Compounds > 6-chloro-2-(1-piperazinyl)pyrazine
Page last updated: 2024-09-02

6-chloro-2-(1-piperazinyl)pyrazine and haloperidol

6-chloro-2-(1-piperazinyl)pyrazine has been researched along with haloperidol in 5 studies

Compound Research Comparison

Studies
(6-chloro-2-(1-piperazinyl)pyrazine)		Trials
(6-chloro-2-(1-piperazinyl)pyrazine)		Recent Studies (post-2010)
(6-chloro-2-(1-piperazinyl)pyrazine)		Studies
(haloperidol)		Trials
(haloperidol)		Recent Studies (post-2010) (haloperidol)
15782420,3301,7533,294

Protein Interaction Comparison

ProteinTaxonomy6-chloro-2-(1-piperazinyl)pyrazine (IC50)haloperidol (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)2.3
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)1.7
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.6765
Potassium channel subfamily K member 2Homo sapiens (human)5.5
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.836
ATP-dependent translocase ABCB1Homo sapiens (human)5.3
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.054
Cytochrome P450 3A4Homo sapiens (human)0.055
5-hydroxytryptamine receptor 1AHomo sapiens (human)1.5
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.1754
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.89
Alpha-2A adrenergic receptorHomo sapiens (human)4.973
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)2.3
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M1Homo sapiens (human)5.5
Cytochrome P450 2C9 Homo sapiens (human)4.69
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)7
D(2) dopamine receptorHomo sapiens (human)0.0897
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.1467
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0852
Alpha-2B adrenergic receptorHomo sapiens (human)1.354
Alpha-2C adrenergic receptorHomo sapiens (human)1.845
DRattus norvegicus (Norway rat)0.1103
D(3) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4.3045
D(2) dopamine receptorBos taurus (cattle)0.1332
D(1A) dopamine receptorHomo sapiens (human)0.0575
D(4) dopamine receptorHomo sapiens (human)0.0978
D(1B) dopamine receptorHomo sapiens (human)0.005
Adenylate cyclase type 3Rattus norvegicus (Norway rat)2.3
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0852
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.836
Histamine H2 receptorHomo sapiens (human)1.166
Alpha-1D adrenergic receptorHomo sapiens (human)0.084
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.0067
Adenylate cyclase type 2Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 4Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.1815
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.347
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.018
D(4) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.1754
Sodium-dependent serotonin transporterHomo sapiens (human)3.386
Histamine H1 receptorHomo sapiens (human)2.781
Mu-type opioid receptorHomo sapiens (human)2.443
D(3) dopamine receptorHomo sapiens (human)0.0065
Sodium channel protein type 1 subunit alphaHomo sapiens (human)7
Sodium channel protein type 4 subunit alphaHomo sapiens (human)7
Adenylate cyclase type 8Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.05
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0852
Cytochrome P450 2J2Homo sapiens (human)4.69
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0129
N-acetyltransferase EisMycobacterium tuberculosis H37Rv0.39
Sodium channel protein type 7 subunit alphaHomo sapiens (human)7
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.5
Adenylate cyclase type 6Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 5Rattus norvegicus (Norway rat)1.425
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2634
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.5
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.5
Sodium channel protein type 5 subunit alphaHomo sapiens (human)7
Sodium channel protein type 9 subunit alphaHomo sapiens (human)7
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)2.3
DBos taurus (cattle)0.2509
Sodium channel protein type 2 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.07
Sodium channel protein type 3 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)0.0013
Sodium channel protein type 11 subunit alphaHomo sapiens (human)7
Sodium channel protein type 8 subunit alphaHomo sapiens (human)7
Sodium channel protein type 10 subunit alphaHomo sapiens (human)7

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP1
Clineschmidt, BV; McGuffin, JC; Pflueger, AB; Totaro, JA1
Meltzer, HY; Nash, JF1
Gudelsky, GA; Meltzer, HY; Nash, JF1
Ishikane, T1

Other Studies

5 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and haloperidol

ArticleYear
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:5

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship

1989
A 5-hydroxytryptamine-like mode of anorectic action for 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212).
    British journal of pharmacology, 1978, Volume: 62, Issue:4

    Topics: 5,6-Dihydroxytryptamine; Animals; Appetite Depressants; Clomipramine; Female; Haloperidol; p-Chloroamphetamine; Piperazines; Pyrazines; Raphe Nuclei; Rats; Serotonin; Serotonin Antagonists

1978
Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Electric Stimulation; Haloperidol; Male; Methoxydimethyltryptamines; Methyltyrosines; Prolactin; Pyrazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes

1989
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
    European journal of pharmacology, 1988, Jul-14, Volume: 151, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Body Temperature; Butyrophenones; Chlorpromazine; Clozapine; Corticosterone; Haloperidol; Male; Neurosecretory Systems; Pyrazines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1988
[Effects of serotonergic drugs on the up-regulation of dopamine D2 receptors induced by haloperidol in rat striatum].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1998, Volume: 73, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Dyskinesia Agents; Antipsychotic Agents; Citalopram; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Pyrazines; Rats; Rats, Wistar; Receptors, Dopamine D2; Ritanserin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Up-Regulation

1998