6-chloro-3,5-diaminopyrazine-3-carboxamide has been researched along with amiloride in 13 studies
| Studies (6-chloro-3,5-diaminopyrazine-3-carboxamide) | Trials (6-chloro-3,5-diaminopyrazine-3-carboxamide) | Recent Studies (post-2010) (6-chloro-3,5-diaminopyrazine-3-carboxamide) | Studies (amiloride) | Trials (amiloride) | Recent Studies (post-2010) (amiloride) |
|---|---|---|---|---|---|
| 13 | 0 | 0 | 7,584 | 339 | 788 |
| Protein | Taxonomy | 6-chloro-3,5-diaminopyrazine-3-carboxamide (IC50) | amiloride (IC50) |
|---|---|---|---|
| Urokinase-type plasminogen activator | Homo sapiens (human) | 4.7 | |
| Urokinase-type plasminogen activator | Mus musculus (house mouse) | 2.3 | |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | 3.909 | |
| Sodium/hydrogen exchanger 1 | Rattus norvegicus (Norway rat) | 1 | |
| Amiloride-sensitive sodium channel subunit alpha | Homo sapiens (human) | 0.776 | |
| Sodium/hydrogen exchanger 2 | Oryctolagus cuniculus (rabbit) | 1 | |
| Acid-sensing ion channel 3 | Homo sapiens (human) | 4.4 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crowe, WE; Millinoff, LP; Wills, NK | 1 |
| Baxendale, LM; Helman, SI | 1 |
| Dawson, DC; Wilkinson, DJ | 1 |
| Clauss, W; Fischer, H; Krattenmacher, R; van Driessche, W | 1 |
| Granitzer, M; Mountian, I; Van Driessche, W | 1 |
| De Smet, P; Erlij, D; Van Driessche, W | 1 |
| Baldwin, K; Baxendale-Cox, LM; Duncan, RL; Els, WJ; Helman, SI; Liu, X | 1 |
| Smets, I; Steels, P; Van Driessche, W; Zeiske, W | 1 |
| Beir-Simaels, JD; Flonta, ML; Mesotten, D; Van Driessche, W | 1 |
| Baldwin, K; Blazer-Yost, BL; Els, WJ; Helman, SI; Liu, X | 1 |
| Blazer-Yost, BL; Helman, SI; Liu, X | 1 |
| Clauss, W; Eckstein-Ludwig, U; Fronius, M; Rehn, M | 1 |
| Adebamiro, A; Bridges, RJ; Cheng, Y; Johnson, JP | 1 |
13 other study(ies) available for 6-chloro-3,5-diaminopyrazine-3-carboxamide and amiloride
| Article | Year |
|---|---|
Na+ channel activity in cultured renal (A6) epithelium: regulation by solution osmolarity.
Topics: Amiloride; Animals; Cell Line; Electric Conductivity; Epithelium; Kidney; Kinetics; Membrane Potentials; Osmolar Concentration; Potassium; Sodium; Sodium Channels; Xenopus laevis | 1991 |
Blocker-related changes of channel density. Analysis of a three-state model for apical Na channels of frog skin.
Topics: Amiloride; Animals; Biological Transport; Epithelium; Homeostasis; In Vitro Techniques; Membrane Potentials; Models, Biological; Rana pipiens; Skin; Skin Physiological Phenomena; Sodium; Sodium Channels | 1990 |
Cholinergic modulation of apical Na+ channels in turtle colon: analysis of CDPC-induced fluctuations.
Topics: Amiloride; Animals; Carbachol; Colon; Epithelium; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials; Models, Theoretical; Muscle, Smooth; Sodium Channels; Turtles | 1990 |
Noise analysis of cAMP-stimulated Na current in frog colon.
Topics: Amiloride; Animals; Colon; Cyclic AMP; Electrochemistry; In Vitro Techniques; Oxytocin; Rana esculenta; Rana temporaria; Sodium Channels | 1988 |
Effect of dexamethasone on sodium channel block and densities in A6 cells.
Topics: Amiloride; Animals; Cell Differentiation; Cell Line; Dexamethasone; Diuretics; Glucocorticoids; Kidney; Kinetics; Sodium Channels; Xenopus laevis | 1995 |
Effect of insulin on area and Na+ channel density of apical membrane of cultured toad kidney cells.
Topics: Amiloride; Animals; Anura; Biological Transport; Cell Line; Electric Conductivity; Electrophysiology; Epithelium; Insulin; Intracellular Membranes; Kidney; Nystatin; Receptors, Somatomedin; Sodium Channels | 1994 |
Steroid hormone-dependent expression of blocker-sensitive ENaCs in apical membranes of A6 epithelia.
Topics: Aldosterone; Amiloride; Cell Culture Techniques; Cell Division; Cell Line; Corticosterone; Culture Media; Electric Conductivity; Epithelial Cells; Epithelial Sodium Channels; Ion Channel Gating; Membrane Potentials; Probability; Sodium Channel Blockers; Sodium Channels | 1997 |
Na+ dependence of single-channel current and channel density generate saturation of Na+ uptake in A6 cells.
Topics: Amiloride; Amphibians; Animals; Biological Transport; Cell Line; Epithelial Cells; Kinetics; Patch-Clamp Techniques; Sodium; Sodium Channel Blockers; Sodium Channels | 1998 |
Cu2+ reveals different binding sites of amiloride and CDPC on the apical Na channel of frog skin.
Topics: Amiloride; Animals; Binding Sites; Binding, Competitive; Copper; Electric Conductivity; Ion Channel Gating; Rana temporaria; Sodium Channels | 1998 |
Time-dependent stimulation by aldosterone of blocker-sensitive ENaCs in A6 epithelia.
Topics: Aldosterone; Amiloride; Animals; Cell Line; Electric Conductivity; Epithelial Cells; Kidney; Sodium Channels; Time Factors | 1998 |
Hormonal regulation of ENaCs: insulin and aldosterone.
Topics: Aldosterone; Amiloride; Animals; Cell Line; Drug Interactions; Electric Conductivity; Epithelial Sodium Channels; Insulin; Kidney; Sodium Channels; Xenopus laevis | 1998 |
Inhibitory non-genomic effects of progesterone on Na+ absorption in epithelial cells from Xenopus kidney (A6).
Topics: Amiloride; Animals; Artifacts; Biological Transport; Cell Line; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Epithelial Cells; Epithelial Sodium Channels; Kidney; Membrane Potentials; Osmotic Pressure; Progesterone; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Xenopus | 2001 |
Endogenous protease activation of ENaC: effect of serine protease inhibition on ENaC single channel properties.
Topics: Amiloride; Amphibians; Animals; Aprotinin; Cell Line; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Kidney; Membrane Potentials; Serine Endopeptidases; Serine Proteinase Inhibitors; Sodium; Sodium Channel Blockers; Sodium Channels; Time Factors | 2005 |