Compounds > 5-hydroxypropafenone
Page last updated: 2024-09-02

5-hydroxypropafenone and digoxin

5-hydroxypropafenone has been researched along with digoxin in 3 studies

Compound Research Comparison

Studies
(5-hydroxypropafenone)		Trials
(5-hydroxypropafenone)		Recent Studies (post-2010)
(5-hydroxypropafenone)		Studies
(digoxin)		Trials
(digoxin)		Recent Studies (post-2010) (digoxin)
593311,4839581,289

Protein Interaction Comparison

ProteinTaxonomy5-hydroxypropafenone (IC50)digoxin (IC50)
STAT3, partialHomo sapiens (human)1.862
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)0.32
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)0.0055
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.19
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-1Canis lupus familiaris (dog)0.5
Nuclear receptor ROR-gammaHomo sapiens (human)3.4798
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)0.0055
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.2359

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erstad, BL; Furman, C; Hoyer, GL; Kirsten, EB; Marcus, FI; Nolan, PE1
Giesbrecht, E; Ito, S; Koren, G; Verjee, Z; Woodland, C1
Bachmakov, I; Eichelbaum, M; Fromm, MF; Hofmann, U; Rekersbrink, S1

Other Studies

3 other study(ies) available for 5-hydroxypropafenone and digoxin

ArticleYear
Effects of coadministration of propafenone on the pharmacokinetics of digoxin in healthy volunteer subjects.
    Journal of clinical pharmacology, 1989, Volume: 29, Issue:1

    Topics: Adult; Digoxin; Drug Interactions; Half-Life; Humans; Male; Propafenone

1989
The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Dogs; Drug Interactions; Female; Kidney Tubules; Propafenone; Vinblastine

1997
Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:3

    Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cyclosporins; Digoxin; Dose-Response Relationship, Drug; Humans; Propafenone; Stereoisomerism

2005