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6-aminomethyl-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide and gamma-aminobutyric acid

6-aminomethyl-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide has been researched along with gamma-aminobutyric acid in 5 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Compound Research Comparison

Studies
(6-aminomethyl-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide)
Trials
(6-aminomethyl-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide)
Recent Studies (post-2010)
(6-aminomethyl-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
250040,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomy6-aminomethyl-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atkinson, JG; Girard, Y; Haubrich, DR; Williams, M; Yarbrough, GG1
Ente, P; Fariello, RG; Golden, GT1
Ahtee, L; Vahala, ML1
Kimura, H; Okamoto, K; Sakai, Y1
Ebner, K; Engelmann, M; Landgraf, R; Lubec, G; Ludwig, M; Sabatier, N; Singewald, N; Wotjak, CT1

Other Studies

5 other study(ies) available for 6-aminomethyl-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide and gamma-aminobutyric acid

ArticleYear
Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Animals; Benzothiadiazines; Brain; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Taurine

1982
The epileptogenic action of 6-aminomethyl-3-methyl,1-4H-1,2,6-benzothiadiazine-1,1-diazide hydrochloride (TAG): non-specific versus specific antitaurine pathogenesis.
    Brain research, 1986, Aug-13, Volume: 380, Issue:1

    Topics: Action Potentials; Animals; Benzothiadiazines; Cerebral Cortex; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Male; Neurons; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Taurine

1986
Taurine and its derivatives alter brain dopamine metabolism similarly to GABA in mice and rats.
    Progress in clinical and biological research, 1985, Volume: 179

    Topics: Animals; Apomorphine; Benzothiadiazines; Brain; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Mice; Rats; Taurine

1985
Antagonistic action of 6-aminomethyl-3-methyl-4H, 1,2,4-benzothiadiazine-1, 1-dioxide (TAG), and evidence for a transmitter role of taurine in stellate interneurons in the cerebellum.
    Progress in clinical and biological research, 1983, Volume: 125

    Topics: Animals; Benzothiadiazines; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Guinea Pigs; Purkinje Cells; Taurine

1983
Taurine selectively modulates the secretory activity of vasopressin neurons in conscious rats.
    The European journal of neuroscience, 2001, Volume: 14, Issue:7

    Topics: Action Potentials; Animals; Aspartic Acid; Benzothiadiazines; Bicuculline; Consciousness; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neural Inhibition; Neurons; Oxytocin; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Physiological; Supraoptic Nucleus; Swimming; Taurine; Vasopressins

2001