5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with buspirone in 14 studies
| Studies (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Trials (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Recent Studies (post-2010) (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Studies (buspirone) | Trials (buspirone) | Recent Studies (post-2010) (buspirone) |
|---|---|---|---|---|---|
| 218 | 0 | 12 | 2,096 | 351 | 382 |
| Protein | Taxonomy | 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50) | buspirone (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.025 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 1.75 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.024 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.323 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 2.125 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| D | Rattus norvegicus (Norway rat) | 0.12 | |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0266 | |
| D(2) dopamine receptor | Bos taurus (cattle) | 4 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.077 | |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 2.286 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.016 | |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 2.125 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.044 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.75 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.2055 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 3.9811 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.025 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.7 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.2666 | |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | 0.03 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Glennon, RA | 1 |
| Buckingham, J; Glen, RC; Hill, AP; Hyde, RM; Martin, GR; Robertson, AD; Salmon, JA; Woollard, PM | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Mos, J; Olivier, B; Slangen, JL; Ybema, CE | 1 |
| Auerbach, SB; Kamalakannan, N; Rutter, JJ | 1 |
| Berendsen, HH; Broekkamp, CL; Jenck, F | 1 |
| Berthold, H; Engel, G; Fozard, JR | 1 |
| Curzon, G; Dourish, CT; Kennett, GA | 1 |
| Gardner, CR | 1 |
| De Vivo, M; Maayani, S | 1 |
| Korneyev, AY; Seredenin, SB | 1 |
| Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A | 1 |
2 review(s) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and buspirone
| Article | Year |
|---|---|
Central serotonin receptors as targets for drug research.
Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin | 1987 |
Potential use of drugs modulating 5HT activity in the treatment of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Humans; Imidazoles; Indoles; Ondansetron; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1988 |
12 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and buspirone
| Article | Year |
|---|---|
Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT1D receptor: discovery of compounds with potential anti-migraine properties.
Topics: Animals; Aorta; Computer-Aided Design; Drug Design; Haplorhini; In Vitro Techniques; Migraine Disorders; Models, Chemical; Rabbits; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Saphenous Vein; Serotonin Receptor Agonists; Structure-Activity Relationship; Tryptamines | 1995 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
Discriminative stimulus properties of the serotonergic compound eltoprazine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dose-Response Relationship, Drug; Generalization, Stimulus; Indoles; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
TFMPP and RU24969 enhance serotonin release from rat hippocampus.
Topics: Animals; Buspirone; Dose-Response Relationship, Drug; Hippocampus; Indicators and Reagents; Indoles; Male; Methiothepin; Piperazines; Potassium; Rats; Serotonin; Serotonin Antagonists | 1990 |
Selective activation of 5HT1A receptors induces lower lip retraction in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Dose-Response Relationship, Drug; Indoles; Lip; Male; Muscles; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1989 |
5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Buspirone; Dioxanes; Female; Fenclonine; Idazoxan; Indoles; Mice; Morphine Dependence; Naloxone; Prazosin; Receptors, Serotonin; Tetrahydronaphthalenes | 1989 |
Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Buspirone; Depressive Disorder; Disease Models, Animal; Drug Interactions; Indoles; Male; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Restraint, Physical; Serotonin; Stress, Psychological; Tetrahydronaphthalenes | 1987 |
Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Buspirone; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Indoles; Lisuride; Mathematics; Pyrimidines; Rats; Receptors, Serotonin; Tetrahydronaphthalenes | 1986 |
Effect of 5-HT-1A receptor agonists on paw licking reaction on hot plate and unpunished drinking in rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Drinking Behavior; Indoles; Male; Pain; Prosencephalon; Punishment; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Thirst; Time Factors | 1993 |
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 1997 |