Compounds > 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole
Page last updated: 2024-09-02

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and colforsin

5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with colforsin in 4 studies

Compound Research Comparison

Studies
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)		Trials
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)		Recent Studies (post-2010)
(5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole)		Studies
(colforsin)		Trials
(colforsin)		Recent Studies (post-2010) (colforsin)
21801213,460461,298

Protein Interaction Comparison

ProteinTaxonomy5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50)colforsin (IC50)
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)1.729
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.041
Adenylate cyclase type 1Homo sapiens (human)0.0955

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burkhart, CA; Heym, JH; Ives, JL; Lebel, LA; Macor, JE; Newman, ME; Nielsen, JA; Ryan, K; Schulz, DW; Torgersen, LK1
Galzin, AM; Langer, SZ; Ramdine, R1
De Vivo, M; Maayani, S1
Leysen, JE; Pauwels, PJ; Van Gompel, P1

Other Studies

4 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and colforsin

ArticleYear
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Adenylyl Cyclase Inhibitors; Animals; Chemical Phenomena; Chemistry; Colforsin; Cyclization; Eating; Guinea Pigs; Hippocampus; Indoles; Molecular Structure; Paraventricular Hypothalamic Nucleus; Pyridines; Pyrroles; Rats; Receptors, Serotonin; Serotonin; Substantia Nigra

1990
Phorbol-12,13-dibutyrate antagonizes while forskolin potentiates the presynaptic autoreceptor-mediated inhibition of [3H]-5-hydroxytryptamine release in rat hypothalamic slices.
    Synapse (New York, N.Y.), 1989, Volume: 3, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Drug Interactions; Drug Synergism; Electric Stimulation; Evoked Potentials; Hypothalamus; Indoles; Male; Methiothepin; Phorbol 12,13-Dibutyrate; Phorbol Esters; Polymyxin B; Rats; Rats, Inbred Strains; Serotonin

1989
Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Buspirone; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Indoles; Lisuride; Mathematics; Pyrimidines; Rats; Receptors, Serotonin; Tetrahydronaphthalenes

1986
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.
    Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Colforsin; Cyclic AMP; HeLa Cells; Humans; Indoles; Lysergic Acid Diethylamide; Models, Biological; Pindolol; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Transfection

1993