6-chloro-2-(1-piperazinyl)pyrazine has been researched along with 4-iodo-2,5-dimethoxyphenylisopropylamine in 27 studies
| Studies (6-chloro-2-(1-piperazinyl)pyrazine) | Trials (6-chloro-2-(1-piperazinyl)pyrazine) | Recent Studies (post-2010) (6-chloro-2-(1-piperazinyl)pyrazine) | Studies (4-iodo-2,5-dimethoxyphenylisopropylamine) | Trials (4-iodo-2,5-dimethoxyphenylisopropylamine) | Recent Studies (post-2010) (4-iodo-2,5-dimethoxyphenylisopropylamine) |
|---|---|---|---|---|---|
| 157 | 8 | 24 | 843 | 1 | 127 |
| Protein | Taxonomy | 6-chloro-2-(1-piperazinyl)pyrazine (IC50) | 4-iodo-2,5-dimethoxyphenylisopropylamine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.0032 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB | 1 |
| Dupre, A; Egan, C; Grinde, E; Hake, M; Herrick-Davis, K; Roth, BL; Teitler, M | 1 |
| Etienne, N; Guesnier, L; Hickel, P; Maroteaux, L; Schaerlinger, B | 1 |
| Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R | 1 |
| Alvarez Sanz, MC; Brownfield, MS; Levy, AD; Li, Q; Rittenhouse, PA; Van de Kar, LD | 1 |
| Berendsen, HH; Broekkamp, CL | 4 |
| Gudelsky, GA; Meltzer, HY; Nash, JF | 1 |
| Harris, LT; McCall, RB; Patel, BN | 1 |
| Albinsson, A; Andersson, G; Palazidou, E; Stephenson, J | 1 |
| Battaglia, G; Brownfield, MS; Cabrera, TM; Levy, AD; Li, Q; Rittenhouse, PA; van de Kar, LD | 1 |
| Berendsen, HH; Broekkamp, CL; Kester, RC; Peeters, BW | 1 |
| Meltzer, HY; Willins, DL | 1 |
| Jordan, D; Sévoz-Couche, C; Spyer, KM | 2 |
| Basura, GJ; Goshgarian, HG; Zhou, SY | 1 |
| Goto, F; Obata, H; Saito, S; Sakurazawa, S; Sasaki, M; Usui, T | 1 |
| Mellerup, E; Nedergaard, P; Sanchez, C | 1 |
| Bubar, MJ; Cunningham, KA; Filip, M | 1 |
| Hochman, S; Machacek, DW; Sawchuk, M; Shay, BL | 1 |
| Cunningham, KA; Frankel, PS; Herin, DV; Ross, JD; Thomas, ML | 1 |
| Kozhemiakina, RV; Naumenko, VS; Pliusnina, IZ; Popova, NK | 1 |
| Gomes, KS; Nunes-De-Souza, RL | 1 |
| Kozhemyakina, RV; Naumenko, VS; Plyusnina, IZ; Popova, NK | 1 |
| Bazovkina, DV; Kondaurova, EM; Naumenko, VS; Ponimaskin, E | 1 |
27 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and 4-iodo-2,5-dimethoxyphenylisopropylamine
| Article | Year |
|---|---|
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature | 1993 |
Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.
Topics: Animals; Cell Line; Computer Simulation; GTP-Binding Proteins; Inositol Phosphates; Kinetics; Phosphatidylinositols; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Recombinant Proteins; Serotonin Receptor Agonists; Signal Transduction; Transfection; Tritium | 2000 |
Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.
Topics: Amphetamines; Animals; Binding, Competitive; Cell Line; Cyclic GMP; Dihydroergotamine; Humans; Inositol Phosphates; Iodine Radioisotopes; Kinetics; Migraine Disorders; Radioligand Assay; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Time Factors; Treatment Outcome | 2003 |
Physical binding pocket induction for affinity prediction.
Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A | 2009 |
Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI.
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Cocaine; Corticosterone; Hormones; Male; Oxytocin; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Renin; Serotonin Receptor Agonists | 1992 |
Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Male; Mianserin; Penile Erection; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes; Tranylcypromine | 1991 |
Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Body Temperature; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1990 |
Selective cross-tolerance to 5-HT1A and 5-HT2 receptor-mediated temperature and corticosterone responses.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Body Temperature Regulation; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Male; Methoxydimethyltryptamines; Naphthalenes; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes; Tryptamines | 1989 |
Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Blood Pressure; Cats; Heart Rate; Piperazines; Pyrazines; Receptors, Serotonin; Serotonin Antagonists; Sympathetic Nervous System; Tetrahydronaphthalenes | 1987 |
Comparison of stimulus properties of fluoxetine and 5-HT receptor agonists in a conditioned taste aversion procedure.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Avoidance Learning; Conditioning, Classical; Fluoxetine; Male; Mice; Paroxetine; Pyrazines; Serotonin Receptor Agonists; Taste | 1994 |
Involvement of the 5-HT2 receptor in the 5-HT receptor-mediated stimulation of prolactin release.
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Drug Interactions; Male; Piperazines; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI).
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Desipramine; Drug Synergism; Fluoxetine; Hormones; Ketanserin; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Vasopressins | 1993 |
Modulation of 5-HT receptor subtype-mediated behaviours by corticosterone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Corticosterone; Locomotion; Male; Pyrazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists | 1996 |
Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Conditioning, Operant; Fluoxetine; Male; Mianserin; Mice; Mice, Inbred ICR; Mirtazapine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Taste | 1997 |
Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Microdialysis; Morphine; Narcotic Antagonists; Nucleus Accumbens; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
Inhibition of rat nucleus tractus solitarius neurones by activation of 5-HT2C receptors.
Topics: Amphetamines; Animals; Evoked Potentials; Ligands; Male; Neural Inhibition; Neurons; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Solitary Nucleus; Spiro Compounds; Sulfonamides; Vagus Nerve | 2000 |
In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine(2) receptors in rats.
Topics: Afferent Pathways; Amphetamines; Animals; Antihypertensive Agents; Electric Conductivity; Evoked Potentials; Heart; Indoles; Lung; Male; Medulla Oblongata; Nerve Fibers, Myelinated; Neurons; Organic Chemicals; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Solitary Nucleus; Spiro Compounds; Sulfonamides; Thiophenes; Vagus Nerve | 2000 |
Serotonin(2) receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats.
Topics: Amphetamines; Animals; Asphyxia; Cervical Vertebrae; Female; Ketanserin; Phrenic Nerve; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reference Values; Respiratory Physiological Phenomena; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord Injuries; Spiro Compounds; Sulfonamides | 2001 |
Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury.
Topics: Amphetamines; Animals; Indoles; Injections, Spinal; Ketanserin; Ligation; Lumbar Vertebrae; Male; Neuralgia; Nociceptors; Piperazines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Nerves; Spiro Compounds; Sulfonamides; Thiophenes | 2004 |
Different roles of 5-HT2A and 5-HT2C receptors in regulation of female rat paced mating behaviour.
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Estradiol; Female; Male; Motivation; Progesterone; Pyrazines; Rats; Rats, Wistar; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Sexual Behavior, Animal; Statistics, Nonparametric | 2004 |
Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses.
Topics: Amphetamines; Animals; Cocaine; Drug Interactions; Fluorobenzenes; Hyperkinesis; Indoles; Male; Phenols; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 2004 |
Serotonin 5-HT2 receptors induce a long-lasting facilitation of spinal reflexes independent of ionotropic receptor activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Animals, Newborn; Clozapine; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Female; Ganglia, Spinal; Immunohistochemistry; In Vitro Techniques; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT2; Reflex; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Time Factors | 2005 |
Chronic treatment with a serotonin(2) receptor (5-HT(2)R) agonist modulates the behavioral and cellular response to (+)-3,4-methylenedioxymethamphetamine [(+)-MDMA].
Topics: Amphetamines; Analysis of Variance; Animals; Behavior, Animal; Down-Regulation; Hallucinogens; Humans; Immunohistochemistry; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT2; Serotonin 5-HT2 Receptor Agonists; Serotonin Agents; Serotonin Receptor Agonists | 2006 |
[Functional correlates of the brain 5-HT2A and 5-HT2C serotonin receptors and expression of 5-HT2A AND 5-HT2C genes in aggressive and nonaggressive Norway rats].
Topics: Aggression; Amphetamines; Animals; Behavior, Animal; Frontal Lobe; Gene Expression Regulation; Hypothalamus; Male; Nerve Tissue Proteins; Pyrazines; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists | 2009 |
Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Microinjections; Motor Activity; Periaqueductal Gray; Pyrazines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reproducibility of Results; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Serotonin Agents | 2009 |
Functional characteristics of serotonin 5-HT2A and 5-HT2C receptors in the brain and the expression of the 5-HT2A and 5-HT2C receptor genes in aggressive and non-aggressive rats.
Topics: Aggression; Amphetamines; Animals; Behavior, Animal; Frontal Lobe; Gene Expression Regulation; Hypothalamus; Male; Nerve Tissue Proteins; Pyrazines; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists | 2010 |
Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity.
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Genotype; Head Movements; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Motor Activity; Pyrazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Species Specificity; Spiro Compounds; Sulfonamides | 2015 |