Compounds > 6-cyano-7-nitroquinoxaline-2-3-dione

6-cyano-7-nitroquinoxaline-2-3-dione and 4-aza-4-methylpregnane-3-20-dione

6-cyano-7-nitroquinoxaline-2-3-dione has been researched along with 4-aza-4-methylpregnane-3-20-dione* in 1 studies

Other Studies

1 other study(ies) available for 6-cyano-7-nitroquinoxaline-2-3-dione and 4-aza-4-methylpregnane-3-20-dione

Article	Year
CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy. Epilepsy research, 1991, Volume: 9, Issue:2 The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spike wave discharges in a dose-dependent way. Coinjection of CNQX (100 nmol/5 microliters) and AMPA (0.1 pmol/5 microliters), kainic acid (0.01 nmol/5 microliters) or NMDA (50 pmol/5 microliters) attenuated the CNQX response, indicating that CNQX acts on both non-NMDA and NMDA receptors. The observed effects appear to be specific manipulations of the epilepsy not mediated by behavioral changes. Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Azasteroids; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Female; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Postural Balance; Pregnanediones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1991

Article

Year

CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy.

Epilepsy research, 1991, Volume: 9, Issue:2

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spike wave discharges in a dose-dependent way. Coinjection of CNQX (100 nmol/5 microliters) and AMPA (0.1 pmol/5 microliters), kainic acid (0.01 nmol/5 microliters) or NMDA (50 pmol/5 microliters) attenuated the CNQX response, indicating that CNQX acts on both non-NMDA and NMDA receptors. The observed effects appear to be specific manipulations of the epilepsy not mediated by behavioral changes.

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Azasteroids; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Female; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Postural Balance; Pregnanediones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate

1991