6-7-dihydroxyflavone and 7-hydroxyflavone

Flavonoids are a class of compounds that having the benzo-γ-pyrone skeleton, which possess anti-inflammatory properties in vitro and in vivo. The aim of this study was to investigate the inhibition of two flavonoids 7-hydroxyflavone (HF) and 7,8-dihydroxyflavone (DHF) on the production of pro-inflammatory mediators in RAW264.7 cells activated by lipopolysaccharides (LPS).. For this purpose, we selected four pro-inflammatory mediators including nitric oxide (NO), prostaglandin E. In this regard, we showed that HF and DHF dose-dependently reduced the production of NO, PGE. Consider together, these findings suggest that DHF and HF can inhibit LPS-induced inflammation via attenuating the production of NO, PGE

Topics: Animals; Anti-Inflammatory Agents; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Flavones; Flavonoids; Inflammation; Inflammation Mediators; Interleukin-6; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; RNA, Messenger; Tumor Necrosis Factor-alpha