Page last updated: 2024-09-03

6-bromoconduritol and inositol

6-bromoconduritol has been researched along with inositol in 22 studies

*Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction. [MeSH]

*Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction. [MeSH]

Compound Research Comparison

Studies
(6-bromoconduritol)
Trials
(6-bromoconduritol)
Recent Studies (post-2010)
(6-bromoconduritol)
Studies
(inositol)
Trials
(inositol)
Recent Studies (post-2010) (inositol)
22018,2684002,050

Protein Interaction Comparison

ProteinTaxonomy6-bromoconduritol (IC50)inositol (IC50)
Chain B, Pulmonary surfactant-associated protein DHomo sapiens (human)5700
Chain A, Pulmonary surfactant-associated protein DHomo sapiens (human)5700
Sodium/myo-inositol cotransporter 2Homo sapiens (human)104

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199011 (50.00)18.7374
1990's7 (31.82)18.2507
2000's2 (9.09)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Holland, PC; Trudel, GC3
Elias, PM; Holleran, WM; Imokawa, G; Jackson, S; Lee, JM; Takagi, Y1
Olden, K; Yeo, KT; Yeo, TK1
Beuth, J; Ko, HL; Ohshima, Y; Pulverer, G; Roszkowski, K; Uhlenbruck, G; Yassin, A1
Herscovics, A; Holland, PC; Trudel, GC1
Bieberich, E; Legler, G1
Bause, E; Fuhrmann, U; Ploegh, H1
Elbein, AD1
Bosch, JV; Schwarz, RT1
Bosch, FX; Legler, G; Orlich, M; Rott, R; Schwarz, RT1
Datema, R; Romero, PA; Rott, R; Schwarz, RT1
Datema, R; Legler, G; Romero, PA; Schwarz, RT1
Elias, PM; Fartasch, M; Ginns, EI; Grundmann, JU; Holleran, WM; McKinney, CE; Menon, GK; Sidransky, E1
Alonso, JM; Calvo, P; Santa-Cecilia, A1
Candurra, NA; Damonte, EB; Silber, AM1
Elias, PM; Feingold, KR; Holleran, WM; Legler, G; Menon, GK; Takagi, Y1
Saito, T; Yamaguchi, I1
Salvucci, M1
Ito, Y; Matsuo, I; Takeda, Y; Totani, K1
Cressey, R; Inboot, N; Khaodee, W; Kumsaiyai, W; Udomsom, S1

Reviews

2 review(s) available for 6-bromoconduritol and inositol

ArticleYear
Inhibitors of oligosaccharide processing.
    Biochimica et biophysica acta, 1985, Jun-24, Volume: 825, Issue:2

    Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Biological Transport; Carbohydrate Conformation; Cyclohexenes; Glucosamine; Glucosidases; Glucosyltransferases; Indolizines; Inositol; Intracellular Fluid; Mannosidases; Models, Chemical; Oligosaccharides; Polysaccharides; Swainsonine

1985
Inhibitors of the biosynthesis and processing of N-linked oligosaccharides.
    CRC critical reviews in biochemistry, 1984, Volume: 16, Issue:1

    Topics: 1-Deoxynojirimycin; Acetylglucosamine; Alkaloids; Animals; Anti-Bacterial Agents; Asparagine; Bacitracin; Biological Transport; Carbohydrate Conformation; Cyclohexenes; Dolichol Phosphates; Glucosamine; Glucose; Glycoproteins; Hydroxycholesterols; Indolizines; Inositol; Lipopeptides; Lovastatin; Mannose; Naphthalenes; Oligopeptides; Oligosaccharides; Peptides; Peptides, Cyclic; Phospholipids; Polyisoprenyl Phosphate Monosaccharides; Pyrimidine Nucleosides; Showdomycin; Structure-Activity Relationship; Swainsonine; Tunicamycin; Uracil

1984

Other Studies

20 other study(ies) available for 6-bromoconduritol and inositol

ArticleYear
Inhibitors of glycoprotein processing act at an early stage of myogenesis.
    Biochemical and biophysical research communications, 1992, Apr-15, Volume: 184, Issue:1

    Topics: 1-Deoxynojirimycin; Actins; Animals; Blotting, Northern; Blotting, Western; Cell Line; Cyclohexenes; DNA Probes; Glucosamine; Glycoproteins; Glycoside Hydrolases; Inositol; Mice; Muscle Proteins; Muscles; MyoD Protein; Myogenin; Rats; RNA

1992
beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation.
    Journal of lipid research, 1992, Volume: 33, Issue:8

    Topics: Animals; beta-Glucosidase; Cell Differentiation; Cyclohexenes; Dose-Response Relationship, Drug; Epidermis; Glucosides; Glucosylceramidase; Hymecromone; Inositol; Male; Mice; Mice, Hairless; RNA, Messenger; Taurocholic Acid; Tissue Distribution

1992
The glycoprotein-processing inhibitors bromoconduritol and N-methyl-1-deoxynojirimycin alter the adhesion phenotype of skeletal myoblasts.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, Volume: 68, Issue:12

    Topics: 1-Deoxynojirimycin; Amino Acid Sequence; Animals; Cell Adhesion; Cell Differentiation; Cell Fusion; Chick Embryo; Collagen; Cyclohexenes; Extracellular Matrix; Fibronectins; Glucosamine; Glycosylation; Inositol; Integrins; Laminin; Molecular Sequence Data; Muscles; Phenotype; Protein Processing, Post-Translational; Rats; Stem Cells

1990
Effect of inhibitors of glycoprotein processing on integrin and the adhesion of myoblasts to extracellular matrix proteins.
    Biochemical and biophysical research communications, 1989, Sep-29, Volume: 163, Issue:3

    Topics: 1-Deoxynojirimycin; Animals; Cell Adhesion; Cells, Cultured; Chick Embryo; Cyclohexenes; Extracellular Matrix; Fibronectins; Glucosamine; Glycoproteins; Glycoside Hydrolases; Inositol; Integrins; Kinetics; Laminin; Membrane Glycoproteins; Muscles; Protein Processing, Post-Translational; Rats

1989
Bromoconduritol treatment delays intracellular transport of secretory glycoproteins in human hepatoma cell cultures.
    Biochemical and biophysical research communications, 1989, Jun-30, Volume: 161, Issue:3

    Topics: Carcinoma, Hepatocellular; Cell Line; Cyclohexenes; Glucosidases; Glycoproteins; Humans; Inositol; Kinetics; Liver Neoplasms; Methionine; Neoplasm Proteins; Protein Processing, Post-Translational; Tumor Cells, Cultured

1989
Glycoprotein modifications of sarcoma L-1 tumor cells by tunicamycin, swainsonine, bromoconduritol or 1-desoxynojirimycin treatment inhibits their metastatic lung colonization in Balb/c-mice.
    Journal of cancer research and clinical oncology, 1988, Volume: 114, Issue:2

    Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Carbohydrates; Cyclohexenes; Glucosamine; Glycoproteins; Inositol; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Sarcoma, Experimental; Swainsonine; Tunicamycin

1988
Inhibition of myoblast fusion by bromoconduritol.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988, Volume: 66, Issue:10

    Topics: 1-Deoxynojirimycin; Animals; Anti-Bacterial Agents; Catalysis; Cell Fusion; Cell Line; Cyclohexenes; Glucosamine; Glucosidases; Inositol; Lactoperoxidase; Membrane Proteins; Molecular Weight; Muscles; Rats

1988
Active site directed inhibition of a cytosolic beta-glucosidase from calf liver by bromoconduritol B epoxide and bromoconduritol F.
    Archives of biochemistry and biophysics, 1988, Volume: 260, Issue:1

    Topics: Animals; beta-Glucosidase; Carbohydrate Conformation; Cattle; Cyclohexenes; Cytosol; Glucosidases; Hydrolysis; Inositol; Liver; Stereoisomerism; Substrate Specificity

1988
Processing of gPr92env, the precursor to the glycoproteins of Rous sarcoma virus: use of inhibitors of oligosaccharide trimming and glycoprotein transport.
    Virology, 1984, Jan-15, Volume: 132, Issue:1

    Topics: 1-Deoxynojirimycin; Avian Sarcoma Viruses; Biological Transport, Active; Cells, Cultured; Cyclohexenes; Glucosamine; Glycoproteins; Inositol; Kinetics; Oligosaccharides; Viral Proteins; Virion

1984
Effect of inhibitors of glycosylation on proteolytic activation of avian influenza virus hemagglutinins: discrimination between tryptic cleavage and elimination of the connecting peptide.
    Virology, 1984, Jan-15, Volume: 132, Issue:1

    Topics: 1-Deoxynojirimycin; Carbohydrate Metabolism; Cyclohexenes; Deoxyglucose; Glucosamine; Hemagglutinins, Viral; Influenza A virus; Inositol; Trypsin; Tunicamycin; Virion

1984
On the role of oligosaccharide trimming in the maturation of Sindbis and influenza virus.
    Archives of virology, 1984, Volume: 81, Issue:1-2

    Topics: Animals; Cell Line; Chick Embryo; Cricetinae; Cyclohexenes; Glycoproteins; Glycoside Hydrolases; Influenza A virus; Inositol; Kidney; Oligosaccharides; Sindbis Virus; Viral Proteins

1984
Inhibition of formation of complex oligosaccharides by the glucosidase inhibitor bromoconduritol.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:22

    Topics: Animals; Carbohydrate Conformation; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cyclohexenes; Glucosidases; Glycoproteins; Glycoside Hydrolase Inhibitors; Influenza A virus; Inositol; Kinetics; Oligosaccharides; Orthomyxoviridae

1982
Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease.
    The Journal of clinical investigation, 1994, Volume: 93, Issue:4

    Topics: Animals; Cyclohexenes; Epidermis; Gaucher Disease; Glucosylceramidase; Humans; Inositol; Mice; Mice, Hairless; Mice, Transgenic; Permeability; Sphingolipids

1994
Effect of bromoconduritol on glucosidase II from rat liver. A new kinetic model for the binding and hydrolysis of the substrate.
    European journal of biochemistry, 1993, Jul-01, Volume: 215, Issue:1

    Topics: alpha-Glucosidases; Animals; Cyclohexenes; Glycoside Hydrolase Inhibitors; Hydrolysis; Inositol; Kinetics; Liver; Male; Models, Biological; Rats; Rats, Wistar

1993
The effects of oligosaccharide trimming inhibitors on glycoprotein expression and infectivity of Junin virus.
    FEMS microbiology letters, 1993, May-01, Volume: 109, Issue:1

    Topics: 1-Deoxynojirimycin; alpha-Glucosidases; Animals; Arenaviruses, New World; Cyclohexenes; Fluorescent Antibody Technique; Glycoproteins; Glycoside Hydrolase Inhibitors; Inositol; Oligosaccharides; Swainsonine; Vero Cells; Viral Proteins; Virus Replication

1993
Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:4

    Topics: Administration, Topical; Animals; Cell Membrane Permeability; Cyclohexenes; Epidermal Cells; Epidermis; Epoxy Compounds; Glucosidases; Glucosylceramides; Inositol; Male; Mice; Mice, Hairless; Skin; Sphingolipids

1993
Effect of glycosylation and glucose trimming inhibitors on the influenza A virus glycoproteins.
    The Journal of veterinary medical science, 2000, Volume: 62, Issue:6

    Topics: 1-Deoxynojirimycin; Animals; Antibodies, Monoclonal; Antiviral Agents; Cell Line; Colony Count, Microbial; Cyclohexenes; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Glucosidases; Glycosylation; Hemagglutinin Glycoproteins, Influenza Virus; Indolizines; Influenza A virus; Inositol; Neuraminidase; Reassortant Viruses; Tunicamycin

2000
Effect of the alpha-glucosidase inhibitor, bromoconduritol, on carbohydrate metabolism in the silverleaf whitefly, Bemisia argentifolii.
    Archives of insect biochemistry and physiology, 2000, Volume: 45, Issue:3

    Topics: alpha-Glucosidases; Animals; Cyclohexenes; Disaccharides; Eating; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Hemiptera; Inositol; Isoelectric Focusing; Ligases; Sucrose

2000
The action of bromoconduritol on ER glucosidase II.
    Bioorganic & medicinal chemistry letters, 2010, Sep-01, Volume: 20, Issue:17

    Topics: Cyclohexenes; Endoplasmic Reticulum; Enzyme Inhibitors; Glucosides; Inositol

2010
Glucosidase II beta subunit (GluIIβ) plays a role in autophagy and apoptosis regulation in lung carcinoma cells in a p53-dependent manner.
    Cellular oncology (Dordrecht), 2017, Volume: 40, Issue:6

    Topics: alpha-Glucosidases; Apoptosis; Autophagy; Blotting, Western; Calcium-Binding Proteins; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclohexenes; Glucosidases; Humans; Inositol; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Signal Transduction; Tumor Suppressor Protein p53

2017