5-hydroxythiabendazole has been researched along with thiabendazole in 15 studies
| Studies (5-hydroxythiabendazole) | Trials (5-hydroxythiabendazole) | Recent Studies (post-2010) (5-hydroxythiabendazole) | Studies (thiabendazole) | Trials (thiabendazole) | Recent Studies (post-2010) (thiabendazole) |
|---|---|---|---|---|---|
| 17 | 0 | 3 | 1,939 | 44 | 213 |
| Protein | Taxonomy | 5-hydroxythiabendazole (IC50) | thiabendazole (IC50) |
|---|---|---|---|
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.8 | |
| Methionine aminopeptidase | Escherichia coli K-12 | 0.472 | |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | 0.472 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arroyo, JC; Brown, A | 1 |
| Gokhales, RD; Hardee, GE; Moore, JN; Tshabalala, MA | 1 |
| Bogan, JA; Weir, AJ | 1 |
| Bauer, LA; Raisys, VA; Watts, MT | 1 |
| Eeckhoutte, C; Ferre, N; Galtier, P; Larrieu, G; Pineau, T; Rey-Grobellet, X | 1 |
| Alvinerie, M; Coulet, M; Dacasto, M; Eeckhoutte, C; Galtier, P; Larrieu, G; Macé, K; Pfeifer, AM; Sutra, JF | 1 |
| Cannavan, A; Haggan, SA; Kennedy, DG | 1 |
| Alvinerie, M; Coulet, M; De Angelis, I; Eeckhoutte, C; Galtier, P; Larrieu, G; Macé, K; Pfeifer, A; Stammati, AL; Sutra, JF; Vignoli, AL; Zucco, F | 1 |
| Alvinerie, M; Hubert, J; Kerboeuf, D | 1 |
| MULLINS, JF; STONE, OJ; WILLIS, CJ | 1 |
| Bowlin, S; Dalvie, D; Deese, A; Smith, E | 1 |
| Dolgos, H; Masimirembwa, CM; Thelingwani, RS; Ungell, AL; Zvada, SP | 1 |
| Dalvie, DK; Jamieson, JD; Smith, EB; Stevens, GJ; Yanochko, GM | 1 |
| Guo, J; Li, Q; Shang, N; Shao, B; Wang, H; Zhang, J; Zhang, Y | 1 |
| Flemming, AJ; Jones, LM; Rayson, SJ; Urwin, PE | 1 |
15 other study(ies) available for 5-hydroxythiabendazole and thiabendazole
| Article | Year |
|---|---|
Concentrations of thiabendazole and parasite-specific IgG antibodies in the cerebrospinal fluid of a patient with disseminated strongyloidiasis.
Topics: Female; Humans; Immunoglobulin E; Immunoglobulin G; Middle Aged; Strongyloides; Strongyloidiasis; Thiabendazole | 1987 |
HPLC determination and pharmacokinetics of thiabendazole and its major metabolite 5-OH thiabendazole in equine plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Horses; Intubation, Gastrointestinal; Kinetics; Thiabendazole | 1987 |
Thiabendazole and 5-hydroxythiabendazole in the plasma of sheep.
Topics: Animals; Sheep; Thiabendazole | 1985 |
Determination of thiabendazole and 5-hydroxythiabendazole in human serum by fluorescence-detected high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Fluorescence; Humans; Reference Values; Thiabendazole; Uremia | 1982 |
Structural requirements for the induction of cytochromes P450 by benzimidazole anthelmintic derivatives in cultured rabbit hepatocytes.
Topics: Animals; Anthelmintics; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Blotting, Western; Cambendazole; Carbamates; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Gene Expression; Liver; Mixed Function Oxygenases; Oxidoreductases; Rabbits; Thiabendazole | 1996 |
Identification of human and rabbit cytochromes P450 1A2 as major isoforms involved in thiabendazole 5-hydroxylation.
Topics: Animals; Anticholesteremic Agents; beta-Naphthoflavone; Bronchi; Cells, Cultured; Clofibrate; Cytochrome P-450 CYP1A2; Enzyme Induction; Enzyme Inhibitors; Epithelial Cells; Humans; Hydroxylation; Isoenzymes; Liver; Male; Mixed Function Oxygenases; Rabbits; Species Specificity; Thiabendazole | 1998 |
Simultaneous determination of thiabendazole and its major metabolite, 5-hydroxythiabendazole, in bovine tissues using gradient liquid chromatography with thermospray and atmospheric pressure chemical ionisation mass spectrometry.
Topics: Animals; Antinematodal Agents; Atmospheric Pressure; Cattle; Chromatography, High Pressure Liquid; Mass Spectrometry; Thiabendazole | 1998 |
Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells.
Topics: Animals; Antinematodal Agents; Biological Transport; Bronchi; Caco-2 Cells; Cells, Cultured; Colony-Forming Units Assay; Cytochrome P-450 CYP1A2; Enzyme Induction; Epithelial Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Isoenzymes; Liver; Male; Protein Binding; Proteins; Rabbits; Thiabendazole | 2000 |
Localization and migration of benzimidazole resistant and susceptible adult Cooperia curticei in the small intestine of sheep after treatment with thiabendazole.
Topics: Animals; Anthelmintics; Benzimidazoles; Drug Resistance; Feces; Intestine, Small; Parasite Egg Count; Sheep; Sheep Diseases; Thiabendazole; Trichostrongyloidea; Trichostrongyloidiasis | 2000 |
COMPARISON OF THIABENDAZOLE AND 5-HYDROXY-THIABENDAZOLE (FOR ANTHELMINTIC EFFECT).
Topics: Ancylostoma; Animals; Anthelmintics; Pharmacology; Thiabendazole | 1965 |
In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.
Topics: Animals; Antinematodal Agents; Cytochrome P-450 Enzyme System; Glutathione; Horseradish Peroxidase; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Seminal Vesicles; Sheep; Thiabendazole | 2006 |
In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions.
Topics: Catalytic Domain; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Thiabendazole; Thiazoles; Time Factors | 2009 |
Myeloperoxidase-mediated bioactivation of 5-hydroxythiabendazole: a possible mechanism of thiabendazole toxicity.
Topics: Animals; Antifungal Agents; Biotransformation; Caspase 3; Caspase 7; Cell Line; Epithelial Cells; L-Lactate Dehydrogenase; Male; Necrosis; Neutrophils; Peroxidase; Rats; Rats, Wistar; Rutin; Thiabendazole | 2011 |
[Distribution and elimination of thiabendazole and its metabolite residue in laying hens].
Topics: Animals; Antinematodal Agents; Chickens; Drug Residues; Thiabendazole; Tissue Distribution | 2011 |
Adaptive and specialised transcriptional responses to xenobiotic stress in Caenorhabditis elegans are regulated by nuclear hormone receptors.
Topics: Adaptation, Physiological; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Gene Knockdown Techniques; Genes, Reporter; Green Fluorescent Proteins; Metabolic Detoxication, Phase II; Oviposition; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; Stress, Physiological; Thiabendazole; Transcription Factors; Transcription, Genetic; Xenobiotics | 2013 |