6-chloro-2-(1-piperazinyl)pyrazine has been researched along with clomipramine in 3 studies
| Studies (6-chloro-2-(1-piperazinyl)pyrazine) | Trials (6-chloro-2-(1-piperazinyl)pyrazine) | Recent Studies (post-2010) (6-chloro-2-(1-piperazinyl)pyrazine) | Studies (clomipramine) | Trials (clomipramine) | Recent Studies (post-2010) (clomipramine) |
|---|---|---|---|---|---|
| 157 | 8 | 24 | 2,929 | 541 | 304 |
| Protein | Taxonomy | 6-chloro-2-(1-piperazinyl)pyrazine (IC50) | clomipramine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.034 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.071 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.241 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.091 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.005 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.053 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.707 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 3.9465 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.091 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.413 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.005 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0505 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.7065 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.005 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.17 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 1.113 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.0678 | |
| Histamine H2 receptor | Homo sapiens (human) | 2.049 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.18 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.067 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.034 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.005 | |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | 0.0002 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.035 | |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.005 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.085 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.139 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.005 | |
| Trypanothione reductase | Trypanosoma brucei brucei | 3.4 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.239 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 0.72 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.245 | |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | 9 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 2.7615 | |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.005 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.362 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.005 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clineschmidt, BV; McGuffin, JC; Pflueger, AB; Totaro, JA | 2 |
| Barr, LC; Charney, DS; Goodman, WK; McDougle, CJ; Price, LH | 1 |
1 review(s) available for 6-chloro-2-(1-piperazinyl)pyrazine and clomipramine
| Article | Year |
|---|---|
The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies.
Topics: Biomarkers; Clomipramine; Humans; Neurotransmitter Uptake Inhibitors; Obsessive-Compulsive Disorder; Piperazines; Pyrazines; Pyrimidines; Serotonin | 1992 |
2 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and clomipramine
| Article | Year |
|---|---|
A 5-hydroxytryptamine-like mode of anorectic action for 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212).
Topics: 5,6-Dihydroxytryptamine; Animals; Appetite Depressants; Clomipramine; Female; Haloperidol; p-Chloroamphetamine; Piperazines; Pyrazines; Raphe Nuclei; Rats; Serotonin; Serotonin Antagonists | 1978 |
Inhibition of the serotoninergic uptake system by MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine)
Topics: Animals; Cerebral Cortex; Clomipramine; Depression, Chemical; Desipramine; Dopamine; Female; In Vitro Techniques; Neurons; Norepinephrine; p-Chloroamphetamine; Piperazines; Pyrazines; Rats; Serotonin | 1978 |