Page last updated: 2024-08-25

5-hydroxymethylcytosine and sofosbuvir

5-hydroxymethylcytosine has been researched along with sofosbuvir in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's53 (81.54)24.3611
2020's12 (18.46)2.80

Authors

AuthorsStudies
Collins, LB; Dai, Q; He, C; Ito, S; Shen, L; Swenberg, JA; Wu, SC; Zhang, Y1
Chen, Z; Dai, Q; Ding, J; He, C; He, YF; Jia, Y; Li, BZ; Li, L; Li, X; Li, Z; Liu, P; Song, CX; Sun, Y; Tang, Q; Wang, Y; Xu, GL; Zhang, K1
Kohli, RM; Nabel, CS1
Dai, Q; He, C; Inoue, A; Shen, L; Zhang, Y1
Bapat, B; Olkhov-Mitsel, E1
D'Alessio, AC; Diep, D; Fung, HL; Shen, L; Wu, H; Yamaguchi, S; Zhang, K; Zhang, Y1
Jin, P; Yao, B1
Feng, YQ; Liu, YL; Vargas, M; Wang, Y; Xing, XW; Yuan, BF; Zhou, X1
An, R; Ming, GL; Shin, J; Song, H; Weng, YL1
Cheng, X; Corrêa, IR; Dai, N; Fu, ZQ; Hashimoto, H; Pais, JE; Saleh, L; Zhang, X; Zheng, Y1
Rao, A; Tsagaratou, A1
Aravind, L; Chen, W; Dai, Q; Fu, Y; He, C; Hu, J; Iyer, LM; Wang, G; Yu, M; Zhang, L1
Aluru, N; Ci, W; Duan, J; Gao, X; He, C; Huang, X; Li, G; Li, W; Liu, J; Lu, X; Tang, F; Wang, L; Yang, L; Zhang, J; Zhou, Q; Zhu, W1
Collins, LB; Hanaoka, F; Ito, S; Iwai, S; Kanao, R; Koseki, H; Kuraoka, I; Masuda, Y; Masutani, C; Shibata, M; Shibutani, T; Swenberg, JA; Toda, M; Urabe, M1
Huang, Y; Rao, A1
Hahn, MA; Pfeifer, GP; Szabó, PE1
Shen, L; Wu, H; Wu, X; Zhang, Y1
Cho, IH; Chowdhury, B; Hahn, N; Irudayaraj, J1
Banerjee, S; Brooks, S; Egli, M; Eichman, BF; Joachimiak, A; Nocek, B; Pallan, PS; Stone, MP; Szulik, MW; Voehler, M1
Golla, JP; Sathyanarayana, BK; Sayeed, SK; Vinson, C; Zhao, J1
Chevassut, T; Cho, IH; Choudhury, SR; Chowdhury, B; Cooper, B; Cui, Y; Irudayaraj, J; Lossie, AC; McGovern, A1
Ito, S; Kuraoka, I1
Chan, WY; Chung, JP; Kong, GW; Lee, TL; Qian, Y; Tang, NL; Tu, J1
Chen, L; Chong, J; Fu, XD; He, C; Li, H; Lu, X; Wang, D; Wang, L; Xiao, R; Xu, L; Zhou, Y1
Wu, H; Zhang, Y1
Han, D; He, C; Jiang, X; Liu, M; Lu, X; Sun, Z; Xia, B; Xie, W; Yi, C; Yin, Q; Zeng, H; Zhou, A1
Gackowski, D; Modrzejewska, M; Olinski, R; Starczak, M; Zarakowska, E1
Aksimentiev, A; Dai, Q; Ha, T; He, C; Ngo, TT; Yoo, J; Zhang, Q1
He, Y; Jin, P; Tang, B; Wang, Z1
Incarnato, D; Krepelova, A; Neri, F; Oliviero, S; Parlato, C1
Abbes, S; Bernard, OA; Cabagnols, X; Della Valle, V; Ishchenko, AA; Mahfoudhi, E; Plo, I; Rameau, P; Saparbaev, M; Secardin, L; Talhaoui, I; Vainchenker, W1
Chang, PM; Chou, NH; Kang, CH; Lam, HC; Li, GC; Liu, SI; Tsai, CY; Tsai, KW; Tu, YT; Wang, KC1
Pfeifer, GP; Song, J1
Han, YW; Harada, Y; Kizaki, S; Li, Y; Sugiyama, H; Suzuki, Y; Zou, T1
Cheng, GJ; Hu, Y; Irudayaraj, J; Ouyang, L; Zhu, L1
Shimbo, T; Wade, PA1
Cheng, X; Hong, S1
Foksinski, M; Gackowski, D; Gawronski, M; Modrzejewska, M; Olinski, R; Rzeszowska-Wolny, J; Skonieczna, M; Starczak, M; Zarakowska, E1
Klungland, A; Robertson, AB1
Chen, Z; Guo, L; He, J; Li, Y; Luo, M; Shi, X1
Bronner, C; Dimitrov, S; Gras, SL; Hamiche, A; Ibrahim, A; Jost, B; Menoni, H; Papin, C; Stoll, I; Velt, A1
Bieńkiewicz, A; Bryś, M; Ciesielski, P; Cwonda, Ł; Forma, E; Jóźwiak, P; Krześlak, A; Szczepaniec, S; Wójcik-Krowiranda, K1
Allgayer, J; Carell, T; Geier, N; Khobta, A; Kitsera, N; Parsa, E; Rossa, M1
Brown, T; Hardwick, JS; Lane, AN1
Giehr, P; Kyriakopoulos, C; Lepikhov, K; Wallner, S; Walter, J; Wolf, V1
Borre, M; Høyer, S; Lynnerup, AS; Storebjerg, TM; Strand, SH; Sørensen, KD; Ørntoft, TF1
Cao, Z; Chen, Z; Gao, D; Khan, IM; Luo, L; Tong, X; Wang, Y; Xu, T; Zhang, D; Zhang, L; Zhang, M; Zhang, Y1
Wang, P; Yan, Y; Yu, W; Zhang, H1
Bian, K; Chen, F; Drennan, CL; Essigmann, JM; Jost, M; Lenz, SAP; Li, D; Qi, R; Tang, Q; Wetmore, SD1
Daumann, LJ; Jonasson, NSW1
Cao, LL; Jia, M; Liu, H; Pei, L; Wang, H; Yue, Z1
Cai, C; Chen, D; Chen, J; Dai, Z; Liu, SY; Ma, Y; Mo, M; Wang, Y; Xu, Y; Zhang, J; Zhang, L; Zhang, Y; Zou, X1
Abdelhamid, MAS; Ehiabor, MO; Grigg, MC; Irving, K; Smith, NM; Waller, ZAE; Wright, EP1
Abakir, A; Fossdal, CG; Gackowski, D; Krutovsky, KV; Olinski, R; Ruzov, A; Starczak, M; Viejo, M; Yakovlev, IA1
Del Rio-Tsonis, K; Fausey, A; Grajales-Esquivel, E; Kosse, S; Liang, C; Liu, L; Luz-Madrigal, A; Tangeman, J; Tsonis, PA; Wang, K1
Gackowski, D; Gawronski, M; Olinski, R; Starczak, M1
Gering, M; Jessop, P1
Fossdal, CG; Viejo, M; Yakovlev, I1
Celik-Uzuner, S1
Abakir, A; Alenezi, F; Ruzov, A1
Assad, N; Durell, S; Ray, S; Tillo, D; Ufot, A; Vinson, C1
DeNizio, JE; Dow, BJ; Drohat, AC; Ghanty, U; Kohli, RM; Serrano, JC1
Eden, HE; Huang, Z; Robertson, KD; Rothbart, SB; Tiedemann, RL1
Bellacosa, A; Georges, RO; González-Avalos, E; Lio, CJ; Nakayama, T; Onodera, A; Rao, A1
Bai, L; Ding, C; Feng, J; Gong, T; Li, J; Li, X; Li, Z; Liu, M; Lyu, J; Qin, J; Qin, Z; Wang, Y; Yang, G; Yang, W1

Reviews

14 review(s) available for 5-hydroxymethylcytosine and sofosbuvir

ArticleYear
Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.
    Cancer medicine, 2012, Volume: 1, Issue:2

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; Disease; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genetic Markers; Humans; Restriction Mapping; Sequence Analysis, DNA

2012
Cytosine modifications in neurodevelopment and diseases.
    Cellular and molecular life sciences : CMLS, 2014, Volume: 71, Issue:3

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA-Cytosine Methylases; Humans; Models, Molecular; Nervous System Diseases; Neurogenesis

2014
DNA modifications and neurological disorders.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013, Volume: 10, Issue:4

    Topics: 5-Methylcytosine; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Nervous System Diseases; Neurons

2013
Connections between TET proteins and aberrant DNA modification in cancer.
    Trends in genetics : TIG, 2014, Volume: 30, Issue:10

    Topics: 5-Methylcytosine; Azacitidine; Cytosine; Decitabine; Dioxygenases; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Hematologic Neoplasms; Humans; Isocitrate Dehydrogenase; Mixed Function Oxygenases; Molecular Targeted Therapy; Mutation; Neoplasms; Proto-Oncogene Proteins; Small Molecule Libraries

2014
5-Hydroxymethylcytosine: a stable or transient DNA modification?
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; DNA Replication; DNA-Binding Proteins; Humans

2014
Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword.
    DNA repair, 2015, Volume: 32

    Topics: 5-Methylcytosine; Base Pair Mismatch; CpG Islands; Cytosine; Deamination; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Gene Expression; Humans; Molecular Mimicry; Oxidation-Reduction; Thymine DNA Glycosylase

2015
DNA methylation dynamics in neurogenesis.
    Epigenomics, 2016, Volume: 8, Issue:3

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Stem Cells; Epigenesis, Genetic; Histones; Humans; Mammals; Neurogenesis

2016
Are there specific readers of oxidized 5-methylcytosine bases?
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2016, Volume: 38, Issue:10

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA-Binding Proteins; Humans

2016
Proteins That Read DNA Methylation.
    Advances in experimental medicine and biology, 2016, Volume: 945

    Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Protein Domains

2016
DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications.
    Advances in experimental medicine and biology, 2016, Volume: 945

    Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Eukaryota; Prokaryotic Cells; Protein Domains

2016
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.
    Free radical biology & medicine, 2017, Volume: 107

    Topics: 5-Methylcytosine; Animals; Carcinogenesis; Cell Self Renewal; Cytosine; DNA; DNA Methylation; DNA Repair; Humans; Oxidation-Reduction; Transcription, Genetic

2017
Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis.
    Oncotarget, 2017, Jan-03, Volume: 8, Issue:1

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Humans; Lymphatic Metastasis; Neoplasms; Prognosis

2017
Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2018, Volume: 40, Issue:3

    Topics: 5-Methylcytosine; Animals; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Mammals; Models, Molecular; Nucleic Acid Conformation

2018
Role of ten-eleven translocation proteins and 5-hydroxymethylcytosine in hepatocellular carcinoma.
    Cell proliferation, 2019, Volume: 52, Issue:4

    Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Humans; Liver Neoplasms; MicroRNAs; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA Processing, Post-Transcriptional; Transcription, Genetic

2019

Other Studies

51 other study(ies) available for 5-hydroxymethylcytosine and sofosbuvir

ArticleYear
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
    Science (New York, N.Y.), 2011, Sep-02, Volume: 333, Issue:6047

    Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Recombinant Fusion Proteins

2011
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
    Science (New York, N.Y.), 2011, Sep-02, Volume: 333, Issue:6047

    Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; RNA, Small Interfering; Thymine DNA Glycosylase; Transfection

2011
Molecular biology. Demystifying DNA demethylation.
    Science (New York, N.Y.), 2011, Sep-02, Volume: 333, Issue:6047

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase

2011
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.
    Cell research, 2011, Volume: 21, Issue:12

    Topics: 5-Methylcytosine; Animals; Antibodies; Cytosine; DNA Replication; DNA-Directed DNA Polymerase; Embryonic Development; Immunohistochemistry; Male; Mice

2011
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.
    Cell, 2013, Apr-25, Volume: 153, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA Repair; Embryonic Stem Cells; Epigenesis, Genetic; Genetic Techniques; Genome-Wide Association Study; Heterochromatin; Mice; Oxidation-Reduction; Regulatory Elements, Transcriptional; Thymine DNA Glycosylase

2013
Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Escherichia coli; High-Throughput Nucleotide Sequencing; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2013
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
    Nature, 2014, Feb-20, Volume: 506, Issue:7488

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Escherichia coli Proteins; HEK293 Cells; Humans; Hydrogen Bonding; Mice; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Naegleria; Proto-Oncogene Proteins; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity

2014
TET proteins and 5-methylcytosine oxidation in the immune system.
    Cold Spring Harbor symposia on quantitative biology, 2013, Volume: 78

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Profiling; Humans; Immunoprecipitation; Mice; Mixed Function Oxygenases; Oxidoreductases; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins

2013
A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine.
    Journal of the American Chemical Society, 2014, Apr-02, Volume: 136, Issue:13

    Topics: 5-Methylcytosine; Agaricales; Cytosine; Dioxygenases; Fungal Proteins

2014
Programming and inheritance of parental DNA methylomes in mammals.
    Cell, 2014, May-08, Volume: 157, Issue:4

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Development; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Promoter Regions, Genetic

2014
Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication.
    Scientific reports, 2014, Jun-09, Volume: 4

    Topics: 5-Methylcytosine; Base Pairing; Cell Proliferation; Cytosine; DNA; DNA Mismatch Repair; DNA Replication; Epigenesis, Genetic; Guanine; Humans; Thymine DNA Glycosylase

2014
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing.
    Nature biotechnology, 2014, Volume: 32, Issue:12

    Topics: 5-Methylcytosine; Animals; Base Sequence; Chromatin; Cytosine; DNA Methylation; DNA Repair; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Methyltransferases; Mice; Thymine DNA Glycosylase

2014
Quantification of 5-methylcytosine, 5-hydroxymethylcytosine and 5-carboxylcytosine from the blood of cancer patients by an enzyme-based immunoassay.
    Analytica chimica acta, 2014, Dec-10, Volume: 852

    Topics: 5-Methylcytosine; Cytosine; DNA; Epigenesis, Genetic; Humans; Immunoenzyme Techniques; Limit of Detection; Neoplasms

2014
Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
    Biochemistry, 2015, Feb-10, Volume: 54, Issue:5

    Topics: 5-Methylcytosine; Cytosine; DNA; Oligonucleotides; Thymine DNA Glycosylase

2015
C/EBPβ (CEBPB) protein binding to the C/EBP|CRE DNA 8-mer TTGC|GTCA is inhibited by 5hmC and enhanced by 5mC, 5fC, and 5caC in the CG dinucleotide.
    Biochimica et biophysica acta, 2015, Volume: 1849, Issue:6

    Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Crystallography, X-Ray; Cytosine; Cytosine Nucleotides; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Nucleotide Motifs; Transcription Factors

2015
The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells.
    Scientific reports, 2015, Apr-22, Volume: 5

    Topics: 5-Methylcytosine; Azacitidine; Catalytic Domain; Chromatography, High Pressure Liquid; CpG Islands; Cytosine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; HL-60 Cells; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; MCF-7 Cells; Microscopy, Fluorescence; Mixed Function Oxygenases; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Fluorescence; Tandem Mass Spectrometry

2015
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
    The international journal of biochemistry & cell biology, 2015, Volume: 67

    Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Histones; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Oocytes; Ovary; Protein Isoforms; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Vinyl Compounds

2015
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
    Nature, 2015, Jul-30, Volume: 523, Issue:7562

    Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA Methylation; DNA Repair; Epigenesis, Genetic; Hydrogen Bonding; Kinetics; RNA Polymerase II; Saccharomyces cerevisiae; Substrate Specificity; Templates, Genetic; Thymine DNA Glycosylase; Transcription Elongation, Genetic

2015
Charting oxidized methylcytosines at base resolution.
    Nature structural & molecular biology, 2015, Volume: 22, Issue:9

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mammals; Oxidation-Reduction

2015
Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale.
    Nature methods, 2015, Volume: 12, Issue:11

    Topics: 5-Methylcytosine; Animals; Cell Line; CpG Islands; Cytosine; DNA Methylation; DNA Primers; Epigenomics; Gene Expression Regulation; Genome; Mice; Mice, Transgenic; Oligonucleotides; Oxygen; Polymerase Chain Reaction; Sequence Analysis, DNA; Stem Cells; Sulfites

2015
Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: 5-Methylcytosine; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression; Kidney; Liver; Lung; Male; Myocardium; Organ Specificity; Pentoxyl; Rats; Rats, Wistar; Swine; Tandem Mass Spectrometry; Thymus Gland

2015
Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability.
    Nature communications, 2016, Feb-24, Volume: 7

    Topics: 5-Methylcytosine; Biomechanical Phenomena; Cytosine; DNA; DNA Methylation; Molecular Dynamics Simulation; Nucleosomes; Oxidation-Reduction

2016
Methylation-assisted bisulfite sequencing to simultaneously map 5fC and 5caC on a genome-wide scale for DNA demethylation analysis.
    Nature protocols, 2016, Volume: 11, Issue:7

    Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Line; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Mice; Sequence Analysis, DNA; Sulfites

2016
TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.
    DNA repair, 2016, Volume: 43

    Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Line; Cytosine; Dioxygenases; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Fibroblasts; Genomic Instability; Humans; Hydroxylation; Megakaryocyte Progenitor Cells; Mice; Mutagenesis; Proto-Oncogene Proteins; S Phase; Thymine DNA Glycosylase; Tumor Suppressor Protein p53

2016
Isocitrate Dehydrogenase 2 Dysfunction Contributes to 5-hydroxymethylcytosine Depletion in Gastric Cancer Cells.
    Anticancer research, 2016, Volume: 36, Issue:8

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Female; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Male; Stomach Neoplasms

2016
Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Nov-07, Volume: 22, Issue:46

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Nucleosomes; Oxidation-Reduction

2016
A reusable laser wrapped graphene-Ag array based SERS sensor for trace detection of genomic DNA methylation.
    Biosensors & bioelectronics, 2017, Jun-15, Volume: 92

    Topics: 5-Methylcytosine; Antibodies, Immobilized; Biosensing Techniques; Cell Line, Tumor; Cytosine; DNA; DNA Methylation; Equipment Design; Gold; Graphite; Humans; Metal Nanoparticles; Reproducibility of Results; Silver; Spectrum Analysis, Raman

2017
Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA.
    Free radical biology & medicine, 2016, Volume: 101

    Topics: 5-Methylcytosine; Ascorbic Acid; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Pentoxyl; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine

2016
Combinatorial DNA methylation codes at repetitive elements.
    Genome research, 2017, Volume: 27, Issue:6

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; DNA Transposable Elements; Epigenesis, Genetic; Fibroblasts; Genome; Mice; Mouse Embryonic Stem Cells; Primary Cell Culture; Repetitive Sequences, Nucleic Acid; Thymine DNA Glycosylase

2017
Differential expression of ten-eleven translocation genes in endometrial cancers.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:3

    Topics: 5-Methylcytosine; Aged; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Endometrial Neoplasms; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Middle Aged; Mixed Function Oxygenases; Prognosis; Proto-Oncogene Proteins

2017
Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.
    Nucleic acids research, 2017, Nov-02, Volume: 45, Issue:19

    Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cyclic AMP Response Element-Binding Protein; Cytosine; DNA; DNA Methylation; Gene Expression Regulation; Humans; Promoter Regions, Genetic; Protein Binding; Thymine DNA Glycosylase

2017
Two are better than one: HPoxBS - hairpin oxidative bisulfite sequencing.
    Nucleic acids research, 2018, 09-06, Volume: 46, Issue:15

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Sulfites

2018
Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer.
    Clinical epigenetics, 2018, 08-07, Volume: 10, Issue:1

    Topics: 5-Methylcytosine; Adult; Aged; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Prognosis; Prostatic Neoplasms; Receptors, Estrogen; Tissue Array Analysis

2018
Vitrification of murine mature metaphase II oocytes perturbs DNA methylation reprogramming during preimplantation embryo development.
    Cryobiology, 2019, Volume: 87

    Topics: 5-Methylcytosine; Animals; Blastocyst; Cryopreservation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Female; Fertilization in Vitro; Metaphase; Mice; Morula; Oocytes; Oogenesis; Pregnancy; Proto-Oncogene Proteins; Vitrification

2019
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
    Nucleic acids research, 2019, 06-20, Volume: 47, Issue:11

    Topics: 5-Methylcytosine; AlkB Enzymes; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Animals; Computational Biology; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Molecular Structure; Oxidation-Reduction

2019
5-Methylcytosine is Oxidized to the Natural Metabolites of TET Enzymes by a Biomimetic Iron(IV)-Oxo Complex.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2019, Sep-18, Volume: 25, Issue:52

    Topics: 5-Methylcytosine; Biomimetic Materials; Cerium; Coordination Complexes; Cytosine; Dioxygenases; Epigenesis, Genetic; Iron; Kinetics; Oxidation-Reduction; Thermodynamics

2019
The clinical values of dysregulated DNA methylation and demethylation intermediates in acute lymphoblastic leukemia.
    Hematology (Amsterdam, Netherlands), 2019, Volume: 24, Issue:1

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Area Under Curve; Biomarkers, Tumor; Cell Lineage; Child; Cytosine; Demethylation; DNA Methylation; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; ROC Curve; Young Adult

2019
Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input.
    Nucleic acids research, 2019, 11-04, Volume: 47, Issue:19

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; DNA-Directed DNA Polymerase; Epigenomics; Genome; Humans; Mice; Oxides; Polymerase Chain Reaction; Polymerization; Rats

2019
Epigenetic modification of cytosines fine tunes the stability of i-motif DNA.
    Nucleic acids research, 2020, 01-10, Volume: 48, Issue:1

    Topics: 5-Methylcytosine; Cell Line; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Hydrogen-Ion Concentration; MCF-7 Cells; Nucleotide Motifs

2020
Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome.
    Scientific reports, 2019, 12-17, Volume: 9, Issue:1

    Topics: 5-Methylcytosine; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome, Plant; Mass Spectrometry; Norway; Picea

2019
DNA demethylation is a driver for chick retina regeneration.
    Epigenetics, 2020, Volume: 15, Issue:9

    Topics: 5-Methylcytosine; Animals; Avian Proteins; Chick Embryo; Chromatin; Cytosine; Dioxygenases; DNA Methylation; Fibroblast Growth Factor 2; Histone Code; Regeneration; Retinal Pigment Epithelium

2020
Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS).
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Hydrolysis; Tandem Mass Spectrometry; Zebrafish

2021
Immunohistochemical Detection of 5-Hydroxymethylcytosine and 5-Carboxylcytosine in Sections of Zebrafish Embryos.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Embryo, Nonmammalian; Immunohistochemistry; Zebrafish

2021
Immunochemical Detection of Modified Species of Cytosine in Plant Tissues.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Dyes; Immunohistochemistry; Plants

2021
Antigen Retrieval for Immunostaining of Modified Cytosine Species.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Antibodies; Antigens; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Antibody Technique; Humans

2021
Analysis of 5-Carboxylcytosine Distribution Using DNA Immunoprecipitation.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Chromatin Immunoprecipitation; Cytosine; DNA; DNA Methylation; Humans; Immunoprecipitation

2021
bZIP Dimers CREB1, ATF2, Zta, ATF3|cJun, and cFos|cJun Prefer to Bind to Some Double-Stranded DNA Sequences Containing 5-Formylcytosine and 5-Carboxylcytosine.
    Biochemistry, 2020, 09-29, Volume: 59, Issue:38

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Basic-Leucine Zipper Transcription Factors; Cytosine; DNA; Mice; Protein Array Analysis; Protein Binding

2020
TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.
    Journal of molecular biology, 2021, 04-16, Volume: 433, Issue:8

    Topics: 5-Methylcytosine; CpG Islands; Cytosine; Dioxygenases; DNA Demethylation; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase

2021
Distinguishing Active Versus Passive DNA Demethylation Using Illumina MethylationEPIC BeadChip Microarrays.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2272

    Topics: 5-Methylcytosine; Computational Biology; Cytosine; DNA; DNA Demethylation; DNA Methylation; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Microarray Analysis; Oxidation-Reduction; Sulfites

2021
Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells.
    Genome biology, 2021, 06-22, Volume: 22, Issue:1

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Proliferation; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression; Genetic Loci; Hematopoiesis; Interleukin-4; Isoenzymes; Lipopolysaccharides; Longevity; Macrophages; Mice; Mice, Knockout; T-Lymphocytes; Thymine DNA Glycosylase

2021
Proteome-Wide Profiling of Readers for DNA Modification.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021, Volume: 8, Issue:19

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Humans; Mice; Mice, Inbred C57BL; Models, Animal; Proteome; Transcription Factors

2021