Compounds > 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole

Page last updated: 2024-09-02

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and ipsapirone

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with ipsapirone in 10 studies

Compound Research Comparison

Studies (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)	Trials (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)	Recent Studies (post-2010) (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)	Studies (ipsapirone)	Trials (ipsapirone)	Recent Studies (post-2010) (ipsapirone)
218	0	12	373	58	14

Protein Interaction Comparison

Protein	Taxonomy	5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50)	ipsapirone (IC50)
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)		10
Alpha-2A adrenergic receptor	Homo sapiens (human)		1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)		10
Alpha-2B adrenergic receptor	Homo sapiens (human)		1
Alpha-2C adrenergic receptor	Homo sapiens (human)		1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)		0.0082
D(4) dopamine receptor	Homo sapiens (human)		1.8
Alpha-1D adrenergic receptor	Homo sapiens (human)		0.5
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)		10
Alpha-1A adrenergic receptor	Homo sapiens (human)		0.5
Alpha-1B adrenergic receptor	Homo sapiens (human)		0.5
D(3) dopamine receptor	Homo sapiens (human)		1.2
D(2) dopamine receptor	Rattus norvegicus (Norway rat)		2.9

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (60.00)	18.7374
1990's	4 (40.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Glennon, RA	1
Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L	1
Hollingsworth, PJ; Smith, CB; Walker, EA; Woods, JH; Yamamoto, T	1
Berendsen, HH; Broekkamp, CL; Jenck, F	1
Agmo, A; Escalante, A; Fernández-Guasti, A	1
Curzon, G; Dourish, CT; Kennett, GA	1
De Souza, RJ; Goodwin, GM; Green, AR	1
De Souza, RJ; Goodwin, GM; Green, AR; Heal, DJ	1
Korneyev, AY; Seredenin, SB	1
Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A	1

Reviews

1 review(s) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and ipsapirone

Article	Year
Central serotonin receptors as targets for drug research. Journal of medicinal chemistry, 1987, Volume: 30, Issue:1 Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin	1987

Other Studies

9 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and ipsapirone

Article	Year
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3 Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes	1998
Discriminative-stimulus effects of quipazine and l-5-hydroxytryptophan in relation to serotonin binding sites in the pigeon. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2 Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Binding Sites; Binding, Competitive; Brain; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Indoles; Ketanserin; Kinetics; Male; Pyrimidines; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Tritium	1991
Selective activation of 5HT1A receptors induces lower lip retraction in the rat. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Dose-Response Relationship, Drug; Indoles; Lip; Male; Muscles; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1989
Inhibitory action of various 5-HT1B receptor agonists on rat masculine sexual behaviour. Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:4 Topics: Animals; Indoles; Male; Piperazines; Psychomotor Performance; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sexual Behavior, Animal	1989
Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression. European journal of pharmacology, 1987, Feb-24, Volume: 134, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Buspirone; Depressive Disorder; Disease Models, Animal; Drug Interactions; Indoles; Male; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Restraint, Physical; Serotonin; Stress, Psychological; Tetrahydronaphthalenes	1987
The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats. Psychopharmacology, 1986, Volume: 89, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Drug Interactions; Indoles; Male; Methoxydimethyltryptamines; Mice; Mice, Inbred C57BL; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Tetrahydronaphthalenes	1986
Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. British journal of pharmacology, 1986, Volume: 89, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Brain Chemistry; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Motor Activity; Naphthalenes; Pyrimidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1986
Effect of 5-HT-1A receptor agonists on paw licking reaction on hot plate and unpunished drinking in rat. Life sciences, 1993, Volume: 52, Issue:12 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Drinking Behavior; Indoles; Male; Pain; Prosencephalon; Punishment; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Thirst; Time Factors	1993
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles	1997