6-chloro-2-(1-piperazinyl)pyrazine has been researched along with metergoline in 8 studies
| Studies (6-chloro-2-(1-piperazinyl)pyrazine) | Trials (6-chloro-2-(1-piperazinyl)pyrazine) | Recent Studies (post-2010) (6-chloro-2-(1-piperazinyl)pyrazine) | Studies (metergoline) | Trials (metergoline) | Recent Studies (post-2010) (metergoline) |
|---|---|---|---|---|---|
| 157 | 8 | 24 | 656 | 37 | 44 |
| Protein | Taxonomy | 6-chloro-2-(1-piperazinyl)pyrazine (IC50) | metergoline (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.0007 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.366 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.0041 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.058 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.2 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.063 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.016 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.189 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0062 | |
| Substance-K receptor | Homo sapiens (human) | 4.071 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.074 | |
| Acetylcholinesterase | Homo sapiens (human) | 1.344 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.366 | |
| Histamine H2 receptor | Homo sapiens (human) | 0.975 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.136 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.0004 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.0007 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.0062 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.59 | |
| Histamine H1 receptor | Homo sapiens (human) | 4.133 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.0077 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.0004 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.028 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.063 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Clineschmidt, BV; McGuffin, JC | 1 |
| Clineschmidt, BV; Hanson, HM; McGuffin, JC; Pflueger, AB | 1 |
| Brazell, C; Dourish, CT; King, BH; Middlemiss, DN | 1 |
| Barrett, JE; Brady, LS | 1 |
| Barrett, JE; Mansbach, RS | 1 |
| Neuman, RS; White, SR | 1 |
8 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and metergoline
| Article | Year |
|---|---|
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature | 1993 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
Pharmacological differentiation of the central 5-hydroxytryptamine-like actions of MK-212 (6-chloro-2[1-piperazinyl]-pyrazine),p-methoxyamphetamine and fenfluramine in an in vivo model system.
Topics: Amphetamines; Animals; Dextroamphetamine; Drug Interactions; Fenclonine; Fenfluramine; Fluoxetine; In Vitro Techniques; Male; Metergoline; Muscle Contraction; Piperazines; Pyrazines; Rats; Serotonin; Time Factors | 1978 |
Anorexigenic and ancillary actions of MK-212 (6-chloro-2-(1-piperazinyl)-pyrazine; CPP).
Topics: Animals; Appetite Depressants; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Eating; Female; Fenfluramine; Male; Metergoline; Motor Activity; Piperazines; Pyrazines; Rats; Self Administration | 1977 |
MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype.
Topics: Adrenocorticotropic Hormone; Animals; Antiparkinson Agents; Ergolines; Ketanserin; Male; Metergoline; Pindolol; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1989 |
Effects of serotonin receptor agonists and antagonists on schedule-controlled behavior of squirrel monkeys.
Topics: 5-Hydroxytryptophan; Animals; Cinanserin; Conditioning, Operant; Cyproheptadine; Electroshock; Female; Ketanserin; Male; Metergoline; Methysergide; Piperazines; Piperidines; Pyrazines; Quipazine; Receptors, Serotonin; Saimiri | 1985 |
Effects of MK-212 (6-chloro-2[1-piperazinyl]pyrazine) on schedule-controlled behavior and their reversal by 5-HT antagonists in the pigeon.
Topics: Animals; Columbidae; Conditioning, Operant; Cues; Generalization, Stimulus; Ketanserin; Male; Metergoline; Methysergide; Piperidines; Pyrazines; Receptors, Serotonin; Reinforcement Schedule | 1986 |
Serotonin-like actions of quipazine and CPP on spinal motoneurones.
Topics: 5,7-Dihydroxytryptamine; Animals; Glutamates; Male; Metergoline; Methysergide; Motor Neurons; p-Chloroamphetamine; Pyrazines; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord | 1982 |