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5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and fluoxetine

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with fluoxetine in 12 studies

Compound Research Comparison

Studies
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Trials
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Recent Studies (post-2010)
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)
Studies
(fluoxetine)
Trials
(fluoxetine)
Recent Studies (post-2010) (fluoxetine)
21801210,1001,6633,263

Protein Interaction Comparison

ProteinTaxonomy5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50)fluoxetine (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)5.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.119
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.303
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.358
Cytochrome P450 2D6Homo sapiens (human)0.7
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.203
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)5.2
Alpha-2B adrenergic receptorHomo sapiens (human)1.528
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.595
AcetylcholinesteraseHomo sapiens (human)0.13
Prostaglandin G/H synthase 1Homo sapiens (human)6
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.8332
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.452
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.1395
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)5.2
Sodium-dependent serotonin transporterHomo sapiens (human)0.0342
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0538
Cytochrome P450 2C19Homo sapiens (human)0.0525
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)5.2
5-hydroxytryptamine receptor 6Homo sapiens (human)1.661
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)5.2
Sodium-dependent dopamine transporter Homo sapiens (human)5.984
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.3513
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)5.2
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0094
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)5.2
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.6751
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)5.2

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's8 (66.67)18.2507
2000's1 (8.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, ET; Luo, S1
Auerbach, SB; Juliano, PJ; Rutter, JJ1
Li, ET; Luo, SQ2
Frances, H; Khidichian, F1
Cooper, SJ; Neill, JC1
Kruk, ZL; O'Connor, JJ1
Callaway, CW; Geyer, MA; Rempel, NL1
Li, MY; Reith, ME1
Ansorge, M; Dulawa, SC; Geyer, MA; Gingrich, JA; Hen, R; Holick Pierz, KA; Masten, VL; Shanahan, NA; Waeber, C1
Bobrow, DN; Kantak, PA; Nyby, JG1
Dulawa, SC; Ho, EV; Katzka, WR; Knowles, JA; Sharifi, MF; Thompson, SL1

Other Studies

12 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and fluoxetine

ArticleYear
Effect of 5-HT agonists on rats fed single diets with varying proportions of carbohydrate and protein.
    Psychopharmacology, 1992, Volume: 109, Issue:1-2

    Topics: Animals; Dietary Carbohydrates; Dietary Proteins; Dose-Response Relationship, Drug; Eating; Fenfluramine; Fluoxetine; Indoles; Male; Rats; Rats, Wistar; Serotonin Receptor Agonists

1992
Substituted piperazine and indole compounds increase extracellular serotonin in rat diencephalon as determined by in vivo microdialysis.
    Neuropharmacology, 1991, Volume: 30, Issue:4

    Topics: Animals; Dialysis; Diencephalon; Dose-Response Relationship, Drug; Extracellular Space; Fluoxetine; Indoles; Male; Piperazines; Rats; Serotonin

1991
Effects of repeated administration of serotonergic agonists on diet selection and body weight in rats.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:3

    Topics: Animals; Body Weight; Diet; Drug Administration Schedule; Fenfluramine; Fluoxetine; Indoles; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin

1991
Chronic but not acute antidepressants interfere with serotonin (5-HT1B) receptors.
    European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2

    Topics: Animals; Antidepressive Agents; Escape Reaction; Fluoxetine; Indoles; Injections, Intraperitoneal; Male; Mice; Phenelzine; Piperazines; Receptors, Serotonin; Time Factors

1990
Food intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969.
    Brain research bulletin, 1990, Volume: 24, Issue:6

    Topics: Animals; Feeding Behavior; Fenfluramine; Fluoxetine; Indoles; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin

1990
Selective reduction by serotonergic agents of hypertonic saline consumption in rats: evidence for possible 5-HT1C receptor mediation.
    Psychopharmacology, 1989, Volume: 99, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Fenfluramine; Fluoxetine; Hypertonic Solutions; Indoles; Male; Piperazines; Pyrazines; Quinoxalines; Quipazine; Rats; Receptors, Serotonin; Serotonin

1989
Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro.
    Brain research, 1994, Mar-21, Volume: 640, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Electric Stimulation; Electrophysiology; Fluoxetine; In Vitro Techniques; Indoles; Male; Methiothepin; Presynaptic Terminals; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Serotonin Receptor Agonists; Suprachiasmatic Nucleus

1994
Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1993, Volume: 8, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Caffeine; Designer Drugs; Dopamine Agents; Dose-Response Relationship, Drug; Fluoxetine; Indoles; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Scopolamine; Serotonin; Serotonin Receptor Agonists; Synapses

1993
Effect of quinine on autoreceptor-regulated serotonin release in the rat hippocampus.
    European journal of pharmacology, 1997, Dec-11, Volume: 340, Issue:2-3

    Topics: Animals; Autoreceptors; Chromatography, High Pressure Liquid; Fluoxetine; Hippocampus; Indoles; Male; Methiothepin; Microdialysis; Potassium Channels; Quinine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin

1997
Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.
    Biological psychiatry, 2009, Mar-01, Volume: 65, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Fluoxetine; Globus Pallidus; Indoles; Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Reflex, Startle; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra

2009
Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG).
    Behavioural pharmacology, 2014, Volume: 25, Issue:1

    Topics: Animals; Antidepressive Agents, Second-Generation; Dietary Supplements; Disease Models, Animal; Exploratory Behavior; Fluoxetine; Freeze Drying; Indoles; Lactobacillus; Male; Mice; Mice, Inbred BALB C; Motor Activity; Obsessive-Compulsive Disorder; Probiotics; Serotonin Receptor Agonists; Social Behavior; Time Factors; Vocalization, Animal

2014
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation.
    Psychopharmacology, 2016, Volume: 233, Issue:1

    Topics: Animals; Corpus Striatum; Desipramine; Exploratory Behavior; Female; Fluoxetine; Indoles; Mice; Mice, Inbred C57BL; Obsessive-Compulsive Disorder; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Receptor Agonists; Stereotyped Behavior; Treatment Outcome

2016