6-7-4--trihydroxyisoflavone and glycitein

6-7-4--trihydroxyisoflavone has been researched along with glycitein* in 2 studies

Other Studies

2 other study(ies) available for 6-7-4--trihydroxyisoflavone and glycitein

Article	Year
In vitro and in vivo metabolism of the soy isoflavone glycitein. Molecular nutrition & food research, 2007, Volume: 51, Issue:7 Glycitein (GLY) is a major isoflavone of soy germ which is used as a functional ingredient to enrich foods with isoflavones as well as a component of soy supplements. Since data on the metabolism of GLY are incomplete, the in vitro phase I metabolism of GLY using rat liver microsomes, human liver microsomes (HLM), as well as human fecal flora was investigated. Furthermore, the in vivo metabolism has been studied after administration of GLY to Sprague-Dawley rats. The identification of the formed metabolites has been elucidated using HPLC/DAD, HPLC/API-ES MS, GC/MS, as well as reference compounds. With respect to the phase I metabolism, GLY has been converted to ten metabolites by liver microsomes of Aroclor-induced Wistar rats with 8-hydroxy(OH)-GLY as the main metabolite. HLM converted GLY to six metabolites with 8-OH-GLY and 6-OH-daidzein (DAI) being the major products. No sex-related differences were observed in each system. Intestinal metabolism of GLY led to four metabolites with 6-OH-DAI as the main product. The in vivo metabolism in rat urine after single-dose administration of GLY resulted in the identification of three oxidative and two bacterial metabolites as well as the demethylation product 6-OH-DAI as the main metabolite. Topics: Animals; Aroclors; Bacteria; Feces; Female; Glycine max; Humans; In Vitro Techniques; Isoflavones; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Rats, Wistar	2007
Isolation of 8-hydroxyglycitein and 6-hydroxydaidzein from soybean miso. Bioscience, biotechnology, and biochemistry, 2004, Volume: 68, Issue:6 We isolated from soybean miso 8-hydroxyglycitein and 6-hydroxydaidzein as DPPH-radical scavengers, and elucidated their chemical structures by mass spectrometric, and (1)H- and (13)C-NMR spectrosopic analyses. These compounds showed DPPH-radical scavenging activity as high as that of alpha-tocopherol, 8-hydroxygenistein and 8-hydroxydaidzein. This is the first report of the isolation of 8-hydroxyglycitein from a natural source. Topics: Biphenyl Compounds; Cell Proliferation; Free Radical Scavengers; Glycine max; HL-60 Cells; Humans; Hydrazines; Isoflavones; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phytoestrogens; Picrates	2004

Article

Year

In vitro and in vivo metabolism of the soy isoflavone glycitein.

Molecular nutrition & food research, 2007, Volume: 51, Issue:7

Glycitein (GLY) is a major isoflavone of soy germ which is used as a functional ingredient to enrich foods with isoflavones as well as a component of soy supplements. Since data on the metabolism of GLY are incomplete, the in vitro phase I metabolism of GLY using rat liver microsomes, human liver microsomes (HLM), as well as human fecal flora was investigated. Furthermore, the in vivo metabolism has been studied after administration of GLY to Sprague-Dawley rats. The identification of the formed metabolites has been elucidated using HPLC/DAD, HPLC/API-ES MS, GC/MS, as well as reference compounds. With respect to the phase I metabolism, GLY has been converted to ten metabolites by liver microsomes of Aroclor-induced Wistar rats with 8-hydroxy(OH)-GLY as the main metabolite. HLM converted GLY to six metabolites with 8-OH-GLY and 6-OH-daidzein (DAI) being the major products. No sex-related differences were observed in each system. Intestinal metabolism of GLY led to four metabolites with 6-OH-DAI as the main product. The in vivo metabolism in rat urine after single-dose administration of GLY resulted in the identification of three oxidative and two bacterial metabolites as well as the demethylation product 6-OH-DAI as the main metabolite.

Topics: Animals; Aroclors; Bacteria; Feces; Female; Glycine max; Humans; In Vitro Techniques; Isoflavones; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Rats, Wistar

2007

Isolation of 8-hydroxyglycitein and 6-hydroxydaidzein from soybean miso.

Bioscience, biotechnology, and biochemistry, 2004, Volume: 68, Issue:6

We isolated from soybean miso 8-hydroxyglycitein and 6-hydroxydaidzein as DPPH-radical scavengers, and elucidated their chemical structures by mass spectrometric, and (1)H- and (13)C-NMR spectrosopic analyses. These compounds showed DPPH-radical scavenging activity as high as that of alpha-tocopherol, 8-hydroxygenistein and 8-hydroxydaidzein. This is the first report of the isolation of 8-hydroxyglycitein from a natural source.

Topics: Biphenyl Compounds; Cell Proliferation; Free Radical Scavengers; Glycine max; HL-60 Cells; Humans; Hydrazines; Isoflavones; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phytoestrogens; Picrates

2004