6-chloro-2-(1-piperazinyl)pyrazine and mirtazapine

6-chloro-2-(1-piperazinyl)pyrazine has been researched along with mirtazapine in 2 studies

Compound Research Comparison

Studies (6-chloro-2-(1-piperazinyl)pyrazine)	Trials (6-chloro-2-(1-piperazinyl)pyrazine)	Recent Studies (post-2010) (6-chloro-2-(1-piperazinyl)pyrazine)	Studies (mirtazapine)	Trials (mirtazapine)	Recent Studies (post-2010) (mirtazapine)
157	8	24	1,538	324	646

Protein Interaction Comparison

Protein	Taxonomy	mirtazapine (IC50)
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.0851
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	0.2239
Alpha-2B adrenergic receptor	Homo sapiens (human)	0.2239
Alpha-2C adrenergic receptor	Homo sapiens (human)	0.1995
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	0.2239
Alpha-1A adrenergic receptor	Homo sapiens (human)	3.1623
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	0.2239
Transporter	Rattus norvegicus (Norway rat)	0.26

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R	1
Berendsen, HH; Broekkamp, CL	1

Other Studies

2 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and mirtazapine

Article	Year
Physical binding pocket induction for affinity prediction. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A	2009
Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapine. Psychopharmacology, 1997, Volume: 133, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Conditioning, Operant; Fluoxetine; Male; Mianserin; Mice; Mice, Inbred ICR; Mirtazapine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Taste	1997

Article

Year

Physical binding pocket induction for affinity prediction.

Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A

2009

Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapine.

Psychopharmacology, 1997, Volume: 133, Issue:3

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Conditioning, Operant; Fluoxetine; Male; Mianserin; Mice; Mice, Inbred ICR; Mirtazapine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Taste

1997