5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole has been researched along with 1-(3-trifluoromethylphenyl)piperazine in 41 studies
| Studies (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Trials (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Recent Studies (post-2010) (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole) | Studies (1-(3-trifluoromethylphenyl)piperazine) | Trials (1-(3-trifluoromethylphenyl)piperazine) | Recent Studies (post-2010) (1-(3-trifluoromethylphenyl)piperazine) |
|---|---|---|---|---|---|
| 218 | 0 | 12 | 281 | 7 | 23 |
| Protein | Taxonomy | 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole (IC50) | 1-(3-trifluoromethylphenyl)piperazine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.57 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.57 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.29 | |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | 0.61 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.15 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.039 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.57 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (29.27) | 18.7374 |
| 1990's | 27 (65.85) | 18.2507 |
| 2000's | 2 (4.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamblin, MW; Metcalf, MA | 1 |
| Burkhart, CA; Heym, JH; Ives, JL; Lebel, LA; Macor, JE; Newman, ME; Nielsen, JA; Ryan, K; Schulz, DW; Torgersen, LK | 1 |
| Glennon, RA | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Amlaiky, N; Boschert, U; Grailhe, R; Hen, R; Mattei, MG; Matthes, H; Muscatelli, F; Plassat, JL | 1 |
| Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB | 1 |
| Druck, T; Hamblin, MW; Huebner, K; Khan, N; Kohen, R; Lachowicz, JE; Meltzer, HY; Metcalf, MA; Roth, BL; Sibley, DR | 1 |
| Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Barrett, JE; Gleeson, S; Seggel, MR; Weissman, BA | 1 |
| Coscina, DV; Fletcher, PJ; Ming, ZH; Zack, MH | 1 |
| Mos, J; Olivier, B; Slangen, JL; Ybema, CE | 1 |
| Frances, H; Monier, C | 1 |
| Curzon, G | 1 |
| Auerbach, SB; Juliano, PJ; Rutter, JJ | 1 |
| Auerbach, SB; Kamalakannan, N; Rutter, JJ | 1 |
| Broekkamp, CL; Jenck, F; Van Delft, AM | 1 |
| Lucot, JB | 1 |
| Fermanian, J; Frances, H; Lienard, C | 1 |
| Frances, H; Khidichian, F | 1 |
| Cooper, SJ; Neill, JC | 1 |
| Agmo, A; Escalante, A; Fernández-Guasti, A | 1 |
| Curzon, G; Kennett, GA | 2 |
| Appel, JB; Cunningham, KA | 1 |
| Peroutka, SJ | 1 |
| Balestre, MN; Bockaert, J; Cory, RN; Guillon, G; Rouot, B; Sladeczek, F | 1 |
| Petti, DT; Winter, JC | 1 |
| Curzon, G; Donohoe, TP; Hutson, PH | 1 |
| Curzon, G; Dourish, CT; Kennett, GA | 1 |
| Boddeke, HW; Kalkman, HO; Timmermans, PB; Van Zwieten, PA | 1 |
| Reid, A; Sawynok, J | 1 |
| Dourish, CT; Kitchener, SJ | 1 |
| Rabin, RA; Winter, JC | 1 |
| Grignaschi, G; Samanin, R; Sironi, F | 1 |
| Blier, P; de Montigny, C; Piñeyro, G; Weiss, M | 1 |
| Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A | 1 |
| Colombo, G; Gatto, GJ; Grant, KA | 1 |
| Cook, DF; Wirtshafter, D | 1 |
| Coscina, DV; Currie, PJ | 1 |
| Grant, KA; Porcu, P | 1 |
2 review(s) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and 1-(3-trifluoromethylphenyl)piperazine
| Article | Year |
|---|---|
Central serotonin receptors as targets for drug research.
Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin | 1987 |
Effects of tryptophan and of 5-hydroxytryptamine receptor subtype agonists on feeding.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Appetite; Brain; Dietary Carbohydrates; Feeding Behavior; Female; Food Deprivation; Food Preferences; Humans; Indoles; Male; Motor Activity; Piperazines; Rats; Receptors, Serotonin; Serotonin Antagonists; Sex Factors; Tetrahydronaphthalenes; Tryptophan | 1991 |
39 other study(ies) available for 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole and 1-(3-trifluoromethylphenyl)piperazine
| Article | Year |
|---|---|
Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cyclic AMP; GTP-Binding Proteins; Humans; Molecular Sequence Data; Pertussis Toxin; Receptors, Serotonin; Virulence Factors, Bordetella | 1991 |
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Topics: Adenylyl Cyclase Inhibitors; Animals; Chemical Phenomena; Chemistry; Colforsin; Cyclization; Eating; Guinea Pigs; Hippocampus; Indoles; Molecular Structure; Paraventricular Hypothalamic Nucleus; Pyridines; Pyrroles; Rats; Receptors, Serotonin; Serotonin; Substantia Nigra | 1990 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Chromosome Mapping; Cloning, Molecular; DNA; Gene Expression; Humans; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Serotonin; Serotonin Receptor Agonists | 1993 |
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature | 1993 |
Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line, Transformed; Chlorocebus aethiops; Chromosome Mapping; Chromosomes, Human, Pair 1; Cloning, Molecular; Clozapine; DNA, Complementary; Genes; Humans; Kinetics; Molecular Sequence Data; Open Reading Frames; Protein Conformation; Rats; Receptors, Serotonin; Recombinant Proteins; Sequence Alignment; Sequence Homology, Nucleic Acid; Serotonin Agents; Signal Transduction; Species Specificity | 1996 |
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
Neurochemical effects of 5-HT1 receptor ligands in pigeons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Brain; Columbidae; Hydroxyindoleacetic Acid; Indoles; Male; Methoxyhydroxyphenylglycol; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1992 |
A comparison of the effects of the 5-HT1 agonists TFMPP and RU 24969 on feeding following peripheral or medial hypothalamic injection.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Eating; Food Deprivation; Hypothalamus, Middle; Indoles; Male; Microinjections; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
Discriminative stimulus properties of the serotonergic compound eltoprazine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dose-Response Relationship, Drug; Generalization, Stimulus; Indoles; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
Tolerance to the behavioural effect of serotonergic (5-HT1B) agonists in the isolation-induced social behavioural deficit test.
Topics: Animals; Behavior, Animal; Drug Tolerance; Indoles; Male; Mice; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Serotonin; Social Isolation | 1991 |
Substituted piperazine and indole compounds increase extracellular serotonin in rat diencephalon as determined by in vivo microdialysis.
Topics: Animals; Dialysis; Diencephalon; Dose-Response Relationship, Drug; Extracellular Space; Fluoxetine; Indoles; Male; Piperazines; Rats; Serotonin | 1991 |
TFMPP and RU24969 enhance serotonin release from rat hippocampus.
Topics: Animals; Buspirone; Dose-Response Relationship, Drug; Hippocampus; Indicators and Reagents; Indoles; Male; Methiothepin; Piperazines; Potassium; Rats; Serotonin; Serotonin Antagonists | 1990 |
5-HT1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats.
Topics: Amphetamines; Animals; Cyproheptadine; Indoles; Ketanserin; Male; Periaqueductal Gray; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reinforcement, Psychology; Ritanserin; Serotonin; Serotonin Antagonists | 1990 |
RU 24969-induced emesis in the cat: 5-HT1 sites other than 5-HT1A, 5-HT1B or 5-HT1C implicated.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cats; Dose-Response Relationship, Drug; Drug Interactions; Emetics; Female; Indoles; Injections, Subcutaneous; Piperazines; Receptors, Histamine H1; Tetrahydronaphthalenes | 1990 |
Improvement of the isolation-induced social behavioural deficit involves activation of the 5-HT1B receptors.
Topics: Animals; Cyproheptadine; Escape Reaction; Indoles; Male; Mianserin; Mice; Mice, Inbred Strains; Penbutolol; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Social Behavior; Social Isolation; Spiperone; Tropisetron | 1990 |
Chronic but not acute antidepressants interfere with serotonin (5-HT1B) receptors.
Topics: Animals; Antidepressive Agents; Escape Reaction; Fluoxetine; Indoles; Injections, Intraperitoneal; Male; Mice; Phenelzine; Piperazines; Receptors, Serotonin; Time Factors | 1990 |
Selective reduction by serotonergic agents of hypertonic saline consumption in rats: evidence for possible 5-HT1C receptor mediation.
Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Fenfluramine; Fluoxetine; Hypertonic Solutions; Indoles; Male; Piperazines; Pyrazines; Quinoxalines; Quipazine; Rats; Receptors, Serotonin; Serotonin | 1989 |
Inhibitory action of various 5-HT1B receptor agonists on rat masculine sexual behaviour.
Topics: Animals; Indoles; Male; Piperazines; Psychomotor Performance; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sexual Behavior, Animal | 1989 |
Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Ergolines; Feeding Behavior; Food Deprivation; Indoles; Male; Mianserin; Motor Activity; Pindolol; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tropisetron | 1988 |
Possible 5-hydroxytryptamine1 (5-HT1) receptor involvement in the stimulus properties of 1-(m-trifluoromethylphenyl)piperazine (TFMPP).
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Indoles; Lysergic Acid Diethylamide; Male; Metergoline; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1986 |
Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Frontal Lobe; Indoles; Methysergide; Mianserin; Piperazines; Rats; Serotonin; Tetrahydronaphthalenes | 1986 |
The 5-hydroxytryptamine (5-HT2) receptor stimulates inositol phosphate formation in intact and broken WRK1 cells: determination of occupancy-response relationships for 5-HT agonists.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bufotenin; Cell Line; Dibenzylchlorethamine; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; Indoles; Inositol Phosphates; Kinetics; Mammary Neoplasms, Experimental; Mathematics; N,N-Dimethyltryptamine; Piperazines; Quipazine; Rats; Receptors, Serotonin; Sugar Phosphates; Tetrahydronaphthalenes; Tryptamines | 1987 |
The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: a possible role for 5-HT1A receptors in memory.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Indoles; Lysergic Acid Diethylamide; Male; Memory; Methoxydimethyltryptamines; Naphthalenes; Piperazines; Rats; Rats, Inbred F344; Receptors, Serotonin; Tetrahydronaphthalenes | 1987 |
Infusion of the 5-hydroxytryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia.
Topics: Animals; Feeding Behavior; Indoles; Injections; Injections, Subcutaneous; Male; Piperazines; Rats; Rats, Inbred Strains; Ventromedial Hypothalamic Nucleus | 1988 |
The antiemetic drug trimethobenzamide prevents hypophagia due to acetyl salicylate, but not to 5-HT1B or 5-HT1C agonists.
Topics: Animals; Antiemetics; Aspirin; Benzamides; Feeding Behavior; Food Deprivation; Indoles; Male; Piperazines; Rats; Rats, Inbred Strains; Serotonin | 1988 |
5-HT1B agonists induce anorexia at a postsynaptic site.
Topics: Animals; Appetite Depressants; Haloperidol; Indoles; Ketanserin; Male; Motor Activity; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Synapses | 1987 |
Calcium-dependency of the pressor responses to selective 5-hydroxytryptamine receptor agonists in pithed rats.
Topics: 5-Methoxytryptamine; Animals; Blood Pressure; Calcium; Indoles; Methoxydimethyltryptamines; Piperazines; Prazosin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spinal Cord; Yohimbine | 1983 |
Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine.
Topics: 5,7-Dihydroxytryptamine; Amphetamines; Analgesia; Analgesics; Analysis of Variance; Animals; Binding Sites; Indoles; Injections, Spinal; Male; Pain; Piperazines; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Up-Regulation | 1994 |
An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats.
Topics: Amphetamines; Animals; Eating; Feeding Behavior; Grooming; Indoles; Male; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Satiety Response; Serotonin Receptor Agonists | 1994 |
Discriminative stimulus properties of m-chlorophenylpiperazine.
Topics: Animals; Discrimination Learning; Generalization, Stimulus; Indoles; Male; Piperazines; Pyrazines; Rats; Rats, Inbred F344; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Stimulation of 5-HT2A receptors in the paraventricular hypothalamus attenuates neuropeptide Y-induced hyperphagia through activation of corticotropin releasing factor.
Topics: Amphetamines; Animals; Corticotropin-Releasing Hormone; Feeding Behavior; Hyperphagia; Indoles; Male; Neuropeptide Y; Paraventricular Hypothalamic Nucleus; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Receptor Agonists; Spiperone | 1996 |
Autoregulatory properties of dorsal raphe 5-HT neurons: possible role of electrotonic coupling and 5-HT1D receptors in the rat brain.
Topics: Action Potentials; Animals; Dendrites; Electric Stimulation; Electrophysiology; Extracellular Space; Indoles; Male; Mianserin; Piperazines; Propranolol; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses | 1996 |
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 1997 |
Characterization of the ethanol-like discriminative stimulus effects of 5-HT receptor agonists as a function of ethanol training dose.
Topics: Animals; Central Nervous System Depressants; Conditioning, Operant; Discrimination, Psychological; Ethanol; Indoles; Male; Piperazines; Quinoxalines; Rats; Serotonin Receptor Agonists | 1997 |
Quinpirole attenuates striatal c-fos induction by 5-HT, opioid and muscarinic receptor agonists.
Topics: Amphetamines; Animals; Corpus Striatum; Dopamine Agonists; Fenfluramine; Immunohistochemistry; Indoles; Male; Morphine; Muscarinic Antagonists; Pilocarpine; Piperazines; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Opioid, mu; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
5-Hydroxytryptaminergic receptor agonists: effects on neuropeptide Y potentiation of feeding and respiratory quotient.
Topics: Animals; Drug Synergism; Eating; Indoles; Male; Microinjections; Neuropeptide Y; Oxygen Consumption; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1998 |
Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Indoles; Midazolam; Pentobarbital; Phencyclidine; Piperazines; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1B; Serotonin Receptor Agonists | 2004 |