Page last updated: 2024-09-04

6-aminophenanthridine and guanabenz

6-aminophenanthridine has been researched along with guanabenz in 6 studies

Compound Research Comparison

Studies
(6-aminophenanthridine)
Trials
(6-aminophenanthridine)
Recent Studies (post-2010)
(6-aminophenanthridine)
Studies
(guanabenz)
Trials
(guanabenz)
Recent Studies (post-2010) (guanabenz)
10094464296

Protein Interaction Comparison

ProteinTaxonomy6-aminophenanthridine (IC50)guanabenz (IC50)
trace amine-associated receptor 1Homo sapiens (human)1.173
Solute carrier family 22 member 1 Homo sapiens (human)4.85
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.204
Alpha-2A adrenergic receptorHomo sapiens (human)0.041
Alpha-2B adrenergic receptorHomo sapiens (human)0.149
Alpha-2C adrenergic receptorHomo sapiens (human)1.106
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)2.068
Amine oxidase [flavin-containing] AHomo sapiens (human)1.787
Alpha-1D adrenergic receptorHomo sapiens (human)0.472
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.392
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.204
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)2.068
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.097

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bach, S; Blondel, M; Desban, N; Galons, H; Gug, F; Oumata, N; Tribouillard-Tanvier, D; Voisset, C1
Barbezier, N; Bidet, Y; Blondel, M; Buttstedt, A; Chartier, A; Galons, H; Schwarz, E; Simonelig, M; Voisset, C1
Blondel, M; Galons, H; Pang, Y; Reis, SD; Sanyal, S; Vishnu, N; Voisset, C1
Blondel, M; Saupe, SJ; Voisset, C1
Banerjee, D; Sanyal, S1
Blondel, M; Chédin, S; Contesse, MA; Evrard, J; Friocourt, G; Gillet, R; Hasin, N; Jones, GW; Nguyen, PH; Soubigou, F; Stahl, G; Voisset, C1

Reviews

2 review(s) available for 6-aminophenanthridine and guanabenz

ArticleYear
The various facets of the protein-folding activity of the ribosome.
    Biotechnology journal, 2011, Volume: 6, Issue:6

    Topics: Guanabenz; Molecular Chaperones; Muscular Dystrophy, Oculopharyngeal; Phenanthridines; Prion Diseases; Protein Biosynthesis; Protein Folding; Proteins; Ribosomes; RNA, Ribosomal

2011
Protein folding activity of the ribosome (PFAR) -- a target for antiprion compounds.
    Viruses, 2014, Oct-23, Volume: 6, Issue:10

    Topics: Aminoquinolines; Binding Sites; Guanabenz; Humans; Imiquimod; Phenanthridines; Prion Diseases; Prions; Protein Folding; Ribosomes; RNA, Ribosomal

2014

Other Studies

4 other study(ies) available for 6-aminophenanthridine and guanabenz

ArticleYear
Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography.
    Bioconjugate chemistry, 2010, Feb-17, Volume: 21, Issue:2

    Topics: Binding, Competitive; Chlorpromazine; Chromatography, Affinity; Guanabenz; Microspheres; Phenanthridines; Prions; Quinacrine; Ribosomes; RNA, Ribosomal; Sepharose

2010
Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy.
    EMBO molecular medicine, 2011, Volume: 3, Issue:1

    Topics: Animals; Drosophila; Guanabenz; Larva; Muscular Dystrophy, Oculopharyngeal; Phenanthridines; Phenotype; Poly(A)-Binding Protein II; Prion Diseases; Protein Folding; RNA, Ribosomal

2011
Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding.
    Biochimie, 2011, Volume: 93, Issue:6

    Topics: Carbonic Anhydrases; Escherichia coli Proteins; Guanabenz; Humans; Phenanthridines; Prions; Protein Folding; Ribosomes; Saccharomyces cerevisiae Proteins

2011
Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation.
    Scientific reports, 2016, 09-16, Volume: 6

    Topics: Guanabenz; Heat-Shock Proteins; Mutation; Peptide Termination Factors; Phenanthridines; Prions; Protein Folding; Ribosomes; RNA, Ribosomal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

2016