6-chloro-2-(1-piperazinyl)pyrazine has been researched along with 1-(3-trifluoromethylphenyl)piperazine in 17 studies
| Studies (6-chloro-2-(1-piperazinyl)pyrazine) | Trials (6-chloro-2-(1-piperazinyl)pyrazine) | Recent Studies (post-2010) (6-chloro-2-(1-piperazinyl)pyrazine) | Studies (1-(3-trifluoromethylphenyl)piperazine) | Trials (1-(3-trifluoromethylphenyl)piperazine) | Recent Studies (post-2010) (1-(3-trifluoromethylphenyl)piperazine) |
|---|---|---|---|---|---|
| 157 | 8 | 24 | 281 | 7 | 23 |
| Protein | Taxonomy | 6-chloro-2-(1-piperazinyl)pyrazine (IC50) | 1-(3-trifluoromethylphenyl)piperazine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.57 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.57 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.29 | |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | 0.61 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.15 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.039 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.57 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Huff, JR; King, SW; Martin, GE; Saari, WS; Springer, JP; Williams, M | 1 |
| Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB | 1 |
| Dupre, A; Egan, C; Grinde, E; Hake, M; Herrick-Davis, K; Roth, BL; Teitler, M | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Berendsen, HH; Broekkamp, CL | 1 |
| McKearney, JW | 2 |
| Cooper, SJ; Neill, JC | 1 |
| Frazer, A; Lucki, I; Ward, HR | 1 |
| Barrett, JE; Brady, LS | 1 |
| Clineschmidt, BV; Pettibone, DJ; Reiss, DR; Robinson, JL | 1 |
| Harris, LT; McCall, RB; Patel, BN | 1 |
| Rabin, RA; Winter, JC | 1 |
| Fiorella, D; Helsley, S; Rabin, RA; Winter, JC | 1 |
| Alves, SH; Cruz, AP; Landeira-Fernandez, J; Motta, V; Pinheiro, G | 1 |
| Goto, F; Obata, H; Saito, S; Sakurazawa, S; Sasaki, M; Usui, T | 1 |
17 other study(ies) available for 6-chloro-2-(1-piperazinyl)pyrazine and 1-(3-trifluoromethylphenyl)piperazine
| Article | Year |
|---|---|
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
Bioactive conformation of 1-arylpiperazines at central serotonin receptors.
Topics: Animals; Central Nervous System; Chemical Phenomena; Chemistry; Female; Frontal Lobe; Mice; Molecular Conformation; Piperazines; Posture; Pyrazines; Quinolines; Rats; Receptors, Serotonin; Serotonin; Spiperone; Structure-Activity Relationship | 1985 |
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature | 1993 |
Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.
Topics: Animals; Cell Line; Computer Simulation; GTP-Binding Proteins; Inositol Phosphates; Kinetics; Phosphatidylinositols; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Recombinant Proteins; Serotonin Receptor Agonists; Signal Transduction; Transfection; Tritium | 2000 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Body Temperature; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1990 |
Effects of serotonin agonists on operant behavior in the squirrel monkey: quipazine, MK-212, trifluoromethylphenylpiperazine, and chlorophenylpiperazine.
Topics: Animals; Conditioning, Operant; Male; Piperazines; Pyrazines; Quipazine; Receptors, Serotonin; Saimiri; Serotonin Antagonists | 1990 |
Selective reduction by serotonergic agents of hypertonic saline consumption in rats: evidence for possible 5-HT1C receptor mediation.
Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Fenfluramine; Fluoxetine; Hypertonic Solutions; Indoles; Male; Piperazines; Pyrazines; Quinoxalines; Quipazine; Rats; Receptors, Serotonin; Serotonin | 1989 |
Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Male; Monoamine Oxidase Inhibitors; Motor Activity; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1989 |
Apparent antinociceptive properties of piperazine-type serotonin agonists: trifluoromethylphenylpiperazine, chlorophenylpiperazine, and MK-212.
Topics: Animals; Dose-Response Relationship, Drug; Male; Methysergide; Nociceptors; Piperazines; Pyrazines; Receptors, Serotonin; Saimiri | 1989 |
Effects of serotonin receptor agonists and antagonists on schedule-controlled behavior of squirrel monkeys.
Topics: 5-Hydroxytryptophan; Animals; Cinanserin; Conditioning, Operant; Cyproheptadine; Electroshock; Female; Ketanserin; Male; Metergoline; Methysergide; Piperazines; Piperidines; Pyrazines; Quipazine; Receptors, Serotonin; Saimiri | 1985 |
Characterization of 5-hydroxytryptamine receptors in rat stomach fundus.
Topics: Animals; Binding, Competitive; Brain Chemistry; Gastric Fundus; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Piperazines; Piperidines; Propranolol; Pyrazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium | 1985 |
Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Blood Pressure; Cats; Heart Rate; Piperazines; Pyrazines; Receptors, Serotonin; Serotonin Antagonists; Sympathetic Nervous System; Tetrahydronaphthalenes | 1987 |
Discriminative stimulus properties of m-chlorophenylpiperazine.
Topics: Animals; Discrimination Learning; Generalization, Stimulus; Indoles; Male; Piperazines; Pyrazines; Rats; Rats, Inbred F344; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
5-HT2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine.
Topics: Animals; Choroid Plexus; Conditioning, Operant; DOM 2,5-Dimethoxy-4-Methylamphetamine; Drug Interactions; Ketanserin; Lysergic Acid Diethylamide; Ondansetron; Phosphatidylinositols; Piperazines; Pyrazines; Quipazine; Rats; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1995 |
Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but not dorsal hippocampus.
Topics: Animals; Arousal; Brain Mapping; Dose-Response Relationship, Drug; Fear; Hippocampus; Male; Maze Learning; Microinjections; Piperazines; Pyrazines; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists | 2004 |
Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury.
Topics: Amphetamines; Animals; Indoles; Injections, Spinal; Ketanserin; Ligation; Lumbar Vertebrae; Male; Neuralgia; Nociceptors; Piperazines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Nerves; Spiro Compounds; Sulfonamides; Thiophenes | 2004 |