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5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and quipazine

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with quipazine in 12 studies

Compound Research Comparison

Studies
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Trials
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Recent Studies (post-2010)
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Studies
(quipazine)
Trials
(quipazine)
Recent Studies (post-2010) (quipazine)
218012658041

Protein Interaction Comparison

ProteinTaxonomy5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50)quipazine (IC50)
5-hydroxytryptamine receptor 3EHomo sapiens (human)0.0004
5-hydroxytryptamine receptor 3BHomo sapiens (human)0.0004
5-hydroxytryptamine receptor 1AHomo sapiens (human)1.4454
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.47
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)1.4
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)2.7
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0617
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.7297
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.0035
5-hydroxytryptamine receptor 3AHomo sapiens (human)0.0004
5-hydroxytryptamine receptor 1DSus scrofa (pig)3.7153
Adenylate cyclase type 5Rattus norvegicus (Norway rat)1.4454
5-hydroxytryptamine receptor 3DHomo sapiens (human)0.0004
5-hydroxytryptamine receptor 2ABos taurus (cattle)3.4674
5-hydroxytryptamine receptor 3CHomo sapiens (human)0.0004
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.0035

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19908 (66.67)18.7374
1990's3 (25.00)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Glennon, RA1
Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB1
Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D1
Eide, PK1
Hollingsworth, PJ; Smith, CB; Walker, EA; Woods, JH; Yamamoto, T1
Cooper, SJ; Neill, JC1
Amoroso, S; Annunziato, L; Basile, V; Canzoniero, L; Di Renzo, G; Fatatis, A; Taglialatela, M1
Fedele, E; Maura, G; Raiteri, M1
Goodwin, GM; Green, AR1
Middlemiss, DN1
Balestre, MN; Bockaert, J; Cory, RN; Guillon, G; Rouot, B; Sladeczek, F1
Boddeke, HW; Kalkman, HO; Timmermans, PB; Van Zwieten, PA1

Reviews

1 review(s) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and quipazine

ArticleYear
Central serotonin receptors as targets for drug research.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:1

    Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin

1987

Other Studies

11 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and quipazine

ArticleYear
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature

1993
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:2

    Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists

2004
Stimulation of 5-HT1 receptors in the spinal cord changes substance P-induced behaviour.
    Neuropharmacology, 1992, Volume: 31, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analgesia; Animals; Indoles; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nerve Endings; Neurons; Pain; Piperazines; Quipazine; Receptors, Serotonin; Reference Values; Serotonin; Serotonin Antagonists; Spinal Cord; Stereotyped Behavior; Substance P

1992
Discriminative-stimulus effects of quipazine and l-5-hydroxytryptophan in relation to serotonin binding sites in the pigeon.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Binding Sites; Binding, Competitive; Brain; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Indoles; Ketanserin; Kinetics; Male; Pyrimidines; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Tritium

1991
Selective reduction by serotonergic agents of hypertonic saline consumption in rats: evidence for possible 5-HT1C receptor mediation.
    Psychopharmacology, 1989, Volume: 99, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Fenfluramine; Fluoxetine; Hypertonic Solutions; Indoles; Male; Piperazines; Pyrazines; Quinoxalines; Quipazine; Rats; Receptors, Serotonin; Serotonin

1989
Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion.
    European journal of pharmacology, 1989, Mar-21, Volume: 162, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Fenfluramine; Indoles; Male; Piperidines; Prolactin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Tetrahydronaphthalenes

1989
Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine.
    European journal of pharmacology, 1989, Jun-20, Volume: 165, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Electric Stimulation; Fenfluramine; Hippocampus; In Vitro Techniques; Indoles; Male; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1989
A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors.
    British journal of pharmacology, 1985, Volume: 84, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Body Temperature; Brain Chemistry; Histamine H2 Antagonists; Hydroxyindoleacetic Acid; Indoles; Kinetics; Male; Methoxydimethyltryptamines; Mice; Mice, Inbred C57BL; Motor Activity; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Species Specificity; Tetrahydronaphthalenes

1985
The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:6

    Topics: Animals; Cerebral Cortex; Dioxanes; Idazoxan; In Vitro Techniques; Indoles; Male; Methiothepin; Potassium; Propranolol; Quipazine; Rats; Receptors, Serotonin; Serotonin

1985
The 5-hydroxytryptamine (5-HT2) receptor stimulates inositol phosphate formation in intact and broken WRK1 cells: determination of occupancy-response relationships for 5-HT agonists.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bufotenin; Cell Line; Dibenzylchlorethamine; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; Indoles; Inositol Phosphates; Kinetics; Mammary Neoplasms, Experimental; Mathematics; N,N-Dimethyltryptamine; Piperazines; Quipazine; Rats; Receptors, Serotonin; Sugar Phosphates; Tetrahydronaphthalenes; Tryptamines

1987
Calcium-dependency of the pressor responses to selective 5-hydroxytryptamine receptor agonists in pithed rats.
    Journal of autonomic pharmacology, 1983, Volume: 3, Issue:4

    Topics: 5-Methoxytryptamine; Animals; Blood Pressure; Calcium; Indoles; Methoxydimethyltryptamines; Piperazines; Prazosin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spinal Cord; Yohimbine

1983