5-hydroxymethylcytosine has been researched along with ascorbic acid in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (73.08) | 24.3611 |
| 2020's | 7 (26.92) | 2.80 |
| Authors | Studies |
|---|---|
| Court, BL; Minor, EA; Wang, G; Young, JI | 1 |
| Blaschke, K; Ebata, KT; Goyal, P; Hirst, M; Karimi, MM; Laird, DJ; Lorincz, MC; Mahapatra, S; Ramalho-Santos, M; Rao, A; Tam, A; Zepeda-Martínez, JA | 1 |
| Dickson, KM; Gustafson, CB; Wang, G; Young, JI; Züchner, S | 1 |
| Godley, LA; Jeff-Eke, M; Litwin, E; Mariani, CJ; Moen, EL; Nikitas, JN; Zullow, H | 1 |
| DeSimone, J; Ibanez, V; Lavelle, D; Mahmud, N; Rivers, A; Ruiz, MA; Vaitkus, K | 1 |
| Chen, J; Chen, L; Dai, Q; Gao, Q; He, C; Jin, P; Li, L; Lin, L; Song, MM; Sun, M; Tao, J; Wei, B; Xu, Z; Yao, B; Zhou, X | 1 |
| Balestrieri, C; Barozzi, I; Della Chiara, G; Emming, S; Ko, M; Leoni, C; Montagner, S; Monticelli, S; Natoli, G; Piccolo, V; Rao, A; Togher, S | 1 |
| Foksinski, M; Gackowski, D; Gawronski, M; Modrzejewska, M; Olinski, R; Rzeszowska-Wolny, J; Skonieczna, M; Starczak, M; Zarakowska, E | 1 |
| An, XR; Hou, J; Li, JW; Wang, QQ; Zhang, YM; Zhong, X | 1 |
| Chen, J; Gustafson, CB; Mustafi, S; Sant, DW; Slingerland, JM; Wang, G | 1 |
| Ci, W; Ge, G; Guan, B; He, Q; Li, X; Peng, D; Xin, Z; Xu, Z; Zhou, L; Zhou, Y | 1 |
| Ci, W; Ge, G; Gong, Y; Guan, B; Hao, H; He, S; He, Z; Li, X; Li, Y; Peng, D; Shi, Y; Xiong, G; Xu, Z; Zhan, Y; Zhang, C; Zhou, L; Zhou, Y | 1 |
| Gao, W; Han, L; Hao, J; Lin, C; Qi, M; Wang, D; Wang, L; Yu, X | 1 |
| Agarwal, B; Bhagat, TD; Bhattacharyya, S; Boorjian, SA; Cheville, J; Choudhary, G; Gartrell, B; Gordon-Mitchell, S; Greally, JM; Gross, L; Leibovich, B; Lohse, C; Machha, V; Pagliaro, L; Pradhan, K; Rakheja, D; Ressigue, E; Shenoy, N; Steidl, U; Susztak, K; Suzuki, M; Thompson, RH; Tischer, A; Verma, A; Witzig, T; Wong, LF; Wu, X; Zou, Y | 1 |
| Hao, J; Hao, Y; Li, C; Lin, C; Liu, D; Shi, S; Wang, D; Zhong, X | 1 |
| An, Y; Li, F; Lian, CG; Liu, C; Liu, Y; Mi, B; Murphy, GF; Orgill, DP; Sang, S; Xu, S; Zu, T | 1 |
| Cheng, S; Lindsey, RC; Mohan, S | 1 |
| Chang, H; Chen, H; Fu, L; Lei, Z; Quan, F; Wang, Z; Xie, X; Zhang, Y | 1 |
| Fang, F; Li, H; Li, Z; Xiong, C; Zhao, Q | 1 |
| Gao, E; Guan, H; Hou, J; Liu, K; Shan, D; Tian, H; Wang, Q; Xu, H; Yan, F; Zhang, S; Zhang, Y | 1 |
| Bhagat, T; Jacobs, WR; Levine, M; Luchtel, RA; Pradhan, K; Shenoy, N; Verma, A | 1 |
| Chen, L; Cui, H; Li, W; Liu, J; Liu, Y; Luo, F; Luo, Z; Song, H; Zheng, W | 1 |
| Cao, N; Chen, R; Gong, C; Huang, G; Jiang, G; Li, J; Lu, H; Shu, W; Xiang, L | 1 |
| Davaa, G; Hong, JY; Hong, K; Hyun, JK; Yoo, H | 1 |
| Abraham, AG; Blake, A; Blancher, C; Burns, A; D'Costa, Z; Eyres, M; Goldin, R; Hubert, A; Hughes, D; Hughes, S; Jones, S; Lanfredini, S; Maughan, T; Mukherjee, S; O'Neill, E; Sabbagh, A; Schuh, A; Silva, M; Soonawalla, Z; Thapa, A; Vavoulis, D; Verrill, C; Willenbrock, F; Xu, H | 1 |
| Ci, W; Huang, C; Qi, J; Shi, Y; Tan, Y; Wang, J; Zhang, J; Zhang, Q | 1 |
1 review(s) available for 5-hydroxymethylcytosine and ascorbic acid
| Article | Year |
|---|---|
New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cytosine; Diet; DNA Methylation; Folic Acid; Hematologic Neoplasms; Humans; MicroRNAs; Promoter Regions, Genetic; Structure-Activity Relationship; Transcription Factors | 2015 |
25 other study(ies) available for 5-hydroxymethylcytosine and ascorbic acid
| Article | Year |
|---|---|
Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cells, Cultured; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Knockdown Techniques; Hydroxylation; Mice; Mice, Inbred C57BL; Phloretin; Proto-Oncogene Proteins; RNA, Small Interfering | 2013 |
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
Topics: 5-Methylcytosine; Animals; Antioxidants; Ascorbic Acid; Blastocyst; Cell Line; Culture Media; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Mice; Protein Binding; Proto-Oncogene Proteins; Recombinant Proteins | 2013 |
Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Fibroblasts; Iron; Isocitrate Dehydrogenase; Ketoglutaric Acids; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Sodium-Coupled Vitamin C Transporters | 2013 |
Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Antineoplastic Agents; Ascorbic Acid; Azacitidine; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cytosine; Decitabine; Dioxygenases; DNA Methylation; Erythroid Cells; gamma-Globins; Histone Demethylases; Humans; Hydroxyurea; Liver; Papio anubis; Promoter Regions, Genetic; Tranylcypromine | 2015 |
5-Hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human.
Topics: 5-Methylcytosine; Adult; Ascorbic Acid; Diabetes, Gestational; Dioxygenases; DNA Methylation; DNA Transposable Elements; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Humans; Pre-Eclampsia; Pregnancy; Proto-Oncogene Proteins | 2016 |
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.
Topics: 5-Methylcytosine; Ascorbic Acid; Biocatalysis; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cell Proliferation; Cytokines; Dioxygenases; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation; Gene Knockdown Techniques; Genome; HEK293 Cells; Humans; Male; Mast Cells; Proto-Oncogene Proteins; Sequence Analysis, RNA; Transcription, Genetic | 2016 |
Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA.
Topics: 5-Methylcytosine; Ascorbic Acid; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Pentoxyl; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine | 2016 |
Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cell Differentiation; Cell Line; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Mice; Muscle Development; Myoblasts, Skeletal; Promoter Regions, Genetic; Proto-Oncogene Proteins | 2017 |
Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression.
Topics: 5-Methylcytosine; Apoptosis; Ascorbic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sodium-Coupled Vitamin C Transporters; TNF-Related Apoptosis-Inducing Ligand | 2018 |
Restoration of 5-hydroxymethylcytosine by ascorbate blocks kidney tumour growth.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Dioxygenases; DNA-Binding Proteins; Enhancer Elements, Genetic; Humans; Kidney Neoplasms; Mice; Proto-Oncogene Proteins; Transcriptome; Xenograft Model Antitumor Assays | 2018 |
Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer.
Topics: 5-Methylcytosine; Aged; Animals; Ascorbic Acid; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Male; Mice; Middle Aged; Prognosis; Sequence Analysis, DNA; Sequence Analysis, RNA; Survival Analysis; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2018 |
Ascorbic acid improves parthenogenetic embryo development through TET proteins in mice.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Blastocyst; Dioxygenases; DNA-Binding Proteins; Embryonic Development; Female; Gene Expression Regulation, Developmental; Glycine; Male; Mice; Mice, Inbred C57BL; Parthenogenesis; Proto-Oncogene Proteins; Signal Transduction | 2019 |
Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.
Topics: 5-Methylcytosine; Adult; Alcohol Oxidoreductases; Animals; Ascorbic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Female; Gene Deletion; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Male; Mice | 2019 |
The expression of TET3 regulated cell proliferation in HepG2 cells.
Topics: 5-Methylcytosine; Ascorbic Acid; Cell Proliferation; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Hep G2 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Proto-Oncogene Proteins; Transcriptome | 2019 |
Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid.
Topics: 5-Methylcytosine; Ascorbic Acid; Cell Hypoxia; Cells, Cultured; Cicatrix; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit | 2019 |
Vitamin C effects on 5-hydroxymethylcytosine and gene expression in osteoblasts and chondrocytes: Potential involvement of PHD2.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cell Differentiation; Cells, Cultured; Chondrocytes; Gene Expression; Hypoxia-Inducible Factor-Proline Dioxygenases; Mice; Osteoblasts | 2019 |
The effects of TETs on DNA methylation and hydroxymethylation of mouse oocytes after vitrification and warming.
Topics: 5-Methylcytosine; Amino Acids, Dicarboxylic; Animals; Ascorbic Acid; Cryopreservation; Cryoprotective Agents; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo Research; Female; Gene Expression; Mice; Oocytes; Proto-Oncogene Proteins; Vitrification | 2019 |
Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells.
Topics: 5-Methylcytosine; Ascorbic Acid; Cell Line; Epigenesis, Genetic; Genes, Reporter; Germ Cells; Human Embryonic Stem Cells; Humans; Positive Regulatory Domain I-Binding Factor 1 | 2019 |
Vitamin C treatment of embryos, but not donor cells, improves the cloned embryonic development in sheep.
Topics: 5-Methylcytosine; Animals; Antioxidants; Ascorbic Acid; Blastocyst; Cloning, Organism; Culture Media; DNA Methylation; Embryonic Development; Fibroblasts; Male; Nuclear Transfer Techniques; Sheep | 2020 |
High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
Topics: 5-Methylcytosine; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Ascorbic Acid; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Drug Synergism; Female; Granzymes; Immunotherapy; Lymphoma; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Tumor Microenvironment | 2020 |
PHLPP2 is a novel biomarker and epigenetic target for the treatment of vitamin C in pancreatic cancer.
Topics: 5-Methylcytosine; Ascorbic Acid; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Phosphoprotein Phosphatases; Prognosis; Promoter Regions, Genetic; Sodium-Coupled Vitamin C Transporters; Survival Analysis; Up-Regulation | 2020 |
Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons.
Topics: 5-Methylcytosine; Adult; Aged; Ascorbic Acid; Cell Differentiation; Cell Line; Cell Lineage; Chromatin Assembly and Disassembly; Dioxygenases; DNA-Binding Proteins; Dopamine; Dopaminergic Neurons; Epigenesis, Genetic; Humans; Induced Pluripotent Stem Cells; Mesencephalon; Middle Aged; Models, Biological; Proto-Oncogene Proteins | 2020 |
Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Axons; Contusions; Dioxygenases; Epigenesis, Genetic; Female; Motor Cortex; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries | 2020 |
TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.
Topics: 5-Methylcytosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Differentiation; Cell Line, Tumor; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Epigenome; Epigenomics; GATA6 Transcription Factor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice, Nude; Mice, Transgenic; Pancreatic Neoplasms; Retrospective Studies; Smad4 Protein; Transcription, Genetic; Transcriptome; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2021 |
Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways.
Topics: 5-Methylcytosine; Ascorbic Acid; Carcinogenesis; DNA; DNA Methylation; Fibrin; Humans; Magnesium; Male; Phosphates; Prostatic Neoplasms; Urogenital Neoplasms | 2022 |