6-chloro-2-(1-piperazinyl)pyrazine has been researched along with cocaine in 14 studies
| Studies (6-chloro-2-(1-piperazinyl)pyrazine) | Trials (6-chloro-2-(1-piperazinyl)pyrazine) | Recent Studies (post-2010) (6-chloro-2-(1-piperazinyl)pyrazine) | Studies (cocaine) | Trials (cocaine) | Recent Studies (post-2010) (cocaine) |
|---|---|---|---|---|---|
| 157 | 8 | 24 | 32,461 | 1,096 | 9,400 |
| Protein | Taxonomy | 6-chloro-2-(1-piperazinyl)pyrazine (IC50) | cocaine (IC50) |
|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.338 | |
| Fatty acid-binding protein, heart | Homo sapiens (human) | 0.367 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0855 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0855 | |
| D | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.2861 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.4321 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0855 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.5442 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.8885 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.3796 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5.541 | |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | 0.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.05 | |
| Transporter | Rattus norvegicus (Norway rat) | 3.2277 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Bethea, CL; Brownfield, MS; Carnes, M; Lent, SJ; O'Connor, P; Palionis, T; Rittenhouse, PA; Van de Kar, LD | 1 |
| Alvarez Sanz, MC; Brownfield, MS; Levy, AD; Li, Q; Rittenhouse, PA; Van de Kar, LD | 1 |
| Appel, JB; White, FJ | 1 |
| Lee, MA; Meltzer, HY | 1 |
| Meltzer, HY; Willins, DL | 1 |
| George, FR; Kreifeldt, MJ; O'Dell, LE; Ritz, MC | 1 |
| Cunningham, KA; Filip, M | 2 |
| Bubar, MJ; Cunningham, KA; Filip, M | 1 |
| Acosta, JI; Neisewander, JL | 1 |
| Cunningham, KA; dela Cruz, AM; Grady, JJ; Herin, DV | 1 |
| Conway, SM; Neisewander, JL; Pentkowski, NS; Pockros, LA; Ullman, TE; Zwick, KR | 1 |
| Arenas, MC; Manzanedo, C; Mateos-García, A; Miñarro, J | 1 |
1 trial(s) available for 6-chloro-2-(1-piperazinyl)pyrazine and cocaine
| Article | Year |
|---|---|
Blunted oral body temperature response to MK-212 in cocaine addicts.
Topics: Adult; Body Temperature Regulation; Cocaine; Humans; Hydrocortisone; Male; Prolactin; Pyrazines; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Substance-Related Disorders | 1994 |
13 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and cocaine
| Article | Year |
|---|---|
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212.
Topics: Adrenocorticotropic Hormone; Animals; Arousal; Brain; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Hormones; Injections, Intraperitoneal; Male; Neurosecretory Systems; Oxytocin; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Renin; Synaptic Transmission; Vasopressins | 1992 |
Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI.
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Cocaine; Corticosterone; Hormones; Male; Oxytocin; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Renin; Serotonin Receptor Agonists | 1992 |
A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine.
Topics: Animals; Cocaine; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Hallucinogens; Lisuride; Lysergic Acid Diethylamide; Male; p-Chloroamphetamine; Piperazines; Pyrazines; Quipazine; Rats; Serotonin; Serotonin Antagonists | 1981 |
Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Microdialysis; Morphine; Narcotic Antagonists; Nucleus Accumbens; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions.
Topics: Animals; Cocaine; Male; Mice; Mice, Inbred C57BL; Piperazines; Pyrazines; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Seizures; Species Specificity | 1999 |
Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine.
Topics: Animals; Cocaine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylamines; Hyperkinesis; Indoles; Male; Microinjections; Motor Activity; Nucleus Accumbens; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides | 2002 |
Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex.
Topics: Animals; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Microinjections; Motor Activity; Prefrontal Cortex; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride; Spiro Compounds; Sulfonamides | 2003 |
Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses.
Topics: Amphetamines; Animals; Cocaine; Drug Interactions; Fluorobenzenes; Hyperkinesis; Indoles; Male; Phenols; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 2004 |
Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats.
Topics: Aminopyridines; Animals; Behavior, Addictive; Cocaine; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Indoles; Male; Motor Activity; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Self Administration | 2007 |
Novel approach to data analysis in cocaine-conditioned place preference.
Topics: Animals; Benzazepines; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Models, Animal; N-Methyl-3,4-methylenedioxyamphetamine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serotonin Receptor Agonists; Time Factors | 2009 |
5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen.
Topics: Animals; Caudate Nucleus; Cocaine; Fluorobenzenes; Gene Expression Regulation; Locomotion; Male; Piperidines; Proto-Oncogene Proteins c-fos; Putamen; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2012 |
The negative allosteric modulator of mGluR5, MPEP, potentiates the rewarding properties of cocaine in priming-induced reinstatement of CPP.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Extinction, Psychological; Female; Male; Mice; Pyrazines; Receptor, Metabotropic Glutamate 5 | 2020 |