5-trifluoromethyl-2'-deoxyuridylic acid has been researched along with fluorodeoxyuridylate in 5 studies
| Studies (5-trifluoromethyl-2'-deoxyuridylic acid) | Trials (5-trifluoromethyl-2'-deoxyuridylic acid) | Recent Studies (post-2010) (5-trifluoromethyl-2'-deoxyuridylic acid) | Studies (fluorodeoxyuridylate) | Trials (fluorodeoxyuridylate) | Recent Studies (post-2010) (fluorodeoxyuridylate) |
|---|---|---|---|---|---|
| 8 | 0 | 0 | 348 | 6 | 24 |
| Protein | Taxonomy | 5-trifluoromethyl-2'-deoxyuridylic acid (IC50) | fluorodeoxyuridylate (IC50) |
|---|---|---|---|
| Thymidylate synthase | Mus musculus (house mouse) | 0.0223 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, CT; Edwards, MW; Mertes, MP; Torrence, PF | 1 |
| Hansch, C; Santi, DV; Wataya, Y | 1 |
| Balzarini, J; Bentrude, WG; Béres, J; De Clercq, E; Otvös, L; Sági, G | 1 |
| Danenberg, PV; Lockshin, A | 1 |
| Rode, W | 1 |
2 review(s) available for 5-trifluoromethyl-2'-deoxyuridylic acid and fluorodeoxyuridylate
| Article | Year |
|---|---|
Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chemical Phenomena; Chemistry; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Kinetics; Methyltransferases; Thymidylate Synthase; Thymine Nucleotides; Trifluridine | 1981 |
[Inhibition of thymidylate synthase in chemotherapy].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Substrate Specificity; Thymidylate Synthase; Thymine Nucleotides | 1996 |
3 other study(ies) available for 5-trifluoromethyl-2'-deoxyuridylic acid and fluorodeoxyuridylate
| Article | Year |
|---|---|
5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase.
Topics: Deoxyuracil Nucleotides; Lacticaseibacillus casei; Methyltransferases; Nitriles; Structure-Activity Relationship; Thymidylate Synthase | 1979 |
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.
Topics: Deoxyuracil Nucleotides; Kinetics; Lacticaseibacillus casei; Methyltransferases; Structure-Activity Relationship; Thymidylate Synthase | 1977 |
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Deoxyuracil Nucleotides; Drug Evaluation, Preclinical; Humans; Hydrocarbons, Halogenated; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Simplexvirus; Structure-Activity Relationship; Vaccinia virus; Vesicular stomatitis Indiana virus | 1986 |