Compounds > 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole

Page last updated: 2024-09-02

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and gr 127935

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with gr 127935 in 10 studies

Compound Research Comparison

Studies (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)	Trials (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)	Recent Studies (post-2010) (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)	Studies (gr 127935)	Trials (gr 127935)	Recent Studies (post-2010) (gr 127935)
218	0	12	221	0	28

Protein Interaction Comparison

Protein	Taxonomy	5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50)	gr 127935 (IC50)
5-hydroxytryptamine receptor 1D	Homo sapiens (human)		0.052
Sodium-dependent serotonin transporter	Homo sapiens (human)		1

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (60.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fernández, AG; O'Neill, MF; Palacios, JM	1
Hen, R; Lucas, JJ; Segu, L	1
Koob, GF; Parsons, LH; Weiss, F	1
Harrison, AA; Koob, GF; Markou, A; Parsons, LH	1
Chaouloff, F; Courvoisier, H; Moisan, MP; Mormède, P	1
Bankson, MG; Cunningham, KA; McCreary, AC	1
O'Neill, MF; Tomkins, DM	1
Conway, MW; O'Neill, MF	1
Clifton, PG; Dourish, CT; Hewitt, KN; Lee, MD	1
Ansorge, M; Dulawa, SC; Geyer, MA; Gingrich, JA; Hen, R; Holick Pierz, KA; Masten, VL; Shanahan, NA; Waeber, C	1

Other Studies

10 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and gr 127935

Article	Year
GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test. Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:3 Topics: Animals; Dose-Response Relationship, Drug; Indoles; Locomotion; Male; Mice; Mice, Inbred Strains; Oxadiazoles; Piperazines; Serotonin Antagonists; Serotonin Receptor Agonists; Tail	1996
5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935. Molecular pharmacology, 1997, Volume: 51, Issue:5 Topics: Animals; Cocaine; Corpus Striatum; Gene Expression Regulation; Genes, fos; Indoles; Mice; Mice, Knockout; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists	1997
Serotonin1B receptor stimulation enhances cocaine reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Dec-01, Volume: 18, Issue:23 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists	1998
RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist. Psychopharmacology, 1999, Volume: 141, Issue:3 Topics: Animals; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Indoles; Male; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Self Stimulation; Serotonin Antagonists; Serotonin Receptor Agonists	1999
GR 127935 reduces basal locomotor activity and prevents RU 24969-, but not D-amphetamine-induced hyperlocomotion, in the Wistar-Kyoto hyperactive (WKHA) rat. Psychopharmacology, 1999, Volume: 141, Issue:3 Topics: Animals; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Indoles; Male; Motor Activity; Oxadiazoles; Piperazines; Rats; Rats, Inbred WKY; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists	1999
Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Drug Administration Schedule; Frontal Lobe; Indoles; Male; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride	1999
Effect of 5-HT(1B) receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:1 Topics: Alcohol Drinking; Animals; Conditioning, Operant; Ethanol; Indoles; Male; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration	2000
Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Dose-Response Relationship, Drug; Female; Imipramine; Indoles; Mice; Mice, Inbred Strains; Motor Activity; Oxadiazoles; Piperazines; Piperidines; Pyridines; Reaction Time; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming	2001
Serotonin 2C receptor agonists and the behavioural satiety sequence in mice. Pharmacology, biochemistry, and behavior, 2002, Volume: 71, Issue:4 Topics: Aminopyridines; Animals; Diet; Dose-Response Relationship, Drug; Ethylamines; Feeding Behavior; Indoles; Mice; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Satiety Response; Serotonin Antagonists; Serotonin Receptor Agonists	2002
Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biological psychiatry, 2009, Mar-01, Volume: 65, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Fluoxetine; Globus Pallidus; Indoles; Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Reflex, Startle; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra	2009