6-chloro-2-(1-piperazinyl)pyrazine and fenfluramine

6-chloro-2-(1-piperazinyl)pyrazine has been researched along with fenfluramine in 12 studies

Compound Research Comparison

Studies (6-chloro-2-(1-piperazinyl)pyrazine)	Trials (6-chloro-2-(1-piperazinyl)pyrazine)	Recent Studies (post-2010) (6-chloro-2-(1-piperazinyl)pyrazine)	Studies (fenfluramine)	Trials (fenfluramine)	Recent Studies (post-2010) (fenfluramine)
157	8	24	3,112	478	222

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (66.67)	18.7374
1990's	3 (25.00)	18.2507
2000's	1 (8.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Clineschmidt, BV; McGuffin, JC	1
Clineschmidt, BV; Hanson, HM; McGuffin, JC; Pflueger, AB	1
Cooper, SJ; Neill, JC	1
Bethea, CL; Lorens, SA; Urban, JH; Van de Kar, LD	1
Lorens, SA; Van de Kar, LD	1
Moses, PL; Wurtman, RJ	1
Appel, JB; White, FJ	1
Antelman, SM; Kocan, D; Rowland, N	1
Maes, M; Meltzer, HY; Thompson, PA	1
Barber, DJ; Cooper, SJ	1
Baumgarten, HG; Grozdanovic, Z	1
Cunningham, KA; Filip, M; McCreary, AC	1

Reviews

1 review(s) available for 6-chloro-2-(1-piperazinyl)pyrazine and fenfluramine

Article	Year
Role of serotonin in obsessive-compulsive disorder. The British journal of psychiatry. Supplement, 1998, Issue:35 Topics: Biogenic Monoamines; Fenfluramine; Humans; Neuropeptides; Obsessive-Compulsive Disorder; Piperazines; Pyrazines; Pyrimidines; Serotonin; Serotonin Syndrome; Synaptic Transmission; Tryptophan	1998

Trials

1 trial(s) available for 6-chloro-2-(1-piperazinyl)pyrazine and fenfluramine

Article	Year
Effect of the placebo control condition in neuroendocrine challenge studies. Psychiatry research, 1994, Volume: 52, Issue:3 Topics: 5-Hydroxytryptophan; Antipsychotic Agents; Apomorphine; Bias; Buspirone; Data Interpretation, Statistical; Depressive Disorder; Female; Fenfluramine; Growth Hormone; Humans; Hydrocortisone; Male; Prolactin; Pyrazines; Schizophrenia; Schizophrenic Psychology; Serotonin Receptor Agonists	1994

Article

Year

Effect of the placebo control condition in neuroendocrine challenge studies.

Psychiatry research, 1994, Volume: 52, Issue:3

Topics: 5-Hydroxytryptophan; Antipsychotic Agents; Apomorphine; Bias; Buspirone; Data Interpretation, Statistical; Depressive Disorder; Female; Fenfluramine; Growth Hormone; Humans; Hydrocortisone; Male; Prolactin; Pyrazines; Schizophrenia; Schizophrenic Psychology; Serotonin Receptor Agonists

1994

Other Studies

10 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and fenfluramine

Article	Year
Pharmacological differentiation of the central 5-hydroxytryptamine-like actions of MK-212 (6-chloro-2[1-piperazinyl]-pyrazine),p-methoxyamphetamine and fenfluramine in an in vivo model system. European journal of pharmacology, 1978, Aug-15, Volume: 50, Issue:4 Topics: Amphetamines; Animals; Dextroamphetamine; Drug Interactions; Fenclonine; Fenfluramine; Fluoxetine; In Vitro Techniques; Male; Metergoline; Muscle Contraction; Piperazines; Pyrazines; Rats; Serotonin; Time Factors	1978
Anorexigenic and ancillary actions of MK-212 (6-chloro-2-(1-piperazinyl)-pyrazine; CPP). Psychopharmacology, 1977, Nov-24, Volume: 55, Issue:1 Topics: Animals; Appetite Depressants; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Eating; Female; Fenfluramine; Male; Metergoline; Motor Activity; Piperazines; Pyrazines; Rats; Self Administration	1977
Selective reduction by serotonergic agents of hypertonic saline consumption in rats: evidence for possible 5-HT1C receptor mediation. Psychopharmacology, 1989, Volume: 99, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Fenfluramine; Fluoxetine; Hypertonic Solutions; Indoles; Male; Piperazines; Pyrazines; Quinoxalines; Quipazine; Rats; Receptors, Serotonin; Serotonin	1989
Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonist on prolactin secretion. Neuropharmacology, 1989, Volume: 28, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ergolines; Fenfluramine; Indoles; Male; Prolactin; Pyrazines; Radioimmunoassay; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1989
Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology, 1987, Volume: 45, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corticosterone; Ergolines; Fenfluramine; Male; Pyrazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Renin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1987
The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet. Life sciences, 1984, Sep-17, Volume: 35, Issue:12 Topics: Animals; Appetite Depressants; Benzphetamine; Chlorphentermine; Dextroamphetamine; Dietary Carbohydrates; Eating; Fenfluramine; Male; Pyrazines; Rats; Rats, Inbred Strains; Serotonin	1984
A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine. Psychopharmacology, 1981, Volume: 73, Issue:2 Topics: Animals; Cocaine; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Hallucinogens; Lisuride; Lysergic Acid Diethylamide; Male; p-Chloroamphetamine; Piperazines; Pyrazines; Quipazine; Rats; Serotonin; Serotonin Antagonists	1981
Differences among 'serotonergic' anorectics in a cross-tolerance paradigm: do they all act on serotonin systems? European journal of pharmacology, 1982, Jun-16, Volume: 81, Issue:1 Topics: Animals; Appetite Depressants; Body Weight; Drug Tolerance; Fenfluramine; Male; Pyrazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin	1982
Effects of d-fenfluramine, MK-212, and ondansetron on saline drinking in two-choice tests in the rehydrating rat. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3 Topics: Animals; Drinking Behavior; Fenfluramine; Isotonic Solutions; Male; Ondansetron; Pyrazines; Rats; Saline Solution, Hypertonic; Serotonin Receptor Agonists; Sodium Chloride; Taste; Water Deprivation	1993
Discriminative stimulus properties of (+/-)-fenfluramine: the role of 5-HT2 receptor subtypes. Behavioral neuroscience, 2003, Volume: 117, Issue:2 Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Fenfluramine; Fluorobenzenes; Indoles; Ketanserin; Male; Piperidines; Pyrazines; Pyridines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Thiophenes	2003