5-hydroxytryptophan has been researched along with sapropterin in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 12 (36.36) | 29.6817 |
| 2010's | 6 (18.18) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Hasegawa, H; Ichiyama, A; Kaneko, E; Kobayashi, T | 1 |
| Hayaishi, O; Kagamiyama, H; Suzuki, S; Tsubokura, S; Watanabe, Y | 1 |
| Hayashi, T; Nakane, A; Naruse, H; Takesada, M; Yamazaki, K | 1 |
| Ishida, A; Kobayashi, Y; Takada, G; Takai, K; Toyoshima, I | 1 |
| Higashi, O; Ishida, A; Kobayashi, Y; Takada, G; Takai, K; Toyoshima, I | 1 |
| Fujita, N; Miyatake, T; Nakajima, T; Ohwada, M; Tanaka, K | 1 |
| Matsuura, S; Nagatsu, T; Sawada, M; Sugimoto, T | 1 |
| Blonder, J; Cohen, BE; Normand, M; Peled, I; Quint, J; Szeinberg, A | 1 |
| Curtius, HC; Endres, W; Niederwieser, A; Ohrt, B; Schaub, J; Wang, M | 1 |
| Koshimura, K; Masaki, T; Miwa, S; Ohue, T; Takagi, Y; Watanabe, Y | 1 |
| Blau, N; Dhondt, JL | 1 |
| Suzuki, T | 1 |
| Hashiguchi, H; Ishida, Y; Ishizuka, Y; Kuwahara, I; Mitsuyama, Y; Nakane, H; Todaka, K | 1 |
| Chiang, SH; Hsiao, KJ; Liu, TT; Wu, SJ | 1 |
| Chiang, SC; Chien, YH; Chiu, YN; Chou, SP; Chu, SY; Huang, A; Hwu, WL; Lin, JM; Wang, TR | 1 |
| Cianchetti, C; di Porzio, U; Lilliu, V; Mancosu, C; Sorrentino, G; Zuddas, A | 1 |
| Blau, N; Burki, K; Elzaouk, L; Ledermann, B; Leimbacher, W; Thony, B; Turri, M | 1 |
| Chien, YH; Hwu, WL; Liu, HM; Peng, SS; Tseng, WY | 1 |
| Capistrano-Estrada, SB; Nyhan, WL | 1 |
| Blau, N; Connolly, MB; Demos, MK; Hyland, K; Lillquist, Y; Makhseed, N; Vallance, HD; Waters, PJ | 1 |
| Cheng, LY; Chiu, PC; Hsiao, KJ; Lee, NC; Liu, TT; Niu, DM | 1 |
| Chang, M; Fu, GX; He, C; Hsiao, KJ; Li, XW; Liu, TT; Shen, M; Shen, S; Wang, L; Yu, WM; Zhao, SP | 1 |
| Kato, M; Kondo, H; Matsuo, N; Muramatsu, T; Nukazawa, T; Okano, Y; Saito, F; Sato, S; Shintaku, H; Tanaka, Y | 1 |
| Kanazawa, M; Kitani, Y; Kohno, Y; Ogawa, A; Shintaku, H; Takayanagi, M | 1 |
| Christensen, HE; Harris, P; Petersen, CR; Windahl, MS | 1 |
| Brent, DA; Diler, RS; Madan-Khetarpal, S; Mcguire, M; McKain, BW; Pan, L; Perel, JM; Vockley, J | 1 |
| Gorska, KI; Haruki, H; Johnsson, K; Pedersen, MG; Pojer, F | 1 |
| Cao, Z; Han, B; Liu, Y; Zhu, W; Zou, H | 1 |
| Fukuda, K | 1 |
| Feng, X; Sheng, J; Wu, C; Zhang, J | 1 |
| Cai, J; Huang, L; Lian, J; Liu, W; Qu, L; Shi, F; Wang, H; Xu, Z | 1 |
| Feist, AM; Herrgard, M; Kim, SH; Luo, H; Palsson, BØ; Wulff, T; Yang, L | 1 |
| Ichinose, H; Ikemoto, K; Kano, T; Kondo, K; Matsui, T; Suganuma, Y; Sumi-Ichinose, C | 1 |
2 review(s) available for 5-hydroxytryptophan and sapropterin
| Article | Year |
|---|---|
[Inborn errors of catecholamine metabolism].
Topics: 5-Hydroxytryptophan; Aromatic-L-Amino-Acid Decarboxylases; Biopterins; Catecholamines; Diagnosis, Differential; Dopamine beta-Hydroxylase; Droxidopa; Humans; Metabolism, Inborn Errors; Prognosis | 1998 |
Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae.
Topics: 5-Hydroxytryptophan; Biopterins; Folic Acid; Gene Expression Regulation, Fungal; Phenylalanine Hydroxylase; Saccharomyces cerevisiae; Tryptophan Hydroxylase | 2016 |
2 trial(s) available for 5-hydroxytryptophan and sapropterin
| Article | Year |
|---|---|
[Metabolic changes in aromatic amino acids and monoamines in infantile autism and development of new treatment related to the finding].
Topics: 5-Hydroxytryptophan; Amino Acids; Autistic Disorder; Biogenic Monoamines; Biopterins; Carbon Isotopes; Child; Child, Preschool; Clinical Trials as Topic; Deuterium; Double-Blind Method; Humans; Levodopa; Phenylalanine; Tryptophan | 1989 |
Atypical phenylketonuria due to biopterin deficiency. Early treatment with tetrahydrobiopterin and neurotransmitter precursors, trials of monotherapy.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Clinical Trials as Topic; Humans; Infant; Levodopa; Male; Phenylketonurias; Pteridines | 1982 |
29 other study(ies) available for 5-hydroxytryptophan and sapropterin
| Article | Year |
|---|---|
Gastrointestinal serotonin: depletion due to tetrahydrobiopterin deficiency induced by 2,4-diamino-6-hydroxypyrimidine administration.
Topics: 5-Hydroxytryptophan; Animals; Biopterins; Brain; Digestive System; Dopamine; Fenclonine; Hypoxanthines; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Serotonin | 1991 |
Decrease in tetrahydrobiopterin content and neurotransmitter amine biosynthesis in rat brain by an inhibitor of guanosine triphosphate cyclohydrolase.
Topics: 5-Hydroxytryptophan; Adrenal Glands; Aminohydrolases; Animals; Biogenic Amines; Biopterins; Brain; Dihydroxyphenylalanine; Dopamine; GTP Cyclohydrolase; Hydrazines; Hydroxyindoleacetic Acid; Hypoxanthines; Liver; Male; Neurotransmitter Agents; Norepinephrine; Organ Specificity; Rats; Rats, Inbred Strains; Serotonin | 1988 |
Effect of tetrahydrobiopterin and 5-hydroxytryptophan on hereditary progressive dystonia with marked diurnal fluctuation: a suggestion of the serotonergic system involvement.
Topics: 5-Hydroxytryptophan; Adult; Biopterins; Child; Circadian Rhythm; Dystonia; Female; Humans; Levodopa | 1988 |
[Serotonergic disturbance in hereditary progressive dystonia--clinical effects of tetrahydrobiopterin and 5-hydroxytryptophan].
Topics: 5-Hydroxytryptophan; Adult; Biopterins; Child; Dopamine; Dystonia; Female; Humans; Levodopa; Neurons; Serotonin | 1988 |
[A deficiency of dihydrobiopterin synthesis. The effects of L-dopa, 5HTP and BH4].
Topics: 5-Hydroxytryptophan; Biopterins; Drug Therapy, Combination; Humans; Levodopa; Male; Middle Aged | 1988 |
(6R)-tetrahydrobiopterin increases the activity of tryptophan hydroxylase in rat raphe slices.
Topics: 5-Hydroxytryptophan; Animals; Biopterins; Male; Pterins; Raphe Nuclei; Rats; Rats, Inbred Strains; Tryptophan Hydroxylase | 1986 |
Malignant phenylketonuria due to defective synthesis of dihydrobiopterin.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Drug Combinations; Female; Humans; Infant, Newborn; Levodopa; Male; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine | 1985 |
Enhancement of acetylcholine release in the hippocampus by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin is mediated by 5-hydroxytryptamine.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Biopterins; Chromatography, High Pressure Liquid; Dialysis; Fenclonine; Hippocampus; Levodopa; Male; Methyltyrosines; Rats; Rats, Wistar; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
Tetrahydrobiopterin deficiency and an international database of patients.
Topics: 5-Hydroxytryptophan; Alcohol Oxidoreductases; Biomarkers; Biopterins; Carbidopa; Child; Dihydropteridine Reductase; GTP Cyclohydrolase; Humans; Hydro-Lyases; Information Systems; Levodopa; Metabolism, Inborn Errors; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Pterins; Registries | 1993 |
Peripherally administered tetrahydrobiopterin increases in vivo tryptophan hydroxylase activity in the striatum after transplantation of fetal ventral mesencephalon in six hydroxydopamine lesioned rats.
Topics: 5-Hydroxytryptophan; Animals; Antioxidants; Biopterins; Brain Tissue Transplantation; Corpus Striatum; Denervation; Embryo, Mammalian; Female; Fetal Tissue Transplantation; Functional Laterality; Injections, Intraperitoneal; Mesencephalon; Methamphetamine; Microdialysis; Motor Activity; Oxidopamine; Prosencephalon; Rats; Rats, Wistar; Rotation; Tryptophan Hydroxylase | 1998 |
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
Topics: 5-Hydroxytryptophan; Biopterins; Diagnosis, Differential; Dihydropteridine Reductase; Female; Genetic Carrier Screening; Humans; Incidence; Levodopa; Mass Screening; Mutation; Phenylketonurias; Phosphorus-Oxygen Lyases; Pregnancy; Prenatal Diagnosis; Taiwan; Treatment Outcome | 2001 |
Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations.
Topics: 5-Hydroxytryptophan; Base Sequence; Biopterins; DNA Mutational Analysis; Founder Effect; Humans; Infant, Newborn; Intelligence; Levodopa; Mutation; Neonatal Screening; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Taiwan; Treatment Outcome | 2001 |
6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Biopterins; Dopamine; Dopamine Antagonists; Dystonic Disorders; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Models, Biological; Monoamine Oxidase Inhibitors; Neuroblastoma; Neurons; Serotonin; Serotonin Antagonists; Substantia Nigra; Tryptophan Hydroxylase; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 2002 |
Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterin.
Topics: 5-Hydroxytryptophan; Animals; Biopterins; Body Weight; Cell Division; Dopamine; Dwarfism; Gene Deletion; Genetic Vectors; Genotype; Heterozygote; Homozygote; Insulin-Like Growth Factor I; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Phenotype; Phosphorus-Oxygen Lyases; Polymerase Chain Reaction; Thyroxine; Time Factors | 2003 |
Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment.
Topics: 5-Hydroxytryptophan; Axons; Biopterins; Brain Damage, Chronic; Cerebral Cortex; Child; Child, Preschool; Combined Modality Therapy; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Dominance, Cerebral; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intelligence; Levodopa; Male; Neonatal Screening; Nerve Fibers, Myelinated; Phenylalanine; Phenylketonurias; Pregnancy | 2004 |
6-pyruvoyl tetrahydropterin synthase deficiency: a case report.
Topics: 5-Hydroxytryptophan; Biopterins; Dihydroxyphenylalanine; Female; Humans; Infant, Newborn; Neonatal Screening; Neopterin; Phenylketonurias; Phosphorus-Oxygen Lyases | 2003 |
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Cerebral Palsy; Child; Developmental Disabilities; Diagnostic Errors; Dopamine Agents; Female; Humans; Levodopa; Movement Disorders; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Seizures | 2005 |
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Asian People; Biopterins; Child; Child, Preschool; China; Female; Follow-Up Studies; Humans; Infant; Intellectual Disability; Levodopa; Male; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Seizures; Time Factors | 2006 |
[Study on tetrahydrobiopterin deficiency in Northern Chinese population].
Topics: 5-Hydroxytryptophan; Asian People; Biopterins; Child, Preschool; China; Dihydropteridine Reductase; Humans; Infant; Levodopa; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases | 2006 |
Early initiation of L-dopa therapy enables stable development of executive function in tetrahydrobiopterin (BH4) deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Biopterins; Child; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Neuropsychological Tests; Phosphorus-Oxygen Lyases; Problem Solving; Treatment Outcome; Wechsler Scales | 2007 |
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
Topics: 5-Hydroxytryptophan; Biomarkers; Biopterins; Brain Diseases, Metabolic; Child, Preschool; Dopamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Hypothalamo-Hypophyseal System; Levodopa; Phosphorus-Oxygen Lyases; Predictive Value of Tests; Prolactin | 2008 |
Crystal structure of tryptophan hydroxylase with bound amino acid substrate.
Topics: 5-Hydroxytryptophan; Animals; Biopterins; Catalysis; Catalytic Domain; Chickens; Crystallography, X-Ray; Humans; Isoenzymes; Protein Structure, Secondary; Protein Structure, Tertiary; Serotonin; Tryptophan Hydroxylase | 2008 |
GTP-cyclohydrolase deficiency responsive to sapropterin and 5-HTP supplementation: relief of treatment-refractory depression and suicidal behaviour.
Topics: 5-Hydroxytryptophan; Adolescent; Antidepressive Agents, Second-Generation; Biopterins; Depressive Disorder, Major; GTP Cyclohydrolase; Humans; Male; Suicidal Ideation | 2011 |
Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
Topics: 5-Hydroxytryptophan; Adult; Alcohol Oxidoreductases; Anti-Infective Agents; Biopterins; Cell Line; Central Nervous System; Crystallography, X-Ray; Fibroblasts; Humans; Levodopa; NADP; Nausea; Pneumonia, Pneumocystis; Protein Conformation; Structure-Activity Relationship; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Drug Combination; Vomiting | 2013 |
Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China.
Topics: 5-Hydroxytryptophan; Biopterins; Child, Preschool; China; Follow-Up Studies; Genotype; Humans; Infant; Infant, Newborn; Intelligence Tests; Levodopa; Mutation; Neopterin; Phenylalanine; Phenylketonurias; Treatment Outcome | 2015 |
Integrated theory to unify status among schizophrenia and manic depressive illness.
Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biopterins; Bipolar Disorder; Blood-Brain Barrier; Depression; Depression, Postpartum; Dopamine; Female; Hallucinations; Humans; Kynurenic Acid; Levodopa; Male; Neuroleptic Malignant Syndrome; Neurotransmitter Agents; Paranoid Disorders; Premenstrual Syndrome; Schizophrenia; Seasonal Affective Disorder; Serotonin; Serotonin Syndrome; Tyrosine | 2015 |
Metabolic pathway engineering for high-level production of 5-hydroxytryptophan in Escherichia coli.
Topics: 5-Hydroxytryptophan; Biopterins; Escherichia coli; Humans; Metabolic Engineering; Tryptophan Hydroxylase | 2018 |
Directed Metabolic Pathway Evolution Enables Functional Pterin-Dependent Aromatic-Amino-Acid Hydroxylation in
Topics: 5-Hydroxytryptophan; Amino Acids, Aromatic; Biopterins; Dihydroxyphenylalanine; Directed Molecular Evolution; Escherichia coli; GTP Cyclohydrolase; Hydroxylation; Metabolic Networks and Pathways; Mutation; Phenylalanine Hydroxylase; Pterins; Tryptophan | 2020 |
Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice.
Topics: 5-Hydroxytryptophan; Adenosine Diphosphate; Animals; Biopterins; Catecholamines; Collagen; Dihydropteridine Reductase; Mice; Platelet Aggregation; Receptor, Serotonin, 5-HT2A; Serotonin | 2022 |