia; Bioreactors; Biotechnology; Cell Count; Culture Media; Erythromycin; Escherichia coli; Fermentation; Propionates; Streptomyces coelicolor; Time Factors	2004
API-mass spectrometry of polyketides. II. Fragmentation analysis of 6-deoxyerythronolide B analogs. The Journal of antibiotics, 2004, Volume: 57, Issue:9 Topics: Atmospheric Pressure; Erythromycin; Genetic Engineering; Mass Spectrometry	2004
Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli. Biochemistry, 2004, Dec-21, Volume: 43, Issue:50 Topics: Aminoglycosides; Erythromycin; Escherichia coli; Polyketide Synthases; Protein Structure, Tertiary; Protein Subunits	2004
Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. Applied and environmental microbiology, 2005, Volume: 71, Issue:8 Topics: Culture Media; Erythromycin; Escherichia coli; Genetic Engineering; Industrial Microbiology; Magnetic Resonance Spectroscopy; Mutation; Polyketide Synthases; Streptomyces coelicolor; Thioglycolates	2005
Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli. Biotechnology and bioengineering, 2006, Nov-05, Volume: 95, Issue:4 Topics: Anti-Bacterial Agents; Carbon; Drug Industry; Erythromycin; Escherichia coli; Glucose; Industrial Microbiology; Models, Biological	2006
Formal synthesis of 6-deoxyerythronolide B. Organic letters, 2006, May-11, Volume: 8, Issue:10 Topics: Aldehydes; Erythromycin; Molecular Structure; Thiazolidines	2006
Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. Journal of industrial microbiology & biotechnology, 2007, Volume: 34, Issue:1 Topics: Catalytic Domain; Erythromycin; Macrolides; Polyketide Synthases; Protein Engineering; Sequence Deletion; Streptomyces; Streptomyces coelicolor	2007
The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. Bioorganic & medicinal chemistry letters, 2007, Jun-01, Volume: 17, Issue:11 Topics: Biosynthetic Pathways; Catalysis; Cysteamine; Erythromycin; Esters; Hydrolysis; Natamycin; Polyketide Synthases; Protein Structure, Tertiary; Recombinant Proteins; Substrate Specificity; Sulfur Compounds; Thiolester Hydrolases	2007
Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. Applied microbiology and biotechnology, 2007, Volume: 77, Issue:2 Topics: Biotechnology; Cloning, Molecular; Culture Media; Enzyme Activation; Erythromycin; Escherichia coli; Gene Deletion; Gene Expression Regulation, Bacterial; Methionine Adenosyltransferase; Polymerase Chain Reaction; S-Adenosylmethionine; Streptomyces; Up-Regulation	2007
6-deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. Metabolic engineering, 2008, Volume: 10, Issue:1 Topics: Chromosomes, Bacterial; Erythromycin; Escherichia coli; Gene Transfer Techniques; Genetic Engineering; Indicators and Reagents; Plasmids; Polyketide Synthases; Reverse Transcriptase Polymerase Chain Reaction	2008
Crystal structure of the erythromycin polyketide synthase dehydratase. Journal of molecular biology, 2008, Dec-26, Volume: 384, Issue:4 Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Catalytic Domain; Crystallography, X-Ray; Erythromycin; Hydro-Lyases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Polyketide Synthases; Protein Structure, Tertiary	2008
Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnology and bioengineering, 2010, Feb-15, Volume: 105, Issue:3 Topics: Acyl Coenzyme A; Coenzyme A-Transferases; Erythromycin; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Gene Dosage; Gene Expression; Macrolides; Methylmalonyl-CoA Decarboxylase; Methylmalonyl-CoA Mutase	2010
Construction and performance of heterologous polyketide-producing K-12- and B-derived Escherichia coli. Letters in applied microbiology, 2010, Volume: 51, Issue:2 Topics: Anti-Bacterial Agents; Biosynthetic Pathways; Codon; Erythromycin; Escherichia coli; Genetic Engineering; Humans; Plasmids; Recombinant Proteins; Recombination, Genetic; RNA Stability	2010
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America, 2010, Dec-21, Volume: 107, Issue:51 Topics: Acyl Carrier Protein; Bacterial Proteins; Erythromycin; Polyketide Synthases; Protein Structure, Tertiary	2010
Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. Microbial biotechnology, 2009, Volume: 2, Issue:3 Topics: Anti-Bacterial Agents; Erythromycin; Escherichia coli; Escherichia coli Proteins	2009
Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnology and bioengineering, 2011, Volume: 108, Issue:6 Topics: Base Sequence; Erythromycin; Escherichia coli; Gene Expression Regulation, Bacterial; Macrolides; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Polyketide Synthases; Propionates; Signal Transduction	2011
Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation. Nature chemistry, 2009, Volume: 1, Issue:7 Topics: Crystallography, X-Ray; Cyclization; Erythromycin; Models, Molecular; Molecular Structure; Oxidation-Reduction; Stereoisomerism	2009
Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. Journal of industrial microbiology & biotechnology, 2011, Volume: 38, Issue:11 Topics: Alkenes; Biological Products; Bioreactors; Diterpenes; Erythromycin; Escherichia coli; Polyketides; Terpenes	2011
Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. Biochemistry, 2012, May-08, Volume: 51, Issue:18 Topics: Acyl Carrier Protein; Acyltransferases; Arginine; Erythromycin; Models, Molecular; Polyketide Synthases; Protein Structure, Tertiary; Saccharopolyspora	2012
6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. Organic letters, 2012, May-04, Volume: 14, Issue:9 Topics: Catalysis; Cyclization; Erythromycin; Macrolides; Molecular Structure; Polyketide Synthases; Stereoisomerism	2012
[Reconstruction of erythromycin macrocyclic lactone synthesis pathway in Escherichia coli]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2012, Volume: 28, Issue:2 Topics: Anti-Bacterial Agents; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Erythromycin; Escherichia coli; Genetic Vectors	2012
Total synthesis of 6-deoxyerythronolide B via C-C bond-forming transfer hydrogenation. Journal of the American Chemical Society, 2013, Mar-20, Volume: 135, Issue:11 Topics: Alcohols; Anti-Bacterial Agents; Catalysis; Erythromycin; Hydrogenation	2013
Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field. PloS one, 2014, Volume: 9, Issue:9 Topics: Aryl Hydrocarbon Hydroxylases; Bacterial Proteins; Biosynthetic Pathways; Erythromycin; Genes, Bacterial; Molecular Sequence Data; Multigene Family; Saccharopolyspora	2014
Improving heterologous polyketide production in Escherichia coli by transporter engineering. Applied microbiology and biotechnology, 2015, Volume: 99, Issue:20 Topics: Biological Transport, Active; Erythromycin; Escherichia coli; Membrane Transport Proteins; Metabolic Engineering; Polyketides; Recombinant Proteins	2015
Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis. Applied and environmental microbiology, 2015, Volume: 81, Issue:24 Topics: Anti-Bacterial Agents; Bacterial Proteins; Chromatography, Liquid; Erythromycin; Genetic Engineering; Glycosylation; Mass Spectrometry; Multienzyme Complexes; Multigene Family; Plasmids; Streptomyces	2015
Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis. Applied microbiology and biotechnology, 2016, Volume: 100, Issue:3 Topics: Bacillus subtilis; Bacterial Proteins; Erythromycin; Metabolic Engineering; Polyketides; Saccharopolyspora	2016
Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. Biochimica et biophysica acta, 2016, Volume: 1860, Issue:3 Topics: Catalytic Domain; Erythromycin; Protein Structure, Tertiary; Substrate Specificity; Thiolester Hydrolases	2016
Construction of polyketide overproducing Escherichia coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis. Biotechnology journal, 2016, Volume: 11, Issue:4 Topics: Anti-Bacterial Agents; Computer Simulation; Down-Regulation; Erythromycin; Escherichia coli; Escherichia coli Proteins; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Metabolic Engineering; Pentose Phosphate Pathway; RNA, Antisense	2016
Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. Biochemistry, 2018, 10-30, Volume: 57, Issue:43 Topics: Antibodies, Monoclonal; Catalysis; Crystallography, X-Ray; Erythromycin; Humans; Models, Molecular; Molecular Structure; Polyketide Synthases; Protein Conformation; Substrate Specificity	2018
Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry, 2023, 06-06, Volume: 62, Issue:11 Topics: Acyltransferases; Antibodies; Erythromycin; Polyketide Synthases	2023