5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with pindolol in 19 studies
| Studies (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Trials (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Recent Studies (post-2010) (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Studies (pindolol) | Trials (pindolol) | Recent Studies (post-2010) (pindolol) |
|---|---|---|---|---|---|
| 218 | 0 | 12 | 3,718 | 662 | 92 |
| Protein | Taxonomy | 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50) | pindolol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 0.0005 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.0009 | |
| Beta-3 adrenergic receptor | Homo sapiens (human) | 0.088 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.048 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.048 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 10 (52.63) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Glennon, RA | 1 |
| Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Barrett, JE; Gleeson, S | 1 |
| Combs, MR; Jones, DJ; Matsumoto, I | 1 |
| Schwab, EF; Zemlan, FP | 1 |
| Bom, AH; Saxena, PR; Verdouw, PD; Villalón, CM | 1 |
| Curzon, G; Kennett, GA | 1 |
| el-Yassir, N; Fleetwood-Walker, SM; Mitchell, R | 1 |
| De Jonge, A; Doods, HN; Kalkman, HO; Thoolen, MJ; Timmermans, PB; Van Zwieten, PA; Wilffert, B | 1 |
| Classen, K; Fink, K; Göthert, M; Schlicker, E | 1 |
| Cortés, R; Palacios, JM; Pazos, A | 1 |
| Amara, DA; Buhot, MC; Dierich, A; Hen, R; LeMeur, M; Ramboz, S; Saudou, F; Segu, L | 1 |
| Galvan, I; Pranzatelli, MR | 1 |
| Leysen, JE; Pauwels, PJ; Van Gompel, P | 1 |
| Bourin, M; MacSweeney, CP; Redrobe, JP | 1 |
| Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A | 1 |
| Baker, GB; Bourin, M; Colombel, MC; Redrobe, JP | 1 |
| Yan, QS; Yan, SE | 1 |
1 review(s) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and pindolol
| Article | Year |
|---|---|
Central serotonin receptors as targets for drug research.
Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin | 1987 |
18 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and pindolol
| Article | Year |
|---|---|
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
Discriminative stimulus effects of 8-OH-DPAT in pigeons: antagonism studies with the putative 5-HT1A receptor antagonists BMY 7378 and NAN-190.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Indoles; Pindolol; Piperazines; Prazosin; Serotonin Antagonists | 1992 |
Characterization of 5-hydroxytryptamine1B receptors in rat spinal cord via [125I]iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release.
Topics: Animals; Binding, Competitive; Indoles; Iodine Radioisotopes; Iodocyanopindolol; Male; Microscopy, Electron; Pindolol; Potassium; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spinal Cord; Synaptosomes | 1992 |
Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; GTP-Binding Proteins; Indoles; Male; Pindolol; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spinal Cord; Tetrahydronaphthalenes; Tissue Distribution | 1991 |
The 5-HT1-like receptor mediating reduction of porcine carotid arteriovenous shunting by RU 24969 is not related to either the 5-HT1A or the 5-HT1B subtype.
Topics: Animals; Blood Pressure; Carotid Arteries; Heart Rate; Hemodynamics; Indoles; Ketanserin; Methiothepin; Microspheres; Pindolol; Receptors, Serotonin; Swine | 1989 |
Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Ergolines; Feeding Behavior; Food Deprivation; Indoles; Male; Mianserin; Motor Activity; Pindolol; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tropisetron | 1988 |
Heterogeneous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Indoles; Ketanserin; Male; Neurons, Afferent; Pain; Physical Stimulation; Pindolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spinal Cord; Tetrahydronaphthalenes | 1988 |
Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Binding Sites; Blood Pressure; In Vitro Techniques; Indoles; Male; Naphthalenes; Pentobarbital; Pindolol; Rats; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1985 |
Effects of RU 24969 on serotonin release in rat brain cortex: further support for the identity of serotonin autoreceptors with 5-HT1B sites.
Topics: Animals; Cerebral Cortex; Electric Stimulation; In Vitro Techniques; Indoles; Male; Monoamine Oxidase; Pindolol; Potassium; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Synaptosomes | 1987 |
Quantitative receptor autoradiography: application to the characterization of multiple receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Autoradiography; Benzodiazepinones; Binding, Competitive; Brain; Carbachol; Hippocampus; Indoles; Oxotremorine; Pindolol; Pirenzepine; Rats; Receptors, Muscarinic; Receptors, Serotonin; Superior Colliculi; Tetrahydronaphthalenes | 1984 |
Enhanced aggressive behavior in mice lacking 5-HT1B receptor.
Topics: Aggression; Animals; Brain Chemistry; Chimera; Female; Indoles; Male; Mice; Motor Activity; Mutation; Pindolol; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombination, Genetic; Serotonin Receptor Agonists | 1994 |
Ontogeny of [125I]iodocyanopindolol-labelled 5-hydroxytryptamine1B-binding sites in the rat CNS.
Topics: Aging; Animals; Animals, Newborn; Binding Sites; Binding, Competitive; Central Nervous System; Indoles; Iodine Radioisotopes; Iodocyanopindolol; Pindolol; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Tissue Distribution | 1994 |
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Colforsin; Cyclic AMP; HeLa Cells; Humans; Indoles; Lysergic Acid Diethylamide; Models, Biological; Pindolol; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Transfection | 1993 |
The role of 5-HT1A and 5-HT1B receptors in antidepressant drug actions in the mouse forced swimming test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Immobilization; Indoles; Male; Mice; Pindolol; Receptors, Serotonin; Swimming | 1996 |
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 1997 |
Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Animals; Antidepressive Agents; Apomorphine; Brain; Clonidine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Hypothermia; Indoles; Male; Mice; Motor Activity; Norepinephrine; Paroxetine; Pindolol; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 1998 |
Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Indoles; Male; Oxadiazoles; Pindolol; Piperazines; Potassium; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Ventral Tegmental Area | 2001 |