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5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and propranolol

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with propranolol in 9 studies

Compound Research Comparison

Studies
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Trials
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Recent Studies (post-2010)
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Studies
(propranolol)
Trials
(propranolol)
Recent Studies (post-2010) (propranolol)
21801233,3103,4063,218

Protein Interaction Comparison

ProteinTaxonomy5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50)propranolol (IC50)
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)0.0347
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.294
Cytochrome P450 1A2Homo sapiens (human)4
Beta-2 adrenergic receptorHomo sapiens (human)0.0114
Beta-1 adrenergic receptorHomo sapiens (human)0.0575
5-hydroxytryptamine receptor 1AHomo sapiens (human)3.9811
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.012
Cytochrome P450 2D6Homo sapiens (human)2.9706
Beta-3 adrenergic receptorHomo sapiens (human)0.0493
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0288
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0827
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0288
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.012
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.466
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.243
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0288
Sodium-dependent serotonin transporterHomo sapiens (human)0.38
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.342
5-hydroxytryptamine receptor 6Homo sapiens (human)3.065
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.017
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0288
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.828
Sodium channel protein type 5 subunit alphaHomo sapiens (human)2.1
Sodium/bile acid cotransporterHomo sapiens (human)5.5
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0288
GABA theta subunitRattus norvegicus (Norway rat)0.0288
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.87
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0288

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19906 (66.67)18.7374
1990's3 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schwab, EF; Zemlan, FP1
Goodwin, GM; Green, AR1
Middlemiss, DN1
Bonanno, G; Maura, G; Pittaluga, A; Raiteri, M1
Bonanno, G; Maura, G; Raiteri, M1
De Souza, RJ; Goodwin, GM; Green, AR; Wood, AJ1
Gardner, CR; Green, AR; Guy, AP1
Callaway, CW; Geyer, MA; Rempel, NL1
Blier, P; de Montigny, C; PiƱeyro, G; Weiss, M1

Other Studies

9 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and propranolol

ArticleYear
Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein.
    Journal of neurochemistry, 1991, Volume: 57, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; GTP-Binding Proteins; Indoles; Male; Pindolol; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spinal Cord; Tetrahydronaphthalenes; Tissue Distribution

1991
A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors.
    British journal of pharmacology, 1985, Volume: 84, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Body Temperature; Brain Chemistry; Histamine H2 Antagonists; Hydroxyindoleacetic Acid; Indoles; Kinetics; Male; Methoxydimethyltryptamines; Mice; Mice, Inbred C57BL; Motor Activity; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Species Specificity; Tetrahydronaphthalenes

1985
The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:6

    Topics: Animals; Cerebral Cortex; Dioxanes; Idazoxan; In Vitro Techniques; Indoles; Male; Methiothepin; Potassium; Propranolol; Quipazine; Rats; Receptors, Serotonin; Serotonin

1985
Differential pharmacology and function of two 5-HT1 receptors modulating transmitter release in rat cerebellum.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebellum; Glutamates; Glutamic Acid; In Vitro Techniques; Indoles; Male; Neurotransmitter Agents; Potassium; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes

1986
Pharmacological characterization of release-regulating serotonin autoreceptors in rat cerebellum.
    European journal of pharmacology, 1986, Jul-31, Volume: 126, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebellum; In Vitro Techniques; Indoles; Male; Methiothepin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Synaptosomes; Tetrahydronaphthalenes

1986
The enhancement by lithium of the 5-HT1A mediated serotonin syndrome produced by 8-OH-DPAT in the rat: evidence for a post-synaptic mechanism.
    Psychopharmacology, 1986, Volume: 90, Issue:4

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Carbidopa; Drug Synergism; Fenclonine; Indoles; Lithium; Male; Methoxydimethyltryptamines; Motor Activity; Naphthalenes; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes

1986
The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants.
    Neuropharmacology, 1984, Volume: 23, Issue:6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Brain; Indoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1984
Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1993, Volume: 8, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Caffeine; Designer Drugs; Dopamine Agents; Dose-Response Relationship, Drug; Fluoxetine; Indoles; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Scopolamine; Serotonin; Serotonin Receptor Agonists; Synapses

1993
Autoregulatory properties of dorsal raphe 5-HT neurons: possible role of electrotonic coupling and 5-HT1D receptors in the rat brain.
    Synapse (New York, N.Y.), 1996, Volume: 22, Issue:1

    Topics: Action Potentials; Animals; Dendrites; Electric Stimulation; Electrophysiology; Extracellular Space; Indoles; Male; Mianserin; Piperazines; Propranolol; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses

1996