Page last updated: 2024-08-25

5-hydroxymethylcytosine and cytosine

5-hydroxymethylcytosine has been researched along with cytosine in 602 studies

Research

Studies (602)

TimeframeStudies, this research(%)All Research%
pre-199014 (2.33)18.7374
1990's4 (0.66)18.2507
2000's7 (1.16)29.6817
2010's546 (90.70)24.3611
2020's31 (5.15)2.80

Authors

AuthorsStudies
Hayatsu, H; Shiragami, M1
Childs, JD; Gentner, NE; Paterson, MC; Smith, BP1
Cambell, JL; Fleischman, RA; Richardson, CC1
Khomov, IS; Tikhonenko, TI1
Annan, RS; Giese, RW; Kresbach, GM; Vouros, P1
Cannon, SV; Cummings, A; Teebor, GW1
Macdonald, PM; Mosig, G1
Childs, JD; Ellison, MJ; Pilon, R1
Goldberg, EB; Levy, JN1
Pearson, RE; Snyder, L1
Warren, RA1
Hong, H; Janosi, L; Kaji, A; Yonemitsu, H1
Cohen, SS1
Castro, GD; Castro, JA; Díaz Gómez, MI1
Fujimoto, J; Lin, SS; Sowers, LC; Tardy-Planechaud, S1
CHASE, M; DIXON, J; HERSHEY, AD1
COHEN, SS; WYATT, GR1
COHEN, SS; WEED, LL1
Larivière, L; Moréra, S1
Bird, A; Burdzy, A; Rogstad, DK; Sowers, LC; Tsai, HH; Valinluck, V1
Bair, CL; Black, LW1
Bair, CL; Black, LW; Rifat, D1
Deng, Z; He, X; Li, L; Wu, J; Xu, X; Xu, Z; Zabriskie, TM; Zhang, Y1
Agarwal, S; Aravind, L; Bandukwala, H; Brudno, Y; Iyer, LM; Koh, KP; Liu, DR; Pastor, WA; Rao, A; Shen, Y; Tahiliani, M1
Heintz, N; Kriaucionis, S1
Hemberger, M1
Huang, Y; Liu, DR; Pastor, WA; Rao, A; Shen, Y; Tahiliani, M1
Jin, SG; Kadam, S; Pfeifer, GP1
Dunican, D; Meehan, R; Nestor, C; Ruzov, A1
Biel, M; Brückl, T; Carell, T; Globisch, D; Michalakis, S; Müller, M; Münzel, M; Wagner, M; Welzmiller, V1
D'Alessio, AC; Hong, K; Ito, S; Sowers, LC; Taranova, OV; Zhang, Y1
Bultmann, S; Leonhardt, H; Schmidt, CS; Spada, F; Szwagierczak, A1
Carell, T; Lercher, L; Müller, M; Münzel, M1
Bayley, H; Donohoe, TJ; Heron, AJ; Maglia, G; Mikhailova, E; Stoddart, D; Wallace, EV1
Larson, GP; Lee, DH; Oates, N; Pfeifer, GP; Rivas, GE; Singh, P; Szabó, PE; Tran, DA1
Carell, T; Globisch, D; Münzel, M; Trindler, C1
Chen, CH; Dai, Q; Fu, Y; Godley, LA; He, C; Hicks, LM; Jian, X; Jin, P; Lahn, BT; Li, X; Li, Y; Looney, TJ; Song, CX; Szulwach, KE; Wang, J; Yi, C; Zhang, B; Zhang, L; Zhang, W1
Benner, J; Cohen-Karni, D; Drndic, M; Fields, L; Johnson, RR; Klein, ML; Peterman, N; Wanunu, M; Zheng, Y1
Biel, M; Brückl, T; Carell, T; Globisch, D; Koch, S; Michalakis, S; Müller, M; Münzel, M; Wagner, M1
Frye, S; Guan, KL; Ito, S; Jiang, WQ; Kim, SH; Lei, QY; Liu, J; Liu, LX; Liu, Y; Wang, B; Wang, P; Xiao, MT; Xiong, Y; Xu, W; Xu, YH; Yang, C; Yang, H; Yang, Y; Zhang, JY; Zhang, Y; Zhao, SM1
Fan, G; Faull, KF; Kim, KP; Le, T1
Cunniff, K; Daley, GQ; Huang, Y; Koh, KP; Lahesmaa, R; Laiho, A; Mostoslavsky, G; Nardone, J; Orkin, SH; Rao, A; Rao, S; Rodig, SJ; Sommer, CA; Tahiliani, M; Yabuuchi, A1
Dahl, JA; Klungland, A; Krokan, HE; Robertson, AB; Tripathi, P; Vågbø, CB1
Davis, T; Vaisvila, R1
Moran, RG; Peterson, EJ; Shock, LS; Taylor, SM; Thakkar, PV1
Iqbal, K; Jin, SG; Pfeifer, GP; Szabó, PE1
Dahl, C; Grønbæk, K; Guldberg, P1
Grigaitytė, I; Klimašauskas, S; Kriukienė, E; Liutkevičiūtė, Z; Masevičius, V1
Brachmann, A; Bultmann, S; Leonhardt, H; Schmidt, CS; Spada, F; Szwagierczak, A1
Jin, SG; Li, AX; Pfeifer, GP; Wu, X1
Arand, J; Boiani, M; Lepikhov, K; Marques, CJ; Nakamura, T; Nakano, T; Reik, W; Walter, J; Wossidlo, M; Zakhartchenko, V1
Cui, K; D'Alessio, AC; Ito, S; Sun, YE; Wang, Z; Wu, H; Xia, K; Zhang, Y; Zhao, K1
Brown, T; El-Sagheer, AH; Hansen, AS; Schofield, CJ; Thalhammer, A1
Cui, K; D'Alessio, AC; Ito, S; Sun, YE; Wang, Z; Wu, H; Zhang, Y; Zhao, K1
Andrews, S; Branco, MR; Ficz, G; Hore, TA; Krueger, F; Marques, CJ; Reik, W; Santos, F; Seisenberger, S1
Dai, Q; He, C; Pan, T; Song, CX1
Höbartner, C1
Christensen, J; Cloos, PA; Helin, K; Johansen, JV; Pedersen, MT; Rappsilber, J; Williams, K1
Ikeda, S; Okamoto, A; Sugizaki, K; Yanagisawa, H1
Barbera, AJ; Chen, T; Deng, J; Huang, S; Kong, L; Min, J; Nicholson, T; Shi, Y; Shi, YG; Tan, L; Wu, F; Xiong, L; Xu, G; Xu, Y; Zhang, H; Zhang, K; Zheng, L1
Dai, Q; He, C; Song, CX; Yu, M1
He, C; Song, CX3
Agarwal, S; Brudno, Y; Daley, GQ; Ecker, JR; Henderson, HR; Huang, Y; Kapranov, P; Ko, M; Lister, R; Liu, XS; Mahapatra, S; McLoughlin, EM; Milos, PM; Pape, UJ; Pastor, WA; Rao, A; Tahiliani, M1
Peters, AH; Véron, N1
Bitinaite, J; Chin, HG; Estève, PO; Feng, S; Jacobsen, SE; Kinney, SM; Pradhan, S; Stroud, H; Vaisvila, R; Zheng, Y1
Brenner, C; Chia, N; Lu, X; Ruden, DM; Senut, MC; Wang, L1
Bohlander, SK; Bultmann, S; Dufour, A; Herold, T; Kakadia, PM; Konstandin, N; Ksienzyk, B; Leonhardt, H; Mulaw, M; Schneider, F; Schneider, S; Spiekermann, K; Szwagierczak, A1
Dai, Q; He, C1
Dai, Q; He, C; Lu, XY; Song, CX; Sun, Y; Yang, CG; Yu, M1
Carell, T; Globisch, D; Münzel, M1
Feng, S; Jacobsen, SE; Morey Kinney, S; Pradhan, S; Stroud, H1
Nomura, A; Okamoto, A; Sugizaki, K; Yanagisawa, H1
Klungland, A; Robertson, AB; Robertson, J1
Carell, T; Deiml, CA; Hackner, B; Hagemeier, C; Müller, M; Münzel, M; Pfaffeneder, T; Truss, M1
Abramowitz, LK; Alberti, C; Bartolomei, MS; Bassi, MR; Bellacosa, A; Bruno, T; Caretti, E; Cigliano, A; Cortellino, S; Davidson, I; Devarajan, K; Fanciulli, M; Klein-Szanto, AJ; Kobi, D; Larue, L; Le Coz, M; Matsumoto, Y; Moore, R; Rambow, F; Renner, C; Sannai, M; Soprano, D; Wessels, A; Xu, J1
Han, JW; He, C; Hermetz, K; Jin, P; Kim, JJ; Kim, S; Li, X; Li, Y; Namburi, S; Ren, B; Rudd, MK; Song, CX; Szulwach, KE; Yoon, YS1
Antes, I; Bultmann, S; Cardoso, MC; Casa, V; Frauer, C; Hoffmann, T; Leonhardt, H1
Almire, C; Bernard, OA; Carbonne, B; Casadevall, N; da Costa Reis Monte Mor, B; Delhommeau, F; Droin, N; Godley, LA; Larghero, J; Le Couédic, JP; Massé, A; Mokrani, H; Pendino, F; Plo, I; Pronier, E; Ravanat, JL; Simon, A; Solary, E; Vainchenker, W; Vasanthakumar, A1
Bai, Y; Bradley, M; Chandran, S; Chebotareva, T; De Sousa, P; Dudnakova, T; Fletcher, J; Hannoun, Z; Hay, DC; Pells, S; Ruzov, A; Serio, A; Sullivan, G; Tsenkina, Y; Wilmut, I1
Wu, H; Zhang, Y3
Collins, LB; Dai, Q; He, C; Ito, S; Shen, L; Swenberg, JA; Wu, SC; Zhang, Y1
Guo, JU; Ming, GL; Song, H; Su, Y; Zhong, C1
Cohen-Karni, D; Guan, S; Pradhan, S; Quimby, A; Roberts, RJ; Wang, H; Wilson, G; Zheng, Y; Zhu, Z1
Cheng, AW; Choi, SW; Dawlaty, MM; Ganz, K; Gao, Q; Hu, YC; Jaenisch, R; Kim, J; Markoulaki, S; Page, DC; Powell, BE1
Chen, Z; Dai, Q; Ding, J; He, C; He, YF; Jia, Y; Li, BZ; Li, L; Li, X; Li, Z; Liu, P; Song, CX; Sun, Y; Tang, Q; Wang, Y; Xu, GL; Zhang, K1
Ku, CS; Naidoo, N; Soong, R; Wu, M1
Huang, TT; Li, Y; Pu, XY; Tang, H; Yamamura, KI1
Cheng, X; Horton, JR; Upadhyay, AK; Zhang, X1
Kohli, RM; Nabel, CS1
Deng, Z; Gu, TP; Guo, F; He, X; Iqbal, K; Jin, SG; Li, J; Liu, W; Pfeifer, GP; Shi, L; Shi, YG; Szabó, PE; Wu, HP; Xie, ZG; Xu, GF; Xu, GL; Yang, H1
Argani, P; Chaux, A; De Marzo, AM; Esopi, DM; Gerber, J; Haffner, MC; Iacobuzio-Donahue, C; Meeker, AK; Nelson, WG; Netto, GJ; Pellakuru, LG; Toubaji, A; Yegnasubramanian, S1
Ikeda, S; Nakamura, A; Okamoto, A; Sugizaki, K; Yanagisawa, H1
Inoue, A; Zhang, Y1
Kohli, RM; Manning, SA; Nabel, CS1
Chang, Q; Cheng, X; Dai, Q; Gearing, M; Godley, LA; He, C; Irier, H; Jin, P; Levey, AI; Li, X; Li, Y; Song, CX; Szulwach, KE; Upadhyay, AK; Vasanthakumar, A; Wu, H1
Chase, KA; Dong, E; Gavin, DP; Guidotti, A; Matrisciano, F; Sharma, RP1
Jiang, Y; Jin, SG; Krex, D; Lu, Q; Pfeifer, GP; Qiu, R; Rauch, TA; Schackert, G; Wang, Y1
Carell, T; Deiml, CA; Gnerlich, FA; Karaghiosoff, K; Koch, SC; Lischke, U; Münzel, M; Pfaffeneder, T; Stathis, D1
Branco, MR; Ficz, G; Reik, W1
Chang, Q; Chestnut, BA; Lesuisse, C; Martin, LJ; Price, A; Wong, M1
Clark, TA; Dai, Q; He, C; Kislyuk, A; Korlach, J; Lu, XY; Song, CX; Turner, SW1
Dixon, JM; Dunican, D; Harrison, DJ; Katz, E; Meehan, RR; Nestor, CE; Ottaviano, R; Reddington, J; Reinhardt, D; Sproul, D1
Flax, JD; Soloway, PD1
Dai, Q; He, C; Inoue, A; Shen, L; Zhang, Y1
Acevedo, LG; Jelinek, MA; Sanz, A1
Christensen, J; Helin, K; Williams, K1
Carrillo-de Santa Pau, E; Matarese, F; Stunnenberg, HG1
Chen, PB; Dong, X; Ee, LS; Fazzio, TG; Hung, JH; Li, R; Rando, OJ; Weng, Z; Yildirim, O1
Salbert, G; Weber, M1
Cuddapah, S; Freudenberg, JM; Ghosh, S; Hu, G; Jothi, R; Lackford, BL; Li, R; Wade, PA; Yellaboina, S; Zheng, X1
Bitinaite, J; Pradhan, S; Terragni, J; Zheng, Y1
Carell, T; Eigenbrod, S; Feiden, W; Globisch, D; Hackner, B; Kraus, TF; Kretzschmar, HA; Müller, M; Münzel, M; Pfaffeneder, T; Schüller, U; Wagner, M; Widmann, D1
Tsukada, Y1
Chen, Y; Gao, F; Guan, J; Li, Z; Su, L; Tang, B; Wang, Z; Yin, Y; Zhang, P; Zhang, S1
Chouliaras, L; Hof, PR; Keitel, S; Kenis, G; Rutten, BP; Schmitz, C; Steinbusch, HW; van den Hove, DL; van Os, J1
Chouliaras, L; Rutten, BP; van den Hove, DL1
Dahl, JA; Klungland, A; Ougland, R; Robertson, AB1
Irier, HA; Jin, P1
Aburatani, H; Asaoka, Y; Ijichi, H; Koike, K; Kudo, Y; Nagae, G; Tateishi, K; Yamamoto, K; Yamamoto, S; Yoshida, H1
Agirre, X; Alvarez, S; Boultwood, J; Calasanz, MJ; Cross, NC; Cruz Cigudosa, J; Delabesse, E; Fernandez-Mercado, M; Garate, L; Martín-Subero, JI; Martínez-Calle, N; Pérez, C; Prósper, F; Rifon, J; Segura, V; Varea, S; Wainscoat, JS1
Chang, Y; Cheng, X; Hashimoto, H; Howerton, SB; Liu, Y; Upadhyay, AK; Vertino, PM; Zhang, X1
Bai, F; Guan, KL; Ling, ZQ; Liu, J; Liu, Y; Ma, SH; Xiong, Y; Xu, ZD; Yang, H; Ye, D; Zhang, JY; Zhu, HG1
Almeida, RD; De Sousa, PA; Johnson, AD; Loose, M; Ruzov, A; Sottile, V1
Almeida, RD; Denning, C; Gering, M; Johnson, AD; Loose, M; Matsa, E; Ruzov, A; Sottile, V; Young, L1
Chen, H; Dzitoyeva, S; Manev, H3
Dunn, JJ; He, C; Kumaran, D; Song, CX; Yao, Q1
Karlic, H; Klaushofer, K; Spitzer, S; Thaler, R; Varga, F1
Balasubramanian, S; Booth, MJ; Branco, MR; Ficz, G; Krueger, F; Oxley, D; Reik, W1
Bocker, MT; Breiling, A; Lyko, F; Musch, T; Raddatz, G; Tuorto, F; Xu, M; Yang, FC1
Shi, YG; Tan, L1
Rugg-Gunn, PJ1
Dai, Q; He, C; Hon, GC; Jin, P; Kim, A; Li, X; Min, JH; Park, B; Ren, B; Shen, Y; Song, CX; Szulwach, KE; Yu, M; Zhang, L1
Cang, J; Huang, N; Tan, L; Wang, H; Xue, Z1
Cai, C; Chen, L; Kang, JX; Xie, A; Ye, X; Zhang, J; Zhang, L; Zhou, K1
Gao, KR; Yu, SY; Zhang, YX1
Becker, A; Denkhaus, D; Freihoff, D; Freihoff, J; Gessi, M; Hammes, J; Isselstein, LJ; Luxen, D; Müller, T; Pietsch, T; Simon, M; Waha, A; zur Mühlen, A1
Aguirre-Lavin, T; Beaujean, N; Boulesteix, C; Debey, P; Lehmann, G; Salvaing, J1
Guz, J; Jurgowiak, M; Oliński, R1
Inoue, K; Liu, YJ; Matoba, S; Nakamura, T; Nakano, T; Nakashima, H; Ogura, A; Shinkai, Y; Tachibana, M; Umehara, H1
Avner, S; Barloy-Hubler, F; Bizot, M; Durand, E; Eeckhoute, J; Froguel, P; Gheeraert, C; Lefebvre, P; Lucchetti-Miganeh, C; Madigou, T; Métivier, R; Oger, F; Palierne, G; Percevault, F; Péron, CL; Salbert, G; Sérandour, AA; Staels, B1
Chouliaras, L; Delbroek, L; Prickaerts, J; Rostamian, S; Rutten, BP; Sierksma, AS; Steinbusch, HW; van den Hove, DL1
Eberhart, CG; Haffner, MC; Nelson, WG; Orr, BA; Yegnasubramanian, S1
Klimašauskas, S; Kriukienė, E; Liutkevičiūtė, Z1
Couvé, S; Grin, I; Henriot, V; Ishchenko, AA; Moréra, S; Saparbaev, M; Vigouroux, A1
Wilkinson, J1
Leonard, K; Lloyd, AJ; López, CM; Wilkinson, MJ1
Balasubramanian, S; Beraldi, D; Booth, MJ; Branco, MR; Burgess, HE; Ficz, G; Murat, P; Oxley, D; Raiber, EA; Reik, W1
Ando, Y; Furuhata, E; Hasegawa, R; Hayashizaki, Y; Kubosaki, A; Shin, JW; Simon, C; Suzuki, H; Suzuki, T; Tomaru, Y1
Cai, C; Chen, L; Zhang, L1
Kinney, SR; Pradhan, S1
Belsham, D; Blencowe, BJ; Irimia, M; Jia, P; Kapranov, P; Khare, T; Klimasauskas, S; Koncevicius, K; Kriukiene, E; Kustra, R; Labrie, V; Liutkeviciute, Z; Moréra, S; Nazarians, A; Pai, S; Pal, M; Petronis, A; Ptak, C; Tice, R; Tochigi, M; Wang, SC; Wong, AH; Xia, M1
Ceol, C; Dresser, K; Duncan, LM; Fang, R; Houvras, Y; Hu, D; Hu, Y; Kaiser, UB; Kakavand, H; Khorasani, AJ; Kleffel, S; Larson, A; Lee, CW; Lezcano, C; Lian, BQ; Lian, CG; Mihm, MC; Murphy, GF; Neiswender, J; Schatton, T; Scolyer, RA; Shi, YG; Tan, L; Thompson, JF; Woda, BA; Wu, F; Xu, W; Xu, Y; Yang, Y; Zhan, Q; Zon, LI1
Miller, AK; Schüler, P1
Huang, Y; Pastor, WA; Rao, A; Zepeda-Martínez, JA1
Agarwal, S; Henderson, HR; Huang, Y; Pastor, WA; Rao, A1
Ding, W; Xing, TY1
Bolognani, F; Hackett, JA; Lempiäinen, H; Meehan, RR; Moggs, JG; Müller, A; Nestor, CE; Oakeley, EJ; Reinhardt, D; Schübeler, D; Terranova, R; Thomson, JP1
Duan, R; He, C; Jin, P; Li, X; Lin, L; Pan, Q; Song, CX; Szulwach, KE; Wang, T; Warren, ST; Wu, H1
He, C; Jin, P; Li, Y; Song, CX1
Fu, Y; He, C1
Kawamura, F; Kimura, H; Kubiura, M; Okano, M; Tada, M1
Bellini, M; Jones, P; Morgan, GT1
He, C; Hon, GC; Jin, P; Ren, B; Song, CX; Szulwach, KE; Yu, M1
Down, TA; Hackett, JA; Lee, C; Murakami, K; Sengupta, R; Surani, MA; Zylicz, JJ1
Du, J; Guo, Z; Liu, Y; Tang, B; Wang, Y; Wu, Y; Yang, L; Zhang, Y1
Ayata, P; Dewell, S; Heintz, N; Kriaucionis, S; Mellén, M1
Arita, K; Ariyoshi, M; Kato, T; Kimura, H; Kinoshita, M; Otani, J; Shirakawa, M; Suetake, I; Tajima, S1
Bapat, B; Olkhov-Mitsel, E1
Chen, ML; Feng, YQ; Huang, W; Liu, SM; Qi, JH; Shen, F; Wang, Y; Yuan, BF1
Borgaro, JG; Cheng, X; Guan, S; Jolyon, T; Liu, Y; Pradhan, S; Sun, D; Sun, Z; Terragni, J; Wang, H; Yu, L; Zheng, Y; Zhu, Z1
Barrasa, MI; Breiling, A; Cheng, AW; Dawlaty, MM; Faull, KF; Gao, Q; Jaenisch, R; Le, T; Li, Z; Lyko, F; Powell, BE; Raddatz, G; Xu, M1
Bernard, O; Calonne, E; Daniels, DL; Dawson, MA; Defrance, M; Delatte, B; Deplus, R; Fuks, F; Levine, RL; Méndez, J; Mercher, T; Murphy, N; Putmans, P; Schwinn, MK; Shih, AH; Solary, E; Urh, M; Volkmar, M1
Albasanz, JL; Barrachina, M; Blanch, M; Ferrer, I; Martín, M; Pereira-Veiga, T; Pérez-Navarro, E; Tyebji, S; Villar-Menéndez, I1
Hong, K; Inoue, A; Liu, R; Shen, L; Yamaguchi, S; Zhang, K; Zhang, Y1
Hahn, MA; Jiang, Y; Jin, SG; Jui, J; Li, AX; Lu, Q; Pfeifer, GP; Qiu, R; Wang, J; Wu, X; Zhang, H1
Mariappa, D; Pathak, S; van Aalten, DM1
Huang, N; Kong, L; Schwartz, L; Shi, Y; Shi, YG; Tan, L; Wu, F; Xiong, L; Xu, W; Xu, Y; Zheng, L1
Chen, Y; Oztürk, NC; Resendiz, M; Zhou, FC1
Calvopiña, JH; Chen, PY; Clark, AT; Fan, G; Faull, K; Feng, S; Huang, Y; Jacobsen, SE; Le, T; Lee, SA; Nee, K; Pellegrini, M; Rao, A; Vincent, JJ; Yoon, AJ1
Badoo, M; Baribault, C; Crain, CM; Crawford, GE; Ehrlich, M; Gertz, J; Lacey, M; Myers, RM; Pradhan, S; Song, L; Terragni, J; Tsumagari, K; Varley, KE1
Liu, S; Liu, X; Luo, Y; Pei, M; Shen, J; Xiao, L; Xu, Y; Yi, Y; Zhang, G; Zheng, W; Zhong, H1
Bauer, C; Boelens, R; Brinkman, AB; Carell, T; Eberl, HC; Gnerlich, F; Jansen, PW; Khan, F; Leonhardt, H; Lephikov, K; Mensinga, A; Müller, M; Müller, U; Münzel, M; Pfaffeneder, T; Smits, AH; Spruijt, CG; van Ingen, H; Vermeulen, M; Wagner, M; Walter, J1
Andreazza, AC; Carvalho, AF; Machado-Vieira, R; Moreno, RA; Soeiro-de-Souza, MG; Young, LT1
Bagci, H; Brown, KE; Dawlaty, MM; Feytout, A; Fisher, AG; Hajkova, P; Jaenisch, R; Kriaucionis, S; Landeira, D; Leitch, HG; Merkenschlager, M; Mooijman, D; Piccolo, FM; Soza-Ried, J; Tada, T1
Gambichler, T; Sand, M; Skrygan, M1
Borgaro, JG; Zhu, Z1
Shen, L; Zhang, Y1
Koh, KP; Rao, A1
Cai, T; Chen, J; Gao, S; Gao, Y; Huang, B; Huang, H; Jiang, Y; Kang, L; Kou, X; Li, K; Liu, W; Liu, X; Lu, Z; Wang, H; Wu, T; Xu, Z; Yao, C; Zhang, Y1
Gao, F; Gao, Z; Han, X; Huang, X; Lin, Z; Lu, H; Luo, H; Wang, J; Wen, B; Xia, Y; Yang, H; Yao, Y; Yi, N; Zhang, J; Zhang, X; Zhou, B1
Godley, LA; Madzo, J; Vasanthakumar, A1
Cai, C; Chen, LY; Kang, JX; Xie, AM; Ye, XX; Zhang, JJ; Zhang, LJ; Zhang, LT1
Court, BL; Minor, EA; Wang, G; Young, JI1
Bayley, H; Gong, L; Li, WW1
Amano, T; Anzai, M; Hatanaka, Y; Hosoi, Y; Kato, H; Kishigami, S; Matsumoto, K; Mitani, T; Nishihara, T; Nishikawa, S; Shimizu, N; Shin, SW; Tokoro, M1
Guibert, S; Weber, M1
Hunter, JM; Lempiäinen, H; Meehan, RR; Moggs, JG; Müller, A; Terranova, R; Thomson, JP1
D'Alessio, AC; Diep, D; Fung, HL; Shen, L; Wu, H; Yamaguchi, S; Zhang, K; Zhang, Y1
Chen, X; Hong, T; Hu, J; Mao, W; Wang, S; Xing, X; Zhou, X1
Akrap, I; Feliciello, I; Parazajder, J; Ugarković, D1
Guo, C; Han, C; Liao, YQ; Lin, X; Luo, HR; Sun, Q; Tang, TS; Wang, D; Wang, F; Wang, JQ; Wu, YS; Xie, W; Yang, Y; Yang, YG; Zhu, S1
Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z1
De Marzo, AM; Ghosh, S; Haffner, MC; Lotan, TL; Nelson, WG; Pellakuru, LG; Yegnasubramanian, S1
Jin, SG; Kim, SI; Pfeifer, GP1
Chu, JM; Feng, YQ; Huang, W; Tang, Y; Xing, XW; Xiong, J; Yuan, BF; Zhou, X1
Ananiev, G; Chamberlain, SJ; Chang, Q; Chen, IP; Dodd, A; Goldlust, IS; Gong, H; Han, JW; He, C; Jin, P; Li, X; Li, Y; Lin, L; Rudd, MK; Song, CX; Szulwach, KE; Wang, T; Warren, ST; Wu, H; Yoon, YS; Yu, M1
Li, Y; O'Neill, C1
Cong, R; Jia, Y; Li, R; Parvizi, N; Sun, Q; Yang, X; Zhao, R1
Andreesen, R; Gebhard, C; Klug, M; Rehli, M; Schmidhofer, S1
Chen, T; Zhao, H1
Adema, C; Bulla, J; Cosseau, C; Dheilly, N; Fneich, S; Grunau, C; Reichelt, M; Rognon, A1
Hornick, JL; Mason, EF1
Ebenstein, Y; Grunwald, A; Hoch, R; Michaeli, Y; Shahal, T; Torchinsky, D1
Gan, H; Han, C; He, C; Liao, S; Lin, X; Liu, J; Ma, T; Song, CX; Tang, F; Wang, M; Wen, L1
He, C; Lu, X1
Aston, KI; Cairns, BR; Carrell, DT; Jenkins, TG1
Blaschke, K; Ebata, KT; Goyal, P; Hirst, M; Karimi, MM; Laird, DJ; Lorincz, MC; Mahapatra, S; Ramalho-Santos, M; Rao, A; Tam, A; Zepeda-Martínez, JA1
Arnovitz, S; Chen, J; Chen, P; Dawlaty, M; Elkahloun, AG; Gurbuxani, S; He, C; Hong, GM; Huang, H; Jaenisch, R; Jiang, X; Jin, P; Li, Y; Li, Z; Lin, L; Liu, PP; Mulloy, JC; Neilly, MB; Rowley, JD; Song, CX; Street, C; Sun, M; Szulwach, K; Wang, J; Wunderlich, M; Xu, M; Yang, FC1
Błasiak, J; Głowacki, S1
Behrens, MM; Dwork, AJ; Ecker, JR; Esteller, M; Haghighi, FG; He, C; Heyn, H; Hu, S; Huang, Y; Johnson, ND; Lister, R; Lucero, J; Mukamel, EA; Nery, JR; Puddifoot, CA; Rao, A; Schultz, MD; Sejnowski, TJ; Tonti-Filippini, J; Urich, M; Wu, JC; Yu, M1
De Jonge, CJ1
Ala, U; Beringer, G; Brikbak, NJ; Cantley, LC; Ng, C; Pandolfi, PP; Poliseno, L; Richardson, AL; Song, MS; Song, SJ; Webster, K; Yuan, X1
Bhagat, TD; Bhattacharyya, S; Campbell, N; Christopeit, M; Godley, L; Greally, JM; Maitra, A; Mazdo, J; Nischal, S; Parekh, S; Steidl, U; Suzuki, M; Vasanthakumar, A; Verma, A; Yu, Y1
Hirose, K; Kikuchi, Y; Shimoda, N1
Fujiki, K; Kano, F; Murata, M; Sato, R; Shinoda, A; Shirahige, K1
Jin, P; Yao, B1
Gabel, HW; Greenberg, ME1
Bressler, JP; Coulter, JB; O'Driscoll, CM1
Barragan, I; Ingelman-Sundberg, M; Ivanov, M; Kacevska, M; Kals, M; Kasuga, K; Metspalu, A; Milani, L; Rane, A1
Blacque, O; Renciuk, D; Spingler, B; Vorlickova, M1
Hong, EE; Qu, J; Smith, AD; Song, Q; Zhou, M1
Allen, WE; Barnea, G; Colquitt, BM; Lomvardas, S1
Cho, IH; Chowdhury, B; Cui, Y; Irudayaraj, J1
He, N; Hou, P; Ji, M; Jin, W; Shi, B; Wu, K; Yang, Q1
Carell, T; Hackner, B; Höfner, G; Kashiwazaki, G; Ochsenfeld, C; Pfaffeneder, T; Sadeghian, K; Schiesser, S; Schröder, AS; Steigenberger, B; Steinbacher, J; Wanner, KT1
Bogomazova, AN; Kiselev, SL; Lagarkova, MA; Nekrasov, ED; Panova, AV1
Incarnato, D; Krepelova, A; Neri, F; Oliviero, S; Pagnani, A; Parlato, C; Rapelli, S; Zecchina, R1
Kubota, T; Li, Y; Miyanari, Y; Nitta, H; Ohashi, H; Okamoto, A; Sasaki, H; Shirane, K1
Chen, Y; Ding, F; Guo, P; Hong, T; Ma, J; Wang, T; Wu, F; Wu, J; Xing, X; Zhou, X1
Bender, A; Weber, M1
Meehan, RR; Moggs, JG; Thomson, JP; Wolf, CR1
Balasubramanian, S; Bell, NM; Beraldi, D; Booth, MJ; Branco, MR; Ost, TW; Reik, W1
Dickson, KM; Gustafson, CB; Wang, G; Young, JI; Züchner, S1
Al-Mahdawi, S; Mouro Pinto, R; Pook, MA; Sandi, C1
Ballestar, E; Christensen, J; de la Rica, L; García, M; Gómez-Vaquero, C; Helin, K; Hernando, H; Islam, AB; Rodríguez-Ubreva, J; Urquiza, JM1
Cadet, J; Wagner, JR1
Feng, YQ; Liu, YL; Vargas, M; Wang, Y; Xing, XW; Yuan, BF; Zhou, X1
Bollig-Fischer, A; Cao, X; Chen, CC; Cingolani, P; Coon, M; Garfinkel, MD; Huang, Y; Hudson, ME; Khetani, RS; Land, S; Robinson, GE; Ruden, DM; Sammak, A; Zhong, S1
Kang, TW; Kim, HJ; Kim, M; Kim, SY; Kim, YS; Lee, D; Lee, SH; Park, JL; Park, YK; Rhee, YH1
Bitinaite, J; Chin, HG; Corrêa, IR; Dai, N; Pradhan, S1
Galloway, JN; Jin, P; Lin, L; Nelson, DL; Street, RC; Wu, H; Yao, B; Zalewski, ZA1
Fu, X; Hu, J; Huang, W; Jin, L; Ku, HT; Luo, A; Riggs, AD; Tsark, WM; Wang, X; Zheng, X1
Chen, J; Chen, S; Cheng, J; D'Alessio, AC; Ding, Y; Guo, S; Guo, Y; Heydari, K; Hysolli, E; Li, D; Liu, C; Liu, J; Lu, J; Mastriano, SJ; Megyola, CM; Pan, W; Park, IH; Roden, CA; Yao, H; Zhang, Y; Zhou, XL1
Hasséus, B; Jäwert, F; Kjeller, G; Larsson, L; Magnusson, B; Sand, L1
Feng, YQ; Huang, JT; Huang, W; Liu, SM; Liu, YJ; Qi, JH; Shen, F; Yuan, BF; Zhou, X1
An, R; Ming, GL; Shin, J; Song, H; Weng, YL1
Kohli, RM; Zhang, Y1
Benson, M; Meehan, RR; Nestor, CE; Reddington, JP1
Meehan, RR; Nestor, CE1
Bartlett, JJ; Brinkerhoff, H; Derrington, IM; Gundlach, JH; Langford, KW; Laszlo, AH; Nova, IC; Pavlenok, M; Samson, JM1
Abu-Shumays, R; Akeson, M; Baatar, B; Karplus, K; Schreiber, J; Vivian, JT; Wescoe, ZL1
Ashida, A; Hayashi, K; Kiniwa, Y; Koga, H; Ogawa, E; Okuyama, R; Takazawa, Y; Uchiyama, A; Uchiyama, R; Uhara, H1
Dunican, DS; Hunter, JM; Meehan, RR; Moggs, JG; Nestor, CE; Terranova, R; Thomson, JP1
Chong, Z; Huang, H; Jiang, G; Jin, KX; Li, C; Rendtlew Danielsen, JM; Song, M; Song, SH; Sun, BF; Wang, H; Wang, X; Wu, D; Xu, GL; Yang, Y; Yang, YG; Yin, R; Zhao, B; Zhao, C; Zhu, BZ1
Li, L; Ye, C1
Challen, GA; Chavez, L; Chen, R; Darlington, GJ; Godley, LA; Goodell, MA; Göttgens, B; Gunaratne, P; Hannah, R; Huang, Y; Jeong, M; Kim, SB; Ko, M; Lee, JS; Li, W; Luo, M; Rao, A; Rodriguez, B; Sun, D; Wang, H; Yang, L; Zhang, X1
Harrison, DJ; Laird, A; Meehan, RR; Thomson, JP1
Brown, T; El-Sagheer, AH; Kriaucionis, S; Lercher, L; McDonough, MA; Schofield, CJ; Thalhammer, A1
Fragou, A; Fragou, D; Kouidou, S; Kovatsi, L; Njau, S; Samanidou, V1
Chen, Y; Hu, J; Weng, X; Wu, F; Xing, X; Xu, J; Xu, X; Xu, Z; Zhou, X1
Cao, Z; Li, N; Li, Y; Wu, R; Zhang, Y; Zhou, N1
Cao, X; Chen, CC; He, C; Song, CX; Wang, T; Xiao, S; Xie, D; Zhong, S1
Endo, TA; Kawakami, T; Kimura, H; Koseki, H; Mishima, Y; Otani, J; Sharif, J; Shirakawa, M; Suetake, I; Tajima, S1
Li, J; Liu, L; Wu, HC; Yang, C; Zhao, K1
Barciszewski, J; Gabryelska, MM1
Burger, L; Feldmann, A; Gaidatzis, D; Ivanek, R; Murr, R; Schübeler, D1
Chappell, J; Dalton, S; Jin, P; Lin, L; Matlock, BK; Singh, AM; Tang, J; Trost, R; Wang, T; Weller, KP; Wu, H; Zhao, S1
Caces, DBD; Duszynski, R; Godley, LA; Grossman, R; He, C; Lahn, BT; Lavelle, D; Lepore, JB; Levine, RL; Liu, H; Looney, TJ; Macrae, T; Madzo, J; Raumann, B; Rodriguez, A; Shih, AH; Song, CX; Sundaravel, S; Vasanthakumar, A; Verma, A; Wickrema, A; Yu, M; Yu, Y; Zhang, L1
Fronhoffs, F; Grewe, MJ; Haas, N; Heukamp, LC; Honecker, F; Kristiansen, G; Nettersheim, D; Schorle, H; Waha, A1
Coppieters, N; Curtis, MA; Dieriks, BV; Dragunow, M; Faull, RL; Lill, C1
Iwamoto, K; Kato, T1
Dresser, KA; Larson, AR; Lezcano, C; Lian, CG; Mihm, MC; Murphy, GF; Scolyer, RA; Shi, YG; Thompson, JF; Woda, BA; Yosufi, B; Zhan, Q1
Cheng, X; Corrêa, IR; Dai, N; Fu, ZQ; Hashimoto, H; Pais, JE; Saleh, L; Zhang, X; Zheng, Y1
Gao, W; Hou, J; Li, J; Li, P; Liu, X; Wong, J; Zhang, Q1
Guan, M; Li, X; Sun, W1
Cowley, AW; Liang, M; Liu, P; Liu, Y; Yang, C1
Chen, Y; Cook, EH; Dong, E; Grayson, DR; Guidotti, A; Zhubi, A1
Bhutani, N; Dhulipala, L; Rath, M; Smeriglio, P; Taylor, SE1
Hasegawa, J; Miura, N; Shomori, K; Tsuno, S; Wang, X1
Haqqi, TM; Haseeb, A; Makki, MS1
Rudenko, A; Tsai, LH1
Alisch, RS; Brown, RM; Chopra, P; Garthwaite, MA; Golos, TG; Hatch, A; Papale, LA; Roseboom, PH; Warren, ST; White, AT1
Ling, ZQ; Wu, YC1
Guo, H; He, C; Hou, Y; Li, R; Li, X; Liu, X; Qiao, J; Song, C; Tan, Y; Tang, F; Wang, Y; Wen, L; Wu, X; Xie, J; Yan, L; Yu, M; Zhang, Y; Zhao, Y; Zhu, P1
Barbier, E; Breton, J; Couté, Y; Gasparutto, D; Kraut, A; Lafaye, C; Miscioscia, A; Plo, I; Ravanat, JL; Saint-Pierre, C1
Cui, D; Dai, J; Jin, W; Ju, G; Ma, Y; Macklin, WB; Mi, Y; Zhao, X1
Rao, A; Tsagaratou, A1
Braeckmans, K; Forier, K; Heras, S; Rombouts, K; Van Soom, A1
Bochtler, M; Czapinska, H; Kazrani, AA; Kowalska, M1
Aravind, L; Chen, W; Dai, Q; Fu, Y; He, C; Hu, J; Iyer, LM; Wang, G; Yu, M; Zhang, L1
Bennett, AJ; Massart, R; Provencal, N; Suderman, M; Suomi, S; Szyf, M; Yi, C1
Eichman, BF; Huh, JH; Jang, H; Shin, H1
Crawford, GE; Ehrlich, M; Lacey, M; Pradhan, S; Song, L; Sun, Z; Terragni, J; Zhang, G1
Chouliaras, L; Condliffe, D; Cooper, J; Fernandes, C; Lovestone, S; Lunnon, K; Mill, J; Patel, Y; Proitsi, P; Schalkwyk, L; Troakes, C; Wong, A1
Jiang, G; Li, C; Liu, B; Liu, Z; Song, M; Wang, H; Yin, R; Zhao, B; Zhao, C1
Arias, C; Bermúdez-Rattoni, F; Cadena-del-Castillo, C; Carmona-Aldana, F; Recillas-Targa, F; Valdes-Quezada, C1
Cao, CH; Chen, JJ; Cui, ZZ; Dai, Y; Ou, ML; Sui, WG; Sun, YF; Tan, QP; Xue, W; Yan, Q; Yang, M; Zou, TX1
Dai, Z; Ding, ZB; Fan, J; Jin, L; Liu, WR; Peng, YF; Qiu, SJ; Shen, YH; Shi, YH; Tian, MX; Yang, LX; Zhou, J1
Annibali, V; Bacalini, MG; Caiafa, P; Calabrese, R; Ciccarone, F; Franceschi, C; Guastafierro, T; Mechelli, R; Ricigliano, VA; Salvetti, M; Valentini, E; Zampieri, M1
Baker-Andresen, D; Bredy, TW; D'Alessio, A; Flavell, CR; Li, X; Wei, W; Widagdo, J; Zhang, Y; Zhao, QY1
Cole, SA; Fallin, MD; Francesconi, KA; Goessler, W; Guallar, E; Laclaustra, M; Ledesma, M; Leon, M; Navas-Acien, A; Pollak, J; Shang, Y; Tang, WY; Tellez-Plaza, M; Umans, JG1
Cui, DX; Fu, HL; Hou, P; Jin, WL; Li, BJ; Lu, LG; Ma, Y1
Chen, C; He, N; Hou, P; Ji, M; Jin, T; Liu, S; Liu, W; Qiang, W; Shi, B; Yang, Q1
Aluru, N; Ci, W; Duan, J; Gao, X; He, C; Huang, X; Li, G; Li, W; Liu, J; Lu, X; Tang, F; Wang, L; Yang, L; Zhang, J; Zhou, Q; Zhu, W1
Wang, M; Wong, J; Xiong, J; Xu, RM; Yang, N; Zhou, T; Zhu, B1
Hahn, MA; Jin, SG; Pfeifer, GP; Xiong, W1
Delatte, B; Deplus, R; Fuks, F1
Bhagat, T; Bhattacharyya, S; Cohn, SL; Godley, LA; Madzo, J; Mariani, CJ; Nanduri, J; Prabhakar, NR; Vasanthakumar, A; Verma, A; Wenger, RH; Yesilkanal, A; Yu, Y1
Brandmayr, C; Carell, T; Eisen, D; Hackner, B; Kashiwazaki, G; Kosmatchev, O; Kotljarova, O; Laube, SK; Leonhardt, H; Michalakis, S; Müller, M; Müller, U; Pfaffeneder, T; Raddaoui, N; Schär, P; Schiesser, S; Schuermann, D; Spada, F; Spruijt, CG; Steigenberger, B; Steinbacher, J; Truss, M; Vermeulen, M; Wagner, M1
Bernstein, A; Chen, D; Cheng, Y; Jin, P1
Cadet, J; Eriksson, LA; Grand, A; Jorge, N; Morell, C1
Barton, MC; Estecio, MR; Issa, JP; Jelinek, J; Jin, C; Liang, S; Lu, Y1
Calvo, X; Costa, D; Esteve, J; Monzó, M; Muñoz, C; Navarro, A; Nomdedeu, B; Nomdedeu, M; Peña, O; Pereira, A; Risueño, RM; Tejero, R1
Church, GM; Esvelt, KM; Yaung, SJ1
Ahsan, S; Ballester, LY; Eberhart, CG; Haffner, MC; Nazarian, J; Quezado, M; Raabe, EH; Rodriguez, FJ; Vaghasia, A; Warren, KE1
Borgaro, JG; Cheng, X; Griggs, RM; Guan, S; Horton, JR; Quimby, A; Wilson, GG; Zhang, X; Zheng, Y; Zhu, Z1
Collins, LB; Hanaoka, F; Ito, S; Iwai, S; Kanao, R; Koseki, H; Kuraoka, I; Masuda, Y; Masutani, C; Shibata, M; Shibutani, T; Swenberg, JA; Toda, M; Urabe, M1
Hirota, S; Imai, Y; Matsuda, I1
Filip, M; Frankowska, M; Sadakierska-Chudy, A1
Choi, JH; Ho, T; Liu, C; Putiri, EL; Robertson, KD; Thompson, JJ; Tiedemann, RL1
Aslanyan, MG; Boezeman, JB; Carell, T; de Witte, T; Halkes, CJ; Huls, G; Jansen, JH; Koorenhof-Scheele, TN; Kroeze, LI; Marie, JP; Massop, M; Suciu, S; van der Reijden, BA; van Rooij, A; Wevers, RA1
Goodell, MA; Jeong, M1
Amadori, S; Aslanyan, MG; Cilloni, D; da Silva-Coelho, P; de Witte, T; Jansen, JH; Koorenhof-Scheele, TN; Kroeze, LI; Labar, B; Langemeijer, SM; Marie, JP; Marijt, EW; Massop, M; Muus, P; Saglio, G; Stevens-Linders, E; Suciu, S; Tang, R; Tönnissen, E; van de Locht, LT; van der Heijden, A; van der Reijden, BA; van Hoogen, P; Willemze, R1
Hata, K; Kobayashi, H; Kono, T; Sakashita, A; Sotomaru, Y; Wakai, T1
Bulun, SE; Coon, JS; Dyson, MT; Monsivais, D; Moravek, MB; Navarro, A; Ono, M; Wei, JJ; Yin, P1
Foksinski, M; Gackowski, D; Guz, J; Olinski, R; Rozalski, R1
Bailey, A; Chao, MR; Fragou, D; Hu, CW; Kouidou, S; Kovatsi, L; Zanos, P1
Äijö, T; Huang, Y; Jacobsen, SE; Lähdesmäki, H; Lio, CW; Rao, A; Tsagaratou, A; Yue, X1
Ebenstein, Y; Gilat, N; Michaeli, Y; Redy-Keisar, O; Shabat, D; Shahal, T1
Amato, NJ; Cai, Q; Fu, L; Guerrero, CR; Ji, D; Jin, SG; Liu, S; Liu, Y; Niedernhofer, LJ; Pfeifer, GP; Wang, Y; Xu, GL; Zhong, N1
Granter, SR; Guo, W; Laga, AC; Lee, JJ; Lian, CG; Murphy, GF; Saavedra, AP; Xu, S; Zhan, Q1
Arab, K; Dienemann, H; Dyckhoff, G; Grummt, I; Herold-Mende, C; Lindroth, AM; Lukanova, A; Lundin, E; Meister, M; Niehrs, C; Oakes, C; Park, YJ; Plass, C; Risch, A; Schäfer, A; Weichenhan, D1
Mikoshiba, Y; Ogawa, E; Okuyama, R; Uchiyama, A; Uchiyama, R; Uhara, H1
Du, C; Goto, M; Kahyo, T; Konno, H; Kurabe, N; Matsushima, Y; Ohnishi, I; Shinmura, K; Sugimura, H; Suzuki, M; Tajima, S; Tanioka, F; Tao, H; Yamada, H1
Bochtler, M; Kucharski, R; Maleszka, J; Maleszka, R; Misztal, K; Rafalski, D; Wojciechowski, M1
Choi, I; Kaestner, KH; Kim, R; Lim, HW; Won, KJ1
Huang, Y; Rao, A1
Chen, T; Chen, Y; Frank, MY; Guo, W; Lian, CG; Liu, C; Liu, R; Murphy, GF; Xu, S; Yan, J1
Amouroux, R; Hajkova, P; Hill, PW1
Bibikova, M; Boland, MJ; Cabral-da-Silva, MC; Coleman, RL; Fan, JB; Glenn-Pratola, VL; He, C; Klotzle, B; Loring, JF; Nazor, KL; Peterson, SE; Schell, JP; Schmidt, U; Yu, M1
Ficz, G; Gribben, JG1
Irwin, RE; O' Neill, KM; Thakur, A; Walsh, CP1
Hahn, MA; Pfeifer, GP; Szabó, PE1
Antunes, C; Guedes, M; Marques, CJ; Santiago, M; Sousa, N1
Balazs, R; Gami, P; Lashley, T; Li, A; Revesz, T; Valizadeh, N1
Cai, C; Cheng, Y; Dave, R; Davis, TH; Irier, H; Jin, P; Lin, L; Street, RC; Yao, B1
Li, X; Shu, Q; Sun, W; Zang, L1
Tang, F; Wen, L1
Hajkova, P; Lehner, B; Supek, F; Warnecke, T1
Chung, TH; Cui, L; Jia, XY; Sun, X; Tan, D1
Chung, TH; Jia, XY; Petterson, A; Sun, X; Tan, D1
Mu, X; Peng, S; Shen, H; Wang, X; Zhang, J1
Alamdar, A; Huang, Q; Liu, L; Martin, FL; Mu, X; Shen, H; Tian, M; Xu, W; Zhang, J1
Du, T; Edsall, LE; He, C; Hon, GC; Jin, F; Kuan, S; Lee, AY; Mao, SQ; Ren, B; Selvaraj, S; Song, CX; Wang, BA; Xu, GL; Ye, Z; Yen, CA; Zhao, BS1
Kriaucionis, S; Tahiliani, M1
Akiyama, T; Ino, Y; Katou, Y; Koyama-Nasu, R; Kozuka-Hata, H; Masuda, K; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Ogawa, H; Oyama, M; Saito, N; Sakaguchi, Y; Sato, T; Shirahige, K; Suzuki, T; Takai, H; Todo, T; Toyoshima, C1
James, SJ; Melnyk, S; Pavliv, O; Pogribny, IP; Shpyleva, S1
Chao, MR; Chen, JL; Hsu, YW; Hu, CW; Yen, CC1
De Sousa, PA; Gliddon, C; Horsburgh, K; Ruzov, A; Tsenkina, Y1
Butter, C; Ciccone, NA; Mwangi, W; Nair, V; Ruzov, A; Smith, LP1
Burghart, DR; De Souza, A; Kempf, W; Pfaltz, M; Tinguely, M1
Fusser, M; Klungland, A; Robertson, AB; Robertson, J1
Shen, L; Wu, H; Wu, X; Zhang, Y1
Das, SK; Gao, F1
Clish, CB; Erdmann, RM; Gehring, M; Souza, AL1
Brazauskas, P; Kriaucionis, S1
Bachman, M; Balasubramanian, S; Murrell, A; Uribe-Lewis, S; Williams, M; Yang, X1
Hahn, MA; Li, AX; Pfeifer, GP; Wu, X1
Chatterjee, A; Morison, IM; Rodger, EJ1
Cho, IH; Chowdhury, B; Hahn, N; Irudayaraj, J1
Walsh, C; Xu, G1
Armani, AM; Hawk, RM1
Guibourt, V; Kraus, TF; Kretzschmar, HA1
Cai, JB; Dong, ZR; Fan, J; Gao, DM; Ke, AW; Qiu, SJ; Shi, GM; Sun, HC; Zhang, C; Zhang, PF; Zhou, J1
Abdel-Wahab, O; Ahn, J; Aifantis, I; Alkalin, A; Ciminio, L; Dai, Q; Daniels, D; Ferrando, A; Figueroa, ME; Fuks, F; Godley, LA; He, C; Hricik, T; Levine, RL; Li, Y; Licht, JD; Lu, C; Madzo, J; Mason, CE; Melnick, A; Nimer, S; Paietta, E; Patel, J; Pronier, E; Rampal, R; Shih, A; Tallman, JE; Tallman, MS; Thompson, CB; Tosello, V; Tsai, JJ; Vasanthakumar, A; Ward, PS; Zhao, X1
Sasnauskas, G; Zagorskaitė, E1
Ailamazyan, EK; Baranov, VS; Bogdanova, MA; Chiryaeva, OG; Efimova, OA; Fedorova, ID; Gzgzyan, AM; Kogan, IY; Krapivin, MI; Kuznetzova, TV; Pendina, AA; Shilnikova, EM; Tikhonov, AV1
Godley, LA; Jeff-Eke, M; Litwin, E; Mariani, CJ; Moen, EL; Nikitas, JN; Zullow, H1
Gao, F; Huang, J; Lin, Z; Liu, W; Liu, X; Luo, H; Ou, Y; Wang, J; Wen, B; Xia, Y; Zhang, X; Zhou, B1
Ehrlich, KC; Ehrlich, M1
Anderton, SM; Drake, AJ; Kay, O; Konkel, JE; Leech, MD; McPherson, RC; Meehan, RR; Ottaviano, R; Prendergast, CT; Sweenie, CH; Thomson, JP; Wraith, DC; Zandee, SE1
Lu, M; Mo, J; Wang, H; Yin, R1
Batke, S; Kubik, G; Summerer, D1
Jangiam, W; Rithidech, KN; Tungjai, M1
Jansen, JH; Kroeze, LI; van der Reijden, BA1
Davie, JR; Liyanage, VR; Rastegar, M; Zachariah, RM1
Carvalho, AT; Gouveia, L; Kamerlin, SC; Kanna, CR; Platts, JA; Wärmländer, SK1
Banerjee, S; Brooks, S; Egli, M; Eichman, BF; Joachimiak, A; Nocek, B; Pallan, PS; Stone, MP; Szulik, MW; Voehler, M1
Borgaro, JG; Corrêa, IR; Dai, N; Guan, S; Quimby, A; Sun, D; Sun, Z; Zheng, Y; Zhu, Z1
Lei, X; Lv, Q; Yin, X; Zhang, B; Zheng, T1
Anderton, SM; Benson, M; Cruickshanks, HA; Dunican, DS; Lentini, A; McPherson, RC; Meehan, RR; Mjoseng, HK; Nestor, CE; Ottaviano, R; Pennings, S; Reinhardt, D; Thomson, JP1
Karplus, K; Schreiber, J1
Hua, J; Li, N; Mu, H; Tang, F; Wu, J; Zheng, L; Zhu, H1
Bachman, M; Balasubramanian, S; Huber, SM; Mendil, L; Miska, EA; Smollett, K; van Delft, P; Werner, F1
Kobayashi, Y; Nohara, K; Okamura, K; Sano, T; Takumi, S; Yanagisawa, H1
Arakawa, T; Hori, M; Kimura, T; Nakamura, T; Nakano, T; Nakashima, H; Nakatani, T; Oda, M; Sekita, Y; Yamagata, K1
Cui, L; Shao, F; Wu, Q; Xuan, S; Zhang, D1
Bachman, M; Balasubramanian, S; Beck, S; Beraldi, D; Field, SF; Stewart, SK1
Ghanbarian, AT; Hurst, LD1
Alisch, RS; Barrett-Wilt, GA; Cengiz, P; Kintner, DB; Li, S; Papale, LA; Sabat, G1
Chen, YS; Chong, ZC; Jiao, J; Li, D; Sun, BF; Wang, XL; Wang, XX; Zhao, Y; Zhou, YM1
Cahill, ME; Casaccia, P; Couroussé, T; Estey, D; Fan, G; Faull, KF; Feng, J; Ferguson, D; Huynh, J; Jin, P; Kennedy, P; Koo, JW; Labonte, B; Laitman, BM; Le, T; Li, Y; Mensah, I; Ming, GL; Nestler, EJ; Ribeiro, E; Shao, N; Shen, L; Song, H; Stockman, V; Szulwach, KE; Turecki, G; Vialou, V; Zhong, C1
Cheng, Y; Jin, P; Wang, T; Xie, N1
Golla, JP; Sathyanarayana, BK; Sayeed, SK; Vinson, C; Zhao, J1
West, AE1
Burgess, D; Eichten, SR; Greally, JM; Green, D; Hermanson, PJ; Jeddeloh, J; Li, Q; Patterson, N; Richmond, T; Rosenbaum, H; Springer, NM; Suzuki, M; Wendt, J1
Cao, C; Chen, J; Cui, Z; Dai, Y; Guo, L; Jing, H; Lin, H; Ou, M; Sui, W; Sun, Y; Tan, Q; Xue, W; Yan, Q; Yang, M; Zou, T1
Li, PL; Wang, TZ; Zhang, LY; Zhang, XC1
Biel, M; Carell, T; Eisen, D; Koch, S; Künzel, AF; Laube, SK; Michalakis, S; Mittermeier, N; Müller, M; Perera, A; Schulze, E; Splith, V; Steinbacher, J; Wagner, M1
Bachman, M; Carroll, T; Colin, L; de Bony, EJ; Defrance, M; Delatte, B; Dunning, MJ; Fuks, F; Halim, S; Ibrahim, AE; Ito, Y; Krueger, F; Lynch, AG; Murrell, A; Silva, AL; Stark, R; Stojic, L; Ten Hoopen, R; Uribe-Lewis, S; Vowler, SL1
Aifantis, I; Chen, T; Deng, Y; Dong, C; Ichiyama, K; Kim, BS; Ndiaye-Lobry, D; Tanaka, S; Tian, Q; Wang, X; Wei, L; Yan, X; Zheng, P; Zou, Y1
Sehgal, M; Shukla, A; Singh, TR1
Aifantis, I; Aranda-Orgilles, B; Bakogianni, S; Bhattacharyya, S; Cimmino, L; Dawlaty, MM; Geng, H; Jaenisch, R; King, B; Liu, C; Lobry, C; Mullenders, J; Ndiaye-Lobry, D; Shaknovich, R; Shen, S; Trimarchi, T; Verma, AK; Yap, YS; Yu, Y1
Devi, G; Shao, F; Xu, B1
Godley, LA; Vasanthakumar, A1
Chevassut, T; Cho, IH; Choudhury, SR; Chowdhury, B; Cooper, B; Cui, Y; Irudayaraj, J; Lossie, AC; McGovern, A1
Chavez, L; Choi, J; Etchegaray, JP; Gladden, A; Goren, A; Hochedlinger, K; Huang, Y; Kugel, S; Lienhard, M; Martinez-Pastor, B; Mostoslavsky, G; Mostoslavsky, R; Ramaswamy, S; Rao, A; Ross, KN; Silberman, DM; Sommer, CA; Walsh, RM1
DeSimone, J; Ibanez, V; Lavelle, D; Mahmud, N; Rivers, A; Ruiz, MA; Vaitkus, K1
Ito, S; Kuraoka, I1
Baccarelli, AA; Bertazzi, PA; Byun, HM; Chang, D; Chervona, Y; Díaz, A; Hou, L; Kang, CM; Koutrakis, P; McCracken, JP; Osorio-Yanez, C; Sanchez-Guerra, M; Schwartz, J; Wang, S; Zhang, W; Zhang, X; Zheng, Y; Zhong, J1
Chan, WY; Chung, JP; Kong, GW; Lee, TL; Qian, Y; Tang, NL; Tu, J1
Lagunavičius, A; Serva, S1
Her, YF; Maher, LJ; Nelson-Holte, M1
Kauneckaitė, K; Sasnauskas, G; Siksnys, V; Tamulaitiene, G; Zagorskaitė, E1
Greiner, A; Guibourt, V; Kolck, G; Kraus, TF; Kretzschmar, HA; Schierl, K1
Baccarelli, AA; Cingolani, P; Land, S; Mercado-Garcia, A; Ruden, DM; Sen, A; Senut, MC; Tellez-Rojo, MM; Wright, RO1
Etchegaray, JP; Mostoslavsky, R1
Drake, AJ; Khulan, B; Menon, G; Piyasena, C; Reynolds, RM; Seckl, JR1
Baba, H; Baba, Y; Harada, K; Ishimoto, T; Iwagami, S; Kosumi, K; Kurashige, J; Miyake, K; Miyamoto, Y; Murata, A; Nakao, M; Oda, S; Sakamoto, Y; Watanabe, M; Yamamoto, M; Yoshida, N1
Bachman, M; Balasubramanian, S; Burgess, HE; Iurlaro, M; Murrell, A; Reik, W; Uribe-Lewis, S; Yang, X1
Pan, F; Weeks, O; Xu, M; Yang, FC1
Khan, HA; Sherwani, SI1
Chen, L; Chong, J; Fu, XD; He, C; Li, H; Lu, X; Wang, D; Wang, L; Xiao, R; Xu, L; Zhou, Y1
Chan, WY; Feng, B; Jiang, X; Lee, TL; Liao, J; Luk, AC; Lun Mak, KK; Ng, SH; Rennert, OM; Tu, J1
Caiafa, P; Ciccarone, F; Valentini, E; Zampieri, M1
Carell, T; Giese, A; Hackner, B; Kraus, TF; Kretzschmar, HA; Michalakis, S; Müller, M; Perera, A; Pfaffeneder, T; Steinbacher, J; Wagner, M1
Hu, N; Qu, Y; Wu, W; Xu, H; Yang, J; Yin, ZQ; Zeng, Y1
Grosser, C; Grothaus, K; Horsthemke, B; Wagner, N1
Minamizaki, T; Yoshiko, Y; Yoshioka, H1
Cheng, H; Kong, L; Lan, F; Li, X; Lv, R; Zhu, L1
Chen, L; He, Y; Jin, P; Kong, J; Li, J; Lin, L; Miao, Z; Sun, M; Xin, N; Xu, X1
Burns, KH; Rodić, N; Sharma, R; Taube, JM; Zampella, J1
Chang, HT; Chang, HY; Chen, CC; Chen, CH; Fu, TY; Ger, LP; Huang, JS; Huang, SF; Li, GC; Liou, HH; Pan, HW; Tsai, KW; Tseng, HH; Yeh, MH1
French, BA; French, SW; Li, J; Shen, H; Tillman, BC1
Chen, TT; Dunwell, JM; Dunwell, TL; Hu, SN; Huang, ZY; Li, YL; Liu, S; Pfeifer, GP; Song, SH; Ullah, I; Wamaedeesa, R; Wang, XL; Wang, Y; Wu, YS1
Abdelhay, E; Batalha, AB; Boulhosa, AM; Bueno, AP; Coutinho, DF; Fernandez, TS; Gutiyama, LM; Monte-Mór, BC; Pombo-de-Oliveira, MS; Rouxinol, ST; Vianna, DT; Zalcberg, IR1
Ai, S; Jiang, W; Liu, F; Yang, Z; Yin, H; Zhou, Y1
Benner, C; Chang, HT; Chen, CH; Chen, SF; Gascon, P; Ger, LP; Hishida, T; Izpisua Belmonte, JC; Jan, CI; Lin, YS; Ma, L; Montserrat, N; Nieh, S; Sancho-Martinez, I; Wu, MZ1
Bernotiene, E; Daniunaite, K; Fleury-Cappellesso, S; Gordevicius, J; Jarmalaite, S; Misgirdaite, R; Serenaite, I; Unguryte, A1
Cheng, X; Corrêa, IR; Dai, N; Hashimoto, H; Pais, JE; Zhang, X; Zheng, Y1
Barreiro, LB; Chen, GG; Ernst, C; Gross, JA; Pacis, A; Turecki, G1
Han, D; He, C; Jiang, X; Liu, M; Lu, X; Sun, Z; Xia, B; Xie, W; Yi, C; Yin, Q; Zeng, H; Zhou, A1
Dang, S; He, N; Hou, P; Ji, M; Lu, R; Qui, Y; Shi, B; Sui, F; Yang, Q1
Amato, NJ; Jiang, J; Li, L; Liu, S; Wang, Y; Wang, Z1
Castaño, GO; Dopazo, H; Gianotti, TF; Martino, JS; Pirola, CJ; Rohr, C; Scian, R; Sookoian, S1
Bhutani, N; Li, YH; Rath, M; Smeriglio, P; Taylor, SE; Wong, WH1
Alam, S; Gamble, MV; Graziano, JH; Hall, MN; Ilievski, V; Levy, D; Liu, X; Niedzwiecki, MM; Parvez, F; Siddique, AB; Slavkovich, V; Thomas, T1
Barreiro, LB; Danckaert, A; Dumaine, A; Gicquel, B; Gilad, Y; Grenier, JC; Hansen, KD; He, C; Kobor, MS; Lambourne, J; Luca, F; MacIsaac, JL; Morin, AM; Pacis, A; Pai, A; Pastinen, T; Pique-Regi, R; Tailleux, L; Tung, J; Yotova, V; Yu, M1
Iba, Y; Iwata, K; Kai, Y; Mio, Y1
Fujimura, T; Hayashizaki, Y; Homma, Y; Inoue, S; Misawa, A; Suzuki, T; Takagi, K; Takahashi, S; Takayama, K; Urano, T1
Chen, A; Magliocco, SM; Ranganathan, SV; Shen, F; Sheng, J; Valsangkar, VA; Wang, R1
Blüher, M; Böttcher, Y; Dietrich, A; Keller, M; Rohde, K; Stumvoll, M1
Alisch, RS; Chen, K; Keleş, S; Li, S; Papale, LA; Zhang, Q1
Cook, M; Lee, JJ; Lian, CG; Mihm, MC; Murphy, GF; Wang, TJ; Xu, S; Zhan, Q1
Choi, BY; Kang, GH; Kim, HJ; Kim, M; Kim, SY; Kim, YS; Kwon, OH; Lim, B; Park, JL; Seo, EH; Song, KS1
Bayley, JP; Bovée, JV; Breuning, MH; Briaire-de Bruijn, IH; Cornelisse, CJ; de Graaff, MA; Devilee, P; Frizzell, N; Hoekstra, AS; Hogendoorn, PC; Korpershoek, E; Kunst, HP; Ras, C; Seifar, RM; Suijker, J; van Minderhout, I1
Iatrou, A; Kenis, G; Lardenoije, R; Meuwissen, KPV; Rutten, BPF; Schmitz, C; Steinbusch, HWM; Vaessen, TSJ; van den Hove, DLA; van Hagen, BTJ1
Guibourt, V; Kilinc, S; Kraus, TF; Kretzschmar, HA; Steinmaurer, M; Stieglitz, M1
Chen, J; Hart, RP; Herrup, K; Jiang, D; Li, J; Zhang, Y1
Cheng, J; Cui, Q; Fang, D; Gong, W; He, C; Hou, H; Hu, L; Jiang, H; Li, J; Li, W; Li, Z; Liu, M; Lou, Z; Lu, J; Luo, C; Rao, Q; Sun, C; Tan, X; Wang, P; Wang, Y; Xu, Y; Yang, P; Yin, X; Zhang, L1
Barry, WT; Beroukhim, R; Birkbak, NJ; Clark, AP; Culhane, AC; Eklund, AC; Hill, DE; Landini, S; Lim, E; Neupane, M; Schumacher, SE; Silver, DP; Szallasi, Z; Vidal, M1
An, J; Han, JA; Ko, M1
Feng, YQ; Qi, BL; Xiong, J; Yuan, BF; Zhang, HY1
Bassani, DM; Bullen, GA; Duprey, JL; Peacock, AF; Tucker, JH; Wilkie, J; Zhao, ZY1
Fukuzawa, S; Suetake, I; Tachibana, K; Tajima, S1
Alisch, RS; Chen, L; Chopra, P; Jin, P; Keleş, S; Li, S; Madrid, A; Papale, LA; Zhang, Q1
Bissonnette, MB; Butun, F; Chapman, CG; Chuang, A; Godley, LA; Kwon, JH; Madzo, J; Mariani, CJ; Meckel, K; Wu, F1
Gackowski, D; Modrzejewska, M; Olinski, R; Starczak, M; Zarakowska, E1
Chen, K; Ci, W; Guo, Z; He, C; Ke, Y; Li, X; Li, Z; Liu, J; Liu, Y; Ma, Q; Xu, Z; Ye, X; Yuan, B; Zhang, J; Zhou, L; Zhou, Y1
Biagini Myers, JM; Ji, H; Jurcak, N; Khurana Hershey, GK; Kovacic, MB; Ryan, PH; Somineni, HK; Ulm, A; Zhang, X1
Chapman, VL; Dearman, RJ; Kimber, I; Moggs, JG; Terranova, R1
Belle, KC; Belzil, VV; Benatar, M; Boylan, KB; Dickson, DW; Dykxhoorn, DM; Esanov, R; Petrucelli, L; Rademakers, R; van Blitterswijk, M; Wahlestedt, C; Wuu, J; Zeier, Z1
Amouroux, R; D'Souza, Z; Encheva, V; Hajkova, P; Hill, PW; Koseki, H; Kudo, NR; Matsuda, M; Nakagawa, S; Nakayama, M; Nashun, B; Ndjetehe, E; Sasaki, H; Shirane, K; Turp, A1
Chen, HX; Nie, J; Yuan, F; Zhang, XH; Zhang, XX; Zhou, YL1
Bezerra, SM; Chaux, A; Gonzalez Roibon, N; Haffner, MC; Karram, S; Munari, E; Nelson, WG; Netto, GJ; Taheri, D; Vaghasia, AM; Yegnasubramanian, S1
Chung, TH; Kim, A; Sun, X; Tan, D1
Awe, S; Bonvin, E; Brehm, A; Calonne, E; Collignon, E; Creppe, C; Defrance, M; Delatte, B; Deplus, R; Fuks, F; Gueydan, C; Hassabi, B; Kreher, J; Kruys, V; Limbach, PA; Minakhina, S; Ngoc, LV; Putmans, P; Soin, R; Steward, R; Wang, F; Wetzel, C1
Ghosh, S; Scaria, V; Sengupta, S1
Carrillo de Santa Pau, E; Chung, HR; Juan, D; Marsili, S; Ochoa, D; Perner, J; Rico, D; Valencia, A; Vingron, M1
Nakarakanti, NK; Nivya, MA; Rajakumara, E; Satish, M1
Carlton, PM; Hatada, I; Horii, T; Kafer, GR; Li, X; Suetake, I; Tajima, S1
Chen, CD; Fu, X; Li, J; Li, Q; Li, X; Lin, W; Liu, Y; Wan, Y; Wang, Y; Wang, Z; Xu, Y; Yan, Q; Ye, J; Zhang, F; Zhang, J; Zhang, L; Zhang, M; Zhang, X; Zhang, Z1
Bian, XW; Chen, T; Dong, C; Ichiyama, K; Jin, W; Liu, X; Lu, H; Nallaparaju, KC; Tanaka, S; Tian, Q; Wei, L; Wen, X; Yan, X; Zhang, L; Zhang, X1
Al-Sarraj, S; Burrage, J; Dempster, E; Hannon, E; Kepa, A; Lunnon, K; Mill, J; Schalkwyk, L; Smith, RG; Troakes, C; Wong, C1
Choi, M; Jang, S; Jang, WY; Jeong, J; Kang, MC; Kim, H; Kim, MO; Kim, SH; Kwon, W; Park, S; Ryoo, ZY; Sung, Y1
Aksimentiev, A; Dai, Q; Ha, T; He, C; Ngo, TT; Yoo, J; Zhang, Q1
Bianchessi, V; Capogrossi, MC; Farina, F; Gualdi, V; Lauri, A; Nigro, P; Pompilio, G; Rizzi, V; Vinci, MC1
Creighton, CJ; Hawkins, SM; Loomans, HA; Roca, FJ; Wittman, AT1
Li, J; Li, Q; Xu, Y; Zhang, F; Zhang, M; Zhang, Z1
Cao, JL; Ding, HL; Hao, LY; Li, GF; Li, YQ; Ma, T; Pan, Z; Xue, ZY; Zhang, M; Zhu, LJ1
Choi, JW; Cui, XS; Guo, J; Kim, NH; Liang, S; Lu, WF; Zhao, MH1
He, Y; Jin, P; Tang, B; Wang, Z1
Barazeghi, E; Dina, R; Gill, AJ; Hellman, P; Norlén, O; Palazzo, FF; Sidhu, S; Stålberg, P; Westin, G1
Gershwin, ME; Li, D; Li, M; Liao, W; Lu, Q; Wang, J; Wu, H; Zhang, Y; Zhao, M1
Fang, K; Fu, ZM; Wang, J; Zhang, KX; Zhao, XH1
Avner, S; Guibert, S; Madigou, T; Mahé, EA; Salbert, G; Sérandour, AA; Weber, M1
Brunger, AT; Diao, J; Quake, SR; Song, CX1
Impey, S; Marzulla, T; Pelz, C; Raber, J; Tafessu, A; Turker, MS1
Chen, Z; Feng, X; He, J; Luo, M; Shi, S; Shi, X; Yu, Y; Zhang, Z1
Celarain, N; Echavarri, C; Larumbe, R; Mendioroz, M; Pulido, L; Roldán, M; Sánchez-Ruiz de Gordoa, J; Zelaya, MV1
Korakavi, G; Kuang, H; Liu, Y; Lu, LY; Yu, X; Zhang, B1
Incarnato, D; Krepelova, A; Neri, F; Oliviero, S; Parlato, C1
Abbes, S; Bernard, OA; Cabagnols, X; Della Valle, V; Ishchenko, AA; Mahfoudhi, E; Plo, I; Rameau, P; Saparbaev, M; Secardin, L; Talhaoui, I; Vainchenker, W1
Maunakea, AK; Pang, AP; Sugai, C1
Fukuzawa, S; Suetake, I; Tachibana, K; Tajima, S; Takahashi, S1
Chang, PM; Chou, NH; Kang, CH; Lam, HC; Li, GC; Liu, SI; Tsai, CY; Tsai, KW; Tu, YT; Wang, KC1
Pfeifer, GP; Song, J1
Devlieger, R; Duca, RC; Freson, K; Godderis, L; Huybrechts, I; Koppen, G; Pauwels, S; Straetmans, D; Van Herck, E1
Li, Y; Ma, S; Qi, H; Sun, H; Zheng, J1
Han, YW; Harada, Y; Kizaki, S; Li, Y; Sugiyama, H; Suzuki, Y; Zou, T1
Cheng, GJ; Hu, Y; Irudayaraj, J; Ouyang, L; Zhu, L1
Shimbo, T; Wade, PA1
Cheng, X; Hong, S1
Foksinski, M; Gackowski, D; Gawronski, M; Modrzejewska, M; Olinski, R; Rzeszowska-Wolny, J; Skonieczna, M; Starczak, M; Zarakowska, E1
Klungland, A; Robertson, AB1
Chen, Z; Guo, L; He, J; Li, Y; Luo, M; Shi, X1
Zhang, H; Zuehlke, A1
Li, C; Wang, F; Wang, H1
Bronner, C; Dimitrov, S; Gras, SL; Hamiche, A; Ibrahim, A; Jost, B; Menoni, H; Papin, C; Stoll, I; Velt, A1
Bieńkiewicz, A; Bryś, M; Ciesielski, P; Cwonda, Ł; Forma, E; Jóźwiak, P; Krześlak, A; Szczepaniec, S; Wójcik-Krowiranda, K1
Draghici, G; Nica, D; Popescu, C; Privistirescu, I; Stöger, R; Suciu, M1
Fernández, AF; Fraga, MF; López, V1
Moran, S1
Chen, Y; Chua, MS; Diao, J; Dong, B; Hu, J; Jeffrey, SS; Li, W; Liu, B; Ma, L; Quake, SR; So, S; Song, CX; Tian, Z; Wei, Y; Wheeler, A; Xie, D; Xiong, J; Yin, S; Zhang, W; Zhang, Y; Zhou, Z1
Ayata, P; Heintz, N; Mellén, M1
Allgayer, J; Carell, T; Geier, N; Khobta, A; Kitsera, N; Parsa, E; Rossa, M1
Banerjee, M; Nair, C; Nair, IV; Saradalekshmi, KR; Swathy, B1
Brown, T; Hardwick, JS; Lane, AN1
Cai, C; Chen, H; Feng, JJ; Yang, G; Yang, Y; Zhang, H1
Giehr, P; Kyriakopoulos, C; Lepikhov, K; Wallner, S; Walter, J; Wolf, V1
Cao, D; He, Y; Jiang, J; Liu, D; Liu, J; Mo, J; Wang, H1
Borre, M; Høyer, S; Lynnerup, AS; Storebjerg, TM; Strand, SH; Sørensen, KD; Ørntoft, TF1
Manakova, E; Sasnauskas, G; Zagorskaitė, E1
Ci, W; Lu, H; Ma, Q; Xu, Z; Yuan, B; Zhou, Y1
Cao, Z; Chen, Z; Gao, D; Khan, IM; Luo, L; Tong, X; Wang, Y; Xu, T; Zhang, D; Zhang, L; Zhang, M; Zhang, Y1
Buchholz, F; Calegari, F; Noack, F; Pataskar, A; Schneider, M; Tiwari, VK1
Wang, P; Yan, Y; Yu, W; Zhang, H1
Bian, K; Chen, F; Drennan, CL; Essigmann, JM; Jost, M; Lenz, SAP; Li, D; Qi, R; Tang, Q; Wetmore, SD1
Daumann, LJ; Jonasson, NSW1
Kriegel, AJ; Liang, M; Liu, Y1
Choi, JH; Lodh, A; Poole, CJ; van Riggelen, J1
Cao, LL; Jia, M; Liu, H; Pei, L; Wang, H; Yue, Z1
Cai, C; Chen, D; Chen, J; Dai, Z; Liu, SY; Ma, Y; Mo, M; Wang, Y; Xu, Y; Zhang, J; Zhang, L; Zhang, Y; Zou, X1
Abdelhamid, MAS; Ehiabor, MO; Grigg, MC; Irving, K; Smith, NM; Waller, ZAE; Wright, EP1
Ananda, G; Bohec, M; Dedon, PC; Hammam, E; Preiser, PR; Scheidig-Benatar, C; Scherf, A; Sinha, A; Vembar, SS1
Abakir, A; Fossdal, CG; Gackowski, D; Krutovsky, KV; Olinski, R; Ruzov, A; Starczak, M; Viejo, M; Yakovlev, IA1
Del Rio-Tsonis, K; Fausey, A; Grajales-Esquivel, E; Kosse, S; Liang, C; Liu, L; Luz-Madrigal, A; Tangeman, J; Tsonis, PA; Wang, K1
Fujii, S; Hirano, K; Kojima, N; Kurita, R; Namihira, M; Suda, T1
Gackowski, D; Gawronski, M; Olinski, R; Starczak, M1
Trueman, RC; Wallis, MD1
Gering, M; Jessop, P1
Fossdal, CG; Viejo, M; Yakovlev, I1
Celik-Uzuner, S1
Gackowska, L; Gackowski, D; Labejszo, A1
Abakir, A; Alenezi, F; Ruzov, A1
Huang, Z; Kohli, RM; Meng, Y; Pfeifer, GP; Szabó, PE1
Branco, MR; De Borre, M1
Berrios, KN; Kohli, RM; Luo, M; Schutsky, EK; Wang, T; Wu, H1
Edwards, JR; Singh, MK1
Assad, N; Durell, S; Ray, S; Tillo, D; Ufot, A; Vinson, C1
Bai, M; Cao, X; Chen, F; Fan, C; Su, L; Xue, J; Zhao, Y1
Arensdorf, P; Beadell, AV; Bergamaschi, A; Bissonnette, M; Collin, F; Cui, XL; Deng, Z; Dougherty, U; Ellison, CK; Goel, A; He, C; Karpus, J; Ku, J; Levy, S; Nie, J; Ning, Y; Pekow, J; Sharma, G; Sieh, L; Talwar, R; Wei, J; West-Szymanski, DC; Zhang, W; Zhang, Z; Zhao, CWT1
Chen, S; Li, X; Liu, Y; Ma, Y; Sun, J; Wang, H; Zhang, N1
DeNizio, JE; Dow, BJ; Drohat, AC; Ghanty, U; Kohli, RM; Serrano, JC1
Eden, HE; Huang, Z; Robertson, KD; Rothbart, SB; Tiedemann, RL1
Chen, D; Dai, Z; Li, Y; Liu, SY; Xu, Y; Yu, Z; Zhang, Y; Zou, X1
Bellacosa, A; Georges, RO; González-Avalos, E; Lio, CJ; Nakayama, T; Onodera, A; Rao, A1
Bronner, C; Dimitrov, S; Hamiche, A; Ibrahim, A; Klaholz, BP; Le Gras, S; Mohideen-Abdul, K; Papin, C; Stoll, I1
Bai, L; Ding, C; Feng, J; Gong, T; Li, J; Li, X; Li, Z; Liu, M; Lyu, J; Qin, J; Qin, Z; Wang, Y; Yang, G; Yang, W1
Balaiah, M; Mani, S; Ramasamy, D; Rao, AKDM; Sundersingh, S; Thangarajan, R; Veluswami, S; Vittal Rangan, A1
Pfeifer, GP1
Achrem, M; Gackowski, D; Kalinka, A; Starczak, M; Stępień, E1
Dai, E; Dai, M; Feng, J; Jia, Y; Liu, Z; Ye, L; Zhang, H1
Arvanitakis, Z; Bissonnette, MA; Cai, J; Cai, Q; Cheng, SY; Chiu, BC; Cui, X; He, C; Shi, Y; Wu, K; Zeng, C; Zhang, W; Zhang, X; Zhang, Z2

Reviews

82 review(s) available for 5-hydroxymethylcytosine and cytosine

ArticleYear
Modified bases in bacteriophage DNAs.
    Annual review of microbiology, 1980, Volume: 34

    Topics: 2-Aminopurine; 5-Methylcytosine; Adenine; Bacteriophages; Base Composition; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytosine; Deoxyribonucleases; DNA Replication; DNA, Viral; Nucleic Acid Conformation; Pentoxyl; Substrate Specificity; Templates, Genetic; Thymine; Transcription, Genetic; Uracil

1980
Genetic-epigenetic intersection in trophoblast differentiation: implications for extraembryonic tissue function.
    Epigenetics, 2010, Jan-01, Volume: 5, Issue:1

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Female; Gene Expression Regulation; Humans; Models, Biological; Models, Genetic; Placenta; Plants; Pregnancy; Stem Cells; Trophoblasts

2010
Advances in DNA methylation: 5-hydroxymethylcytosine revisited.
    Clinica chimica acta; international journal of clinical chemistry, 2011, May-12, Volume: 412, Issue:11-12

    Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; DNA; DNA Methylation; Genome; Hematologic Neoplasms; Humans; Oxygenases

2011
Hypothesis: environmental regulation of 5-hydroxymethylcytosine by oxidative stress.
    Epigenetics, 2011, Volume: 6, Issue:7

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Histone Demethylases; Humans; Models, Biological; Oxidative Stress

2011
5-Hydroxymethylcytosine, the sixth base of the genome.
    Angewandte Chemie (International ed. in English), 2011, Jul-11, Volume: 50, Issue:29

    Topics: 5-Methylcytosine; Animals; Bacteriophages; Cell Differentiation; Central Nervous System; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; DNA, Viral; Epigenesis, Genetic; Female; Genome; Humans; Male; Mass Spectrometry; Neoplasms; Pluripotent Stem Cells

2011
Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond.
    Cell cycle (Georgetown, Tex.), 2011, Aug-15, Volume: 10, Issue:16

    Topics: 5-Methylcytosine; Animals; Cell Cycle Proteins; Cytosine; Dioxygenases; DNA Methylation; DNA Repair; DNA-Binding Proteins; Humans; Mixed Function Oxygenases; Nuclear Proteins; Proto-Oncogene Proteins

2011
Studying the epigenome using next generation sequencing.
    Journal of medical genetics, 2011, Volume: 48, Issue:11

    Topics: 5-Methylcytosine; Animals; Base Composition; Cytosine; DNA; DNA Methylation; DNA, Intergenic; Epigenesis, Genetic; Epigenomics; Gene Expression; Genome; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Histones; Humans; Mice; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Quantitative Trait Loci; Quantitative Trait, Heritable

2011
The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.
    ACS chemical biology, 2012, Jan-20, Volume: 7, Issue:1

    Topics: 5-Methylcytosine; Adaptation, Physiological; Animals; Cytosine; Deamination; DNA; DNA Repair; Gene Expression Regulation; Genome; Genomics; Humans; Methylation; Mice; Mice, Knockout; Oxidation-Reduction; Polymorphism, Genetic

2012
Uncovering the role of 5-hydroxymethylcytosine in the epigenome.
    Nature reviews. Genetics, 2011, Nov-15, Volume: 13, Issue:1

    Topics: 5-Methylcytosine; Animals; Blastocyst Inner Cell Mass; Cell Differentiation; Cell Proliferation; Chromatin; CpG Islands; Cytosine; Deamination; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Developmental; Gene Silencing; Genome; Hematopoiesis; Humans; Mice; Mice, Knockout; Mixed Function Oxygenases; Proto-Oncogene Proteins; Tissue Distribution

2011
Novel DNA binding domain-based assays for detection of methylated and nonmethylated DNA.
    Epigenomics, 2011, Volume: 3, Issue:1

    Topics: 5-Methylcytosine; Biomarkers; CpG Islands; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; Humans; Immunoprecipitation; Polymerase Chain Reaction; Protein Interaction Domains and Motifs; Sensitivity and Specificity; Sulfites

2011
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation.
    Genes & development, 2011, Dec-01, Volume: 25, Issue:23

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Models, Biological; Oxidation-Reduction

2011
DNA methylation: TET proteins-guardians of CpG islands?
    EMBO reports, 2011, Dec-23, Volume: 13, Issue:1

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; Humans; Mice; Proto-Oncogene Proteins; Transcription, Genetic

2011
Hydroxylation mediates chromatin demethylation.
    Journal of biochemistry, 2012, Volume: 151, Issue:3

    Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; DNA Methylation; Humans; Hydroxylation; Methylation

2012
Dynamics of DNA methylation in aging and Alzheimer's disease.
    DNA and cell biology, 2012, Volume: 31 Suppl 1

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; DNA; DNA Methylation; Humans; Neurodegenerative Diseases

2012
Tet family proteins and 5-hydroxymethylcytosine in development and disease.
    Development (Cambridge, England), 2012, Volume: 139, Issue:11

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Epigenesis, Genetic; Humans; Mice; Mice, Knockout; Molecular Structure; Multigene Family; Neoplasms; Oxidation-Reduction; Protein Structure, Tertiary; Proto-Oncogene Proteins

2012
Epigenetic features of the mouse trophoblast.
    Reproductive biomedicine online, 2012, Volume: 25, Issue:1

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Fetal Growth Retardation; Gene Expression Regulation, Developmental; Histones; Mice; Models, Animal; Pregnancy; Pregnancy Complications; Trophoblasts

2012
[Progress of research on 5-hydroxymethylcytosine].
    Yi chuan = Hereditas, 2012, Volume: 34, Issue:5

    Topics: 5-Methylcytosine; Animals; Cytosine; Epigenesis, Genetic; Humans

2012
[Oxidation and deamination of nucleobases as an epigenetic tool].
    Postepy higieny i medycyny doswiadczalnej (Online), 2012, May-24, Volume: 66

    Topics: 5-Methylcytosine; Animals; Base Composition; Chromatin Assembly and Disassembly; Cytosine; Deamination; DNA; DNA Methylation; DNA-Binding Proteins; Epigenomics; Gene Expression Regulation; Guanine; Mutation; Neoplasms; Oxidation-Reduction; Sequence Analysis, DNA; Transcription, Genetic

2012
5-Hydroxymethylcytosine--the elusive epigenetic mark in mammalian DNA.
    Chemical Society reviews, 2012, Nov-07, Volume: 41, Issue:21

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Epigenesis, Genetic; Humans; Mammals

2012
Ten eleven translocation enzymes and 5-hydroxymethylation in mammalian development and cancer.
    Advances in experimental medicine and biology, 2013, Volume: 754

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Humans; Neoplasms; Proto-Oncogene Proteins

2013
[Recent advance in DNA epigenetic modifications-the sixth base in the genome].
    Sheng li ke xue jin zhan [Progress in physiology], 2012, Volume: 43, Issue:3

    Topics: 5-Methylcytosine; Animals; Biomarkers; Cell Differentiation; Cytosine; DNA; Epigenesis, Genetic; Gene Expression Regulation; Genome; Humans; Methylation

2012
Nucleic acid modifications with epigenetic significance.
    Current opinion in chemical biology, 2012, Volume: 16, Issue:5-6

    Topics: 5-Methylcytosine; Adenosine; Animals; Cytosine; DNA; Epigenesis, Genetic; Humans; Methylation; RNA

2012
Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.
    Cancer medicine, 2012, Volume: 1, Issue:2

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; Disease; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genetic Markers; Humans; Restriction Mapping; Sequence Analysis, DNA

2012
Epigenetic medicine and fetal alcohol spectrum disorders.
    Epigenomics, 2013, Volume: 5, Issue:1

    Topics: 5-Methylcytosine; Cell Differentiation; Cytosine; DNA Methylation; Embryonic Development; Epigenesis, Genetic; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Gene Expression Regulation; Histones; Humans; Pregnancy

2013
5-Hydroxymethylcytosine: generation, fate, and genomic distribution.
    Current opinion in cell biology, 2013, Volume: 25, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Genome; Genome-Wide Association Study; Humans

2013
DNA methylation and methylcytosine oxidation in cell fate decisions.
    Current opinion in cell biology, 2013, Volume: 25, Issue:2

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Chromatin Assembly and Disassembly; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome; Histones; Humans; Oxidation-Reduction; Transcription Factors

2013
Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.
    Seminars in hematology, 2013, Volume: 50, Issue:1

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Isocitrate Dehydrogenase; Mutation; Proto-Oncogene Proteins

2013
Functions of DNA methylation and hydroxymethylation in mammalian development.
    Current topics in developmental biology, 2013, Volume: 104

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Embryonic Development; Gene Expression Regulation, Developmental; Genome; Humans; Mammals

2013
Tet family of 5-methylcytosine dioxygenases in mammalian development.
    Journal of human genetics, 2013, Volume: 58, Issue:7

    Topics: 5-Methylcytosine; Animals; Blastocyst; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Genome; Germ Cells; Humans; Proto-Oncogene Proteins

2013
[Role of 5-hydroxymethylcytosine and TET proteins in epigenetic regulation of gene expression].
    Postepy biochemii, 2013, Volume: 59, Issue:1

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Hematopoiesis; Humans; Mixed Function Oxygenases; Neoplasms; Proto-Oncogene Proteins

2013
Cytosine modifications in neurodevelopment and diseases.
    Cellular and molecular life sciences : CMLS, 2014, Volume: 71, Issue:3

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA-Cytosine Methylases; Humans; Models, Molecular; Nervous System Diseases; Neurogenesis

2014
Epigenetic profiles as defined signatures of xenobiotic exposure.
    Mutation research. Genetic toxicology and environmental mutagenesis, 2014, Volume: 764-765

    Topics: 5-Methylcytosine; Animals; Carcinogens; Chemical Safety; Chromatin; Cytosine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Epigenomics; Genetic Markers; Genome; Humans; Transcriptome; Xenobiotics

2014
TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine.
    Mutation research. Genetic toxicology and environmental mutagenesis, 2014, Volume: 764-765

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA Repair; Humans; Models, Biological; Mutagenesis; Neoplasms; Oxidation-Reduction

2014
DNA modifications and neurological disorders.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013, Volume: 10, Issue:4

    Topics: 5-Methylcytosine; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Nervous System Diseases; Neurons

2013
TET enzymes, TDG and the dynamics of DNA demethylation.
    Nature, 2013, Oct-24, Volume: 502, Issue:7472

    Topics: 5-Methylcytosine; Animals; Blastocyst; Cellular Reprogramming; Cytosine; DNA Methylation; DNA Repair; DNA Replication; Humans; Neoplasms; Oxidation-Reduction; Thymine DNA Glycosylase

2013
Investigating 5-hydroxymethylcytosine (5hmC): the state of the art.
    Methods in molecular biology (Clifton, N.J.), 2014, Volume: 1094

    Topics: 5-Methylcytosine; Animals; Base Sequence; Cytosine; DNA Methylation; Genetic Loci; Mammals; Molecular Biology; Molecular Sequence Data

2014
5-hydroxymethylcytosine: a new insight into epigenetics in cancer.
    Cancer biology & therapy, 2014, Volume: 15, Issue:1

    Topics: 5-Methylcytosine; Animals; Brain Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Leukemia; Mixed Function Oxygenases; Neoplasms; Proto-Oncogene Proteins

2014
5-hydroxymethylcytosine profiling as an indicator of cellular state.
    Epigenomics, 2013, Volume: 5, Issue:6

    Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Models, Genetic; Neoplasms; Organ Specificity; Signal Transduction

2013
Recent advances in the bioanalysis of modified nucleotides in epigenetic studies.
    Bioanalysis, 2013, Volume: 5, Issue:23

    Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Nucleotides

2013
[The world of double helix--"it did not escape our notice"].
    Postepy biochemii, 2013, Volume: 59, Issue:3

    Topics: 5-Methylcytosine; Base Sequence; Chromatin; Cytosine; DNA; DNA Repair; DNA, Catalytic; Epigenomics; Forecasting; Humans; Molecular Biology; Nanotechnology

2013
Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders.
    Neuropharmacology, 2014, Volume: 80

    Topics: 5-Methylcytosine; Animals; Biological Evolution; Brain; Cytosine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mental Disorders; Models, Biological; Nerve Tissue Proteins; Neurogenesis; Neurons; Up-Regulation

2014
5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development.
    Stem cells and development, 2014, May-01, Volume: 23, Issue:9

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Humans; Stem Cells

2014
Epigenetic modifications in the nervous system and their impact upon cognitive impairments.
    Neuropharmacology, 2014, Volume: 80

    Topics: 5-Methylcytosine; Acetylation; Animals; Central Nervous System; Cognition; Cognition Disorders; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histone Deacetylases; Histones; Humans; Learning; Memory; Models, Biological; Nerve Tissue Proteins; Neurons; Protein Processing, Post-Translational; Rett Syndrome; Rubinstein-Taybi Syndrome

2014
The role of TET family proteins and 5-hydroxymethylcytosine in human tumors.
    Histology and histopathology, 2014, Volume: 29, Issue:8

    Topics: 5-Methylcytosine; Cell Transformation, Neoplastic; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Neoplasms

2014
The role of 5-hydroxymethylcytosine in human cancer.
    Cell and tissue research, 2014, Volume: 356, Issue:3

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA, Neoplasm; Humans; Neoplasms; Oxidation-Reduction

2014
Playing TETris with DNA modifications.
    The EMBO journal, 2014, Jun-02, Volume: 33, Issue:11

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Humans; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; Signal Transduction

2014
5-Hydroxymethylcytosine: A new player in brain disorders?
    Experimental neurology, 2015, Volume: 268

    Topics: 5-Methylcytosine; Brain Diseases; Cytosine; Humans

2015
Mitoepigenetics and drug addiction.
    Pharmacology & therapeutics, 2014, Volume: 144, Issue:2

    Topics: 5-Methylcytosine; Amphetamines; Animals; Cocaine; Cytosine; DNA, Mitochondrial; Dose-Response Relationship, Drug; Epigenesis, Genetic; Ethanol; Gene Expression; Humans; Mitochondria; Morphine; Oxidative Stress; Substance-Related Disorders

2014
New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells.
    Experimental hematology, 2014, Volume: 42, Issue:8

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enhancer Elements, Genetic; Hematopoiesis; Hematopoietic Stem Cells; Mice; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid

2014
Connections between TET proteins and aberrant DNA modification in cancer.
    Trends in genetics : TIG, 2014, Volume: 30, Issue:10

    Topics: 5-Methylcytosine; Azacitidine; Cytosine; Decitabine; Dioxygenases; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Hematologic Neoplasms; Humans; Isocitrate Dehydrogenase; Mixed Function Oxygenases; Molecular Targeted Therapy; Mutation; Neoplasms; Proto-Oncogene Proteins; Small Molecule Libraries

2014
DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: an emerging complex story.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Induced Pluripotent Stem Cells; Models, Biological; Oxidation-Reduction

2014
Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Humans; Mixed Function Oxygenases; Neoplasms; Oxidation-Reduction; Proto-Oncogene Proteins

2014
5-Hydroxymethylcytosine: a stable or transient DNA modification?
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; DNA Replication; DNA-Binding Proteins; Humans

2014
TET enzymes and DNA hydroxymethylation in neural development and function - how critical are they?
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Neurogenesis; Neurons; Oxidation-Reduction

2014
From development to diseases: the role of 5hmC in brain.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Nervous System Diseases; Neurons

2014
Genomic distribution and possible functions of DNA hydroxymethylation in the brain.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Genome; Humans; Oxidation-Reduction

2014
Expanding the epigenetic landscape: novel modifications of cytosine in genomic DNA.
    Cold Spring Harbor perspectives in biology, 2014, Oct-01, Volume: 6, Issue:10

    Topics: 5-Methylcytosine; Cytosine; DNA; Epigenesis, Genetic; Models, Genetic; Oxidation-Reduction

2014
Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization.
    Biomolecular concepts, 2014, Volume: 5, Issue:2

    Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; Decidua; DNA Methylation; Embryo Implantation; Epigenesis, Genetic; Female; Gene Expression Regulation; Histones; Humans; Pregnancy; Protein Processing, Post-Translational

2014
5-hydroxymethylcytosine: a potential therapeutic target in cancer.
    Epigenomics, 2014, Volume: 6, Issue:5

    Topics: 5-Methylcytosine; Animals; Antineoplastic Agents; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms

2014
New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.
    Immunological reviews, 2015, Volume: 263, Issue:1

    Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cytosine; Diet; DNA Methylation; Folic Acid; Hematologic Neoplasms; Humans; MicroRNAs; Promoter Regions, Genetic; Structure-Activity Relationship; Transcription Factors

2015
5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer.
    Biochimica et biophysica acta, 2015, Volume: 1855, Issue:2

    Topics: 5-Methylcytosine; Biomarkers, Tumor; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Isocitrate Dehydrogenase; Mutation; Neoplasms; Proto-Oncogene Proteins

2015
DNA methylation and hydroxymethylation in stem cells.
    Cell biochemistry and function, 2015, Volume: 33, Issue:4

    Topics: 5-Methylcytosine; Adult; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Stem Cells

2015
Hydroxymethylation and its potential implication in DNA repair system: A review and future perspectives.
    Gene, 2015, Jun-15, Volume: 564, Issue:2

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Repair; Humans; Mental Disorders; Neoplasms; Neurodegenerative Diseases

2015
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy.
    Cancer genetics, 2015, Volume: 208, Issue:5

    Topics: 5-Methylcytosine; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Humans; Isocitrate Dehydrogenase; Neoplasms; Proto-Oncogene Proteins

2015
Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword.
    DNA repair, 2015, Volume: 32

    Topics: 5-Methylcytosine; Base Pair Mismatch; CpG Islands; Cytosine; Deamination; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Gene Expression; Humans; Molecular Mimicry; Oxidation-Reduction; Thymine DNA Glycosylase

2015
The TET2 interactors and their links to hematological malignancies.
    IUBMB life, 2015, Volume: 67, Issue:6

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Genes, Tumor Suppressor; Hematologic Neoplasms; Hematopoiesis; Humans; Mice; Mutation; Protein Interaction Maps; Proto-Oncogene Proteins

2015
Role of 5-hydroxymethylcytosine in neurodegeneration.
    Gene, 2015, Oct-01, Volume: 570, Issue:1

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Neurodegenerative Diseases

2015
Functions of TET Proteins in Hematopoietic Transformation.
    Molecules and cells, 2015, Volume: 38, Issue:11

    Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Genes, Tumor Suppressor; Hematologic Neoplasms; Hematopoiesis; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mice; Oxidation-Reduction

2015
Practical guidelines and consideration of using RRHP for 5hmC detection.
    Epigenomics, 2016, Volume: 8, Issue:2

    Topics: 5-Methylcytosine; Animals; Computational Biology; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Library; Guidelines as Topic; High-Throughput Nucleotide Sequencing; Humans

2016
Hydroxymethyl cytosine marks in the human mitochondrial genome are dynamic in nature.
    Mitochondrion, 2016, Volume: 27

    Topics: 5-Methylcytosine; Cytosine; DNA, Mitochondrial; Epigenesis, Genetic; Gene Expression Regulation; Genome, Mitochondrial; Humans

2016
DNA methylation dynamics in neurogenesis.
    Epigenomics, 2016, Volume: 8, Issue:3

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Stem Cells; Epigenesis, Genetic; Histones; Humans; Mammals; Neurogenesis

2016
[Advances on the profiling of 5-hydroxymethylcytosine].
    Yi chuan = Hereditas, 2016, Volume: 38, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; Epigenomics; High-Throughput Screening Assays; Humans

2016
High-throughput sequencing offers new insights into 5-hydroxymethylcytosine.
    Biomolecular concepts, 2016, Jun-01, Volume: 7, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Humans; Organ Specificity

2016
Are there specific readers of oxidized 5-methylcytosine bases?
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2016, Volume: 38, Issue:10

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA-Binding Proteins; Humans

2016
Proteins That Read DNA Methylation.
    Advances in experimental medicine and biology, 2016, Volume: 945

    Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Protein Domains

2016
DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications.
    Advances in experimental medicine and biology, 2016, Volume: 945

    Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Eukaryota; Prokaryotic Cells; Protein Domains

2016
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.
    Free radical biology & medicine, 2017, Volume: 107

    Topics: 5-Methylcytosine; Animals; Carcinogenesis; Cell Self Renewal; Cytosine; DNA; DNA Methylation; DNA Repair; Humans; Oxidation-Reduction; Transcription, Genetic

2017
Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis.
    Oncotarget, 2017, Jan-03, Volume: 8, Issue:1

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Humans; Lymphatic Metastasis; Neoplasms; Prognosis

2017
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
    Ageing research reviews, 2017, Volume: 37

    Topics: 5-Methylcytosine; Aging; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms; Oxidation-Reduction

2017
Technologies for Deciphering Epigenomic DNA Patterns.
    Advances in experimental medicine and biology, 2017, Volume: 978

    Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA Methylation; Epigenomics; Formaldehyde; Humans; Microarray Analysis; Paraffin Embedding; Sulfites; Tissue Fixation; Uracil

2017
Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2018, Volume: 40, Issue:3

    Topics: 5-Methylcytosine; Animals; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Mammals; Models, Molecular; Nucleic Acid Conformation

2018
Role of ten-eleven translocation proteins and 5-hydroxymethylcytosine in hepatocellular carcinoma.
    Cell proliferation, 2019, Volume: 52, Issue:4

    Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Humans; Liver Neoplasms; MicroRNAs; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA Processing, Post-Transcriptional; Transcription, Genetic

2019

Trials

1 trial(s) available for 5-hydroxymethylcytosine and cytosine

ArticleYear
Characterization of acute myeloid leukemia based on levels of global hydroxymethylation.
    Blood, 2014, Aug-14, Volume: 124, Issue:7

    Topics: 5-Methylcytosine; Acute Disease; Adolescent; Adult; Aged; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Mutational Analysis; DNA-Binding Proteins; Humans; Isocitrate Dehydrogenase; Leukemia, Myeloid; Middle Aged; Mutation; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins; Survival Analysis; Young Adult

2014

Other Studies

519 other study(ies) available for 5-hydroxymethylcytosine and cytosine

ArticleYear
Reaction of bisulfite with the 5-hydroxymethyl group in pyrimidines and in phage DNAs.
    Biochemistry, 1979, Feb-20, Volume: 18, Issue:4

    Topics: 5-Methylcytosine; Chemical Phenomena; Chemistry; Coliphages; Cytosine; DNA, Viral; Pentoxyl; Pyrimidines; Spectrophotometry, Ultraviolet; Sulfites; Uracil

1979
Evidence for a near UV-induced photoproduct of 5-hydroxymethylcytosine in bacteriophage T4 that can be recognized by endonuclease V.
    Molecular & general genetics : MGG, 1978, Nov-16, Volume: 167, Issue:1

    Topics: 5-Methylcytosine; Coliphages; Cytosine; DNA, Viral; Endonucleases; Substrate Specificity; Ultraviolet Rays

1978
Modification and restriction of T-even bacteriophages. In vitro degradation of deoxyribonucleic acid containing 5-hydroxymethylctosine.
    The Journal of biological chemistry, 1976, Mar-25, Volume: 251, Issue:6

    Topics: 5-Methylcytosine; Coliphages; Cytosine; DNA Restriction Enzymes; DNA, Circular; DNA, Viral; Escherichia coli; Genetic Complementation Test; Kinetics; Mutation; Phenotype; Species Specificity; Templates, Genetic

1976
[Bacteriophage T2 DNA modification by O-methylhydroxylamine].
    Biokhimiia (Moscow, Russia), 1976, Volume: 41, Issue:8

    Topics: 5-Methylcytosine; Chemical Phenomena; Chemistry; Coliphages; Cytosine; DNA, Viral; Hydroxylamines; Nucleic Acid Denaturation; Viral Proteins

1976
Trace detection of modified DNA bases via moving-belt liquid chromatography-mass spectrometry using electrophoric derivatization and negative chemical ionization.
    Journal of chromatography, 1989, Mar-31, Volume: 465, Issue:2

    Topics: 5-Methylcytosine; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cytosine; DNA; Electrophoresis; Mass Spectrometry

1989
5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue.
    Biochemical and biophysical research communications, 1988, Mar-30, Volume: 151, Issue:3

    Topics: 5-Methylcytosine; Animals; Cattle; Chromatography, High Pressure Liquid; Cytosine; DNA Glycosylases; DNA, Viral; N-Glycosyl Hydrolases; T-Phages; Thymus Gland

1988
Cloning and physical mapping of an early region of the bacteriophage T4 genome.
    Genetics, 1984, Volume: 106, Issue:1

    Topics: 5-Methylcytosine; Chromosome Deletion; Chromosome Mapping; Cloning, Molecular; Cytosine; DNA Restriction Enzymes; Genes, Viral; T-Phages

1984
Formation of 5-hydroxymethylcytosine-containing pyrimidine dimers in UV-irradiated bacteriophage T4 DNA.
    Photochemistry and photobiology, 1983, Volume: 37, Issue:5

    Topics: 5-Methylcytosine; Cytosine; DNA, Viral; Escherichia coli; Pyrimidine Dimers; T-Phages; Ultraviolet Rays

1983
Region-specific recombination in phage T4. I. A special glucosyl-dependent recombination system.
    Genetics, 1980, Volume: 94, Issue:3

    Topics: 5-Methylcytosine; Capsid; Cytosine; DNA, Viral; Escherichia coli; Genes, Viral; Glucosyltransferases; Hot Temperature; Mutation; Recombination, Genetic; T-Phages

1980
Shutoff of lambda gene expression by bacteriophage T4: role of the T4 alc gene.
    Journal of virology, 1980, Volume: 35, Issue:1

    Topics: 5-Methylcytosine; Bacteriophage lambda; Cytosine; DNA, Circular; Escherichia coli; Genes, Viral; Mutation; Nucleic Acid Conformation; Nucleic Acid Hybridization; Protein Biosynthesis; RNA, Viral; T-Phages; Time Factors; Transcription, Genetic; Viral Interference

1980
Molecular cloning and expression of a novel hydroxymethylcytosine-specific restriction enzyme (PvuRts1I) modulated by glucosylation of DNA.
    Journal of molecular biology, 1994, Sep-09, Volume: 242, Issue:1

    Topics: 5-Methylcytosine; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cytosine; DNA; DNA Restriction Enzymes; DNA, Viral; Genes, Bacterial; Glucose; Molecular Sequence Data; Substrate Specificity; T-Phages

1994
The Northrop hypothesis and the origins of a virus-induced enzyme.
    Protein science : a publication of the Protein Society, 1994, Volume: 3, Issue:1

    Topics: 5-Methylcytosine; Cytosine; DNA, Viral; Escherichia coli; History, 20th Century; Hydroxymethyl and Formyl Transferases; Models, Biological; T-Phages; Transferases; United States

1994
5-Methylcytosine attack by hydroxyl free radicals and during carbon tetrachloride promoted liver microsomal lipid peroxidation: structure of reaction products.
    Chemico-biological interactions, 1996, Jan-05, Volume: 99, Issue:1-3

    Topics: 5-Methylcytosine; Animals; Carbon Tetrachloride; Cytosine; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydantoins; Hydrogen Peroxide; Hydroxyl Radical; Iron; Lipid Peroxidation; Male; Microsomes, Liver; Molecular Structure; Rats; Rats, Sprague-Dawley; Ultraviolet Rays

1996
Solid phase synthesis and restriction endonuclease cleavage of oligodeoxynucleotides containing 5-(hydroxymethyl)-cytosine.
    Nucleic acids research, 1997, Feb-01, Volume: 25, Issue:3

    Topics: 5-Methylcytosine; Cytosine; Deoxyribonuclease HpaII; DNA Restriction Enzymes; DNA-Cytosine Methylases; Molecular Structure; Oligodeoxyribonucleotides

1997
Nucleic acid economy in bacteria infected with bacteriophage T2. I. Purine and pyrimidine composition.
    The Journal of general physiology, 1953, Volume: 36, Issue:6

    Topics: 5-Methylcytosine; Bacteria; Bacteriophage T4; Bacteriophages; Cytosine; Escherichia coli; Nucleic Acids; Purines

1953
The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine.
    The Biochemical journal, 1953, Volume: 55, Issue:5

    Topics: 5-Methylcytosine; Animals; Bacteriophages; Cytosine; Nucleic Acids; Pyrimidines; Viruses

1953
Some precursors of the 5-hydroxymethylcytosine of T6r+ bacteriophage.
    The Journal of biological chemistry, 1954, Volume: 209, Issue:2

    Topics: 5-Methylcytosine; Bacteriophages; Cytosine; Pyrimidines

1954
Structural evidence of a passive base-flipping mechanism for beta-glucosyltransferase.
    The Journal of biological chemistry, 2004, Aug-13, Volume: 279, Issue:33

    Topics: 5-Methylcytosine; Adenine; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Cytosine; DNA; Glucosyltransferases; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Oligonucleotides; Plasmids; Protein Binding; Protein Conformation; Uridine Diphosphate

2004
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).
    Nucleic acids research, 2004, Volume: 32, Issue:14

    Topics: 5-Methylcytosine; Base Sequence; Binding Sites; Chromosomal Proteins, Non-Histone; CpG Islands; Cytosine; DNA Damage; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Guanosine; Methyl-CpG-Binding Protein 2; Models, Molecular; Oligodeoxyribonucleotides; Oxidative Stress; Protein Structure, Tertiary; Repressor Proteins

2004
A type IV modification dependent restriction nuclease that targets glucosylated hydroxymethyl cytosine modified DNAs.
    Journal of molecular biology, 2007, Feb-23, Volume: 366, Issue:3

    Topics: 5-Methylcytosine; Capsid Proteins; Chromatography, Affinity; Coliphages; Cytosine; DNA Restriction Enzymes; DNA, Viral; Escherichia coli; Escherichia coli Proteins; Evolution, Molecular; Mutant Proteins; Myoviridae; Nucleic Acid Conformation; Nucleotides; Protein Binding; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity

2007
Exclusion of glucosyl-hydroxymethylcytosine DNA containing bacteriophages is overcome by the injected protein inhibitor IPI*.
    Journal of molecular biology, 2007, Feb-23, Volume: 366, Issue:3

    Topics: 5-Methylcytosine; Amino Acid Sequence; Bacteriophage T4; Bacteriophages; Base Sequence; Capsid Proteins; Clone Cells; Cytosine; DNA Restriction Enzymes; DNA, Viral; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Molecular Sequence Data; Prophages; Sequence Analysis, DNA; Substrate Specificity

2007
The mildiomycin biosynthesis: initial steps for sequential generation of 5-hydroxymethylcytidine 5'-monophosphate and 5-hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119.
    Chembiochem : a European journal of chemical biology, 2008, May-23, Volume: 9, Issue:8

    Topics: 5-Methylcytosine; Amino Acid Sequence; Chromatography, High Pressure Liquid; Cloning, Molecular; Cytidine Monophosphate; Cytosine; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multigene Family; Sequence Alignment; Streptomycetaceae; Substrate Specificity

2008
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.
    Science (New York, N.Y.), 2009, May-15, Volume: 324, Issue:5929

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Cell Line; Cytosine; Dinucleoside Phosphates; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Hydroxylation; Mass Spectrometry; Mice; Mixed Function Oxygenases; Molecular Sequence Data; Proto-Oncogene Proteins; RNA Interference; Sequence Alignment; Transfection

2009
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain.
    Science (New York, N.Y.), 2009, May-15, Volume: 324, Issue:5929

    Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cell Line; Cerebellum; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytosine; Deoxycytidine; DNA; DNA Damage; Humans; Mass Spectrometry; Mice; Purkinje Cells

2009
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing.
    PloS one, 2010, Jan-26, Volume: 5, Issue:1

    Topics: 5-Methylcytosine; Base Sequence; Chromatography, Liquid; Cytosine; Mass Spectrometry; Molecular Sequence Data; Polymerase Chain Reaction; Sulfites

2010
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine.
    Nucleic acids research, 2010, Volume: 38, Issue:11

    Topics: 5-Methylcytosine; Antibodies; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Immunoprecipitation; Oligonucleotides; Sequence Analysis, DNA; Sulfites

2010
Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA.
    BioTechniques, 2010, Volume: 48, Issue:4

    Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA; DNA Methylation; DNA Restriction Enzymes; Genes, BRCA1; Humans; Octamer Transcription Factor-3; Polymerase Chain Reaction; Sequence Analysis, DNA; Sulfites

2010
Quantification of the sixth DNA base hydroxymethylcytosine in the brain.
    Angewandte Chemie (International ed. in English), 2010, Jul-19, Volume: 49, Issue:31

    Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cytosine; DNA; DNA Methylation; Mice

2010
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.
    Nature, 2010, Aug-26, Volume: 466, Issue:7310

    Topics: 5-Methylcytosine; Alkaline Phosphatase; Animals; Blastocyst Inner Cell Mass; Cell Proliferation; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Homeodomain Proteins; Mice; Nanog Homeobox Protein; Proto-Oncogene Proteins

2010
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA.
    Nucleic acids research, 2010, Volume: 38, Issue:19

    Topics: 5-Methylcytosine; Animals; Cells, Cultured; Cytosine; DNA; Embryonic Stem Cells; Genetic Techniques; Genome; Glucosyltransferases; Mice

2010
Chemical discrimination between dC and 5MedC via their hydroxylamine adducts.
    Nucleic acids research, 2010, Volume: 38, Issue:21

    Topics: 5-Methylcytosine; Base Pairing; Cytosine; DNA; DNA Adducts; DNA Methylation; Hydroxylamines; Isomerism; Models, Molecular; Oligodeoxyribonucleotides; Sequence Analysis, DNA

2010
Identification of epigenetic DNA modifications with a protein nanopore.
    Chemical communications (Cambridge, England), 2010, Nov-21, Volume: 46, Issue:43

    Topics: 5-Methylcytosine; Cyclodextrins; Cytosine; DNA; Epigenesis, Genetic; Hemolysin Proteins; Nanopores

2010
MIRA-SNuPE, a quantitative, multiplex method for measuring allele-specific DNA methylation.
    Epigenetics, 2011, Volume: 6, Issue:2

    Topics: 5-Methylcytosine; Alleles; Animals; Chromosome Duplication; CpG Islands; Cytosine; DNA Methylation; Genomic Imprinting; Kidney; Liver; Mice; Sensitivity and Specificity; Sequence Analysis, DNA

2011
Efficient synthesis of 5-hydroxymethylcytosine containing DNA.
    Organic letters, 2010, Dec-17, Volume: 12, Issue:24

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Genome; Molecular Structure

2010
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
    Nature biotechnology, 2011, Volume: 29, Issue:1

    Topics: 5-Methylcytosine; Animals; Bacteriophage T4; Biotin; Cerebellum; Cytosine; DNA; Genome; Genome, Human; Glucosyltransferases; HEK293 Cells; HeLa Cells; Humans; Mice; Models, Molecular; Molecular Sequence Data; Sequence Analysis, DNA; Staining and Labeling

2011
Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules.
    Journal of the American Chemical Society, 2011, Jan-26, Volume: 133, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Molecular Dynamics Simulation; Nucleic Acid Conformation; Polymerase Chain Reaction

2011
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.
    PloS one, 2010, Dec-23, Volume: 5, Issue:12

    Topics: 5-Methylcytosine; Animals; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytosine; DNA Methylation; Immunohistochemistry; Mass Spectrometry; Mice; Models, Chemical; Oxygen; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution

2010
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
    Cancer cell, 2011, Jan-18, Volume: 19, Issue:1

    Topics: 5-Methylcytosine; Amino Acid Substitution; Animals; Binding, Competitive; Biocatalysis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Catalytic Domain; Cell Line, Tumor; Cytosine; Dioxygenases; DNA-Binding Proteins; Endostatins; F-Box Proteins; Gene Expression; Glioma; Glutarates; Histone Demethylases; Histones; Homeodomain Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isocitrate Dehydrogenase; Jumonji Domain-Containing Histone Demethylases; Ketoglutaric Acids; Mixed Function Oxygenases; Models, Molecular; Oxalates; Oxidoreductases, N-Demethylating; Procollagen-Proline Dioxygenase; Proto-Oncogene Proteins

2011
A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples.
    Analytical biochemistry, 2011, May-15, Volume: 412, Issue:2

    Topics: 5-Methylcytosine; Animals; Catalytic Domain; Chromatography, Liquid; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Fibroblasts; Humans; Hydroxylation; Induced Pluripotent Stem Cells; Mass Spectrometry; Mice; Mixed Function Oxygenases; Proto-Oncogene Proteins; Reproducibility of Results

2011
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
    Cell stem cell, 2011, Feb-04, Volume: 8, Issue:2

    Topics: 5-Methylcytosine; Animals; Binding Sites; Cell Differentiation; Cell Lineage; Chromatin Immunoprecipitation; Computational Biology; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Mice; Octamer Transcription Factor-3; Proto-Oncogene Proteins; Teratoma

2011
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
    Nucleic acids research, 2011, Volume: 39, Issue:8

    Topics: 5-Methylcytosine; Carrier Proteins; Cytosine; DNA; Embryonic Stem Cells; Gene Expression Regulation; Genome, Human; Genomics; Glucosyltransferases; Humans; Promoter Regions, Genetic; Protozoan Proteins

2011
High sensitivity 5-hydroxymethylcytosine detection in Balb/C brain tissue.
    Journal of visualized experiments : JoVE, 2011, Feb-01, Issue:48

    Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cytosine; DNA; DNA Methylation; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction

2011
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Mar-01, Volume: 108, Issue:9

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Base Sequence; Cell Compartmentation; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Mitochondrial; Genes, Mitochondrial; HCT116 Cells; Humans; Mice; Mitochondria; Molecular Sequence Data; Oxidative Stress; Protein Binding; Protein Sorting Signals; Transcription, Genetic

2011
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Mar-01, Volume: 108, Issue:9

    Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Chromosomal Proteins, Non-Histone; Cleavage Stage, Ovum; Cytosine; DNA-Binding Proteins; Embryo, Mammalian; Female; Fertilization; Gene Expression Regulation, Developmental; Genome; Male; Mice; Oocytes; Oxidation-Reduction; Repressor Proteins; Sequence Analysis, DNA; Sulfites; Zygote

2011
Methyltransferase-directed derivatization of 5-hydroxymethylcytosine in DNA.
    Angewandte Chemie (International ed. in English), 2011, Feb-25, Volume: 50, Issue:9

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; S-Adenosylmethionine; Selenium Compounds; Sulfhydryl Compounds

2011
Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5-hydroxymethylcytosine.
    Nucleic acids research, 2011, Volume: 39, Issue:12

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Cleavage; DNA Restriction Enzymes; Genome; Mice

2011
Genomic mapping of 5-hydroxymethylcytosine in the human brain.
    Nucleic acids research, 2011, Volume: 39, Issue:12

    Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cytosine; DNA; Gene Expression; Genomics; Humans; Mice; Promoter Regions, Genetic

2011
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.
    Nature communications, 2011, Volume: 2

    Topics: 5-Methylcytosine; Animals; Cattle; Cell Nucleus; Chromosomal Proteins, Non-Histone; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Epigenomics; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Mammals; Mice; Mice, Knockout; Nuclear Transfer Techniques; Oxidation-Reduction; Proto-Oncogene Proteins; Rabbits; Repressor Proteins; Sex Factors; Zygote

2011
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.
    Nature, 2011, May-19, Volume: 473, Issue:7347

    Topics: 5-Methylcytosine; Animals; Cell Line; Chromatin; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Silencing; Genome; Mice; Polycomb-Group Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Repressor Proteins; Transcription, Genetic

2011
Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation.
    Chemical communications (Cambridge, England), 2011, May-14, Volume: 47, Issue:18

    Topics: 5-Methylcytosine; Base Sequence; Cytosine; Cytosine Nucleotides; Dinucleoside Phosphates; DNA; DNA Methylation; Humans; Hydroxylation; Methylation; Molecular Sequence Data; Molecular Structure; Polymerase Chain Reaction

2011
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.
    Genes & development, 2011, Apr-01, Volume: 25, Issue:7

    Topics: 5-Methylcytosine; Animals; Cell Line; Chromatin; Cytosine; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Mice; Proto-Oncogene Proteins; Transcription Factors

2011
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.
    Nature, 2011, May-19, Volume: 473, Issue:7347

    Topics: 5-Methylcytosine; Animals; Antibodies; Cell Differentiation; Cell Line; Cell Lineage; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Embryoid Bodies; Embryonic Stem Cells; Euchromatin; Exons; Gene Expression Regulation, Developmental; Gene Silencing; Genome; Mice; Pluripotent Stem Cells; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reproducibility of Results; Sequence Analysis, DNA; Transcription, Genetic

2011
Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.
    The Journal of organic chemistry, 2011, May-20, Volume: 76, Issue:10

    Topics: 5-Methylcytosine; Cytosine; DNA; Organophosphorus Compounds; Siloxanes; Styrenes

2011
Enzymatic labeling of 5-hydroxymethylcytosine in DNA.
    Angewandte Chemie (International ed. in English), 2011, May-02, Volume: 50, Issue:19

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Glycosyltransferases; Humans; Isotope Labeling; Tritium

2011
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
    Nature, 2011, May-19, Volume: 473, Issue:7347

    Topics: 5-Methylcytosine; Animals; Cell Line; CpG Islands; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Embryonic Stem Cells; Gene Knockdown Techniques; Mice; Protein Binding; Proto-Oncogene Proteins; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex; Transcription Initiation Site; Transcription, Genetic

2011
Facile synthesis of hydroxymethylcytosine-containing oligonucleotides and their reactivity upon osmium oxidation.
    Organic & biomolecular chemistry, 2011, Jun-07, Volume: 9, Issue:11

    Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; Models, Molecular; Molecular Structure; Oligonucleotides; Osmium; Oxidation-Reduction; Stereoisomerism; Transition Temperature

2011
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.
    Molecular cell, 2011, May-20, Volume: 42, Issue:4

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Mice; Mixed Function Oxygenases; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins

2011
Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(α)I.
    Bioorganic & medicinal chemistry letters, 2011, Sep-01, Volume: 21, Issue:17

    Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA; DNA-Directed RNA Polymerases; Glycosylation

2011
Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.
    Accounts of chemical research, 2011, Sep-20, Volume: 44, Issue:9

    Topics: 5-Methylcytosine; Animals; Azides; Biotin; Cell Line; Click Chemistry; Cross-Linking Reagents; Cytosine; Diazomethane; DNA; DNA Probes; Genome; Glucosyltransferases; Humans; Mice; Streptavidin; Ultraviolet Rays

2011
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.
    Nature, 2011, May-19, Volume: 473, Issue:7347

    Topics: 5-Methylcytosine; Animals; Biotinylation; Cell Line; Cytosine; DNA Methylation; Embryonic Stem Cells; Exons; Gene Expression Regulation, Developmental; Genome; Glucose; Mice; Periodic Acid; Promoter Regions, Genetic; Sequence Analysis, DNA; Transcription Initiation Site; Transcription, Genetic

2011
Epigenetics: Tet proteins in the limelight.
    Nature, 2011, May-19, Volume: 473, Issue:7347

    Topics: 5-Methylcytosine; Animals; Chromatin; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genome; Mice; Polycomb-Group Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex; Transcription, Genetic

2011
Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes.
    The Journal of biological chemistry, 2011, Jul-15, Volume: 286, Issue:28

    Topics: 5-Methylcytosine; Animals; Brain; CpG Islands; Cytosine; DNA Methylation; Embryonic Stem Cells; Genome, Human; HeLa Cells; Humans; Mice; Myocardium; NIH 3T3 Cells; Organ Specificity

2011
Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia.
    Leukemia, 2011, Volume: 25, Issue:10

    Topics: 5-Methylcytosine; Cytosine; Dioxygenases; DNA-Binding Proteins; Gene Expression Profiling; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myeloid, Acute; Mutation; Proto-Oncogene Proteins

2011
Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
    Organic letters, 2011, Jul-01, Volume: 13, Issue:13

    Topics: 5-Methylcytosine; Cytosine; Deoxycytidine; DNA; Methylation; Molecular Structure; Oligonucleotides; Oxidation-Reduction

2011
Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage β-glucosyltransferase.
    Chembiochem : a European journal of chemical biology, 2011, Jul-25, Volume: 12, Issue:11

    Topics: 5-Methylcytosine; Bacteriophage T4; Cytosine; DNA; Glucose; Glucosyltransferases; Humans

2011
5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells.
    Genome biology, 2011, Jun-20, Volume: 12, Issue:6

    Topics: 5-Methylcytosine; Base Composition; Binding Sites; Cytosine; Embryonic Stem Cells; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Humans; Transcription Factors

2011
Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide.
    Chemical communications (Cambridge, England), 2011, Aug-07, Volume: 47, Issue:29

    Topics: 5-Methylcytosine; Cytosine; DNA; Electrophoretic Mobility Shift Assay; Oxidation-Reduction; Phosphopeptides; Phosphotyrosine; Protein Kinases; Zinc Fingers

2011
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.
    Biochemical and biophysical research communications, 2011, Jul-22, Volume: 411, Issue:1

    Topics: 5-Methylcytosine; Cytosine; Gene Expression Regulation; HeLa Cells; Humans; Promoter Regions, Genetic; Repressor Proteins; RNA Polymerase II; Transcription, Genetic

2011
The discovery of 5-formylcytosine in embryonic stem cell DNA.
    Angewandte Chemie (International ed. in English), 2011, Jul-25, Volume: 50, Issue:31

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Embryonic Stem Cells; Mass Spectrometry; Mice

2011
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
    Cell, 2011, Jul-08, Volume: 146, Issue:1

    Topics: 5-Methylcytosine; Animals; Cell Cycle Proteins; Cytidine Deaminase; Cytosine; DNA Methylation; Embryonic Development; Female; Gene Expression Regulation, Developmental; Gene Knock-In Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins; Promoter Regions, Genetic; Thymine DNA Glycosylase; Transcription, Genetic

2011
Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells.
    PLoS genetics, 2011, Volume: 7, Issue:6

    Topics: 5-Methylcytosine; Binding Sites; Cell Line; Chromosome Mapping; Cytosine; DNA Methylation; Embryonic Stem Cells; Epigenomics; Gene Expression Regulation; Gene Library; Genome, Human; Heterochromatin; Histones; Humans; Immunoblotting; Metaphase; Promoter Regions, Genetic; Sequence Alignment; Transcription Factors

2011
Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: 5-Methylcytosine; Binding Sites; CCAAT-Enhancer-Binding Proteins; CpG Islands; Cytosine; DNA; HEK293 Cells; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Protein Binding; Protein Structure, Tertiary; Thermodynamics

2011
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
    Blood, 2011, Sep-01, Volume: 118, Issue:9

    Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Lineage; Colony-Forming Units Assay; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Erythropoiesis; Fetal Blood; Genetic Vectors; Granulocytes; Hematopoietic Stem Cells; Humans; Lentivirus; Monocytes; Mutation; Myelopoiesis; Proto-Oncogene Proteins; RNA Interference; RNA, Small Interfering

2011
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.
    Cell research, 2011, Volume: 21, Issue:9

    Topics: 5-Methylcytosine; Animals; Antibodies; Bone Marrow; Cell Differentiation; Cell Lineage; Cells, Cultured; CpG Islands; Cytosine; DNA Methylation; Embryonic Development; Embryonic Stem Cells; Genome, Human; Humans; Induced Pluripotent Stem Cells; Intermediate Filament Proteins; Mice; Nerve Tissue Proteins; Nestin; Neurons; Zygote

2011
Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells.
    Cell cycle (Georgetown, Tex.), 2011, Aug-01, Volume: 10, Issue:15

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Profiling; Genome; Mice; Proto-Oncogene Proteins; Transcription, Genetic

2011
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
    Science (New York, N.Y.), 2011, Sep-02, Volume: 333, Issue:6047

    Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Recombinant Fusion Proteins

2011
Comparative characterization of the PvuRts1I family of restriction enzymes and their application in mapping genomic 5-hydroxymethylcytosine.
    Nucleic acids research, 2011, Volume: 39, Issue:21

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Chromosome Mapping; Conserved Sequence; Cytosine; DNA Cleavage; DNA Restriction Enzymes; Genomics; Molecular Sequence Data; Rats; Substrate Specificity

2011
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.
    Cell stem cell, 2011, Aug-05, Volume: 9, Issue:2

    Topics: 5-Methylcytosine; Animals; Animals, Newborn; Body Size; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Embryonic Stem Cells; Female; Fertility; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Genetic Complementation Test; Mice; Mice, Inbred C57BL; Pluripotent Stem Cells; Proto-Oncogene Proteins; Tetraploidy

2011
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
    Science (New York, N.Y.), 2011, Sep-02, Volume: 333, Issue:6047

    Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; RNA, Small Interfering; Thymine DNA Glycosylase; Transfection

2011
Gene expression profiling: identification of genes with altered expression in Ayu17-449 knockout mice.
    Genetics and molecular research : GMR, 2011, Volume: 10, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Gene Expression Profiling; Gene Expression Regulation; Genes, Tumor Suppressor; Genome; Mice; Mice, Knockout; NF-kappa B; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha

2011
Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.
    Current opinion in structural biology, 2011, Volume: 21, Issue:6

    Topics: 5-Methylcytosine; Cytosine; DNA; Histone Demethylases; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Structure-Activity Relationship

2011
Molecular biology. Demystifying DNA demethylation.
    Science (New York, N.Y.), 2011, Sep-02, Volume: 333, Issue:6047

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase

2011
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.
    Nature, 2011, Sep-04, Volume: 477, Issue:7366

    Topics: 5-Methylcytosine; Alleles; Animals; Cellular Reprogramming; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Fertility; Gene Expression Regulation, Developmental; Germ Cells; Male; Mice; Octamer Transcription Factor-3; Oocytes; Oxidation-Reduction; Proto-Oncogene Proteins; Zygote

2011
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.
    Oncotarget, 2011, Volume: 2, Issue:8

    Topics: 5-Methylcytosine; Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Differentiation; Colonic Neoplasms; Cytosine; Down-Regulation; Embryo, Mammalian; Female; Gestational Age; HEK293 Cells; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Prostatic Neoplasms; Stem Cells

2011
5-Hydroxymethylcytosine-selective oxidation with peroxotungstate.
    Chemical communications (Cambridge, England), 2011, Oct-28, Volume: 47, Issue:40

    Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA, Single-Stranded; Oxidation-Reduction; Substrate Specificity; Tungsten Compounds

2011
Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos.
    Science (New York, N.Y.), 2011, Oct-14, Volume: 334, Issue:6053

    Topics: 5-Methylcytosine; Animals; Blastocyst; Chromatids; Chromosomes, Mammalian; Cytosine; Dioxygenases; DNA Replication; DNA-Binding Proteins; Embryonic Development; Mice; Mitosis; Proto-Oncogene Proteins; Sister Chromatid Exchange; Zygote

2011
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
    Nature neuroscience, 2011, Oct-30, Volume: 14, Issue:12

    Topics: 5-Methylcytosine; Aging; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Chromosome Deletion; Chromosome Mapping; Cytosine; Disease Models, Animal; DNA Methylation; Epigenomics; Gene Expression Regulation, Developmental; Hippocampus; Humans; Immunoprecipitation; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Organ Specificity; Phosphopyruvate Hydratase; Rett Syndrome; X Chromosome

2011
Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:2

    Topics: 5-Methylcytosine; Adult; Antigens, Differentiation; Brain-Derived Neurotrophic Factor; Case-Control Studies; Cytosine; DNA Methylation; Female; Gene Expression; Humans; Male; Middle Aged; Parietal Lobe; Prefrontal Cortex; Promoter Regions, Genetic; Psychotic Disorders

2012
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.
    Cancer research, 2011, Dec-15, Volume: 71, Issue:24

    Topics: 5-Methylcytosine; Animals; Base Sequence; Brain; Brain Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; Chromatography, Liquid; Cytosine; DNA-Binding Proteins; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Lung Neoplasms; Male; Mice; Mixed Function Oxygenases; Molecular Structure; Mutation; Neoplasms; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction

2011
Improved synthesis and mutagenicity of oligonucleotides containing 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Dec-02, Volume: 17, Issue:49

    Topics: 5-Methylcytosine; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Molecular Structure; Mutagens; Oligonucleotides; Organophosphorus Compounds; Spectrometry, Mass, Electrospray Ionization

2011
Epigenetic regulation of motor neuron cell death through DNA methylation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46

    Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation

2011
Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.
    Nature methods, 2011, Nov-20, Volume: 9, Issue:1

    Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA; Sensitivity and Specificity; Sequence Analysis, DNA

2011
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.
    Genome research, 2012, Volume: 22, Issue:3

    Topics: 5-Methylcytosine; Animals; Cell Line; Cells, Cultured; Chromosome Mapping; Cluster Analysis; Cytosine; DNA; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Genetic Loci; Humans; Mice; Nuclear Proteins; Organ Specificity; Promoter Regions, Genetic; RNA-Binding Proteins; Transcription, Genetic

2012
Methylation on the mind.
    Nature neuroscience, 2011, Nov-23, Volume: 14, Issue:12

    Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cytosine; Epigenomics; Gene Expression Regulation, Developmental; Hippocampus; Humans

2011
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.
    Cell research, 2011, Volume: 21, Issue:12

    Topics: 5-Methylcytosine; Animals; Antibodies; Cytosine; DNA Replication; DNA-Directed DNA Polymerase; Embryonic Development; Immunohistochemistry; Male; Mice

2011
The hunt for 5-hydroxymethylcytosine: the sixth base.
    Epigenomics, 2011, Volume: 3, Issue:5

    Topics: 5-Methylcytosine; Cytosine; Dioxygenases; Epigenesis, Genetic; Sequence Analysis, DNA

2011
5-Hydroxymethylcytosine: a new kid on the epigenetic block?
    Molecular systems biology, 2011, Dec-20, Volume: 7

    Topics: 5-Methylcytosine; Animals; Cell Line; Chromatin; Cluster Analysis; Cytosine; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mice; Oxygenases; Transcription, Genetic; Translocation, Genetic

2011
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
    Cell, 2011, Dec-23, Volume: 147, Issue:7

    Topics: 5-Methylcytosine; Animals; Chromatin Assembly and Disassembly; Cytosine; DNA Helicases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Knockdown Techniques; Humans; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Mice; Nuclear Proteins; Proto-Oncogene Proteins; RNA Polymerase II; Transcription Factors

2011
Tracking genomic hydroxymethylation by the base.
    Nature methods, 2011, Dec-28, Volume: 9, Issue:1

    Topics: 5-Methylcytosine; Cytosine; DNA; Sequence Analysis, DNA

2011
Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity.
    Nucleic acids research, 2012, Volume: 40, Issue:8

    Topics: 5-Methylcytosine; Animals; Cells, Cultured; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation; Homeodomain Proteins; Leukemia Inhibitory Factor; MAP Kinase Signaling System; Mice; Nanog Homeobox Protein; Proto-Oncogene Proteins; RNA Interference; Signal Transduction; STAT3 Transcription Factor

2012
Biochemical characterization of recombinant β-glucosyltransferase and analysis of global 5-hydroxymethylcytosine in unique genomes.
    Biochemistry, 2012, Feb-07, Volume: 51, Issue:5

    Topics: 5-Methylcytosine; Animals; Arabidopsis Proteins; Bacteriophage T4; Cattle; Cytosine; Deoxyribonucleases, Type II Site-Specific; Escherichia coli; Escherichia coli Proteins; Female; Genome, Plant; Genome, Viral; Glucosyltransferases; HCT116 Cells; HEK293 Cells; Humans; Male; Mice; NIH 3T3 Cells; Rats; Recombinant Proteins; Substrate Specificity

2012
Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.
    International journal of cancer, 2012, Oct-01, Volume: 131, Issue:7

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Anaplasia; Astrocytoma; Brain; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Cytosine; DNA; Epigenesis, Genetic; Female; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Young Adult

2012
The involvement of 5-hydroxymethylcytosine in active DNA demethylation in mice.
    Biology of reproduction, 2012, Volume: 86, Issue:4

    Topics: 5-Methylcytosine; Animals; Blastocyst; Cytosine; DNA; DNA Methylation; Embryo, Mammalian; Gene Expression Regulation, Developmental; Metaphase; Mice; Oocytes; Plasmids

2012
Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction.
    Current Alzheimer research, 2012, Volume: 9, Issue:5

    Topics: 5-Methylcytosine; Age Factors; Animals; Caloric Restriction; Cytosine; DNA Methyltransferase 3A; Gene Expression Regulation; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1; Tissue Distribution

2012
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
    Current Alzheimer research, 2012, Volume: 9, Issue:5

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Humans; Translocation, Genetic

2012
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.
    Nature protocols, 2012, Jan-26, Volume: 7, Issue:2

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Glucosyltransferases; Magnetic Phenomena; Microspheres

2012
Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.
    Cancer science, 2012, Volume: 103, Issue:4

    Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cytosine; DNA Methylation; DNA-Binding Proteins; Gene Knockdown Techniques; Humans; Mixed Function Oxygenases; Mutation; Neoplasms; Proto-Oncogene Proteins; Stomach Neoplasms

2012
TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: 5-Methylcytosine; Computational Biology; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Humans; Isocitrate Dehydrogenase; Janus Kinase 2; Leukemia, Myelomonocytic, Chronic; Mutation; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Proto-Oncogene Proteins; Transcription Factors

2012
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.
    Nucleic acids research, 2012, Volume: 40, Issue:11

    Topics: 5-Methylcytosine; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; DNA-Binding Proteins; Humans; Pentoxyl; Thymine DNA Glycosylase

2012
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation.
    Oncogene, 2013, Jan-31, Volume: 32, Issue:5

    Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cytosine; Dioxygenases; DNA-Binding Proteins; Down-Regulation; Humans; Hydroxylation; Mice; Mixed Function Oxygenases; Neoplasms; Proto-Oncogene Proteins

2013
Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals.
    Epigenetics, 2012, Volume: 7, Issue:2

    Topics: 5-Methylcytosine; Ambystoma mexicanum; Amphibians; Animals; Chickens; Cytosine; DNA-Binding Proteins; Humans; Immunohistochemistry; Mammals; Mice; Phylogeny; Tissue Distribution; Xenopus; Zebrafish

2012
5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development.
    Epigenetics, 2012, Volume: 7, Issue:4

    Topics: 5-Methylcytosine; Animals; Blastocyst; Cell Differentiation; Chick Embryo; Culture Media, Conditioned; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryo, Nonmammalian; Embryonic Development; Embryonic Stem Cells; Female; Gene Expression Regulation, Developmental; Immunohistochemistry; Male; Mice; Organogenesis; Proto-Oncogene Proteins; Time Factors; Vertebrates; Zebrafish

2012
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
    Restorative neurology and neuroscience, 2012, Volume: 30, Issue:3

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Arachidonate 5-Lipoxygenase; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Hippocampus; Male; Mice; Mice, Inbred C57BL; Up-Regulation

2012
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.
    Neurobiology of aging, 2012, Volume: 33, Issue:12

    Topics: 5-Methylcytosine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, Cultured; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; DNA, Mitochondrial; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Developmental; Laser Capture Microdissection; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Proto-Oncogene Proteins

2012
Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: in vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA.
    Protein expression and purification, 2012, Volume: 83, Issue:1

    Topics: 5-Methylcytosine; Arabidopsis Proteins; Cytosine; DNA Methylation; DNA-Binding Proteins; DNA, Plant; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Escherichia coli; Models, Molecular; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Substrate Specificity

2012
DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cells.
    Epigenetics, 2012, Jun-01, Volume: 7, Issue:6

    Topics: 5-Methylcytosine; Animals; Cell Cycle Proteins; Cell Line; Cytosine; Dimethyl Sulfoxide; DNA (Cytosine-5-)-Methyltransferases; DNA Helicases; DNA Methylation; DNA Methyltransferase 3B; DNA-Binding Proteins; Homeodomain Proteins; Mice; Nuclear Proteins; Osteoblasts; Proto-Oncogene Proteins; Repressor Proteins; Stem Cells; Transcription, Genetic

2012
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.
    Science (New York, N.Y.), 2012, May-18, Volume: 336, Issue:6083

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Genes, Intracisternal A-Particle; High-Throughput Nucleotide Sequencing; Long Interspersed Nucleotide Elements; Mice; Oxidation-Reduction; Rhenium; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Uracil

2012
Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster.
    Nature communications, 2012, May-08, Volume: 3

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Line; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Homeodomain Proteins; Humans; Hydroxylation; Mice; Mice, Knockout; Proto-Oncogene Proteins

2012
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
    Cell, 2012, Jun-08, Volume: 149, Issue:6

    Topics: 5-Methylcytosine; Animals; Cytosine; Embryonic Stem Cells; Epigenomics; Gene Expression Regulation; Genome-Wide Association Study; Genome, Human; Humans; Mice; Sequence Analysis, DNA

2012
Reduction of DNA hydroxymethylation in the mouse kidney insulted by ischemia reperfusion.
    Biochemical and biophysical research communications, 2012, Jun-15, Volume: 422, Issue:4

    Topics: 5-Methylcytosine; Animals; Chemokine CXCL10; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Kidney; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Receptors, Interferon; Reperfusion Injury

2012
Simultaneous determination of global DNA methylation and hydroxymethylation levels by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
    Journal of biomolecular screening, 2012, Volume: 17, Issue:7

    Topics: 5-Methylcytosine; Animals; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Tandem Mass Spectrometry

2012
Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas.
    The American journal of pathology, 2012, Volume: 181, Issue:2

    Topics: 5-Methylcytosine; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cytosine; Dioxygenases; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Dual-Specificity Phosphatases; Female; Gene Expression Regulation, Enzymologic; Glioblastoma; Glioma; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Male; Mitogen-Activated Protein Kinase Phosphatases; Mixed Function Oxygenases; Mutation; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Subcellular Fractions; Tumor Suppressor Proteins

2012
5-Methylcytosine and 5-hydroxymethylcytosine spatiotemporal profiles in the mouse zygote.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: 5-Methylcytosine; Animals; Cell Cycle; Cytosine; DNA Methylation; DNA Replication; Female; Heterochromatin; Male; Mice; Time Factors; Zygote

2012
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.
    Nature, 2012, Jun-03, Volume: 486, Issue:7403

    Topics: 5-Methylcytosine; Animals; Chromatin; Chromosomal Proteins, Non-Histone; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Female; Genomic Imprinting; Histones; Lysine; Male; Methylation; Mice; Protein Binding; Proto-Oncogene Proteins; ras-GRF1; Repressor Proteins; RNA, Long Noncoding; RNA, Untranslated; Spermatozoa

2012
Effect of valproic acid on mitochondrial epigenetics.
    European journal of pharmacology, 2012, Sep-05, Volume: 690, Issue:1-3

    Topics: 3T3-L1 Cells; 5-Methylcytosine; Animals; Anticonvulsants; Base Sequence; Benzamides; Cell Nucleus; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA, Mitochondrial; Epigenesis, Genetic; Mice; Mitochondria; Molecular Sequence Data; Pyridines; RNA, Messenger; Valproic Acid

2012
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers.
    Nucleic acids research, 2012, Sep-01, Volume: 40, Issue:17

    Topics: 3T3-L1 Cells; 5-Methylcytosine; Animals; Binding Sites; Cell Differentiation; Cell Line, Tumor; Chromatin; Cytosine; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Homeodomain Proteins; Mice; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Neurogenesis; Proto-Oncogene Proteins; Transcription Factors

2012
Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice.
    Neurobiology of aging, 2013, Volume: 34, Issue:1

    Topics: 5-Methylcytosine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavioral Symptoms; Benzofurans; Cognition Disorders; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Female; Hippocampus; Humans; Male; Memory Disorders; Mice; Mice, Transgenic; Pregnancy; Prenatal Exposure Delayed Effects; Presenilin-1; Quinolines; Space Perception; Stress, Psychological

2013
Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: 5-Methylcytosine; Brain; Cell Differentiation; Cytosine; Glioma; Humans; Immunohistochemistry; Neurons; Stem Cells

2012
Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
    Nucleic acids research, 2012, Volume: 40, Issue:19

    Topics: 5-Methylcytosine; Bacteria; Catalytic Domain; Cytosine; DNA; Endodeoxyribonucleases; Humans; Models, Molecular; Pentoxyl; Protein Structure, Tertiary; Substrate Specificity; Thymine; Thymine DNA Glycosylase

2012
New sequencing technique produces high-resolution map of 5-hydroxymethylcytosine.
    Epigenomics, 2012, Volume: 4, Issue:3

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA; Embryonic Stem Cells; Epigenesis, Genetic; Mice; Nucleotide Mapping; Rhenium; Sequence Analysis, DNA

2012
Differential effect of three base modifications on DNA thermostability revealed by high resolution melting.
    Analytical chemistry, 2012, Sep-04, Volume: 84, Issue:17

    Topics: 5-Methylcytosine; Adenine; Cluster Analysis; Cytosine; DNA; Nucleic Acid Denaturation; Phase Transition; Principal Component Analysis; Transition Temperature

2012
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.
    Genome biology, 2012, Aug-17, Volume: 13, Issue:8

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Line; Chromosome Mapping; Computational Biology; CpG Islands; Cytosine; Dioxygenases; DNA Repair; DNA-Binding Proteins; Down-Regulation; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genome; High-Throughput Nucleotide Sequencing; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Transcription, Genetic

2012
CpG site-specific alteration of hydroxymethylcytosine to methylcytosine beyond DNA replication.
    Biochemical and biophysical research communications, 2012, Sep-14, Volume: 426, Issue:1

    Topics: 5-Methylcytosine; Base Sequence; CpG Islands; Cytosine; DNA Methylation; DNA Replication; Genetic Vectors; HEK293 Cells; Humans; Polymerase Chain Reaction

2012
[Analysis of global deoxyribonucleic acid 5-hydroxymethylcytosine in tissue by liquid chromatography-tandem mass spectrometry].
    Se pu = Chinese journal of chromatography, 2012, Volume: 30, Issue:5

    Topics: 5-Methylcytosine; Animals; Brain Chemistry; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; Rats; Tandem Mass Spectrometry

2012
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.
    Nature structural & molecular biology, 2012, Volume: 19, Issue:10

    Topics: 5-Methylcytosine; Alternative Splicing; Animals; Brain; Cell Line; Cytosine; Glucosyltransferases; Humans; Introns; Male; Mice; Mice, Inbred C57BL; Microarray Analysis; Organ Specificity; Reproducibility of Results; RNA Splicing; Synapses

2012
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.
    Cell, 2012, Sep-14, Volume: 150, Issue:6

    Topics: 5-Methylcytosine; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Humans; Isocitrate Dehydrogenase; Melanocytes; Melanoma; Nevus; Proto-Oncogene Proteins

2012
Sequencing the sixth base (5-hydroxymethylcytosine): selective DNA oxidation enables base-pair resolution.
    Angewandte Chemie (International ed. in English), 2012, Oct-22, Volume: 51, Issue:43

    Topics: 5-Methylcytosine; Base Pairing; Cytosine; Deamination; DNA; Oxidation-Reduction; Sequence Analysis, DNA; Sulfites

2012
The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine.
    Nature protocols, 2012, Volume: 7, Issue:10

    Topics: 5-Methylcytosine; Antibodies; Base Sequence; Cytosine; DNA Primers; Genomics; Immunoprecipitation; Molecular Sequence Data; Sulfites

2012
The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine.
    Nature protocols, 2012, Volume: 7, Issue:10

    Topics: 5-Methylcytosine; Base Sequence; Biotinylation; Cytosine; Genomics; Glucose; Molecular Sequence Data; Oxidation-Reduction; Periodic Acid

2012
Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.
    Genome biology, 2012, Oct-03, Volume: 13, Issue:10

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenomics; Gene Expression Profiling; Gene Expression Regulation; Histones; Liver; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phenobarbital; Promoter Regions, Genetic

2012
Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum.
    Human molecular genetics, 2012, Dec-15, Volume: 21, Issue:26

    Topics: 5-Methylcytosine; Adult; Cerebellum; CpG Islands; Cytosine; DNA; DNA Methylation; DNA, Intergenic; Epigenesis, Genetic; Female; Fragile X Mental Retardation Protein; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Genome, Human; Genomics; Humans; Male; RNA, Messenger; Sequence Alignment

2012
Selective capture of 5-hydroxymethylcytosine from genomic DNA.
    Journal of visualized experiments : JoVE, 2012, Oct-05, Issue:68

    Topics: 5-Methylcytosine; Cytosine; DNA; Genome, Human; Humans

2012
Balance of DNA methylation and demethylation in cancer development.
    Genome biology, 2012, Oct-23, Volume: 13, Issue:10

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Liver; Male; Phenobarbital

2012
Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells.
    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2012, Volume: 20, Issue:7

    Topics: 5-Methylcytosine; Animals; Bromodeoxyuridine; Cell Line; Chromosomes, Human, X; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Euchromatin; Female; Gene Deletion; Gene Expression Regulation; Gene Silencing; Genetic Markers; Genomic Imprinting; Heterochromatin; Histones; Humans; In Situ Hybridization, Fluorescence; Male; Mice; Retroelements; Sequence Analysis, DNA

2012
Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin.
    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2012, Volume: 20, Issue:8

    Topics: 5-Methylcytosine; Animals; Chromatin; Chromosomes; Cytosine; DNA; DNA Methylation; Gene Expression Regulation; Humans; Immunoblotting; Methyl-CpG-Binding Protein 2; Mutation; Oocytes; RNA Polymerase II; Sequence Analysis, DNA; Transcription, Genetic; Xenopus laevis

2012
Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
    Nature protocols, 2012, Volume: 7, Issue:12

    Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA-Binding Proteins; Glucosyltransferases; Mice; Polymerase Chain Reaction; Proto-Oncogene Proteins; Sequence Analysis, DNA; Sulfites

2012
Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.
    Science (New York, N.Y.), 2013, Jan-25, Volume: 339, Issue:6118

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Genomic Imprinting; Germ Cells; Germ Layers; Male; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA-Binding Proteins

2013
Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells.
    Molecular biology reports, 2013, Volume: 40, Issue:4

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Line; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Mice; Octamer Transcription Factor-3; Proto-Oncogene Proteins; Pyrazoles; Pyrimidines

2013
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.
    Cell, 2012, Dec-21, Volume: 151, Issue:7

    Topics: 5-Methylcytosine; Animals; Cerebellum; Chromatin; Cytosine; Epigenesis, Genetic; Humans; Methyl-CpG-Binding Protein 2; Mice; Mice, Knockout; Neuroglia; Neurons; Purkinje Cells; Rett Syndrome

2012
Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4.
    The Journal of biological chemistry, 2013, Mar-01, Volume: 288, Issue:9

    Topics: 5-Methylcytosine; Animals; Crystallography, X-Ray; Cytosine; DNA Methylation; Endodeoxyribonucleases; Humans; Mice; Protein Structure, Tertiary; Structure-Activity Relationship

2013
Quantification of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry.
    Clinical chemistry, 2013, Volume: 59, Issue:5

    Topics: 5-Methylcytosine; Biomarkers; Carcinoma, Hepatocellular; Chromatography, Liquid; Cytosine; DNA Methylation; DNA, Neoplasm; Humans; Limit of Detection; Liver Neoplasms; Sequence Analysis, DNA; Tandem Mass Spectrometry

2013
High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells.
    Cell reports, 2013, Feb-21, Volume: 3, Issue:2

    Topics: 5-Methylcytosine; Animals; Cell Line; Chromosome Mapping; Computational Biology; CpG Islands; Cytosine; DNA Methylation; DNA Restriction Enzymes; Embryonic Stem Cells; Genomics; Histones; Hydroxylation; Mice; Sequence Analysis, DNA

2013
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.
    Developmental cell, 2013, Feb-11, Volume: 24, Issue:3

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Embryonic Stem Cells; Epigenesis, Genetic; Female; Fertility; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Genomic Imprinting; Humans; Hydroxylation; Male; Mice; Proto-Oncogene Proteins

2013
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.
    The EMBO journal, 2013, Mar-06, Volume: 32, Issue:5

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Glycosylation; Histone-Lysine N-Methyltransferase; Histones; Host Cell Factor C1; Humans; Immunoprecipitation; Mice; Mice, Knockout; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Transcription, Genetic

2013
Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease.
    Neuromolecular medicine, 2013, Volume: 15, Issue:2

    Topics: 5-Methylcytosine; 5' Untranslated Regions; Adult; Aged; Aged, 80 and over; Animals; Corpus Striatum; Cytosine; Disease Models, Animal; Disease Progression; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Transgenic; Middle Aged; Nerve Tissue Proteins; Putamen; Receptor, Adenosine A2A

2013
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming.
    Cell research, 2013, Volume: 23, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Germ Cells; Heterochromatin; Male; Mice

2013
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.
    Cell reports, 2013, Feb-21, Volume: 3, Issue:2

    Topics: 5-Methylcytosine; Animals; Cells, Cultured; Chromatin; Cytosine; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Histones; Mice; Neurogenesis; Neurons; Oxidation-Reduction; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; RNA, Small Interfering

2013
A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription.
    The EMBO journal, 2013, Mar-06, Volume: 32, Issue:5

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mixed Function Oxygenases; N-Acetylglucosaminyltransferases; Proto-Oncogene Proteins; Transcription, Genetic

2013
Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method.
    Nucleic acids research, 2013, Volume: 41, Issue:7

    Topics: 5-Methylcytosine; Animals; Cell Lineage; Cells, Cultured; Cytosine; DNA Methylation; Embryonic Stem Cells; Gene Expression; Genome; High-Throughput Nucleotide Sequencing; Immunoprecipitation; Mice; Neural Stem Cells; Sequence Analysis, DNA

2013
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.
    Cell stem cell, 2013, Apr-04, Volume: 12, Issue:4

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Genome; Germ Cells; Green Fluorescent Proteins; Mice; Proto-Oncogene Proteins

2013
Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
    Epigenetics, 2013, Volume: 8, Issue:3

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Myosins; Case-Control Studies; CCCTC-Binding Factor; Cell Lineage; Child; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Homeobox; Genome, Human; Guanine Nucleotide Exchange Factors; Histones; Humans; Infant, Newborn; Male; Middle Aged; Mixed Function Oxygenases; Muscle Development; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Dystrophy, Facioscapulohumeral; Myoblasts; Myosin Heavy Chains; Paired Box Transcription Factors; PAX3 Transcription Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Repressor Proteins; Rho Guanine Nucleotide Exchange Factors; T-Box Domain Proteins; Transcription, Genetic

2013
Decreased 5-hydroxymethylcytosine levels are associated with TET2 mutation and unfavorable overall survival in myelodysplastic syndromes.
    Leukemia & lymphoma, 2013, Volume: 54, Issue:11

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Prognosis; Proto-Oncogene Proteins; Young Adult

2013
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.
    Cell, 2013, Feb-28, Volume: 152, Issue:5

    Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Glycosylases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Kruppel-Like Factor 4; Mass Spectrometry; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Regulatory Factor X Transcription Factors; Stem Cells; Transcription Factors; Ubiquitin-Protein Ligases

2013
Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:7

    Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Bipolar Disorder; Cytosine; Deoxyguanosine; DNA; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Multivariate Analysis; Oxidation-Reduction; Oxidative Stress; Young Adult

2013
Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion.
    Molecular cell, 2013, Mar-28, Volume: 49, Issue:6

    Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Fusion; Cell Line; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression; Genomic Imprinting; Germ Cells; Green Fluorescent Proteins; Humans; Insulin-Like Growth Factor II; Mice; Molecular Sequence Data; Octamer Transcription Factor-3; Polymorphism, Single Nucleotide; Proteins; Proto-Oncogene Proteins; RNA, Long Noncoding; Sequence Analysis, DNA

2013
Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma.
    Melanoma research, 2013, Volume: 23, Issue:3

    Topics: 5-Methylcytosine; Biomarkers, Tumor; Cytosine; Dioxygenases; Disease Progression; DNA-Binding Proteins; Epigenomics; Humans; Melanoma; Paraffin Embedding; Proto-Oncogene Proteins; Skin Neoplasms; Translocation, Genetic

2013
Characterization of the 5-hydroxymethylcytosine-specific DNA restriction endonucleases.
    Nucleic acids research, 2013, Volume: 41, Issue:7

    Topics: 5-Methylcytosine; Bacteriophage T4; Cytosine; DNA Cleavage; DNA Restriction Enzymes; DNA, Viral; Glucosyltransferases; Sequence Homology, Amino Acid; Substrate Specificity

2013
Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming.
    Cell stem cell, 2013, Apr-04, Volume: 12, Issue:4

    Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Models, Biological; Octamer Transcription Factor-3; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; SOXB1 Transcription Factors; Transcription, Genetic; Transcriptome

2013
Integrated detection of both 5-mC and 5-hmC by high-throughput tag sequencing technology highlights methylation reprogramming of bivalent genes during cellular differentiation.
    Epigenetics, 2013, Volume: 8, Issue:4

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cells, Cultured; Cytosine; DNA Methylation; Embryoid Bodies; Embryonic Stem Cells; High-Throughput Screening Assays; Humans; Mice; Sequence Analysis, DNA

2013
Quantification of the sixth DNA base 5-hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line.
    Bioanalysis, 2013, Volume: 5, Issue:7

    Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatography, Liquid; Colorectal Neoplasms; Cytosine; DNA Methylation; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Tandem Mass Spectrometry

2013
Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.
    The Journal of biological chemistry, 2013, May-10, Volume: 288, Issue:19

    Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cells, Cultured; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Knockdown Techniques; Hydroxylation; Mice; Mice, Inbred C57BL; Phloretin; Proto-Oncogene Proteins; RNA, Small Interfering

2013
Single-molecule detection of 5-hydroxymethylcytosine in DNA through chemical modification and nanopore analysis.
    Angewandte Chemie (International ed. in English), 2013, Apr-15, Volume: 52, Issue:16

    Topics: 5-Methylcytosine; Cytosine; DNA; Molecular Structure; Nanopores

2013
GSE is a maternal factor involved in active DNA demethylation in zygotes.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: 5-Methylcytosine; Animals; Blastocyst; Chromatin; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Homeodomain Proteins; Long Interspersed Nucleotide Elements; Male; Mice; Nanog Homeobox Protein; Octamer Transcription Factor-3; Protein Binding; Proteins; RNA, Small Interfering; Sex Factors; Zygote

2013
Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.
    Nucleic acids research, 2013, Volume: 41, Issue:11

    Topics: 5-Methylcytosine; Animals; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Cytosine; DNA Methylation; Epigenesis, Genetic; Genetic Markers; Liver; Male; Mice; Oligonucleotide Array Sequence Analysis; Phenobarbital; Promoter Regions, Genetic; Transcriptome

2013
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.
    Cell, 2013, Apr-25, Volume: 153, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA Repair; Embryonic Stem Cells; Epigenesis, Genetic; Genetic Techniques; Genome-Wide Association Study; Heterochromatin; Mice; Oxidation-Reduction; Regulatory Elements, Transcriptional; Thymine DNA Glycosylase

2013
A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences.
    Organic & biomolecular chemistry, 2013, Jun-07, Volume: 11, Issue:21

    Topics: 5-Methylcytosine; Base Sequence; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Cytosine; Electrophoresis, Gel, Two-Dimensional; Sequence Analysis, DNA

2013
First evidence of DNA methylation in insect Tribolium castaneum: environmental regulation of DNA methylation within heterochromatin.
    Epigenetics, 2013, Volume: 8, Issue:5

    Topics: 5-Methylcytosine; Animals; Base Sequence; Blotting, Southern; Cytosine; DNA Methylation; DNA, Satellite; Electrophoresis, Agar Gel; Environment; Genome, Insect; Heterochromatin; Molecular Sequence Data; Tribolium

2013
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.
    Human molecular genetics, 2013, Sep-15, Volume: 22, Issue:18

    Topics: 5-Methylcytosine; Animals; Brain; Corpus Striatum; Cytosine; Disease Models, Animal; DNA Methylation; Epigenomics; Humans; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Sequence Alignment; Sequence Analysis, DNA

2013
Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: 5-Methylcytosine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine; Diethylnitrosamine; Dioxygenases; Disease Progression; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Middle Aged; Mixed Function Oxygenases; Prognosis; Proto-Oncogene Proteins; Rats, Wistar

2013
Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease.
    Cell cycle (Georgetown, Tex.), 2013, Jun-15, Volume: 12, Issue:12

    Topics: 5-Methylcytosine; Cell Differentiation; Cell Line, Tumor; Cytosine; DNA Methylation; Epigenomics; Female; Histones; Humans; In Vitro Techniques; Male; Neoplasms; Polycomb-Group Proteins

2013
Formation of cyclobutane pyrimidine dimers at dipyrimidines containing 5-hydroxymethylcytosine.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, Volume: 12, Issue:8

    Topics: 5-Methylcytosine; Base Sequence; Cells, Cultured; Cytosine; DNA; Fibroblasts; Humans; Keratinocytes; Melanocytes; Pyrimidine Dimers; Ultraviolet Rays

2013
Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection.
    Analytical chemistry, 2013, Jun-18, Volume: 85, Issue:12

    Topics: 5-Methylcytosine; Chromatography, Liquid; Cytosine; HEK293 Cells; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Jurkat Cells; Tandem Mass Spectrometry

2013
Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency.
    Nature cell biology, 2013, Volume: 15, Issue:6

    Topics: 5-Methylcytosine; Cell Differentiation; Cell Line; Cellular Reprogramming; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Enzyme Activation; Epigenesis, Genetic; Fibroblasts; Humans; Induced Pluripotent Stem Cells; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA Interference; RNA, Small Interfering; Sequence Alignment; Transcription Factors

2013
5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: 5-Methylcytosine; Animals; Cell Nucleus; Cytosine; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Male; Mice; Solvents; Temperature; Zygote

2013
Maternal low-protein diet affects epigenetic regulation of hepatic mitochondrial DNA transcription in a sex-specific manner in newborn piglets associated with GR binding to its promoter.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: 5-Methylcytosine; Animals; Animals, Newborn; Cytosine; Dietary Proteins; DNA Methylation; DNA, Mitochondrial; Electron Transport Complex IV; Epigenesis, Genetic; Female; Liver; Male; Mothers; Promoter Regions, Genetic; Protein Binding; Receptors, Glucocorticoid; RNA, Messenger; Sex Characteristics; Swine; Transcription, Genetic

2013
5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes.
    Genome biology, 2013, May-26, Volume: 14, Issue:5

    Topics: 5-Methylcytosine; Cell Differentiation; Cytosine; Dendritic Cells; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Knockdown Techniques; Humans; Mass Spectrometry; Monocytes; Proto-Oncogene Proteins

2013
5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni.
    Parasites & vectors, 2013, Jun-06, Volume: 6

    Topics: 5-Methylcytosine; Animals; Biomphalaria; Chemistry Techniques, Analytical; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic

2013
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2013, Volume: 26, Issue:11

    Topics: 5-Methylcytosine; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cytosine; DNA Mutational Analysis; Down-Regulation; Electron Transport Complex II; Exons; Gastrointestinal Stromal Tumors; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Membrane Proteins; Mutation; Phenotype; Proto-Oncogene Proteins c-kit; Receptor, Platelet-Derived Growth Factor alpha; Succinate Dehydrogenase

2013
Optical detection of epigenetic marks: sensitive quantification and direct imaging of individual hydroxymethylcytosine bases.
    Chemical communications (Cambridge, England), 2013, Oct-07, Volume: 49, Issue:77

    Topics: 5-Methylcytosine; Animals; Bacteriophage lambda; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Dyes; Mice; Models, Molecular; Optical Imaging

2013
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis.
    Nature communications, 2013, Volume: 4

    Topics: 5-Methylcytosine; Animals; Cell Separation; Cell Shape; Chromatin; Chromosomes, Mammalian; Cytosine; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Profiling; Genome; Male; Mice; Microscopy, Phase-Contrast; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Sex Chromosomes; Spermatogenesis; Spermatozoa; Transcriptome; Up-Regulation

2013
Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
    Chembiochem : a European journal of chemical biology, 2013, Jul-22, Volume: 14, Issue:11

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA, Single-Stranded; Nanopores; Sequence Analysis, DNA

2013
Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
    Fertility and sterility, 2013, Volume: 100, Issue:4

    Topics: 5-Methylcytosine; Adult; Age Factors; Aging; Cytosine; DNA; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Humans; Male; Middle Aged; Paternal Age; Prospective Studies; Risk Factors; Spermatozoa; Up-Regulation

2013
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
    Nature, 2013, Aug-08, Volume: 500, Issue:7461

    Topics: 5-Methylcytosine; Animals; Antioxidants; Ascorbic Acid; Blastocyst; Cell Line; Culture Media; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Mice; Protein Binding; Proto-Oncogene Proteins; Recombinant Proteins

2013
TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Jul-16, Volume: 110, Issue:29

    Topics: 5-Methylcytosine; Chromatin Immunoprecipitation; Chromatography, Liquid; Cytosine; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Homeodomain Proteins; Humans; Immunoblotting; Leukemia, Myeloid, Acute; Microarray Analysis; Mixed Function Oxygenases; Myeloid Ecotropic Viral Integration Site 1 Protein; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins; Signal Transduction; Tandem Mass Spectrometry

2013
Global epigenomic reconfiguration during mammalian brain development.
    Science (New York, N.Y.), 2013, Aug-09, Volume: 341, Issue:6146

    Topics: 5-Methylcytosine; Adult; Animals; Base Sequence; Conserved Sequence; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Frontal Lobe; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Humans; Longevity; Mice; Mice, Inbred C57BL; X Chromosome Inactivation

2013
Paternal age and sperm methylation status.
    Fertility and sterility, 2013, Volume: 100, Issue:4

    Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa

2013
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.
    Cell, 2013, Jul-18, Volume: 154, Issue:2

    Topics: 5-Methylcytosine; Animals; Breast Neoplasms; Chromatin Assembly and Disassembly; Cytosine; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; MicroRNAs; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Proto-Oncogene Proteins; RNA Interference; Transplantation, Heterologous

2013
Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.
    Nucleic acids research, 2013, Volume: 41, Issue:16

    Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytosine; DNA, Neoplasm; Gene Expression; Genome, Human; Genomics; Glycosyltransferases; Humans; Mice; Pancreatic Neoplasms; Polymerase Chain Reaction

2013
Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin.
    Epigenetics, 2013, Volume: 8, Issue:9

    Topics: 5-Methylcytosine; Animal Fins; Animals; Animals, Genetically Modified; Cell Dedifferentiation; Cytosine; DNA Methylation; DNA Repair; Embryo, Nonmammalian; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Regeneration; Zebrafish

2013
PPARγ-induced PARylation promotes local DNA demethylation by production of 5-hydroxymethylcytosine.
    Nature communications, 2013, Volume: 4

    Topics: 3T3-L1 Cells; 5-Methylcytosine; Adipocytes; Adipose Tissue; Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Cytosine; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; HEK293 Cells; Humans; Hydroxylation; Mice; Molecular Sequence Data; Phenanthrenes; Poly Adenosine Diphosphate Ribose; PPAR gamma; Protein Binding; Proto-Oncogene Proteins; Response Elements

2013
Genetics. The maturing brain methylome.
    Science (New York, N.Y.), 2013, Aug-09, Volume: 341, Issue:6146

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Frontal Lobe; Gene Expression Regulation, Developmental; Humans

2013
Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase.
    The Journal of biological chemistry, 2013, Oct-04, Volume: 288, Issue:40

    Topics: 5-Methylcytosine; Cell Cycle; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Genome, Human; HEK293 Cells; Humans; Hydroquinones; Mixed Function Oxygenases; Proto-Oncogene Proteins; Reactive Oxygen Species

2013
Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function.
    Genome biology, 2013, Aug-19, Volume: 14, Issue:8

    Topics: 5-Methylcytosine; Adult; Age Factors; Carbohydrate Metabolism; Cytosine; DNA Methylation; Epigenesis, Genetic; Fetus; Gene Expression Regulation, Developmental; Genome, Human; Hepatocytes; Humans; Inactivation, Metabolic; Lipid Metabolism; Liver; Molecular Sequence Annotation; Protein Biosynthesis

2013
Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine.
    Nucleic acids research, 2013, Volume: 41, Issue:21

    Topics: 5-Methylcytosine; Cations; Crystallography, X-Ray; Cytosine; DNA, B-Form; Epigenesis, Genetic; Models, Molecular; Thermodynamics; Water

2013
MLML: consistent simultaneous estimates of DNA methylation and hydroxymethylation.
    Bioinformatics (Oxford, England), 2013, Oct-15, Volume: 29, Issue:20

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; High-Throughput Nucleotide Sequencing; Sequence Analysis, DNA; Software

2013
Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Sep-03, Volume: 110, Issue:36

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Fluorescent Antibody Technique; Gene Expression Profiling; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Olfactory Bulb; Olfactory Mucosa; Olfactory Receptor Neurons; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction

2013
Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy.
    Epigenetics, 2013, Volume: 8, Issue:10

    Topics: 5-Methylcytosine; Azacitidine; Cell Hypoxia; Cytosine; Decitabine; DNA; DNA Modification Methylases; DNA-Binding Proteins; HeLa Cells; Humans; Single-Cell Analysis; Spectrometry, Fluorescence

2013
Decreased 5-hydroxymethylcytosine (5-hmC) is an independent poor prognostic factor in gastric cancer patients.
    Journal of biomedical nanotechnology, 2013, Volume: 9, Issue:9

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; China; Cytosine; Female; Humans; Incidence; Male; Middle Aged; Prognosis; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Stomach Neoplasms; Survival Analysis; Survival Rate

2013
Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine.
    Journal of the American Chemical Society, 2013, Oct-02, Volume: 135, Issue:39

    Topics: 5-Methylcytosine; Carboxylic Acids; Cytosine; Deamination; Oxidation-Reduction; Sulfhydryl Compounds

2013
Reactivation of Х chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation.
    Chromosoma, 2014, Volume: 123, Issue:1-2

    Topics: 5-Methylcytosine; Animals; Cell Line; Cellular Reprogramming; Chromosomes, Human, X; Cytosine; DNA Replication; DNA Replication Timing; Female; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Mice; X Chromosome Inactivation

2014
Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.
    Genome biology, 2013, Aug-29, Volume: 14, Issue:8

    Topics: 5-Methylcytosine; Adult Stem Cells; Animals; Cell Differentiation; Chromatin; Cytosine; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; Genome; Histones; Mice; Pluripotent Stem Cells; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Proto-Oncogene Proteins; Repressor Proteins; RNA, Small Interfering; Sin3 Histone Deacetylase and Corepressor Complex; Transcription, Genetic

2013
Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes.
    Nucleic acids research, 2013, Volume: 41, Issue:19

    Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Nucleus; Cells, Cultured; Chromosomes, Mammalian; Cytosine; DNA Methylation; DNA, Satellite; Embryonic Stem Cells; Humans; In Situ Hybridization, Fluorescence; Male; Mice; Spermatozoa

2013
Fluorescent strategy based on cationic conjugated polymer fluorescence resonance energy transfer for the quantification of 5-(hydroxymethyl)cytosine in genomic DNA.
    Analytical chemistry, 2013, Nov-19, Volume: 85, Issue:22

    Topics: 5-Methylcytosine; Animals; Cations; Chromatography, High Pressure Liquid; Cytosine; DNA; Embryonic Stem Cells; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; HEK293 Cells; HeLa Cells; Humans; Mice; Oxidation-Reduction; Polymers; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Static Electricity

2013
DNA methylation: an identity card for brain cells.
    Genome biology, 2013, Aug-27, Volume: 14, Issue:8

    Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome; Humans; Mice; Neuroglia; Neurons; Organ Specificity

2013
Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.
    Nature protocols, 2013, Volume: 8, Issue:10

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Oxidation-Reduction; Sequence Analysis, DNA

2013
Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate.
    Biochemical and biophysical research communications, 2013, Oct-04, Volume: 439, Issue:4

    Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Fibroblasts; Iron; Isocitrate Dehydrogenase; Ketoglutaric Acids; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Sodium-Coupled Vitamin C Transporters

2013
Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: 5-Methylcytosine; 5' Untranslated Regions; Adolescent; Adult; CCCTC-Binding Factor; Cerebellum; Cytosine; DNA Methylation; Frataxin; Friedreich Ataxia; Genetic Loci; Humans; Iron-Binding Proteins; Microsatellite Repeats; Middle Aged; Myocardium; Protein Binding; Repressor Proteins; Young Adult

2013
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation.
    Genome biology, 2013, Volume: 14, Issue:9

    Topics: 5-Methylcytosine; Binding Sites; Cell Differentiation; CpG Islands; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Monocytes; NF-kappa B; Osteoclasts; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins; RNA, Small Interfering; Trans-Activators; Transcription Factor AP-1

2013
Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Escherichia coli; High-Throughput Nucleotide Sequencing; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2013
Intronic non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees.
    BMC genomics, 2013, Sep-30, Volume: 14

    Topics: 5-Methylcytosine; Africa; Alternative Splicing; Animals; Bees; Behavior, Animal; CpG Islands; Cytosine; DNA Methylation; Europe; Exons; Gene Expression Regulation; Genes, Insect; Honey; Introns; Reproducibility of Results; RNA Splice Sites; RNA, Messenger; Sequence Analysis, DNA; Sulfites

2013
Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.
    Human molecular genetics, 2014, Feb-01, Volume: 23, Issue:3

    Topics: 5-Methylcytosine; Cell Differentiation; Cell Lineage; Cells, Cultured; Cytosine; DNA Methylation; Embryonic Stem Cells; Gene Expression Regulation; Gene Silencing; GPI-Linked Proteins; Homeodomain Proteins; Humans; Mesoderm; Nerve Tissue Proteins; Neurogenesis; Neurons; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor, Notch1; Transcription Factors

2014
Evaluation of UDP-GlcN derivatives for selective labeling of 5-(hydroxymethyl)cytosine.
    Chembiochem : a European journal of chemical biology, 2013, Nov-04, Volume: 14, Issue:16

    Topics: 5-Methylcytosine; Animals; Antibodies; Bacteriophage T4; Cytosine; DNA; Embryonic Stem Cells; Fluorescent Dyes; Glucosamine; Glucosyltransferases; Glycosylation; Mice; Oligonucleotides; Staining and Labeling; Substrate Specificity; Uracil Nucleotides

2013
Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome.
    Human molecular genetics, 2014, Feb-15, Volume: 23, Issue:4

    Topics: 5-Methylcytosine; Animals; Ataxia; Base Sequence; Cerebellum; Consensus Sequence; Cytosine; Disease Models, Animal; DNA Methylation; Fragile X Syndrome; Humans; Mice; Mice, Transgenic; Terminator Regions, Genetic; Transcription Initiation Site; Tremor

2014
MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-29, Volume: 110, Issue:44

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Flow Cytometry; Gene Expression Regulation, Developmental; Islets of Langerhans; Luciferases; Mice; Mice, Transgenic; Microfluidics; MicroRNAs; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Thymine DNA Glycosylase

2013
An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.
    Cell reports, 2013, Oct-31, Volume: 5, Issue:2

    Topics: 3' Untranslated Regions; 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA-Binding Proteins; Down-Regulation; Hematologic Neoplasms; Hematopoiesis; Humans; Mice; MicroRNAs; Phenotype; Proto-Oncogene Proteins

2013
Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma.
    Anticancer research, 2013, Volume: 33, Issue:10

    Topics: 5-Methylcytosine; Carcinoma, Squamous Cell; Case-Control Studies; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Mouth Mucosa; Mouth Neoplasms; Proto-Oncogene Proteins

2013
Association of 5-methylcytosine and 5-hydroxymethylcytosine with mitochondrial DNA content and clinical and biochemical parameters in hepatocellular carcinoma.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Cytosine; DNA, Mitochondrial; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Risk Factors; Tumor Burden; Young Adult

2013
Hydroxymethylated DNA immunoprecipitation (hmeDIP).
    Methods in molecular biology (Clifton, N.J.), 2014, Volume: 1094

    Topics: 5-Methylcytosine; Antibody Specificity; Brain; Breast; Cytosine; DNA; DNA Fragmentation; Epitopes; Female; Humans; Immunoprecipitation; Sonication

2014
Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Nov-19, Volume: 110, Issue:47

    Topics: 5-Methylcytosine; Bayes Theorem; Cytosine; DNA Methylation; Epigenomics; Models, Molecular; Molecular Structure; Nanopores; Porins

2013
Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Nov-19, Volume: 110, Issue:47

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Epigenomics; Nanopores; Research Design

2013
5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi.
    Journal of dermatological science, 2014, Volume: 73, Issue:2

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Humans; Keratinocytes; Male; Melanoma; Middle Aged; Nevus, Epithelioid and Spindle Cell; Nevus, Pigmented; Skin Neoplasms

2014
Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques.
    Nucleic acids research, 2013, Volume: 41, Issue:22

    Topics: 5-Methylcytosine; Animals; Antibodies; Chromatin; CpG Islands; Cytosine; DNA; DNA-Binding Proteins; Genetic Loci; Genomic Imprinting; Immunoassay; Liver; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Tandem Repeat Sequences

2013
Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.
    Nucleic acids research, 2014, Volume: 42, Issue:3

    Topics: 5-Methylcytosine; Animals; Apoferritins; Cell Line; Cell Line, Tumor; Chloranil; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Genome; Humans; Iron; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Quinones

2014
Large conserved domains of low DNA methylation maintained by Dnmt3a.
    Nature genetics, 2014, Volume: 46, Issue:1

    Topics: 5-Methylcytosine; Animals; Base Sequence; Conserved Sequence; CpG Islands; Cytosine; Databases, Genetic; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Gene Expression Regulation; Hematopoietic Stem Cells; Histones; Humans; Leukemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains

2014
Structural insights into how 5-hydroxymethylation influences transcription factor binding.
    Chemical communications (Cambridge, England), 2014, Feb-21, Volume: 50, Issue:15

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Models, Molecular; Nucleic Acid Conformation; Oxidation-Reduction; Protein Binding; Transcription Factors

2014
Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling.
    Bioorganic & medicinal chemistry letters, 2014, Jan-01, Volume: 24, Issue:1

    Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA; Models, Molecular; Molecular Structure

2014
Dynamic reprogramming of 5-hydroxymethylcytosine during early porcine embryogenesis.
    Theriogenology, 2014, Volume: 81, Issue:3

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Embryonic Development; Nuclear Transfer Techniques; Swine

2014
Understanding variation in transcription factor binding by modeling transcription factor genome-epigenome interactions.
    PLoS computational biology, 2013, Volume: 9, Issue:12

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Embryonic Stem Cells; Epigenomics; Genome; Histones; Mice; Models, Biological; Protein Binding; Transcription Factors

2013
Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Proteins; Cell Cycle; Cell Proliferation; Cell Separation; CpG Islands; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Replication; Embryonic Stem Cells; Flow Cytometry; Mice; Mice, Knockout; Multigene Family; Nuclear Proteins; Promoter Regions, Genetic; Protein Structure, Tertiary; Ubiquitin-Protein Ligases

2013
Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor.
    Nature communications, 2013, Volume: 4

    Topics: 5-Methylcytosine; Algorithms; Biological Transport; Biosensing Techniques; Cytosine; DNA; DNA Damage; DNA, Single-Stranded; Escherichia coli; Ions; Lipid Bilayers; Molecular Dynamics Simulation; Nanopores; Nanotechnology; Nanotubes, Carbon; Thermodynamics

2013
Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions.
    PLoS genetics, 2013, Volume: 9, Issue:12

    Topics: 5-Methylcytosine; Animals; Binding Sites; CCCTC-Binding Factor; Cell Differentiation; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; Genome; Mice; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Repressor Proteins; Transcription Factors; Transcription, Genetic

2013
Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells.
    Stem cell reports, 2013, Volume: 1, Issue:6

    Topics: 5-Methylcytosine; Cell Culture Techniques; Cell Cycle Checkpoints; Cell Differentiation; Cytosine; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Pluripotent Stem Cells; Signal Transduction; Transcription Factors

2013
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
    Cell reports, 2014, Jan-16, Volume: 6, Issue:1

    Topics: 5-Methylcytosine; Antigens, CD34; Cells, Cultured; Cytosine; Dioxygenases; DNA Methylation; Erythroid Cells; Erythropoiesis; Histones; Humans; Mutation; Regulatory Sequences, Nucleic Acid; Transcription Factors

2014
Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: 5-Methylcytosine; Carcinoma; Cell Line, Tumor; Cytosine; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Germ Cells; Humans; Immunohistochemistry; Male; Mixed Function Oxygenases; Neoplasms, Germ Cell and Embryonal; Oxidation-Reduction; Proto-Oncogene Proteins; Spermatogenesis; Testis

2013
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.
    Neurobiology of aging, 2014, Volume: 35, Issue:6

    Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Cytosine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Genetic Markers; Humans; Male; Microglia; Middle Aged; Neurons; Parahippocampal Gyrus

2014
Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2014, Volume: 27, Issue:7

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cytosine; DNA Methylation; Female; Humans; Male; Melanoma; Middle Aged; Nevus; Precancerous Conditions; Skin Neoplasms; Young Adult

2014
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
    Nature, 2014, Feb-20, Volume: 506, Issue:7488

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Escherichia coli Proteins; HEK293 Cells; Humans; Hydrogen Bonding; Mice; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Naegleria; Proto-Oncogene Proteins; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity

2014
Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).
    The Journal of biological chemistry, 2014, Feb-28, Volume: 289, Issue:9

    Topics: 5-Methylcytosine; Active Transport, Cell Nucleus; Cell Nucleus; Cytosine; Dioxygenases; DNA Methylation; Glucose; HeLa Cells; Humans; N-Acetylglucosaminyltransferases

2014
Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:4

    Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cytosine; Disease Models, Animal; Epigenomics; Genome-Wide Association Study; Hypertension; Kidney Medulla; Male; Phenotype; Rats; Rats, Inbred Dahl; RNA, Messenger; Sodium Chloride, Dietary; Transcriptome

2014
Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum.
    Translational psychiatry, 2014, Jan-21, Volume: 4

    Topics: 5-Methylcytosine; Cell Adhesion Molecules, Neuronal; Cerebellar Cortex; Child Development Disorders, Pervasive; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Extracellular Matrix Proteins; Glutamate Decarboxylase; Humans; Methyl-CpG-Binding Protein 2; Mixed Function Oxygenases; Nerve Tissue Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reelin Protein; Serine Endopeptidases; Tissue Banks

2014
A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes.
    Arthritis & rheumatology (Hoboken, N.J.), 2014, Volume: 66, Issue:1

    Topics: 5-Methylcytosine; ADAM Proteins; ADAMTS5 Protein; Adolescent; Adult; Aged; Aged, 80 and over; Anterior Cruciate Ligament Reconstruction; Arthroplasty, Replacement, Knee; Biomarkers; Cartilage, Articular; Case-Control Studies; Child; Child, Preschool; Chondrocytes; CpG Islands; Cytokines; Cytosine; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Female; Gene Expression; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Middle Aged; Mixed Function Oxygenases; Osteoarthritis, Knee; Promoter Regions, Genetic; Proto-Oncogene Proteins; Young Adult

2014
Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process.
    Scientific reports, 2014, Jan-24, Volume: 4

    Topics: 5-Methylcytosine; Animals; Carcinoma, Hepatocellular; Cell Dedifferentiation; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cytosine; DNA Methylation; ELAV Proteins; ELAV-Like Protein 2; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genetic Vectors; HEK293 Cells; Homeodomain Proteins; Humans; Lentivirus; Liver; Liver Neoplasms; Metabolomics; Mice; MicroRNAs; Nanog Homeobox Protein; Neoplasm Transplantation; Neoplastic Stem Cells; Octamer Transcription Factor-3; Pluripotent Stem Cells; Proto-Oncogene Proteins c-myc; RNA Interference; RNA, Small Interfering; Serum Albumin; Serum Albumin, Human; Telomerase; Transplantation, Heterologous; Tumor Suppressor Protein p53

2014
Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, α-Ketoglutarate (α-KG), and DNA hydroxymethylation levels by interleukin-1β in primary human chondrocytes.
    The Journal of biological chemistry, 2014, Mar-07, Volume: 289, Issue:10

    Topics: 5-Methylcytosine; Chondrocytes; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Interleukin-1beta; Isocitrate Dehydrogenase; Ketoglutaric Acids; Mixed Function Oxygenases; Primary Cell Culture; Proto-Oncogene Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha

2014
Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice.
    BMC genomics, 2014, Feb-13, Volume: 15

    Topics: 5-Methylcytosine; Animals; Brain; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Genetic Loci; Genome; Genome, Human; Humans; Macaca mulatta; Mice; Oligonucleotide Array Sequence Analysis

2014
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain.
    Genome biology, 2014, Mar-04, Volume: 15, Issue:3

    Topics: 5-Methylcytosine; Adult; Brain; CpG Islands; Cytosine; DNA Methylation; DNA, Antisense; Exons; Female; Gene Expression Regulation, Developmental; Genome, Human; Histones; Humans; Introns; Male; Transcription, Genetic

2014
DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.
    Biochemical and biophysical research communications, 2014, Mar-28, Volume: 446, Issue:1

    Topics: 5-Methylcytosine; Cell Line, Tumor; CpG Islands; Cyclin-Dependent Kinase Inhibitor p21; Cytosine; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; HeLa Cells; Humans; Protein Binding; Repressor Proteins

2014
Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.
    Glia, 2014, Volume: 62, Issue:6

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Animals, Newborn; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Humans; Mice; Mixed Function Oxygenases; Molecular Sequence Data; Oligodendroglia; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley

2014
TET proteins and 5-methylcytosine oxidation in the immune system.
    Cold Spring Harbor symposia on quantitative biology, 2013, Volume: 78

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Profiling; Humans; Immunoprecipitation; Mice; Mixed Function Oxygenases; Oxidoreductases; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins

2013
DNA counterstaining for methylation and hydroxymethylation immunostaining in bovine zygotes.
    Analytical biochemistry, 2014, Jun-01, Volume: 454

    Topics: 5-Methylcytosine; Animals; Cattle; Cytosine; DNA Methylation; Staining and Labeling; Zygote

2014
Crystal structure of the 5hmC specific endonuclease PvuRts1I.
    Nucleic acids research, 2014, Volume: 42, Issue:9

    Topics: 5-Methylcytosine; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Bacteriophage T4; Catalytic Domain; Crystallography, X-Ray; Cytosine; DNA Restriction Enzymes; DNA, Viral; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Secondary; Proteus vulgaris; Substrate Specificity

2014
A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine.
    Journal of the American Chemical Society, 2014, Apr-02, Volume: 136, Issue:13

    Topics: 5-Methylcytosine; Agaricales; Cytosine; Dioxygenases; Fungal Proteins

2014
Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation.
    Neuroscience, 2014, May-30, Volume: 268

    Topics: 5-Methylcytosine; Animals; Cytosine; Databases, Genetic; DNA Methylation; Epigenesis, Genetic; Frontal Lobe; Gene Expression; Macaca mulatta; Maternal Deprivation; Methylation; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Prefrontal Cortex; Promoter Regions, Genetic

2014
Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases.
    Biochemical and biophysical research communications, 2014, Apr-18, Volume: 446, Issue:4

    Topics: 5-Methylcytosine; Animals; Arabidopsis; Arabidopsis Proteins; Cytosine; DNA Glycosylases; DNA Methylation; Mice; N-Glycosyl Hydrolases; Nuclear Proteins; Signal Transduction; Trans-Activators

2014
Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine.
    Epigenetics, 2014, Volume: 9, Issue:6

    Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Cerebellum; Chromatin; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Histones; Humans; Male; Mixed Function Oxygenases; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; Myocardium; Organ Specificity; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptors, Notch

2014
Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.
    Neurobiology of aging, 2014, Volume: 35, Issue:8

    Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cytosine; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Humans; Ivermectin; Male; Methylation

2014
Boronic acid-mediated polymerase chain reaction for gene- and fragment-specific detection of 5-hydroxymethylcytosine.
    Nucleic acids research, 2014, Volume: 42, Issue:9

    Topics: 5-Methylcytosine; Animals; Base Sequence; Boronic Acids; Cells, Cultured; Cytosine; Embryonic Stem Cells; Introns; Mice; PAX5 Transcription Factor; Polymerase Chain Reaction; Sequence Analysis, DNA

2014
Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:3

    Topics: 5-Methylcytosine; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Cytosine; Disease Models, Animal; Gene Expression Regulation; Genotype; Humans; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1; tau Proteins

2014
Genome-wide analysis of DNA 5-hmC in peripheral blood of uremia by hMeDIP-chip.
    Renal failure, 2014, Volume: 36, Issue:6

    Topics: 5-Methylcytosine; Case-Control Studies; CpG Islands; Cytosine; DNA Methylation; Genome-Wide Association Study; Humans; Promoter Regions, Genetic; Uremia

2014
High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma.
    Journal of experimental & clinical cancer research : CR, 2014, Apr-10, Volume: 33

    Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cytosine; DNA Methylation; Female; Hepatectomy; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Retrospective Studies; Treatment Outcome

2014
TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells.
    Biochimica et biophysica acta, 2014, Volume: 1842, Issue:7

    Topics: 5-Methylcytosine; Adult; Case-Control Studies; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression; Humans; Leukocytes, Mononuclear; Male; Multiple Sclerosis; Promoter Regions, Genetic; Proto-Oncogene Proteins

2014
Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, May-13, Volume: 111, Issue:19

    Topics: 5-Methylcytosine; Adaptation, Physiological; Animals; Behavior, Animal; Conditioning, Psychological; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Extinction, Psychological; Fear; Genome-Wide Association Study; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neocortex; Neurons; Proto-Oncogene Proteins

2014
Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples.
    Environmental health perspectives, 2014, Volume: 122, Issue:9

    Topics: 5-Methylcytosine; Aged; Arsenic; Cadmium; Cross-Sectional Studies; Cytosine; DNA; DNA Methylation; Environmental Exposure; Epigenesis, Genetic; Female; Humans; Longitudinal Studies; Male; Metals; Middle Aged

2014
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
    Journal of biomedical nanotechnology, 2014, Volume: 10, Issue:7

    Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cytosine; Dioxygenases; DNA-Activated Protein Kinase; DNA-Binding Proteins; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Gastric Mucosa; Humans; Ki-67 Antigen; Mice; Mixed Function Oxygenases; Nuclear Proteins; Phosphorylation; Phosphoserine; Polycomb Repressive Complex 2; Protein Binding; Proto-Oncogene Proteins; Signal Transduction; Stomach Neoplasms; Tissue Array Analysis; Tumor Suppressor Protein p53; Up-Regulation

2014
PRIMA-1 selectively induces global DNA demethylation in p53 mutant-type thyroid cancer cells.
    Journal of biomedical nanotechnology, 2014, Volume: 10, Issue:7

    Topics: 5-Methylcytosine; Aza Compounds; bcl-2-Associated X Protein; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Mixed Function Oxygenases; Models, Biological; Mutation; Nuclear Proteins; Proto-Oncogene Proteins; Thyroid Neoplasms; Tumor Suppressor Protein p53; Up-Regulation

2014
Programming and inheritance of parental DNA methylomes in mammals.
    Cell, 2014, May-08, Volume: 157, Issue:4

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Development; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Promoter Regions, Genetic

2014
Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2.
    Molecular cell, 2014, Jun-05, Volume: 54, Issue:5

    Topics: 5-Methylcytosine; Binding Sites; Crystallography, X-Ray; Cytosine; Humans; Hydrogen Bonding; Models, Molecular; Oligonucleotides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Ubiquitin-Protein Ligases

2014
TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
    Cell reports, 2014, Jun-12, Volume: 7, Issue:5

    Topics: 5-Methylcytosine; Cell Hypoxia; Cell Line, Tumor; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mixed Function Oxygenases; Neuroblastoma; Proto-Oncogene Proteins; Response Elements; Up-Regulation

2014
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
    Nature chemical biology, 2014, Volume: 10, Issue:7

    Topics: 5-Methylcytosine; Animals; Base Sequence; Carbon Isotopes; Chromatin Assembly and Disassembly; Chromatography, Liquid; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression; Mice; Molecular Sequence Data; Oxidation-Reduction; Pentoxyl; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine; Transcription Factors

2014
Deamination features of 5-hydroxymethylcytosine, a radical and enzymatic DNA oxidation product.
    Journal of molecular modeling, 2014, Volume: 20, Issue:6

    Topics: 5-Methylcytosine; Computer Simulation; Cytosine; Deamination; DNA; Energy Transfer; Hydrolysis; Models, Chemical; Models, Molecular; Molecular Structure; Oxidation-Reduction; Quantum Theory; Structure-Activity Relationship; Water

2014
TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.
    Nucleic acids research, 2014, Volume: 42, Issue:11

    Topics: 5-Methylcytosine; Catalytic Domain; Cell Differentiation; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; HEK293 Cells; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins; Transcription, Genetic

2014
High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome.
    Leukemia research, 2014, Volume: 38, Issue:8

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Bone Marrow; Cytosine; DNA; DNA Methylation; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Survival Analysis

2014
CRISPR/Cas9-mediated phage resistance is not impeded by the DNA modifications of phage T4.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: 5-Methylcytosine; Bacteriophage T4; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR-Associated Proteins; CRISPR-Cas Systems; Cytosine; DNA, Bacterial; Endonucleases; Escherichia coli; Streptococcus pyogenes

2014
Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma.
    Acta neuropathologica communications, 2014, Jun-03, Volume: 2

    Topics: 5-Methylcytosine; Age Factors; Brain Stem Neoplasms; Child; Child, Preschool; Cytosine; DNA Methylation; Epigenomics; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Statistics, Nonparametric; Tissue Array Analysis

2014
Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA.
    Nucleic acids research, 2014, Volume: 42, Issue:12

    Topics: 5-Methylcytosine; CCAAT-Enhancer-Binding Proteins; Cytosine; Dimerization; DNA; DNA Cleavage; DNA Restriction Enzymes; Endodeoxyribonucleases; Models, Molecular; Nuclear Proteins; Protein Structure, Tertiary; Ubiquitin-Protein Ligases

2014
Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication.
    Scientific reports, 2014, Jun-09, Volume: 4

    Topics: 5-Methylcytosine; Base Pairing; Cell Proliferation; Cytosine; DNA; DNA Mismatch Repair; DNA Replication; Epigenesis, Genetic; Guanine; Humans; Thymine DNA Glycosylase

2014
Distinct global DNA methylation status in B-cell lymphomas: immunohistochemical study of 5-methylcytosine and 5-hydroxymethylcytosine.
    Journal of clinical and experimental hematopathology : JCEH, 2014, Volume: 54, Issue:1

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Humans; Immunohistochemistry; Lymphoma, B-Cell; Male; Middle Aged; Young Adult

2014
Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.
    Genome biology, 2014, Jun-23, Volume: 15, Issue:6

    Topics: 5-Methylcytosine; Cell Differentiation; Cell Line, Tumor; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sequence Analysis, DNA

2014
Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial.
    Annals of hematology, 2014, Volume: 93, Issue:8

    Topics: 5-Methylcytosine; Adolescent; Adult; Animals; Chlorocebus aethiops; Clinical Trials as Topic; COS Cells; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA-Binding Proteins; Female; Gene Expression Regulation, Leukemic; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Multicenter Studies as Topic; Mutation; Neoplasm Proteins; Prognosis; Prospective Studies; Proto-Oncogene Proteins; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Transfection; Young Adult

2014
Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth.
    Genes to cells : devoted to molecular & cellular mechanisms, 2014, Volume: 19, Issue:8

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Female; Genome; Mice, Inbred C57BL; Oocytes; Proto-Oncogene Proteins; Zygote

2014
5-Hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: a biological link to a new epigenetic modification in benign tumors.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:11

    Topics: 5-Methylcytosine; Adult; Cell Proliferation; Cytosine; Epigenesis, Genetic; Female; Humans; Leiomyoma; Middle Aged; Uterine Neoplasms

2014
Comparison of the absolute level of epigenetic marks 5-methylcytosine, 5-hydroxymethylcytosine, and 5-hydroxymethyluracil between human leukocytes and sperm.
    Biology of reproduction, 2014, Volume: 91, Issue:3

    Topics: 5-Methylcytosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Leukocytes; Male; Pentoxyl; Poland; Spectrometry, Mass, Electrospray Ionization; Spermatozoa; Tandem Mass Spectrometry; Thymidine; Up-Regulation

2014
Epigenetically modified nucleotides in chronic heroin and cocaine treated mice.
    Toxicology letters, 2014, Sep-17, Volume: 229, Issue:3

    Topics: 5-Methylcytosine; Animals; Brain; Brain Chemistry; Cocaine; Cytosine; Dose-Response Relationship, Drug; Epigenesis, Genetic; Heroin; Liver; Male; Mice; Mice, Inbred C57BL

2014
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Aug-12, Volume: 111, Issue:32

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Lineage; Cytosine; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Developmental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins; T-Lymphocyte Subsets; T-Lymphocytes

2014
Spectroscopic quantification of 5-hydroxymethylcytosine in genomic DNA.
    Analytical chemistry, 2014, Aug-19, Volume: 86, Issue:16

    Topics: 5-Methylcytosine; Animals; Base Sequence; Cytosine; DNA; DNA Methylation; DNA, Fungal; Equipment Design; Genomics; Limit of Detection; Mice; Molecular Sequence Data; Saccharomyces cerevisiae; Spectrometry, Fluorescence

2014
Tet-mediated formation of 5-hydroxymethylcytosine in RNA.
    Journal of the American Chemical Society, 2014, Aug-20, Volume: 136, Issue:33

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; HEK293 Cells; Humans; Mice; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA

2014
5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2015, Volume: 28, Issue:2

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cytosine; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Nevus; Sentinel Lymph Node Biopsy; Skin Neoplasms

2015
Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.
    Molecular cell, 2014, Aug-21, Volume: 55, Issue:4

    Topics: 5-Methylcytosine; Basic Helix-Loop-Helix Transcription Factors; Cell Cycle Proteins; Cell Line, Tumor; CpG Islands; Cytosine; DNA Methylation; DNA Repair; Gene Expression Regulation, Neoplastic; Genome, Human; HEK293 Cells; Humans; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Promoter Regions, Genetic; RNA, Long Noncoding; Thymine DNA Glycosylase

2014
5-Hydroxymethylcytosine is a useful marker to differentiate between dermatofibrosarcoma protuberans and dermatofibroma.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2016, Volume: 30, Issue:1

    Topics: 5-Methylcytosine; Biomarkers, Tumor; Cytosine; Dermatofibrosarcoma; Humans; Skin Neoplasms

2016
Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2015, Volume: 18, Issue:3

    Topics: 5-Methylcytosine; Aged; Chromatography, Liquid; Cytosine; Deoxycytidine; Dioxygenases; DNA-Binding Proteins; Enzymes; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mixed Function Oxygenases; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins; Stomach Neoplasms; Tandem Mass Spectrometry

2015
Insights into DNA hydroxymethylation in the honeybee from in-depth analyses of TET dioxygenase.
    Open biology, 2014, Volume: 4, Issue:8

    Topics: 5-Methylcytosine; Alternative Splicing; Amino Acid Sequence; Animals; Bees; Brain; Catalytic Domain; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Insect Proteins; Male; Molecular Sequence Data; Organ Specificity; Ovary; Sequence Alignment; Testis; Transgenes

2014
5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation.
    BMC genomics, 2014, Aug-09, Volume: 15

    Topics: 5-Methylcytosine; Animals; Binding Sites; Cell Lineage; Cytosine; Embryonic Stem Cells; Enhancer Elements, Genetic; Epigenesis, Genetic; Histones; Mice; RNA, Messenger; Transcription Factors

2014
Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.
    Molecular carcinogenesis, 2015, Volume: 54, Issue:11

    Topics: 5-Methylcytosine; Animals; Aristolochic Acids; Carcinogenesis; Carcinogens; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Liver; Mutation; Neoplasms; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Rats, Transgenic

2015
Application of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Cell Differentiation; Cells, Cultured; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Molecular Sequence Data; Myoblasts, Cardiac; Neural Stem Cells; Pluripotent Stem Cells; Sequence Analysis, DNA

2014
5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Embryonic Stem Cells; Enzyme Inhibitors; Gene Expression Regulation; Gene Knockout Techniques; Genomic Imprinting; Germ Cells; Humans; Mice; Neurons; NIH 3T3 Cells; Sequence Analysis, DNA; Transcription, Genetic

2014
Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease.
    Neuropathology and applied neurobiology, 2015, Volume: 41, Issue:4

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cytosine; DNA Methylation; Entorhinal Cortex; Epigenesis, Genetic; Female; Humans; Male; Middle Aged

2015
Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; Gene Expression Regulation; Gene-Environment Interaction; Hippocampus; Learning; Mice

2014
Hydroxymethylated cytosines are associated with elevated C to G transversion rates.
    PLoS genetics, 2014, Volume: 10, Issue:9

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; Humans; Mice; Mutation

2014
JBP1-seq: a fast and efficient method for genome-wide profiling of 5hmC.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Brain; Cytosine; DNA Methylation; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Magnetic Phenomena; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Sequence Analysis, DNA

2014
RRHP: a tag-based approach for 5-hydroxymethylcytosine mapping at single-site resolution.
    Genome biology, 2014, Sep-24, Volume: 15, Issue:9

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Gene Library; High-Throughput Nucleotide Sequencing; Humans; Liver Neoplasms; Molecular Sequence Annotation; Sequence Analysis, DNA

2014
[Simultaneous analysis of global DNA methylation and hydroxymethylation in tissues by liquid chromatography-tandem mass spectrometry].
    Se pu = Chinese journal of chromatography, 2014, Volume: 32, Issue:7

    Topics: 5-Methylcytosine; Animals; Chromatography, Liquid; Cytidine; Cytosine; Deoxyguanosine; DNA; DNA Methylation; Rats; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
Exposure to arsenic via drinking water induces 5-hydroxymethylcytosine alteration in rat.
    The Science of the total environment, 2014, Nov-01, Volume: 497-498

    Topics: 5-Methylcytosine; Animals; Arsenic; Cytosine; DNA Methylation; Drinking Water; Epigenesis, Genetic; Gene Expression Regulation; Male; Rats; Rats, Sprague-Dawley; Water Pollutants, Chemical

2014
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation.
    Molecular cell, 2014, Oct-23, Volume: 56, Issue:2

    Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Differentiation; Cell Line; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Mice; Mice, Knockout; Oxidation-Reduction; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sequence Analysis, DNA; Transcriptome; Zinc Fingers

2014
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
    Cell reports, 2014, Oct-09, Volume: 9, Issue:1

    Topics: 5-Methylcytosine; Acetylation; Brain Neoplasms; Carcinogenesis; Chromatin; Cytosine; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glioblastoma; HEK293 Cells; Histones; Humans; Methylation; Mixed Function Oxygenases; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins; Repressor Proteins; Transcription Factors; Transcription, Genetic

2014
Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.
    Translational psychiatry, 2014, Oct-07, Volume: 4

    Topics: 5-Methylcytosine; Adolescent; Autistic Disorder; Cerebellum; Cytosine; Female; Gene Expression; Homeodomain Proteins; Humans; Male; Methyl-CpG-Binding Protein 2; Nerve Tissue Proteins; Promoter Regions, Genetic

2014
Trace analysis of methylated and hydroxymethylated cytosines in DNA by isotope-dilution LC-MS/MS: first evidence of DNA methylation in Caenorhabditis elegans.
    The Biochemical journal, 2015, Jan-01, Volume: 465, Issue:1

    Topics: 5-Methylcytosine; Animals; Azacitidine; Cadmium; Caenorhabditis elegans; Chromatography, Liquid; Cytosine; Decitabine; Deoxycytidine; DNA; DNA Methylation; Isotope Labeling; Online Systems; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry

2015
White matter tract and glial-associated changes in 5-hydroxymethylcytosine following chronic cerebral hypoperfusion.
    Brain research, 2014, Dec-10, Volume: 1592

    Topics: 5-Methylcytosine; Animals; Autophagy-Related Proteins; Calcium-Binding Proteins; Cerebrovascular Disorders; Chronic Disease; Corpus Callosum; Cytosine; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Gray Matter; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Microfilament Proteins; Neural Stem Cells; Neuroglia; Oxidative Stress; Pilot Projects; Proto-Oncogene Proteins; Random Allocation; White Matter

2014
A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels.
    Veterinary research, 2014, Oct-23, Volume: 45

    Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Birnaviridae Infections; Bursa of Fabricius; Chickens; Cytosine; DNA Methylation; Genome; Infectious bursal disease virus; Poultry Diseases

2014
Loss of expression of 5-hydroxymethylcytosine in CD30-positive cutaneous lymphoproliferative disorders.
    Journal of cutaneous pathology, 2014, Volume: 41, Issue:12

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Case-Control Studies; Child; Cytosine; Epigenesis, Genetic; Female; Humans; Immunohistochemistry; Ki-1 Antigen; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphomatoid Papulosis; Male; Middle Aged; Retrospective Studies; Skin Neoplasms; Young Adult

2014
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.
    Nucleic acids research, 2014, Dec-01, Volume: 42, Issue:21

    Topics: 5-Methylcytosine; Animals; Catalytic Domain; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Cleavage; Endodeoxyribonucleases; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Recombination, Genetic; Tumor Suppressor p53-Binding Protein 1

2014
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing.
    Nature biotechnology, 2014, Volume: 32, Issue:12

    Topics: 5-Methylcytosine; Animals; Base Sequence; Chromatin; Cytosine; DNA Methylation; DNA Repair; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Methyltransferases; Mice; Thymine DNA Glycosylase

2014
HTS for SMFS, organohalide respiration, new epigenetic mark, and a decoy receptor.
    Chemistry & biology, 2014, Oct-23, Volume: 21, Issue:10

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Epigenomics; High-Throughput Screening Assays; Hydrocarbons, Halogenated; Hydrolases; Microfluidic Analytical Techniques; Oligonucleotide Array Sequence Analysis; Tumor Necrosis Factor Decoy Receptors

2014
5-hydroxymethylcytosine is not present in appreciable quantities in Arabidopsis DNA.
    G3 (Bethesda, Md.), 2014, Nov-06, Volume: 5, Issue:1

    Topics: 5-Methylcytosine; Arabidopsis; Chromatography, Thin Layer; Cytosine; DNA, Plant; Enzyme-Linked Immunosorbent Assay; Immunoprecipitation; Mass Spectrometry; Real-Time Polymerase Chain Reaction

2014
DNA modifications: Another stable base in DNA.
    Nature chemistry, 2014, Volume: 6, Issue:12

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Humans

2014
5-Hydroxymethylcytosine is a predominantly stable DNA modification.
    Nature chemistry, 2014, Volume: 6, Issue:12

    Topics: 5-Methylcytosine; Animals; Cell Cycle; Cell Proliferation; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; MCF-7 Cells; Mice; Mice, Inbred C57BL

2014
Single base resolution analysis of 5-methylcytosine and 5-hydroxymethylcytosine by RRBS and TAB-RRBS.
    Methods in molecular biology (Clifton, N.J.), 2015, Volume: 1238

    Topics: 5-Methylcytosine; Cytosine; Deoxyribonuclease HpaII; Glycosylation; Humans; Oxidation-Reduction; Sequence Analysis, DNA; Sulfites

2015
Quantification of 5-methylcytosine, 5-hydroxymethylcytosine and 5-carboxylcytosine from the blood of cancer patients by an enzyme-based immunoassay.
    Analytica chimica acta, 2014, Dec-10, Volume: 852

    Topics: 5-Methylcytosine; Cytosine; DNA; Epigenesis, Genetic; Humans; Immunoenzyme Techniques; Limit of Detection; Neoplasms

2014
Genomics special issue on 5-hydroxymethylation.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Humans

2014
Label free detection of 5'hydroxymethylcytosine within CpG islands using optical sensors.
    Biosensors & bioelectronics, 2015, Mar-15, Volume: 65

    Topics: 5-Methylcytosine; Animals; Antibodies, Immobilized; Biosensing Techniques; CpG Islands; Cytosine; DNA Methylation; Optics and Photonics

2015
5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:7

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cytosine; Female; Fetus; Gestational Age; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Phosphopyruvate Hydratase; Young Adult

2015
Role of 5-hydroxymethylcytosine level in diagnosis and prognosis prediction of intrahepatic cholangiocarcinoma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:4

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Cytosine; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis

2015
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
    Cell reports, 2014, Dec-11, Volume: 9, Issue:5

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Mice, Knockout; Mutation; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Sequence Analysis, DNA; WT1 Proteins

2014
Chemical display of pyrimidine bases flipped out by modification-dependent restriction endonucleases of MspJI and PvuRts1I families.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: 5-Methylcytosine; Bacterial Proteins; Catalytic Domain; Cytosine; DNA Restriction Enzymes; DNA, Bacterial; Models, Molecular; Protein Binding

2014
Chromosome hydroxymethylation patterns in human zygotes and cleavage-stage embryos.
    Reproduction (Cambridge, England), 2015, Volume: 149, Issue:3

    Topics: 5-Methylcytosine; Blastocyst; Cytosine; DNA Methylation; Female; Genome, Human; Humans; Zygote

2015
Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma.
    Genome biology, 2014, Dec-03, Volume: 15, Issue:12

    Topics: 5-Methylcytosine; Activating Transcription Factors; Carcinoma, Hepatocellular; Cell Line, Tumor; Comparative Genomic Hybridization; Cytosine; DNA Methylation; Epigenesis, Genetic; Extracellular Matrix Proteins; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Molecular Sequence Data; Promoter Regions, Genetic; Sequence Analysis, DNA; T-Box Domain Proteins

2014
DNA cytosine methylation and hydroxymethylation at the borders.
    Epigenomics, 2014, Volume: 6, Issue:6

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Promoter Regions, Genetic

2014
Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.
    eLife, 2014, Dec-29, Volume: 3

    Topics: 5-Methylcytosine; Animals; CD4-Positive T-Lymphocytes; Culture Media; Cytosine; DNA Methylation; Epigenesis, Genetic; Immunotherapy; Mice; Mice, Inbred C57BL; Peptides; Programmed Cell Death 1 Receptor; Promoter Regions, Genetic

2014
Detection of human urinary 5-hydroxymethylcytosine by stable isotope dilution HPLC-MS/MS analysis.
    Analytical chemistry, 2015, Feb-03, Volume: 87, Issue:3

    Topics: 5-Methylcytosine; Adult; Bicarbonates; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Female; Humans; Indicator Dilution Techniques; Isotopes; Male; Solid Phase Extraction; Tandem Mass Spectrometry; Young Adult

2015
Programmable sensors of 5-hydroxymethylcytosine.
    Journal of the American Chemical Society, 2015, Jan-14, Volume: 137, Issue:1

    Topics: 5-Methylcytosine; Cytosine; DNA; Epigenesis, Genetic; Genetic Engineering; Models, Molecular; Molecular Structure; Tandem Repeat Sequences; Trans-Activators

2015
Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice.
    International journal of radiation biology, 2015, Volume: 91, Issue:5

    Topics: 5-Methylcytosine; Animals; Chromosomal Instability; Cytosine; DNA Methylation; Dose-Response Relationship, Radiation; Epigenesis, Genetic; Hematopoietic Stem Cells; Inflammation; Interleukin-1beta; Interleukin-6; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred CBA; NF-kappa B; Oxidative Stress; Time Factors; Titanium; Tumor Necrosis Factor-alpha

2015
Ethanol deregulates Mecp2/MeCP2 in differentiating neural stem cells via interplay between 5-methylcytosine and 5-hydroxymethylcytosine at the Mecp2 regulatory elements.
    Experimental neurology, 2015, Volume: 265

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cells, Cultured; Cytosine; Ethanol; Methyl-CpG-Binding Protein 2; Mice; Neural Stem Cells; Regulatory Elements, Transcriptional

2015
Understanding the structural and dynamic consequences of DNA epigenetic modifications: computational insights into cytosine methylation and hydroxymethylation.
    Epigenetics, 2014, Volume: 9, Issue:12

    Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Models, Molecular; Molecular Dynamics Simulation; Nucleic Acid Conformation; Protein Binding

2014
Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
    Biochemistry, 2015, Feb-10, Volume: 54, Issue:5

    Topics: 5-Methylcytosine; Cytosine; DNA; Oligonucleotides; Thymine DNA Glycosylase

2015
A sensitive approach to map genome-wide 5-hydroxymethylcytosine and 5-formylcytosine at single-base resolution.
    Molecular cell, 2015, Feb-19, Volume: 57, Issue:4

    Topics: 5-Methylcytosine; Animals; Base Sequence; Cytosine; DNA Restriction Enzymes; Embryonic Stem Cells; Epigenesis, Genetic; Gene Library; Histones; Mice; Restriction Mapping

2015
Spatial distribution of 5-hydroxymethyl cytosine in rat brain and temporal distribution in striatum.
    Neurochemical research, 2015, Volume: 40, Issue:4

    Topics: 5-Methylcytosine; Animals; Brain; Corpus Striatum; Cytosine; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley

2015
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.
    Genome biology, 2015, Feb-04, Volume: 16

    Topics: 5-Methylcytosine; Adaptation, Biological; Animals; Cell Culture Techniques; Cells, Cultured; Cellular Reprogramming; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Genetic Loci; Mammals; Mice, Inbred C57BL; Transcriptome

2015
Analysis of nanopore data using hidden Markov models.
    Bioinformatics (Oxford, England), 2015, Jun-15, Volume: 31, Issue:12

    Topics: 5-Methylcytosine; Algorithms; Cytosine; DNA Methylation; Epigenomics; High-Throughput Nucleotide Sequencing; Humans; Markov Chains; Nanopores; Sequence Alignment; Sequence Analysis, DNA

2015
The Tet1 and histone methylation expression pattern in dairy goat testis.
    Theriogenology, 2015, Apr-15, Volume: 83, Issue:7

    Topics: 5-Methylcytosine; Animals; Cells, Cultured; Cytosine; Dairying; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression; Goats; Histones; Male; Methylation; Spermatogenesis; Spermatogonia; Testis

2015
Formation and abundance of 5-hydroxymethylcytosine in RNA.
    Chembiochem : a European journal of chemical biology, 2015, Mar-23, Volume: 16, Issue:5

    Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; Mice; Mice, Inbred C57BL; Molecular Structure; Oxidation-Reduction; RNA; Tandem Mass Spectrometry

2015
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways.
    Journal of applied toxicology : JAT, 2015, Volume: 35, Issue:12

    Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Cytosine; Deoxyguanosine; DNA Methylation; Fatty Liver; Gene Expression Regulation, Enzymologic; Liver; Male; Methionine; Mice, Inbred C57BL; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine

2015
Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation.
    EMBO reports, 2015, Volume: 16, Issue:5

    Topics: 5-Methylcytosine; Animals; Cell Division; Cell Line; Cells, Cultured; Chromosomal Instability; Chromosomal Proteins, Non-Histone; Chromosome Aberrations; Chromosome Segregation; Cytosine; Dioxygenases; DNA Methylation; DNA Replication; DNA-Binding Proteins; Embryo, Mammalian; Epigenesis, Genetic; Female; Gene Knockout Techniques; Histones; Male; Mice; Protein Transport; Proto-Oncogene Proteins; Repressor Proteins; Zygote

2015
5-Hydroxymethylcytosine and 5-formylcytosine containing deoxyoligonucleotides: facile syntheses and melting temperature studies.
    Bioorganic & medicinal chemistry letters, 2015, Mar-15, Volume: 25, Issue:6

    Topics: 5-Methylcytosine; Catalysis; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Copper; Cytosine; Oligonucleotides; Oxidation-Reduction; Transition Temperature

2015
Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).
    PloS one, 2015, Volume: 10, Issue:2

    Topics: 5-Methylcytosine; Adult; Cerebellum; Cytosine; DNA; DNA Methylation; Humans; Male; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Reproducibility of Results; Sulfites

2015
Neighboring Genes Show Correlated Evolution in Gene Expression.
    Molecular biology and evolution, 2015, Volume: 32, Issue:7

    Topics: 5-Methylcytosine; Animals; Cerebellum; Chromosomes, Human, Pair 2; Computer Simulation; Cytosine; Evolution, Molecular; Female; Gene Expression Regulation; Genes; Histones; Humans; Lysine; Male; Methylation; Monte Carlo Method; Organ Specificity; Primates; Statistics, Nonparametric; Up-Regulation

2015
Hippocampal increase of 5-hmC in the glucocorticoid receptor gene following acute stress.
    Behavioural brain research, 2015, Jun-01, Volume: 286

    Topics: 3' Untranslated Regions; 5-Methylcytosine; Acute Disease; Animals; Cytosine; Disease Models, Animal; Hippocampus; Mice; Neurons; Random Allocation; Receptors, Glucocorticoid; Restraint, Physical; Stress, Psychological

2015
Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia.
    Oncotarget, 2015, Mar-30, Volume: 6, Issue:9

    Topics: 5-Methylcytosine; Case-Control Studies; Cell Shape; Cytosine; DNA; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomic Imprinting; Humans; Infertility, Male; Male; Phenotype; Sperm Motility; Spermatogenesis; Spermatozoa

2015
Role of Tet1 and 5-hydroxymethylcytosine in cocaine action.
    Nature neuroscience, 2015, Volume: 18, Issue:4

    Topics: 5-Methylcytosine; Animals; Behavior, Animal; Cocaine; Cytosine; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Gene Expression; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Proto-Oncogene Proteins

2015
C/EBPβ (CEBPB) protein binding to the C/EBP|CRE DNA 8-mer TTGC|GTCA is inhibited by 5hmC and enhanced by 5mC, 5fC, and 5caC in the CG dinucleotide.
    Biochimica et biophysica acta, 2015, Volume: 1849, Issue:6

    Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Crystallography, X-Ray; Cytosine; Cytosine Nucleotides; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Nucleotide Motifs; Transcription Factors

2015
Cocaine shapes chromatin landscapes via Tet1.
    Nature neuroscience, 2015, Volume: 18, Issue:4

    Topics: 5-Methylcytosine; Animals; Cocaine; Cytosine; DNA-Binding Proteins; Gene Expression; Male; Nucleus Accumbens; Proto-Oncogene Proteins

2015
Post-conversion targeted capture of modified cytosines in mammalian and plant genomes.
    Nucleic acids research, 2015, Jul-13, Volume: 43, Issue:12

    Topics: 5-Methylcytosine; Alleles; Animals; Cell Line; Cytosine; DNA Methylation; Genome, Plant; Genomics; High-Throughput Nucleotide Sequencing; Humans; Mice; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Sulfites

2015
Genome-wide analysis of 5-hmC in the peripheral blood of systemic lupus erythematosus patients using an hMeDIP-chip.
    International journal of molecular medicine, 2015, Volume: 35, Issue:5

    Topics: 5-Methylcytosine; Case-Control Studies; Chromosome Mapping; Computational Biology; CpG Islands; Cytosine; DNA Methylation; Gene Expression Profiling; Gene Ontology; Genome-Wide Association Study; Humans; Lupus Erythematosus, Systemic; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Signal Transduction

2015
Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer.
    Archives of gynecology and obstetrics, 2015, Volume: 292, Issue:4

    Topics: 5-Methylcytosine; Adult; Aged; Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Case-Control Studies; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Middle Aged; Neoplasm Grading; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Prognosis; Proto-Oncogene Proteins; Survival Analysis

2015
TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.
    Cell reports, 2015, Apr-14, Volume: 11, Issue:2

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Mice; Neurons; Proto-Oncogene Proteins; Repressor Proteins; Retina; Transcriptional Activation

2015
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer.
    Genome biology, 2015, Apr-01, Volume: 16

    Topics: 5-Methylcytosine; Cell Proliferation; Colonic Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Proto-Oncogene Proteins

2015
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
    Immunity, 2015, Apr-21, Volume: 42, Issue:4

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytokines; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; E1A-Associated p300 Protein; Epigenesis, Genetic; Gene Expression Regulation; Genome; Humans; Mice; Mice, Transgenic; Proto-Oncogene Proteins; STAT4 Transcription Factor; T-Box Domain Proteins; Th1 Cells; Th17 Cells

2015
TET1 is a tumor suppressor of hematopoietic malignancy.
    Nature immunology, 2015, Volume: 16, Issue:6

    Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Cell Differentiation; Cell Lineage; Chromosomal Instability; Cytosine; DNA Methylation; DNA Repair; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Exome; Gene Expression Profiling; Humans; Lymphoma, B-Cell; Mice; Mutation; Proto-Oncogene Proteins; Tumor Suppressor Proteins

2015
Regulation of telomeric i-motif stability by 5-methylcytosine and 5-hydroxymethylcytosine modification.
    Organic & biomolecular chemistry, 2015, May-28, Volume: 13, Issue:20

    Topics: 5-Methylcytosine; Circular Dichroism; Cytosine; DNA; DNA Methylation; Humans; Nucleotide Motifs; Protein Structure, Tertiary; Telomere; Temperature

2015
The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells.
    Scientific reports, 2015, Apr-22, Volume: 5

    Topics: 5-Methylcytosine; Azacitidine; Catalytic Domain; Chromatography, High Pressure Liquid; CpG Islands; Cytosine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; HL-60 Cells; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; MCF-7 Cells; Microscopy, Fluorescence; Mixed Function Oxygenases; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Fluorescence; Tandem Mass Spectrometry

2015
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
    Nature cell biology, 2015, Volume: 17, Issue:5

    Topics: 5-Methylcytosine; Acetylation; Animals; Cell Differentiation; Cell Lineage; Cells, Cultured; Chromatin Assembly and Disassembly; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Genotype; Histones; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Nanog Homeobox Protein; Neurogenesis; Octamer Transcription Factor-3; Phenotype; Proto-Oncogene Proteins; RNA Interference; Signal Transduction; Sirtuins; SOXB1 Transcription Factors; Teratoma; Transfection

2015
Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.
    Epigenetics, 2015, Volume: 10, Issue:5

    Topics: 5-Methylcytosine; Animals; Animals, Newborn; Antineoplastic Agents; Ascorbic Acid; Azacitidine; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cytosine; Decitabine; Dioxygenases; DNA Methylation; Erythroid Cells; gamma-Globins; Histone Demethylases; Humans; Hydroxyurea; Liver; Papio anubis; Promoter Regions, Genetic; Tranylcypromine

2015
Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study.
    Epigenetics, 2015, Volume: 10, Issue:7

    Topics: 5-Methylcytosine; Adolescent; Adult; Air Pollution; Beijing; Cytosine; Environmental Exposure; Female; Humans; Male; Middle Aged; Particulate Matter; Young Adult

2015
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
    The international journal of biochemistry & cell biology, 2015, Volume: 67

    Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Histones; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Oocytes; Ovary; Protein Isoforms; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Vinyl Compounds

2015
Direct conjugation of peptides and 5-hydroxymethylcytosine in DNA.
    Bioconjugate chemistry, 2015, Jun-17, Volume: 26, Issue:6

    Topics: 5-Methylcytosine; Amino Acid Sequence; Cytosine; DNA; DNA-Cytosine Methylases; Models, Molecular; Peptides; Spiroplasma

2015
Oxygen concentration controls epigenetic effects in models of familial paraganglioma.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: 5-Methylcytosine; Animals; Case-Control Studies; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Gene Knockdown Techniques; HEK293 Cells; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids; Mice, Inbred C57BL; Models, Biological; Oxygen; Paraganglioma; Succinate Dehydrogenase; Succinic Acid

2015
Structure-guided sequence specificity engineering of the modification-dependent restriction endonuclease LpnPI.
    Nucleic acids research, 2015, Jul-13, Volume: 43, Issue:12

    Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA; DNA Restriction Enzymes; DNA-Binding Proteins; Models, Molecular; Protein Binding; Protein Engineering; Protein Structure, Tertiary

2015
Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:11

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cytosine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epigenesis, Genetic; Female; Glioblastoma; Histones; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Loss of Heterozygosity; Male; Middle Aged; Mutation; Prognosis; Promoter Regions, Genetic; Tumor Suppressor Proteins

2015
Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood.
    Epigenetics, 2015, Volume: 10, Issue:7

    Topics: 5-Methylcytosine; Cell Line; CpG Islands; Cytosine; DNA Methylation; Environmental Exposure; Fetal Blood; Human Embryonic Stem Cells; Humans; Lead; Mexico; Sequence Analysis, DNA; Sex Factors; Umbilical Cord

2015
Cell Fate by SIRT6 and TETs.
    Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:14

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins; Sirtuins; Transcription Factors

2015
Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth.
    Epigenetics, 2015, Volume: 10, Issue:8

    Topics: 5-Methylcytosine; Birth Weight; Cyclin-Dependent Kinase Inhibitor p57; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Placenta; Pregnancy

2015
TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma.
    Oncotarget, 2015, Sep-15, Volume: 6, Issue:27

    Topics: 5-Methylcytosine; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Cell Survival; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Markers; Humans; Immunohistochemistry; Intestinal Mucosa; Kaplan-Meier Estimate; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prognosis; Proto-Oncogene Proteins; RNA, Messenger; Sequence Analysis, DNA

2015
5-Formylcytosine can be a stable DNA modification in mammals.
    Nature chemical biology, 2015, Volume: 11, Issue:8

    Topics: 5-Methylcytosine; Aging; Animals; Animals, Newborn; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Developmental; Half-Life; Liver; Mice; Mice, Inbred C57BL; Myocardium

2015
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
    Nature, 2015, Jul-30, Volume: 523, Issue:7562

    Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA Methylation; DNA Repair; Epigenesis, Genetic; Hydrogen Bonding; Kinetics; RNA Polymerase II; Saccharomyces cerevisiae; Substrate Specificity; Templates, Genetic; Thymine DNA Glycosylase; Transcription Elongation, Genetic

2015
MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells.
    Nucleic acids research, 2015, Sep-18, Volume: 43, Issue:16

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cells, Cultured; Cytosine; Dioxygenases; DNA-Binding Proteins; Ectoderm; Embryoid Bodies; Endoderm; Epigenesis, Genetic; HEK293 Cells; Humans; Left-Right Determination Factors; Mesoderm; Mice; MicroRNAs; Mouse Embryonic Stem Cells; Proto-Oncogene Proteins; Thymine DNA Glycosylase

2015
5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme.
    Oncotarget, 2015, Sep-15, Volume: 6, Issue:27

    Topics: 5-Methylcytosine; Amino Acid Sequence; Catalytic Domain; Cytosine; DNA Damage; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glutathione Transferase; HEK293 Cells; Humans; Immunoprecipitation; Mixed Function Oxygenases; Molecular Sequence Data; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Recombinant Proteins; Sequence Homology, Amino Acid

2015
Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.
    Angewandte Chemie (International ed. in English), 2015, Oct-12, Volume: 54, Issue:42

    Topics: 5-Methylcytosine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Animals; Brain; Child; Child, Preschool; Cytosine; Humans; Infant; Mice; Middle Aged; Young Adult

2015
A Cell Electrofusion Chip for Somatic Cells Reprogramming.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Cytosine; DNA; DNA Methylation; Electroporation; Homeodomain Proteins; Karyotyping; Mice; Mice, Nude; Microfluidic Analytical Techniques; Mouse Embryonic Stem Cells; Nanog Homeobox Protein; NIH 3T3 Cells; Octamer Transcription Factor-3; Real-Time Polymerase Chain Reaction

2015
Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells.
    Epigenetics, 2015, Volume: 10, Issue:9

    Topics: 5-Methylcytosine; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Knockdown Techniques; HEK293 Cells; Humans; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Up-Regulation

2015
The dynamics of DNA methylation and hydroxymethylation during amelogenesis.
    Histochemistry and cell biology, 2015, Volume: 144, Issue:5

    Topics: 5-Methylcytosine; Amelogenesis; Animals; Cytosine; DNA Methylation; Incisor; Mandible; Mice; Mice, Inbred ICR

2015
Genome-Wide Mapping of 5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: 5-Methylcytosine; Adult; Cytosine; DNA Methylation; Epigenesis, Genetic; ErbB Receptors; Female; Genome-Wide Association Study; Genome, Human; Humans; Pilot Projects; Pre-Eclampsia; Pregnancy; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Signal Transduction

2015
Altering 5-hydroxymethylcytosine modification impacts ischemic brain injury.
    Human molecular genetics, 2015, Oct-15, Volume: 24, Issue:20

    Topics: 5-Methylcytosine; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Male; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reperfusion Injury

2015
Diagnostic utility of 5-hydroxymethylcytosine immunohistochemistry in melanocytic proliferations.
    Journal of cutaneous pathology, 2015, Volume: 42, Issue:11

    Topics: 5-Methylcytosine; Cytosine; Diagnosis, Differential; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; Melanocytes; Melanoma; Nevus, Pigmented; Skin Neoplasms; Tissue Array Analysis

2015
Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype.
    Breast cancer research and treatment, 2015, Volume: 153, Issue:1

    Topics: 5-Methylcytosine; Adult; Aged; Breast Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression; Humans; Immunohistochemistry; Middle Aged; Mixed Function Oxygenases; Neoplasm Grading; Neoplasm Staging; Prognosis; Protein Transport; Proto-Oncogene Proteins; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Survival Analysis; Young Adult

2015
Increased DNA methylation in the livers of patients with alcoholic hepatitis.
    Experimental and molecular pathology, 2015, Volume: 99, Issue:2

    Topics: 5-Methylcytosine; Biomarkers; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Hepatitis, Alcoholic; Hepatocytes; Humans; Immunoenzyme Techniques; Liver

2015
Genome-wide mapping of 5-hydroxymethylcytosine in three rice cultivars reveals its preferential localization in transcriptionally silent transposable element genes.
    Journal of experimental botany, 2015, Volume: 66, Issue:21

    Topics: 5-Methylcytosine; Chromatography, Liquid; Chromosome Mapping; Cytosine; DNA Transposable Elements; DNA, Plant; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Oryza; Sequence Analysis, DNA; Tandem Mass Spectrometry

2015
TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cytopenia of childhood.
    Leukemia research, 2015, Volume: 39, Issue:10

    Topics: 5-Methylcytosine; Adolescent; Case-Control Studies; Child; Child, Preschool; Cytosine; Dioxygenases; DNA Mutational Analysis; DNA-Binding Proteins; Female; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Humans; Infant; Male; MicroRNAs; Mutation; Myelodysplastic Syndromes; Polymerase Chain Reaction; Proto-Oncogene Proteins; Transcriptome

2015
A novel electrochemical immunosensor for the quantitative detection of 5-hydroxymethylcytosine in genomic DNA of breast cancer tissue.
    Chemical communications (Cambridge, England), 2015, Oct-07, Volume: 51, Issue:78

    Topics: 5-Methylcytosine; Biosensing Techniques; Breast Neoplasms; Cytosine; DNA, Neoplasm; Female; Humans

2015
Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis.
    Cancer research, 2015, Sep-15, Volume: 75, Issue:18

    Topics: 5-Methylcytosine; Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Chromatin Immunoprecipitation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Mixed Function Oxygenases; Molecular Sequence Data; Neoplasm Proteins; Neoplastic Stem Cells; p38 Mitogen-Activated Protein Kinases; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Retrospective Studies; Signal Transduction; Tumor Necrosis Factor-alpha

2015
Epigenetic regulation of human adipose-derived stem cells differentiation.
    Molecular and cellular biochemistry, 2015, Volume: 410, Issue:1-2

    Topics: 5-Methylcytosine; Adipose Tissue; Adult Stem Cells; Cell Differentiation; Cell Line; Cell Lineage; Cytosine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Homeodomain Proteins; Humans; Mixed Function Oxygenases; Nanog Homeobox Protein; Octamer Transcription Factor-3; Oligonucleotide Array Sequence Analysis; Osteoblasts; Osteogenesis; Phenotype; Pluripotent Stem Cells; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; SOXB1 Transcription Factors

2015
Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.
    Nucleic acids research, 2015, Dec-15, Volume: 43, Issue:22

    Topics: 5-Methylcytosine; Amino Acid Substitution; Catalytic Domain; Cytosine; Dioxygenases; DNA; Models, Molecular; Naegleria; Thymine

2015
Charting oxidized methylcytosines at base resolution.
    Nature structural & molecular biology, 2015, Volume: 22, Issue:9

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mammals; Oxidation-Reduction

2015
Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution.
    BMC genomics, 2015, Sep-03, Volume: 16

    Topics: 5-Methylcytosine; Adult; Base Pairing; Binding Sites; Chromosomes, Human; Cluster Analysis; Cytosine; Epigenesis, Genetic; Exons; Female; Gene Ontology; Genome, Human; Humans; Introns; Male; Prefrontal Cortex; Protein Processing, Post-Translational; Sequence Analysis, DNA; Sex Characteristics; X Chromosome Inactivation

2015
Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale.
    Nature methods, 2015, Volume: 12, Issue:11

    Topics: 5-Methylcytosine; Animals; Cell Line; CpG Islands; Cytosine; DNA Methylation; DNA Primers; Epigenomics; Gene Expression Regulation; Genome; Mice; Mice, Transgenic; Oligonucleotides; Oxygen; Polymerase Chain Reaction; Sequence Analysis, DNA; Stem Cells; Sulfites

2015
A Strategy for Accurate Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine at CpG Sites Within Gene Promoter.
    Journal of biomedical nanotechnology, 2015, Volume: 11, Issue:6

    Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA Methylation; Female; Humans; Oxidation-Reduction; Promoter Regions, Genetic; Reproducibility of Results; Sequence Analysis, DNA; Tumor Cells, Cultured

2015
Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine.
    Environmental science & technology, 2015, Oct-06, Volume: 49, Issue:19

    Topics: 5-Methylcytosine; Animals; Arsenites; Chromatography, Liquid; Cytosine; DNA; DNA-Binding Proteins; HEK293 Cells; Humans; Hydroxylation; Mice; Mouse Embryonic Stem Cells; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Zinc Fingers

2015
Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins.
    Medicine, 2015, Volume: 94, Issue:36

    Topics: 5-Methylcytosine; Adult; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Genetic Predisposition to Disease; Heat-Shock Proteins; Humans; Liver; Male; Middle Aged; Mitochondria, Liver; Mixed Function Oxygenases; Non-alcoholic Fatty Liver Disease; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Proto-Oncogene Proteins; Transcription Factors

2015
Stable 5-Hydroxymethylcytosine (5hmC) Acquisition Marks Gene Activation During Chondrogenic Differentiation.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, Volume: 31, Issue:3

    Topics: 5-Methylcytosine; Animals; Cartilage; Cell Differentiation; Chondrocytes; Chondrogenesis; Cytosine; DNA-Binding Proteins; DNA, Intergenic; Embryonic Development; Extremities; Gene Expression Regulation, Developmental; Mice; Proto-Oncogene Proteins; Stem Cells; Transcriptional Activation

2016
Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: results from two studies in Bangladesh.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:11

    Topics: 5-Methylcytosine; Adult; Aged; Arsenic; Bangladesh; Cytosine; DNA Methylation; Drinking Water; Environmental Exposure; Female; Homocysteine; Humans; Leukocytes; Male; Middle Aged; Sex Factors; Young Adult

2015
Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
    Genome research, 2015, Volume: 25, Issue:12

    Topics: 5-Methylcytosine; Bacterial Infections; CpG Islands; Cytosine; Dendritic Cells; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Mycobacterium tuberculosis; Transcription Factors; Tuberculosis

2015
Diagnosis of abnormal human fertilization status based on pronuclear origin and/or centrosome number.
    Journal of assisted reproduction and genetics, 2015, Volume: 32, Issue:11

    Topics: 5-Methylcytosine; Aneuploidy; Case-Control Studies; Cell Nucleus; Centrosome; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Fertilization in Vitro; Fluorescent Antibody Technique; Genetic Techniques; Humans; Male; Sperm Injections, Intracytoplasmic; Spermatozoa; Zygote

2015
TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression.
    Nature communications, 2015, Sep-25, Volume: 6

    Topics: 5-Methylcytosine; Aged; Androgens; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Cytosine; Dioxygenases; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hepatocyte Nuclear Factor 3-alpha; Humans; Hydroxylation; Immunohistochemistry; Male; Mice, Inbred BALB C; MicroRNAs; Middle Aged; Neoplasm Transplantation; Prostatic Neoplasms; Proto-Oncogene Proteins; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, RNA; TOR Serine-Threonine Kinases

2015
Water-bridged hydrogen bond formation between 5-hydroxylmethylcytosine (5-hmC) and its 3'-neighbouring bases in A- and B-form DNA duplexes.
    Chemical communications (Cambridge, England), 2015, Nov-25, Volume: 51, Issue:91

    Topics: 5-Methylcytosine; Base Pairing; Crystallography, X-Ray; Cytosine; DNA, A-Form; DNA, B-Form; Hydrogen Bonding; Molecular Dynamics Simulation; Water

2015
DNA 5-hydroxymethylation in human adipose tissue differs between subcutaneous and visceral adipose tissue depots.
    Epigenomics, 2015, Volume: 7, Issue:6

    Topics: 5-Methylcytosine; Adipocytes; Adiposity; Aged; Biomarkers; Cell Size; Cytosine; DNA Methylation; Female; Humans; Intra-Abdominal Fat; Male; Middle Aged; Sex Factors; Subcutaneous Fat; Tomography, X-Ray Computed

2015
Genome-wide disruption of 5-hydroxymethylcytosine in a mouse model of autism.
    Human molecular genetics, 2015, Dec-15, Volume: 24, Issue:24

    Topics: 5-Methylcytosine; Animals; Autistic Disorder; Corpus Striatum; Cytosine; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Annotation; Nerve Tissue Proteins; Reelin Protein

2015
Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma.
    Oncotarget, 2015, Nov-10, Volume: 6, Issue:35

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Small Cell; Cytosine; Epigenomics; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Neoplasm Staging; Nevus, Pigmented; Prognosis; Skin Neoplasms; Young Adult

2015
Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3'-shore.
    Oncotarget, 2015, Nov-10, Volume: 6, Issue:35

    Topics: 3' Untranslated Regions; 5-Methylcytosine; Chromatin Immunoprecipitation; CpG Islands; Cytosine; DNA Methylation; Female; Gene Silencing; Histone Code; Humans; Immunoenzyme Techniques; Male; Middle Aged; Mixed Function Oxygenases; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured

2015
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors.
    Oncotarget, 2015, Nov-17, Volume: 6, Issue:36

    Topics: 5-Methylcytosine; Adrenal Gland Neoplasms; Cell Nucleus; Cytosine; Fumarate Hydratase; Gene Silencing; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Immunohistochemistry; Mixed Function Oxygenases; Paraganglioma; Pheochromocytoma; Proto-Oncogene Proteins; Smooth Muscle Tumor; Succinate Dehydrogenase

2015
Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine.
    Neurobiology of aging, 2015, Volume: 36, Issue:11

    Topics: 5-Methylcytosine; Aging; Animals; Caloric Restriction; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression; Immunohistochemistry; Mice, Inbred C57BL; Purkinje Cells; Superoxide Dismutase; Superoxide Dismutase-1

2015
Profiling of methylation and demethylation pathways during brain development and ageing.
    Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:3

    Topics: 5-Methylcytosine; Aging; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Transcriptome

2016
Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency.
    Brain : a journal of neurology, 2015, Volume: 138, Issue:Pt 12

    Topics: 5-Methylcytosine; Animals; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Behavior, Animal; Cells, Cultured; Cerebellum; Cytosine; DNA Damage; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Mice; Mice, Knockout; Proto-Oncogene Proteins; Purkinje Cells

2015
Structural insight into substrate preference for TET-mediated oxidation.
    Nature, 2015, Nov-05, Volume: 527, Issue:7576

    Topics: 5-Methylcytosine; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Humans; Hydrogen Bonding; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Protein Binding; Proto-Oncogene Proteins; Substrate Specificity

2015
MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy.
    Cancer discovery, 2016, Volume: 6, Issue:1

    Topics: 5-Methylcytosine; Alternative Splicing; Animals; Cell Line, Tumor; Cytosine; Epigenesis, Genetic; Gene Amplification; Humans; Methyl-CpG-Binding Protein 2; Mice; Neoplasm Transplantation; Neoplasms; Protein Isoforms; ras Proteins; Signal Transduction

2016
The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals.
    Chemical communications (Cambridge, England), 2016, Jan-14, Volume: 52, Issue:4

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Mammals; Mass Spectrometry; Oxidation-Reduction; RNA

2016
Single Site Discrimination of Cytosine, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Target DNA Using Anthracene-Tagged Fluorescent Probes.
    ACS chemical biology, 2016, Mar-18, Volume: 11, Issue:3

    Topics: 5-Methylcytosine; Anthracenes; Cytosine; DNA; Fluorescent Dyes; Nucleic Acid Conformation

2016
Selective oxidation of 5-hydroxymethylcytosine with micelle incarcerated oxidants to determine it at single base resolution.
    Bioorganic & medicinal chemistry letters, 2015, Dec-15, Volume: 25, Issue:24

    Topics: 5-Methylcytosine; Base Sequence; Catalysis; Cytosine; Mass Spectrometry; Micelles; Oxidation-Reduction; Sulfites

2015
Genome-wide alterations in hippocampal 5-hydroxymethylcytosine links plasticity genes to acute stress.
    Neurobiology of disease, 2016, Volume: 86

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Stress, Psychological

2016
TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.
    Scientific reports, 2015, Dec-03, Volume: 5

    Topics: 5-Methylcytosine; Adenocarcinoma; Binding Sites; Cell Differentiation; Cell Line, Tumor; Colon; Colonic Neoplasms; Cytosine; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins; Transcription Factors

2015
Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: 5-Methylcytosine; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression; Kidney; Liver; Lung; Male; Myocardium; Organ Specificity; Pentoxyl; Rats; Rats, Wistar; Swine; Tandem Mass Spectrometry; Thymus Gland

2015
Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer.
    Cell research, 2016, Volume: 26, Issue:1

    Topics: 5-Methylcytosine; Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Cytosine; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Isocitrate Dehydrogenase; Kidney; Kidney Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude

2016
Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution.
    The Journal of allergy and clinical immunology, 2016, Volume: 137, Issue:3

    Topics: 5-Methylcytosine; Adolescent; Air Pollution; Alleles; Asthma; Case-Control Studies; Child; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Epithelial Cells; Female; Gene Expression; Humans; Male; Mixed Function Oxygenases; Nasal Mucosa; Promoter Regions, Genetic; Proto-Oncogene Proteins; Risk Factors; RNA, Messenger; Vehicle Emissions

2016
Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.
    Toxicology, 2016, Jan-18, Volume: 340

    Topics: 5-Methylcytosine; Allergens; Animals; Cytosine; Dinitrochlorobenzene; DNA Fragmentation; DNA Methylation; Epigenesis, Genetic; Female; Immunoprecipitation; Local Lymph Node Assay; Lymph Nodes; Mice, Inbred BALB C; Phthalic Anhydrides; Polymerase Chain Reaction; Promoter Regions, Genetic

2016
C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.
    Experimental neurology, 2016, Volume: 277

    Topics: 5-Methylcytosine; Amyotrophic Lateral Sclerosis; Brain; C9orf72 Protein; Coculture Techniques; CpG Islands; Cytosine; DNA Methylation; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Lymphocytes; Motor Neurons; Mutation; Nanog Homeobox Protein; Nestin; Promoter Regions, Genetic; Proteins; RNA, Messenger; SOXB1 Transcription Factors; Time Factors

2016
De novo DNA methylation drives 5hmC accumulation in mouse zygotes.
    Nature cell biology, 2016, Volume: 18, Issue:2

    Topics: 5-Methylcytosine; Animals; Biomarkers; Cellular Reprogramming; Chromatography, Liquid; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Embryo Culture Techniques; Epigenesis, Genetic; Fertilization in Vitro; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Kinetics; Mass Spectrometry; Mice; Mice, Knockout; Proto-Oncogene Proteins; Zygote

2016
Ultrasensitive determination of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA by sheathless interfaced capillary electrophoresis-mass spectrometry.
    Chemical communications (Cambridge, England), 2016, Feb-14, Volume: 52, Issue:13

    Topics: 5-Methylcytosine; Cytosine; DNA; Electrophoresis, Capillary; Genomics; Limit of Detection; Spectrometry, Mass, Electrospray Ionization

2016
Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cytosine; DNA Methylation; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Urogenital Neoplasms

2016
RNA biochemistry. Transcriptome-wide distribution and function of RNA hydroxymethylcytosine.
    Science (New York, N.Y.), 2016, Jan-15, Volume: 351, Issue:6270

    Topics: 5-Methylcytosine; Animals; Brain; Cell Line; Cytosine; Dioxygenases; Drosophila melanogaster; Methylation; RNA, Messenger; Transcriptome

2016
Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs.
    Cell reports, 2016, Feb-09, Volume: 14, Issue:5

    Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; Epigenesis, Genetic; Evolution, Molecular; Mice; Mouse Embryonic Stem Cells; Multiprotein Complexes; Signal Transduction

2016
Mechanistic insights into the recognition of 5-methylcytosine oxidation derivatives by the SUVH5 SRA domain.
    Scientific reports, 2016, Feb-04, Volume: 6

    Topics: 5-Methylcytosine; Base Sequence; Binding Sites; Calorimetry; Crystallography, X-Ray; Cytosine; DNA; Histidine; Methyltransferases; Molecular Dynamics Simulation; Oligopeptides; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins

2016
5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability.
    Cell reports, 2016, Feb-16, Volume: 14, Issue:6

    Topics: 5-Methylcytosine; Animals; Aphidicolin; Cell Line; CRISPR-Cas Systems; Cytosine; Dioxygenases; DNA Damage; DNA Methylation; DNA Repair; DNA Replication; DNA-Binding Proteins; Epigenesis, Genetic; Genome; Genomic Instability; HeLa Cells; Histones; Human Embryonic Stem Cells; Humans; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Rad51 Recombinase; Tumor Suppressor p53-Binding Protein 1

2016
5-hydroxymethylcytosine loss is associated with poor prognosis for patients with WHO grade II diffuse astrocytomas.
    Scientific reports, 2016, Feb-11, Volume: 6

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Antibodies; Astrocytoma; Biomarkers, Tumor; Brain; Central Nervous System Neoplasms; Cytosine; Female; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Ki-67 Antigen; Male; Middle Aged; Mutation; Neoplasm Grading; Prognosis; Spinal Cord; Survival Analysis

2016
Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation.
    Cell reports, 2016, Feb-23, Volume: 14, Issue:7

    Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Differentiation; Cytosine; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genome-Wide Association Study; Germinal Center; Interleukin-4; Interleukins; Macrophages; Mice; Mice, Transgenic; Molecular Sequence Data; Proto-Oncogene Proteins c-bcl-6; Receptors, Interleukin-7; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes, Helper-Inducer

2016
Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.
    Genome biology, 2016, Feb-16, Volume: 17

    Topics: 5-Methylcytosine; Cerebellar Cortex; Cerebellum; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Genome, Human; Humans; Sequence Analysis, DNA; Sulfites

2016
TET1 contributes to neurogenesis onset time during fetal brain development in mice.
    Biochemical and biophysical research communications, 2016, Mar-18, Volume: 471, Issue:4

    Topics: 5-Methylcytosine; Animals; Biomarkers; Brain; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genetic Vectors; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Neurons; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction

2016
Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability.
    Nature communications, 2016, Feb-24, Volume: 7

    Topics: 5-Methylcytosine; Biomechanical Phenomena; Cytosine; DNA; DNA Methylation; Molecular Dynamics Simulation; Nucleosomes; Oxidation-Reduction

2016
Methylation profiling by bisulfite sequencing analysis of the mtDNA Non-Coding Region in replicative and senescent Endothelial Cells.
    Mitochondrion, 2016, Volume: 27

    Topics: 5-Methylcytosine; Cytosine; DNA, Intergenic; DNA, Mitochondrial; Endothelial Cells; Humans; Mitochondria; Sequence Analysis, DNA; Sulfites

2016
Ten-Eleven Translocation Genes are Downregulated in Endometriosis.
    Current molecular medicine, 2016, Volume: 16, Issue:3

    Topics: 5-Methylcytosine; Adult; Aged; Case-Control Studies; Cytosine; Dioxygenases; DNA-Binding Proteins; Endometriosis; Endometrium; Epigenesis, Genetic; Female; Fibroblasts; Humans; Hysterectomy; Menstrual Cycle; Middle Aged; Mixed Function Oxygenases; Primary Cell Culture; Proto-Oncogene Proteins; Signal Transduction; Stromal Cells

2016
[Expression and clinical significance of 5hmC in bladder urothelial carcinoma].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2016, Volume: 32, Issue:2

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Transitional Cell; Cytosine; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Prognosis; Urinary Bladder Neoplasms

2016
Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Mar-02, Volume: 36, Issue:9

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Formaldehyde; Gene Expression Regulation; HEK293 Cells; Humans; Male; Mice; Mice, Inbred Strains; MicroRNAs; Pain; Phosphopyruvate Hydratase; Promoter Regions, Genetic; Proto-Oncogene Proteins; Spinal Cord; Time Factors

2016
Analysis of Ferrous on Ten-Eleven Translocation Activity and Epigenetic Modifications of Early Mouse Embryos by Fluorescence Microscopy.
    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2016, Volume: 22, Issue:2

    Topics: 5-Methylcytosine; Animals; Blastocyst; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryo, Mammalian; Epigenesis, Genetic; Ferrous Compounds; Mice; Microscopy, Fluorescence; Octamer Transcription Factor-3; Proto-Oncogene Proteins

2016
5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma.
    Clinical epigenetics, 2016, Volume: 8

    Topics: 5-Methylcytosine; Adenoma; Adolescent; Adult; Aged; Blotting, Western; Case-Control Studies; Cytosine; DNA-Binding Proteins; Humans; Middle Aged; Mixed Function Oxygenases; Parathyroid Glands; Parathyroid Neoplasms; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Young Adult

2016
Increased 5-hydroxymethylcytosine in CD4(+) T cells in systemic lupus erythematosus.
    Journal of autoimmunity, 2016, Volume: 69

    Topics: 5-Methylcytosine; Adult; Autoimmunity; Case-Control Studies; CD4-Positive T-Lymphocytes; Chromatin Immunoprecipitation; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Humans; Lupus Erythematosus, Systemic; Male; Promoter Regions, Genetic; Protein Binding; Receptors, Interleukin-15; Receptors, Steroid; Repressor Proteins; RNA, Messenger; Severity of Illness Index; Suppressor of Cytokine Signaling 1 Protein; Young Adult

2016
Single-CpG resolution mapping of 5-hydroxymethylcytosine by chemical labeling and exonuclease digestion identifies evolutionarily unconserved CpGs as TET targets.
    Genome biology, 2016, Mar-29, Volume: 17

    Topics: 5-Methylcytosine; Animals; Cells, Cultured; CpG Islands; Cytosine; DNA; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Epigenomics; Exonucleases; Mice; Sequence Analysis, DNA; Staining and Labeling

2016
Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Apr-19, Volume: 113, Issue:16

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Mice; Molecular Imaging

2016
Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus.
    BMC genomics, 2016, Mar-31, Volume: 17

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Heart Ventricles; Hippocampus; Male; Mice; Mice, Inbred C57BL; Protons

2016
Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: 5-Methylcytosine; Carcinoma, Squamous Cell; Cytosine; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Prognosis

2016
TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus.
    Clinical epigenetics, 2016, Volume: 8

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cytosine; DNA Methylation; Female; Genome-Wide Association Study; Hippocampus; Humans; Male; Membrane Glycoproteins; Middle Aged; Receptors, Immunologic; Up-Regulation

2016
Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.
    The Journal of biological chemistry, 2016, Jun-24, Volume: 291, Issue:26

    Topics: 5-Methylcytosine; CCAAT-Enhancer-Binding Proteins; Chromatin; Cytosine; DNA-Binding Proteins; HEK293 Cells; Humans; Ubiquitin-Protein Ligases

2016
Methylation-assisted bisulfite sequencing to simultaneously map 5fC and 5caC on a genome-wide scale for DNA demethylation analysis.
    Nature protocols, 2016, Volume: 11, Issue:7

    Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Line; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Mice; Sequence Analysis, DNA; Sulfites

2016
TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.
    DNA repair, 2016, Volume: 43

    Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Line; Cytosine; Dioxygenases; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Fibroblasts; Genomic Instability; Humans; Hydroxylation; Megakaryocyte Progenitor Cells; Mice; Mutagenesis; Proto-Oncogene Proteins; S Phase; Thymine DNA Glycosylase; Tumor Suppressor Protein p53

2016
Simple and accurate single base resolution analysis of 5-hydroxymethylcytosine by catalytic oxidative bisulfite sequencing using micelle incarcerated oxidants.
    Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18

    Topics: 5-Methylcytosine; Adamantane; Animals; Cyclic N-Oxides; Cytosine; DNA, Single-Stranded; Embryonic Stem Cells; Iodobenzenes; Mice; Micelles; Onium Compounds; Oxidants; Oxidation-Reduction; Sequence Analysis, DNA; Sodium Dodecyl Sulfate; Sulfites; Temperature

2016
Isocitrate Dehydrogenase 2 Dysfunction Contributes to 5-hydroxymethylcytosine Depletion in Gastric Cancer Cells.
    Anticancer research, 2016, Volume: 36, Issue:8

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Female; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Male; Stomach Neoplasms

2016
Maternal Methyl-Group Donor Intake and Global DNA (Hydroxy)Methylation before and during Pregnancy.
    Nutrients, 2016, Aug-06, Volume: 8, Issue:8

    Topics: 5-Methylcytosine; Adult; Belgium; Betaine; Biomarkers; Choline; Cohort Studies; Cytosine; Diet; Dietary Supplements; DNA Methylation; Feeding Behavior; Female; Folic Acid; Humans; Hydroxylation; Leukocytes; Longitudinal Studies; Maternal Nutritional Physiological Phenomena; Methionine; Pregnancy; Prospective Studies; Self Report

2016
Discrimination between 5-Hydroxymethylcytosine and 5-Methylcytosine in DNA via Selective Electrogenerated Chemiluminescence (ECL) Labeling.
    Analytical chemistry, 2016, 10-18, Volume: 88, Issue:20

    Topics: 5-Methylcytosine; Biosensing Techniques; Cytosine; DNA; DNA Probes; Humans; Limit of Detection; Luminescence; Luminol; Nucleic Acid Hybridization; Oxidation-Reduction; Ruthenium

2016
Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Nov-07, Volume: 22, Issue:46

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Nucleosomes; Oxidation-Reduction

2016
A reusable laser wrapped graphene-Ag array based SERS sensor for trace detection of genomic DNA methylation.
    Biosensors & bioelectronics, 2017, Jun-15, Volume: 92

    Topics: 5-Methylcytosine; Antibodies, Immobilized; Biosensing Techniques; Cell Line, Tumor; Cytosine; DNA; DNA Methylation; Equipment Design; Gold; Graphite; Humans; Metal Nanoparticles; Reproducibility of Results; Silver; Spectrum Analysis, Raman

2017
Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA.
    Free radical biology & medicine, 2016, Volume: 101

    Topics: 5-Methylcytosine; Ascorbic Acid; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Pentoxyl; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine

2016
Elevated 5-hydroxymethycytosine and cell apoptosis induced by tetrachloro-1,4-benzoquinone in mouse embryonic stem cells.
    Journal of environmental sciences (China), 2017, Volume: 51

    Topics: 5-Methylcytosine; Animals; Apoptosis; Chloranil; Cytosine; Fungicides, Industrial; Mice; Mouse Embryonic Stem Cells; Toxicity Tests

2017
Tetrachloro-1,4-benzoquinone induces apoptosis of mouse embryonic stem cells.
    Journal of environmental sciences (China), 2017, Volume: 51

    Topics: 5-Methylcytosine; Animals; Apoptosis; Chloranil; Cytosine; Fungicides, Industrial; Mice; Mouse Embryonic Stem Cells; Toxicity Tests

2017
Combinatorial DNA methylation codes at repetitive elements.
    Genome research, 2017, Volume: 27, Issue:6

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; DNA Transposable Elements; Epigenesis, Genetic; Fibroblasts; Genome; Mice; Mouse Embryonic Stem Cells; Primary Cell Culture; Repetitive Sequences, Nucleic Acid; Thymine DNA Glycosylase

2017
Differential expression of ten-eleven translocation genes in endometrial cancers.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:3

    Topics: 5-Methylcytosine; Aged; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Endometrial Neoplasms; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Middle Aged; Mixed Function Oxygenases; Prognosis; Proto-Oncogene Proteins

2017
Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas.
    Environmental science and pollution research international, 2017, Volume: 24, Issue:17

    Topics: 5-Methylcytosine; Animals; Cadmium; Cytosine; Hepatopancreas; Humans; Snails; Water Pollutants, Chemical

2017
5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages.
    Cell research, 2017, Volume: 27, Issue:10

    Topics: 5-Methylcytosine; Adult; Aged; Animals; Cell-Free Nucleic Acids; Circulating Tumor DNA; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Humans; Male; Middle Aged; Neoplasm Staging; Neoplasms

2017
5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 09-12, Volume: 114, Issue:37

    Topics: 5-Methylcytosine; Animals; Cytosine; Demethylation; DNA Methylation; Epigenesis, Genetic; Gene Expression; Methyl-CpG-Binding Protein 2; Mice; Mitosis; Neurons; Promoter Regions, Genetic

2017
Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.
    Nucleic acids research, 2017, Nov-02, Volume: 45, Issue:19

    Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cyclic AMP Response Element-Binding Protein; Cytosine; DNA; DNA Methylation; Gene Expression Regulation; Humans; Promoter Regions, Genetic; Protein Binding; Thymine DNA Glycosylase

2017
Understanding the influence of antipsychotic drugs on global methylation events and its relevance in treatment response.
    Epigenomics, 2018, Volume: 10, Issue:3

    Topics: 5-Methylcytosine; Adult; Antipsychotic Agents; Case-Control Studies; Clozapine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Female; Haloperidol; Hep G2 Cells; Humans; Male; MicroRNAs; Olanzapine; Pharmacogenetics; Schizophrenia; Treatment Outcome

2018
Electrochemical signal-amplified detection of 5-methylcytosine and 5-hydroxymethylcytosine in DNA using glucose modification coupled with restriction endonucleases.
    The Analyst, 2018, Apr-30, Volume: 143, Issue:9

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; DNA Restriction Enzymes; Electrochemical Techniques; Electrodes; Glucose; Gold; Humans; Nucleic Acid Hybridization

2018
Two are better than one: HPoxBS - hairpin oxidative bisulfite sequencing.
    Nucleic acids research, 2018, 09-06, Volume: 46, Issue:15

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Sulfites

2018
Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma.
    Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:1

    Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cytosine; DNA, Neoplasm; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging

2019
Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer.
    Clinical epigenetics, 2018, 08-07, Volume: 10, Issue:1

    Topics: 5-Methylcytosine; Adult; Aged; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Prognosis; Prostatic Neoplasms; Receptors, Estrogen; Tissue Array Analysis

2018
Recognition of modified cytosine variants by the DNA-binding domain of methyl-directed endonuclease McrBC.
    FEBS letters, 2018, Volume: 592, Issue:19

    Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA; DNA Restriction Enzymes; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Molecular Structure; Protein Binding; Protein Domains

2018
Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain.
    Epigenetics & chromatin, 2018, 12-29, Volume: 11, Issue:1

    Topics: 5-Methylcytosine; Animals; Brain; Cerebellar Cortex; Cerebellum; Chromosome Mapping; CpG Islands; Cytosine; DNA Methylation; Female; Genome; Haplotypes; Mice; Mice, Inbred C57BL; Olfactory Bulb; Regulatory Sequences, Nucleic Acid; Sequence Analysis, DNA

2018
Vitrification of murine mature metaphase II oocytes perturbs DNA methylation reprogramming during preimplantation embryo development.
    Cryobiology, 2019, Volume: 87

    Topics: 5-Methylcytosine; Animals; Blastocyst; Cryopreservation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Female; Fertilization in Vitro; Metaphase; Mice; Morula; Oocytes; Oogenesis; Pregnancy; Proto-Oncogene Proteins; Vitrification

2019
Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis.
    Life science alliance, 2019, Volume: 2, Issue:2

    Topics: 5-Methylcytosine; Animals; Cadherins; Cell Differentiation; Cell Lineage; CRISPR-Associated Protein 9; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Oncogene Proteins, Fusion; Pregnancy; Proto-Oncogene Proteins; Transcription Factors; Transcriptome

2019
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
    Nucleic acids research, 2019, 06-20, Volume: 47, Issue:11

    Topics: 5-Methylcytosine; AlkB Enzymes; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Animals; Computational Biology; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Molecular Structure; Oxidation-Reduction

2019
5-Methylcytosine is Oxidized to the Natural Metabolites of TET Enzymes by a Biomimetic Iron(IV)-Oxo Complex.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2019, Sep-18, Volume: 25, Issue:52

    Topics: 5-Methylcytosine; Biomimetic Materials; Cerium; Coordination Complexes; Cytosine; Dioxygenases; Epigenesis, Genetic; Iron; Kinetics; Oxidation-Reduction; Thermodynamics

2019
Library Preparation for Multiplexed Reduced Representation Bisulfite Sequencing with a Universal Adapter.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 2018

    Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; DNA Primers; Gene Library; Rats; Sequence Analysis, DNA; Sulfites

2019
MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL.
    Epigenetics & chromatin, 2019, 07-02, Volume: 12, Issue:1

    Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Leukemic; Humans; Mice; Mice, Transgenic; Mixed Function Oxygenases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc

2019
The clinical values of dysregulated DNA methylation and demethylation intermediates in acute lymphoblastic leukemia.
    Hematology (Amsterdam, Netherlands), 2019, Volume: 24, Issue:1

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Area Under Curve; Biomarkers, Tumor; Cell Lineage; Child; Cytosine; Demethylation; DNA Methylation; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; ROC Curve; Young Adult

2019
Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input.
    Nucleic acids research, 2019, 11-04, Volume: 47, Issue:19

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; DNA-Directed DNA Polymerase; Epigenomics; Genome; Humans; Mice; Oxides; Polymerase Chain Reaction; Polymerization; Rats

2019
Epigenetic modification of cytosines fine tunes the stability of i-motif DNA.
    Nucleic acids research, 2020, 01-10, Volume: 48, Issue:1

    Topics: 5-Methylcytosine; Cell Line; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Hydrogen-Ion Concentration; MCF-7 Cells; Nucleotide Motifs

2020
Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites.
    Nucleic acids research, 2020, 01-10, Volume: 48, Issue:1

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA, Protozoan; Epigenesis, Genetic; Erythrocytes; Genome, Protozoan; High-Throughput Nucleotide Sequencing; Humans; Hydroxylation; Plasmodium falciparum; RNA, Messenger

2020
Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome.
    Scientific reports, 2019, 12-17, Volume: 9, Issue:1

    Topics: 5-Methylcytosine; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome, Plant; Mass Spectrometry; Norway; Picea

2019
DNA demethylation is a driver for chick retina regeneration.
    Epigenetics, 2020, Volume: 15, Issue:9

    Topics: 5-Methylcytosine; Animals; Avian Proteins; Chick Embryo; Chromatin; Cytosine; Dioxygenases; DNA Methylation; Fibroblast Growth Factor 2; Histone Code; Regeneration; Retinal Pigment Epithelium

2020
Quantitative analysis of global 5-methyl- and 5-hydroxymethylcytosine in TET1 expressed HEK293T cells.
    Biosensors & bioelectronics, 2020, Nov-01, Volume: 167

    Topics: 5-Methylcytosine; Animals; Biosensing Techniques; Cytosine; DNA Methylation; HEK293 Cells; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins

2020
Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS).
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Hydrolysis; Tandem Mass Spectrometry; Zebrafish

2021
Immunohistochemical Detection of Modified Cytosine Bases in Rodent Brain.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Antibodies; Brain; Cell Nucleus; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Immunohistochemistry; Mice; Peroxidase; Rats; Rodentia

2021
Immunohistochemical Detection of 5-Hydroxymethylcytosine and 5-Carboxylcytosine in Sections of Zebrafish Embryos.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Embryo, Nonmammalian; Immunohistochemistry; Zebrafish

2021
Immunochemical Detection of Modified Species of Cytosine in Plant Tissues.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Dyes; Immunohistochemistry; Plants

2021
Antigen Retrieval for Immunostaining of Modified Cytosine Species.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Antibodies; Antigens; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Antibody Technique; Humans

2021
Analysis of 5-Hydroxymethyluracil Levels Using Flow Cytometry.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Flow Cytometry; Humans; Oxidation-Reduction; Pentoxyl; Single-Cell Analysis; Tandem Mass Spectrometry; Thymine

2021
Analysis of 5-Carboxylcytosine Distribution Using DNA Immunoprecipitation.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Chromatin Immunoprecipitation; Cytosine; DNA; DNA Methylation; Humans; Immunoprecipitation

2021
High-Resolution Analysis of 5-Hydroxymethylcytosine by TET-Assisted Bisulfite Sequencing.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Genome; Humans; Oxidation-Reduction; Sequence Analysis, DNA; Sulfites

2021
Oxidative Bisulfite Sequencing: An Experimental and Computational Protocol.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Computational Biology; Cytosine; Dioxygenases; DNA; DNA Methylation; High-Throughput Nucleotide Sequencing; Humans; Oxidation-Reduction; Oxidative Stress; Sequence Analysis, DNA; Sulfites

2021
Bisulfite-Free Sequencing of 5-Hydroxymethylcytosine with APOBEC-Coupled Epigenetic Sequencing (ACE-Seq).
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Computational Biology; Cytidine Deaminase; Cytosine; DNA; DNA Methylation; Epigenomics; Humans; Proteins; Sequence Analysis, DNA; Single Molecule Imaging; Sulfites

2021
Integrated Analysis of DNA Methylation, Hydroxymethylation, and Gene Expression Data Using ME-Class2.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2198

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression; Gene Silencing; Genome; Genomics; Humans; Machine Learning; Sequence Analysis, DNA

2021
bZIP Dimers CREB1, ATF2, Zta, ATF3|cJun, and cFos|cJun Prefer to Bind to Some Double-Stranded DNA Sequences Containing 5-Formylcytosine and 5-Carboxylcytosine.
    Biochemistry, 2020, 09-29, Volume: 59, Issue:38

    Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Basic-Leucine Zipper Transcription Factors; Cytosine; DNA; Mice; Protein Array Analysis; Protein Binding

2020
Pairwise Proximity-Differentiated Visualization of Single-Cell DNA Epigenetic Marks.
    Angewandte Chemie (International ed. in English), 2021, 02-15, Volume: 60, Issue:7

    Topics: 5-Methylcytosine; Cell Line; Chromatin; Cytosine; DNA; Humans; Molecular Structure; Single-Cell Analysis

2021
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
    Nature communications, 2020, 12-02, Volume: 11, Issue:1

    Topics: 5-Methylcytosine; Chromosome Mapping; CpG Islands; Cytosine; DNA; DNA Methylation; Enhancer Elements, Genetic; Epigenesis, Genetic; Genome, Human; Histones; Humans; Organ Specificity; Transcription Factors; Transcriptional Activation

2020
One-pot intramolecular cyclization of 5-hydroxymethylcytosine for sequencing DNA hydroxymethylation at single-base resolution.
    The Analyst, 2021, Feb-07, Volume: 146, Issue:3

    Topics: 5-Methylcytosine; Cyclization; Cytosine; DNA; DNA Methylation; Prospective Studies; Sequence Analysis, DNA

2021
TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.
    Journal of molecular biology, 2021, 04-16, Volume: 433, Issue:8

    Topics: 5-Methylcytosine; CpG Islands; Cytosine; Dioxygenases; DNA Demethylation; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase

2021
Distinguishing Active Versus Passive DNA Demethylation Using Illumina MethylationEPIC BeadChip Microarrays.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2272

    Topics: 5-Methylcytosine; Computational Biology; Cytosine; DNA; DNA Demethylation; DNA Methylation; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Microarray Analysis; Oxidation-Reduction; Sulfites

2021
Pearl Necklacelike Strategy Enables Quantification of Global 5-Hydroxymethylcytosine and 5-Formylcytosine by Inductively Coupled Plasma-Atomic Emission Spectrometry.
    Analytical chemistry, 2021, 06-08, Volume: 93, Issue:22

    Topics: 5-Methylcytosine; Cytosine; Spectrum Analysis

2021
Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells.
    Genome biology, 2021, 06-22, Volume: 22, Issue:1

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Proliferation; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression; Genetic Loci; Hematopoiesis; Interleukin-4; Isoenzymes; Lipopolysaccharides; Longevity; Macrophages; Mice; Mice, Knockout; T-Lymphocytes; Thymine DNA Glycosylase

2021
MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion.
    Science (New York, N.Y.), 2021, Jun-25, Volume: 372, Issue:6549

    Topics: 5-Methylcytosine; Animals; Cells, Cultured; Chromatin; Cytosine; Dinucleotide Repeats; DNA Methylation; Embryonic Stem Cells; Fibroblasts; Frontal Lobe; Methyl-CpG-Binding Protein 2; Mice; Microsatellite Repeats; Neurons; Nucleic Acid Conformation; Nucleosomes; Oxidation-Reduction; Protein Binding; Protein Domains; Rett Syndrome; Transcription, Genetic

2021
Proteome-Wide Profiling of Readers for DNA Modification.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021, Volume: 8, Issue:19

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Humans; Mice; Mice, Inbred C57BL; Models, Animal; Proteome; Transcription Factors

2021
Locus-Specific Enrichment Analysis of 5-Hydroxymethylcytosine Reveals Novel Genes Associated with Breast Carcinogenesis.
    Cells, 2022, 09-20, Volume: 11, Issue:19

    Topics: 5-Methylcytosine; Breast Neoplasms; Cell Transformation, Neoplastic; Cytosine; DNA, Intergenic; Female; Humans; Untranslated Regions

2022
5-hydroxymethylcytosine stabilizes transcription by preventing aberrant initiation in gene bodies.
    Nature genetics, 2023, Volume: 55, Issue:1

    Topics: 5-Methylcytosine; Cytosine; DNA Methylation

2023
Global DNA 5-hydroxymethylcytosine level and its chromosomal distribution in four rye species.
    Journal of experimental botany, 2023, 06-27, Volume: 74, Issue:12

    Topics: 5-Methylcytosine; Chromosomes; Cytosine; DNA; DNA Methylation; Secale

2023
Decrease of 5-hydroxymethylcytosine in hepatitis B virus-related hepatocellular carcinoma: A cross-sectional study.
    Medicine, 2023, Jun-02, Volume: 102, Issue:22

    Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cross-Sectional Studies; Cytosine; DNA Methylation; Hepatitis B virus; Humans; Liver Neoplasms; Mixed Function Oxygenases; Proto-Oncogene Proteins

2023
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
    Database : the journal of biological databases and curation, 2023, 06-10, Volume: 2023

    Topics: 5-Methylcytosine; Biomedical Research; Cytosine; Databases, Factual; Humans

2023
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
    Database : the journal of biological databases and curation, 2023, 06-10, Volume: 2023

    Topics: 5-Methylcytosine; Biomedical Research; Cytosine; Databases, Factual; Humans

2023