5-hydroxymethylcytosine has been researched along with 5-methylcytosine in 1091 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (1.28) | 18.7374 |
| 1990's | 4 (0.37) | 18.2507 |
| 2000's | 7 (0.64) | 29.6817 |
| 2010's | 862 (79.01) | 24.3611 |
| 2020's | 204 (18.70) | 2.80 |
| Authors | Studies |
|---|---|
| Hayatsu, H; Shiragami, M | 1 |
| Childs, JD; Gentner, NE; Paterson, MC; Smith, BP | 1 |
| Cambell, JL; Fleischman, RA; Richardson, CC | 1 |
| Khomov, IS; Tikhonenko, TI | 1 |
| Annan, RS; Giese, RW; Kresbach, GM; Vouros, P | 1 |
| Cannon, SV; Cummings, A; Teebor, GW | 1 |
| Macdonald, PM; Mosig, G | 1 |
| Childs, JD; Ellison, MJ; Pilon, R | 1 |
| Goldberg, EB; Levy, JN | 1 |
| Pearson, RE; Snyder, L | 1 |
| Warren, RA | 1 |
| Hong, H; Janosi, L; Kaji, A; Yonemitsu, H | 1 |
| Cohen, SS | 1 |
| Castro, GD; Castro, JA; Díaz Gómez, MI | 1 |
| Fujimoto, J; Lin, SS; Sowers, LC; Tardy-Planechaud, S | 1 |
| CHASE, M; DIXON, J; HERSHEY, AD | 1 |
| COHEN, SS; WYATT, GR | 1 |
| COHEN, SS; WEED, LL | 1 |
| Larivière, L; Moréra, S | 1 |
| Bird, A; Burdzy, A; Rogstad, DK; Sowers, LC; Tsai, HH; Valinluck, V | 1 |
| Bair, CL; Black, LW | 1 |
| Bair, CL; Black, LW; Rifat, D | 1 |
| Deng, Z; He, X; Li, L; Wu, J; Xu, X; Xu, Z; Zabriskie, TM; Zhang, Y | 1 |
| Agarwal, S; Aravind, L; Bandukwala, H; Brudno, Y; Iyer, LM; Koh, KP; Liu, DR; Pastor, WA; Rao, A; Shen, Y; Tahiliani, M | 1 |
| Heintz, N; Kriaucionis, S | 1 |
| Hemberger, M | 1 |
| Huang, Y; Liu, DR; Pastor, WA; Rao, A; Shen, Y; Tahiliani, M | 1 |
| Jin, SG; Kadam, S; Pfeifer, GP | 1 |
| Dunican, D; Meehan, R; Nestor, C; Ruzov, A | 1 |
| Biel, M; Brückl, T; Carell, T; Globisch, D; Michalakis, S; Müller, M; Münzel, M; Wagner, M; Welzmiller, V | 1 |
| D'Alessio, AC; Hong, K; Ito, S; Sowers, LC; Taranova, OV; Zhang, Y | 1 |
| Bultmann, S; Leonhardt, H; Schmidt, CS; Spada, F; Szwagierczak, A | 1 |
| Carell, T; Lercher, L; Müller, M; Münzel, M | 1 |
| Bayley, H; Donohoe, TJ; Heron, AJ; Maglia, G; Mikhailova, E; Stoddart, D; Wallace, EV | 1 |
| Larson, GP; Lee, DH; Oates, N; Pfeifer, GP; Rivas, GE; Singh, P; Szabó, PE; Tran, DA | 1 |
| Carell, T; Globisch, D; Münzel, M; Trindler, C | 1 |
| Chen, CH; Dai, Q; Fu, Y; Godley, LA; He, C; Hicks, LM; Jian, X; Jin, P; Lahn, BT; Li, X; Li, Y; Looney, TJ; Song, CX; Szulwach, KE; Wang, J; Yi, C; Zhang, B; Zhang, L; Zhang, W | 1 |
| Benner, J; Cohen-Karni, D; Drndic, M; Fields, L; Johnson, RR; Klein, ML; Peterman, N; Wanunu, M; Zheng, Y | 1 |
| Biel, M; Brückl, T; Carell, T; Globisch, D; Koch, S; Michalakis, S; Müller, M; Münzel, M; Wagner, M | 1 |
| Frye, S; Guan, KL; Ito, S; Jiang, WQ; Kim, SH; Lei, QY; Liu, J; Liu, LX; Liu, Y; Wang, B; Wang, P; Xiao, MT; Xiong, Y; Xu, W; Xu, YH; Yang, C; Yang, H; Yang, Y; Zhang, JY; Zhang, Y; Zhao, SM | 1 |
| Fan, G; Faull, KF; Kim, KP; Le, T | 1 |
| Cunniff, K; Daley, GQ; Huang, Y; Koh, KP; Lahesmaa, R; Laiho, A; Mostoslavsky, G; Nardone, J; Orkin, SH; Rao, A; Rao, S; Rodig, SJ; Sommer, CA; Tahiliani, M; Yabuuchi, A | 1 |
| Dahl, JA; Klungland, A; Krokan, HE; Robertson, AB; Tripathi, P; Vågbø, CB | 1 |
| Davis, T; Vaisvila, R | 1 |
| Moran, RG; Peterson, EJ; Shock, LS; Taylor, SM; Thakkar, PV | 1 |
| Iqbal, K; Jin, SG; Pfeifer, GP; Szabó, PE | 1 |
| Dahl, C; Grønbæk, K; Guldberg, P | 1 |
| Grigaitytė, I; Klimašauskas, S; Kriukienė, E; Liutkevičiūtė, Z; Masevičius, V | 1 |
| Brachmann, A; Bultmann, S; Leonhardt, H; Schmidt, CS; Spada, F; Szwagierczak, A | 1 |
| Jin, SG; Li, AX; Pfeifer, GP; Wu, X | 1 |
| Arand, J; Boiani, M; Lepikhov, K; Marques, CJ; Nakamura, T; Nakano, T; Reik, W; Walter, J; Wossidlo, M; Zakhartchenko, V | 1 |
| Cui, K; D'Alessio, AC; Ito, S; Sun, YE; Wang, Z; Wu, H; Xia, K; Zhang, Y; Zhao, K | 1 |
| Brown, T; El-Sagheer, AH; Hansen, AS; Schofield, CJ; Thalhammer, A | 1 |
| Cui, K; D'Alessio, AC; Ito, S; Sun, YE; Wang, Z; Wu, H; Zhang, Y; Zhao, K | 1 |
| Andrews, S; Branco, MR; Ficz, G; Hore, TA; Krueger, F; Marques, CJ; Reik, W; Santos, F; Seisenberger, S | 1 |
| Dai, Q; He, C; Pan, T; Song, CX | 1 |
| Höbartner, C | 1 |
| Christensen, J; Cloos, PA; Helin, K; Johansen, JV; Pedersen, MT; Rappsilber, J; Williams, K | 1 |
| Ikeda, S; Okamoto, A; Sugizaki, K; Yanagisawa, H | 1 |
| Barbera, AJ; Chen, T; Deng, J; Huang, S; Kong, L; Min, J; Nicholson, T; Shi, Y; Shi, YG; Tan, L; Wu, F; Xiong, L; Xu, G; Xu, Y; Zhang, H; Zhang, K; Zheng, L | 1 |
| Dai, Q; He, C; Song, CX; Yu, M | 1 |
| He, C; Song, CX | 3 |
| Agarwal, S; Brudno, Y; Daley, GQ; Ecker, JR; Henderson, HR; Huang, Y; Kapranov, P; Ko, M; Lister, R; Liu, XS; Mahapatra, S; McLoughlin, EM; Milos, PM; Pape, UJ; Pastor, WA; Rao, A; Tahiliani, M | 1 |
| Peters, AH; Véron, N | 1 |
| Bitinaite, J; Chin, HG; Estève, PO; Feng, S; Jacobsen, SE; Kinney, SM; Pradhan, S; Stroud, H; Vaisvila, R; Zheng, Y | 1 |
| Brenner, C; Chia, N; Lu, X; Ruden, DM; Senut, MC; Wang, L | 1 |
| Bohlander, SK; Bultmann, S; Dufour, A; Herold, T; Kakadia, PM; Konstandin, N; Ksienzyk, B; Leonhardt, H; Mulaw, M; Schneider, F; Schneider, S; Spiekermann, K; Szwagierczak, A | 1 |
| Dai, Q; He, C | 1 |
| Dai, Q; He, C; Lu, XY; Song, CX; Sun, Y; Yang, CG; Yu, M | 1 |
| Carell, T; Globisch, D; Münzel, M | 1 |
| Feng, S; Jacobsen, SE; Morey Kinney, S; Pradhan, S; Stroud, H | 1 |
| Nomura, A; Okamoto, A; Sugizaki, K; Yanagisawa, H | 1 |
| Klungland, A; Robertson, AB; Robertson, J | 1 |
| Carell, T; Deiml, CA; Hackner, B; Hagemeier, C; Müller, M; Münzel, M; Pfaffeneder, T; Truss, M | 1 |
| Abramowitz, LK; Alberti, C; Bartolomei, MS; Bassi, MR; Bellacosa, A; Bruno, T; Caretti, E; Cigliano, A; Cortellino, S; Davidson, I; Devarajan, K; Fanciulli, M; Klein-Szanto, AJ; Kobi, D; Larue, L; Le Coz, M; Matsumoto, Y; Moore, R; Rambow, F; Renner, C; Sannai, M; Soprano, D; Wessels, A; Xu, J | 1 |
| Han, JW; He, C; Hermetz, K; Jin, P; Kim, JJ; Kim, S; Li, X; Li, Y; Namburi, S; Ren, B; Rudd, MK; Song, CX; Szulwach, KE; Yoon, YS | 1 |
| Antes, I; Bultmann, S; Cardoso, MC; Casa, V; Frauer, C; Hoffmann, T; Leonhardt, H | 1 |
| Almire, C; Bernard, OA; Carbonne, B; Casadevall, N; da Costa Reis Monte Mor, B; Delhommeau, F; Droin, N; Godley, LA; Larghero, J; Le Couédic, JP; Massé, A; Mokrani, H; Pendino, F; Plo, I; Pronier, E; Ravanat, JL; Simon, A; Solary, E; Vainchenker, W; Vasanthakumar, A | 1 |
| Bai, Y; Bradley, M; Chandran, S; Chebotareva, T; De Sousa, P; Dudnakova, T; Fletcher, J; Hannoun, Z; Hay, DC; Pells, S; Ruzov, A; Serio, A; Sullivan, G; Tsenkina, Y; Wilmut, I | 1 |
| Wu, H; Zhang, Y | 3 |
| Collins, LB; Dai, Q; He, C; Ito, S; Shen, L; Swenberg, JA; Wu, SC; Zhang, Y | 1 |
| Guo, JU; Ming, GL; Song, H; Su, Y; Zhong, C | 1 |
| Cohen-Karni, D; Guan, S; Pradhan, S; Quimby, A; Roberts, RJ; Wang, H; Wilson, G; Zheng, Y; Zhu, Z | 1 |
| Cheng, AW; Choi, SW; Dawlaty, MM; Ganz, K; Gao, Q; Hu, YC; Jaenisch, R; Kim, J; Markoulaki, S; Page, DC; Powell, BE | 1 |
| Chen, Z; Dai, Q; Ding, J; He, C; He, YF; Jia, Y; Li, BZ; Li, L; Li, X; Li, Z; Liu, P; Song, CX; Sun, Y; Tang, Q; Wang, Y; Xu, GL; Zhang, K | 1 |
| Ku, CS; Naidoo, N; Soong, R; Wu, M | 1 |
| Huang, TT; Li, Y; Pu, XY; Tang, H; Yamamura, KI | 1 |
| Cheng, X; Horton, JR; Upadhyay, AK; Zhang, X | 1 |
| Kohli, RM; Nabel, CS | 1 |
| Deng, Z; Gu, TP; Guo, F; He, X; Iqbal, K; Jin, SG; Li, J; Liu, W; Pfeifer, GP; Shi, L; Shi, YG; Szabó, PE; Wu, HP; Xie, ZG; Xu, GF; Xu, GL; Yang, H | 1 |
| Argani, P; Chaux, A; De Marzo, AM; Esopi, DM; Gerber, J; Haffner, MC; Iacobuzio-Donahue, C; Meeker, AK; Nelson, WG; Netto, GJ; Pellakuru, LG; Toubaji, A; Yegnasubramanian, S | 1 |
| Ikeda, S; Nakamura, A; Okamoto, A; Sugizaki, K; Yanagisawa, H | 1 |
| Inoue, A; Zhang, Y | 1 |
| Kohli, RM; Manning, SA; Nabel, CS | 1 |
| Chang, Q; Cheng, X; Dai, Q; Gearing, M; Godley, LA; He, C; Irier, H; Jin, P; Levey, AI; Li, X; Li, Y; Song, CX; Szulwach, KE; Upadhyay, AK; Vasanthakumar, A; Wu, H | 1 |
| Chase, KA; Dong, E; Gavin, DP; Guidotti, A; Matrisciano, F; Sharma, RP | 1 |
| Jiang, Y; Jin, SG; Krex, D; Lu, Q; Pfeifer, GP; Qiu, R; Rauch, TA; Schackert, G; Wang, Y | 1 |
| Carell, T; Deiml, CA; Gnerlich, FA; Karaghiosoff, K; Koch, SC; Lischke, U; Münzel, M; Pfaffeneder, T; Stathis, D | 1 |
| Branco, MR; Ficz, G; Reik, W | 1 |
| Chang, Q; Chestnut, BA; Lesuisse, C; Martin, LJ; Price, A; Wong, M | 1 |
| Clark, TA; Dai, Q; He, C; Kislyuk, A; Korlach, J; Lu, XY; Song, CX; Turner, SW | 1 |
| Dixon, JM; Dunican, D; Harrison, DJ; Katz, E; Meehan, RR; Nestor, CE; Ottaviano, R; Reddington, J; Reinhardt, D; Sproul, D | 1 |
| Flax, JD; Soloway, PD | 1 |
| Dai, Q; He, C; Inoue, A; Shen, L; Zhang, Y | 1 |
| Acevedo, LG; Jelinek, MA; Sanz, A | 1 |
| Christensen, J; Helin, K; Williams, K | 1 |
| Carrillo-de Santa Pau, E; Matarese, F; Stunnenberg, HG | 1 |
| Chen, PB; Dong, X; Ee, LS; Fazzio, TG; Hung, JH; Li, R; Rando, OJ; Weng, Z; Yildirim, O | 1 |
| Salbert, G; Weber, M | 1 |
| Cuddapah, S; Freudenberg, JM; Ghosh, S; Hu, G; Jothi, R; Lackford, BL; Li, R; Wade, PA; Yellaboina, S; Zheng, X | 1 |
| Bitinaite, J; Pradhan, S; Terragni, J; Zheng, Y | 1 |
| Carell, T; Eigenbrod, S; Feiden, W; Globisch, D; Hackner, B; Kraus, TF; Kretzschmar, HA; Müller, M; Münzel, M; Pfaffeneder, T; Schüller, U; Wagner, M; Widmann, D | 1 |
| Tsukada, Y | 1 |
| Chen, Y; Gao, F; Guan, J; Li, Z; Su, L; Tang, B; Wang, Z; Yin, Y; Zhang, P; Zhang, S | 1 |
| Chouliaras, L; Hof, PR; Keitel, S; Kenis, G; Rutten, BP; Schmitz, C; Steinbusch, HW; van den Hove, DL; van Os, J | 1 |
| Chouliaras, L; Rutten, BP; van den Hove, DL | 1 |
| Dahl, JA; Klungland, A; Ougland, R; Robertson, AB | 1 |
| Irier, HA; Jin, P | 1 |
| Aburatani, H; Asaoka, Y; Ijichi, H; Koike, K; Kudo, Y; Nagae, G; Tateishi, K; Yamamoto, K; Yamamoto, S; Yoshida, H | 1 |
| Agirre, X; Alvarez, S; Boultwood, J; Calasanz, MJ; Cross, NC; Cruz Cigudosa, J; Delabesse, E; Fernandez-Mercado, M; Garate, L; Martín-Subero, JI; Martínez-Calle, N; Pérez, C; Prósper, F; Rifon, J; Segura, V; Varea, S; Wainscoat, JS | 1 |
| Chang, Y; Cheng, X; Hashimoto, H; Howerton, SB; Liu, Y; Upadhyay, AK; Vertino, PM; Zhang, X | 1 |
| Bai, F; Guan, KL; Ling, ZQ; Liu, J; Liu, Y; Ma, SH; Xiong, Y; Xu, ZD; Yang, H; Ye, D; Zhang, JY; Zhu, HG | 1 |
| Almeida, RD; De Sousa, PA; Johnson, AD; Loose, M; Ruzov, A; Sottile, V | 1 |
| Almeida, RD; Denning, C; Gering, M; Johnson, AD; Loose, M; Matsa, E; Ruzov, A; Sottile, V; Young, L | 1 |
| Chen, H; Dzitoyeva, S; Manev, H | 3 |
| Dunn, JJ; He, C; Kumaran, D; Song, CX; Yao, Q | 1 |
| Karlic, H; Klaushofer, K; Spitzer, S; Thaler, R; Varga, F | 1 |
| Balasubramanian, S; Booth, MJ; Branco, MR; Ficz, G; Krueger, F; Oxley, D; Reik, W | 1 |
| Bocker, MT; Breiling, A; Lyko, F; Musch, T; Raddatz, G; Tuorto, F; Xu, M; Yang, FC | 1 |
| Shi, YG; Tan, L | 1 |
| Rugg-Gunn, PJ | 1 |
| Dai, Q; He, C; Hon, GC; Jin, P; Kim, A; Li, X; Min, JH; Park, B; Ren, B; Shen, Y; Song, CX; Szulwach, KE; Yu, M; Zhang, L | 1 |
| Cang, J; Huang, N; Tan, L; Wang, H; Xue, Z | 1 |
| Cai, C; Chen, L; Kang, JX; Xie, A; Ye, X; Zhang, J; Zhang, L; Zhou, K | 1 |
| Gao, KR; Yu, SY; Zhang, YX | 1 |
| Becker, A; Denkhaus, D; Freihoff, D; Freihoff, J; Gessi, M; Hammes, J; Isselstein, LJ; Luxen, D; Müller, T; Pietsch, T; Simon, M; Waha, A; zur Mühlen, A | 1 |
| Aguirre-Lavin, T; Beaujean, N; Boulesteix, C; Debey, P; Lehmann, G; Salvaing, J | 1 |
| Guz, J; Jurgowiak, M; Oliński, R | 1 |
| Inoue, K; Liu, YJ; Matoba, S; Nakamura, T; Nakano, T; Nakashima, H; Ogura, A; Shinkai, Y; Tachibana, M; Umehara, H | 1 |
| Avner, S; Barloy-Hubler, F; Bizot, M; Durand, E; Eeckhoute, J; Froguel, P; Gheeraert, C; Lefebvre, P; Lucchetti-Miganeh, C; Madigou, T; Métivier, R; Oger, F; Palierne, G; Percevault, F; Péron, CL; Salbert, G; Sérandour, AA; Staels, B | 1 |
| Chouliaras, L; Delbroek, L; Prickaerts, J; Rostamian, S; Rutten, BP; Sierksma, AS; Steinbusch, HW; van den Hove, DL | 1 |
| Eberhart, CG; Haffner, MC; Nelson, WG; Orr, BA; Yegnasubramanian, S | 1 |
| Klimašauskas, S; Kriukienė, E; Liutkevičiūtė, Z | 1 |
| Couvé, S; Grin, I; Henriot, V; Ishchenko, AA; Moréra, S; Saparbaev, M; Vigouroux, A | 1 |
| Wilkinson, J | 1 |
| Leonard, K; Lloyd, AJ; López, CM; Wilkinson, MJ | 1 |
| Balasubramanian, S; Beraldi, D; Booth, MJ; Branco, MR; Burgess, HE; Ficz, G; Murat, P; Oxley, D; Raiber, EA; Reik, W | 1 |
| Ando, Y; Furuhata, E; Hasegawa, R; Hayashizaki, Y; Kubosaki, A; Shin, JW; Simon, C; Suzuki, H; Suzuki, T; Tomaru, Y | 1 |
| Cai, C; Chen, L; Zhang, L | 1 |
| Kinney, SR; Pradhan, S | 1 |
| Belsham, D; Blencowe, BJ; Irimia, M; Jia, P; Kapranov, P; Khare, T; Klimasauskas, S; Koncevicius, K; Kriukiene, E; Kustra, R; Labrie, V; Liutkeviciute, Z; Moréra, S; Nazarians, A; Pai, S; Pal, M; Petronis, A; Ptak, C; Tice, R; Tochigi, M; Wang, SC; Wong, AH; Xia, M | 1 |
| Ceol, C; Dresser, K; Duncan, LM; Fang, R; Houvras, Y; Hu, D; Hu, Y; Kaiser, UB; Kakavand, H; Khorasani, AJ; Kleffel, S; Larson, A; Lee, CW; Lezcano, C; Lian, BQ; Lian, CG; Mihm, MC; Murphy, GF; Neiswender, J; Schatton, T; Scolyer, RA; Shi, YG; Tan, L; Thompson, JF; Woda, BA; Wu, F; Xu, W; Xu, Y; Yang, Y; Zhan, Q; Zon, LI | 1 |
| Miller, AK; Schüler, P | 1 |
| Huang, Y; Pastor, WA; Rao, A; Zepeda-Martínez, JA | 1 |
| Agarwal, S; Henderson, HR; Huang, Y; Pastor, WA; Rao, A | 1 |
| Ding, W; Xing, TY | 1 |
| Bolognani, F; Hackett, JA; Lempiäinen, H; Meehan, RR; Moggs, JG; Müller, A; Nestor, CE; Oakeley, EJ; Reinhardt, D; Schübeler, D; Terranova, R; Thomson, JP | 1 |
| Duan, R; He, C; Jin, P; Li, X; Lin, L; Pan, Q; Song, CX; Szulwach, KE; Wang, T; Warren, ST; Wu, H | 1 |
| He, C; Jin, P; Li, Y; Song, CX | 1 |
| Fu, Y; He, C | 1 |
| Kawamura, F; Kimura, H; Kubiura, M; Okano, M; Tada, M | 1 |
| Bellini, M; Jones, P; Morgan, GT | 1 |
| He, C; Hon, GC; Jin, P; Ren, B; Song, CX; Szulwach, KE; Yu, M | 1 |
| Down, TA; Hackett, JA; Lee, C; Murakami, K; Sengupta, R; Surani, MA; Zylicz, JJ | 1 |
| Du, J; Guo, Z; Liu, Y; Tang, B; Wang, Y; Wu, Y; Yang, L; Zhang, Y | 1 |
| Ayata, P; Dewell, S; Heintz, N; Kriaucionis, S; Mellén, M | 1 |
| Arita, K; Ariyoshi, M; Kato, T; Kimura, H; Kinoshita, M; Otani, J; Shirakawa, M; Suetake, I; Tajima, S | 1 |
| Bapat, B; Olkhov-Mitsel, E | 1 |
| Chen, ML; Feng, YQ; Huang, W; Liu, SM; Qi, JH; Shen, F; Wang, Y; Yuan, BF | 1 |
| Borgaro, JG; Cheng, X; Guan, S; Jolyon, T; Liu, Y; Pradhan, S; Sun, D; Sun, Z; Terragni, J; Wang, H; Yu, L; Zheng, Y; Zhu, Z | 1 |
| Barrasa, MI; Breiling, A; Cheng, AW; Dawlaty, MM; Faull, KF; Gao, Q; Jaenisch, R; Le, T; Li, Z; Lyko, F; Powell, BE; Raddatz, G; Xu, M | 1 |
| Bernard, O; Calonne, E; Daniels, DL; Dawson, MA; Defrance, M; Delatte, B; Deplus, R; Fuks, F; Levine, RL; Méndez, J; Mercher, T; Murphy, N; Putmans, P; Schwinn, MK; Shih, AH; Solary, E; Urh, M; Volkmar, M | 1 |
| Albasanz, JL; Barrachina, M; Blanch, M; Ferrer, I; Martín, M; Pereira-Veiga, T; Pérez-Navarro, E; Tyebji, S; Villar-Menéndez, I | 1 |
| Hong, K; Inoue, A; Liu, R; Shen, L; Yamaguchi, S; Zhang, K; Zhang, Y | 1 |
| Hahn, MA; Jiang, Y; Jin, SG; Jui, J; Li, AX; Lu, Q; Pfeifer, GP; Qiu, R; Wang, J; Wu, X; Zhang, H | 1 |
| Mariappa, D; Pathak, S; van Aalten, DM | 1 |
| Huang, N; Kong, L; Schwartz, L; Shi, Y; Shi, YG; Tan, L; Wu, F; Xiong, L; Xu, W; Xu, Y; Zheng, L | 1 |
| Chen, Y; Oztürk, NC; Resendiz, M; Zhou, FC | 1 |
| Calvopiña, JH; Chen, PY; Clark, AT; Fan, G; Faull, K; Feng, S; Huang, Y; Jacobsen, SE; Le, T; Lee, SA; Nee, K; Pellegrini, M; Rao, A; Vincent, JJ; Yoon, AJ | 1 |
| Badoo, M; Baribault, C; Crain, CM; Crawford, GE; Ehrlich, M; Gertz, J; Lacey, M; Myers, RM; Pradhan, S; Song, L; Terragni, J; Tsumagari, K; Varley, KE | 1 |
| Liu, S; Liu, X; Luo, Y; Pei, M; Shen, J; Xiao, L; Xu, Y; Yi, Y; Zhang, G; Zheng, W; Zhong, H | 1 |
| Bauer, C; Boelens, R; Brinkman, AB; Carell, T; Eberl, HC; Gnerlich, F; Jansen, PW; Khan, F; Leonhardt, H; Lephikov, K; Mensinga, A; Müller, M; Müller, U; Münzel, M; Pfaffeneder, T; Smits, AH; Spruijt, CG; van Ingen, H; Vermeulen, M; Wagner, M; Walter, J | 1 |
| Andreazza, AC; Carvalho, AF; Machado-Vieira, R; Moreno, RA; Soeiro-de-Souza, MG; Young, LT | 1 |
| Bagci, H; Brown, KE; Dawlaty, MM; Feytout, A; Fisher, AG; Hajkova, P; Jaenisch, R; Kriaucionis, S; Landeira, D; Leitch, HG; Merkenschlager, M; Mooijman, D; Piccolo, FM; Soza-Ried, J; Tada, T | 1 |
| Gambichler, T; Sand, M; Skrygan, M | 1 |
| Borgaro, JG; Zhu, Z | 1 |
| Shen, L; Zhang, Y | 1 |
| Koh, KP; Rao, A | 1 |
| Cai, T; Chen, J; Gao, S; Gao, Y; Huang, B; Huang, H; Jiang, Y; Kang, L; Kou, X; Li, K; Liu, W; Liu, X; Lu, Z; Wang, H; Wu, T; Xu, Z; Yao, C; Zhang, Y | 1 |
| Gao, F; Gao, Z; Han, X; Huang, X; Lin, Z; Lu, H; Luo, H; Wang, J; Wen, B; Xia, Y; Yang, H; Yao, Y; Yi, N; Zhang, J; Zhang, X; Zhou, B | 1 |
| Godley, LA; Madzo, J; Vasanthakumar, A | 1 |
| Cai, C; Chen, LY; Kang, JX; Xie, AM; Ye, XX; Zhang, JJ; Zhang, LJ; Zhang, LT | 1 |
| Court, BL; Minor, EA; Wang, G; Young, JI | 1 |
| Bayley, H; Gong, L; Li, WW | 1 |
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| Bian, XW; Chen, T; Dong, C; Ichiyama, K; Jin, W; Liu, X; Lu, H; Nallaparaju, KC; Tanaka, S; Tian, Q; Wei, L; Wen, X; Yan, X; Zhang, L; Zhang, X | 1 |
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| Astudillo, A; Bayón, GF; Bigot, T; Carella, A; Chiara, MD; Corte-Torres, MD; Fernández, AF; Fraga, MF; García, MG; García-Toraño, E; López, V; Mangas, C; Meléndez, B; Mollejo, M; Pérez, RF; Sáenz-de-Santa-María, I; Santamarina-Ojeda, P; Sierra, M; Tejedor, JR; Urdinguio, RG | 1 |
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| Bi, SH; Biekedawulaiti, G; Chen, HY; Chen, L; Chu, JL; Du, LW; Duolikun, M; He, Y; Li, LL; Lin, J; Ma, RY; Maimaiti, Y; Tie, L; Wan, XY; Wang, ZH; Yang, ZQ; Zhang, L; Zheng, MZ | 1 |
| Bhatti, P; Chiu, BC; Derman, BA; He, C; Jakubowiak, A; Karpus, J; Langerman, SS; Luo, L; Sukhanova, M; Zhang, S; Zhang, W; Zhang, Z | 1 |
| Ci, W; Huang, C; Qi, J; Shi, Y; Tan, Y; Wang, J; Zhang, J; Zhang, Q | 1 |
| Balaiah, M; Mani, S; Ramasamy, D; Rao, AKDM; Sundersingh, S; Thangarajan, R; Veluswami, S; Vittal Rangan, A | 1 |
| Aggarwal, R; Alumkal, JJ; Annala, M; Ashworth, A; Beer, TM; Bergamaschi, A; Bjartell, A; Bose, R; Boutros, PC; Chen, S; Chen, WS; Chesner, L; Chi, KN; Chou, J; Cui, XL; Evans, CP; Feng, FY; Fong, L; Foye, A; Fraser, M; Gilbert, LA; Gleave, M; Haffner, MC; He, C; He, HH; Herberts, C; Hua, JT; Huang, FW; Huang, J; Lang, JM; Lara, PN; Levy, S; Li, H; Lloyd, P; Lundberg, A; Luo, J; Mahajan, NP; Maher, CA; Maheshwari, A; Maurice-Dror, C; McCarthy, E; Moreno-Rodriguez, T; Morgans, AK; Ng, SWS; Ning, Y; Perry, MD; Petricca, J; Phillips, T; Posadas, EM; Quigley, DA; Reiter, RE; Rettig, MB; Shrestha, R; Sjöström, M; Small, EJ; Thomas, GV; Tran, PT; Witte, ON; Wyatt, AW; Ye, W; Zhang, M; Zhao, SG; Zoubeidi, A; Zwart, W | 1 |
| Liang, WB; Yang, F; Yang, X; Yuan, R; Zhuo, Y | 1 |
| Cao, F; Hu, X; Liu, Y; Mao, Q; Xia, L; Xie, D; Yan, X; Yan, Z; Yin, S; Yuan, Y; Zhang, J; Zhang, S | 1 |
| Atzberger, A; Boettger, T; Braun, T; Ding, D; Gärtner, U; Günther, S; Kolahian, S; Kuenne, C; Li, X; Liu, H; Liu, S; Looso, M; Offermanns, S; Potente, M; Renz, H; Weissmann, N; Wu, F; Yuan, X; Zhou, Y | 1 |
| Pfeifer, GP | 1 |
| Badiola, JJ; Betancor, M; Bolea, R; Hernaiz, A; López-Pérez, Ó; Martín-Burriel, I; Salinas-Pena, M; Sentre, S; Toivonen, JM; Zaragoza, P | 1 |
| Cai, JB; Chen, Y; Fan, J; Gao, C; Guo, XJ; Huang, XY; Ke, AW; Lu, JC; Pei, YZ; Shen, YH; Shi, GM; Shi, YG; Sun, QM; Wei, CY; Yang, GH; Yang, X; Zhang, PF; Zhou, J | 1 |
| Bang, D; Kim, HP; Kim, TY; Lee, D; Lee, J | 1 |
| Achrem, M; Gackowski, D; Kalinka, A; Starczak, M; Stępień, E | 1 |
| Arvanitakis, Z; Beadell, AV; Bennett, DA; Capuano, AW; He, C; Zhang, W; Zhang, Z | 1 |
| Dai, E; Dai, M; Feng, J; Jia, Y; Liu, Z; Ye, L; Zhang, H | 1 |
| Ganguly, S; He, C; Li, Z; Shah, S; Shao, J; Zu, Y | 2 |
| Arvanitakis, Z; Bissonnette, MA; Cai, J; Cai, Q; Cheng, SY; Chiu, BC; Cui, X; He, C; Shi, Y; Wu, K; Zeng, C; Zhang, W; Zhang, X; Zhang, Z | 2 |
| Avraham, S; Bahr, O; Dankers, A; Ebenstein, Y; Gilat, N; Käver, L; Koren-Michowitz, M; Margalit, S; Michaeli, Y; Nifker, G; Schütz, L; Torchinsky, D; Weinhold, E; Zirkin, S | 1 |
108 review(s) available for 5-hydroxymethylcytosine and 5-methylcytosine
| Article | Year |
|---|---|
Modified bases in bacteriophage DNAs.
Topics: 2-Aminopurine; 5-Methylcytosine; Adenine; Bacteriophages; Base Composition; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytosine; Deoxyribonucleases; DNA Replication; DNA, Viral; Nucleic Acid Conformation; Pentoxyl; Substrate Specificity; Templates, Genetic; Thymine; Transcription, Genetic; Uracil | 1980 |
Genetic-epigenetic intersection in trophoblast differentiation: implications for extraembryonic tissue function.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Female; Gene Expression Regulation; Humans; Models, Biological; Models, Genetic; Placenta; Plants; Pregnancy; Stem Cells; Trophoblasts | 2010 |
Advances in DNA methylation: 5-hydroxymethylcytosine revisited.
Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; DNA; DNA Methylation; Genome; Hematologic Neoplasms; Humans; Oxygenases | 2011 |
Hypothesis: environmental regulation of 5-hydroxymethylcytosine by oxidative stress.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Histone Demethylases; Humans; Models, Biological; Oxidative Stress | 2011 |
5-Hydroxymethylcytosine, the sixth base of the genome.
Topics: 5-Methylcytosine; Animals; Bacteriophages; Cell Differentiation; Central Nervous System; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; DNA, Viral; Epigenesis, Genetic; Female; Genome; Humans; Male; Mass Spectrometry; Neoplasms; Pluripotent Stem Cells | 2011 |
Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond.
Topics: 5-Methylcytosine; Animals; Cell Cycle Proteins; Cytosine; Dioxygenases; DNA Methylation; DNA Repair; DNA-Binding Proteins; Humans; Mixed Function Oxygenases; Nuclear Proteins; Proto-Oncogene Proteins | 2011 |
Studying the epigenome using next generation sequencing.
Topics: 5-Methylcytosine; Animals; Base Composition; Cytosine; DNA; DNA Methylation; DNA, Intergenic; Epigenesis, Genetic; Epigenomics; Gene Expression; Genome; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Histones; Humans; Mice; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Quantitative Trait Loci; Quantitative Trait, Heritable | 2011 |
The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.
Topics: 5-Methylcytosine; Adaptation, Physiological; Animals; Cytosine; Deamination; DNA; DNA Repair; Gene Expression Regulation; Genome; Genomics; Humans; Methylation; Mice; Mice, Knockout; Oxidation-Reduction; Polymorphism, Genetic | 2012 |
Uncovering the role of 5-hydroxymethylcytosine in the epigenome.
Topics: 5-Methylcytosine; Animals; Blastocyst Inner Cell Mass; Cell Differentiation; Cell Proliferation; Chromatin; CpG Islands; Cytosine; Deamination; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Developmental; Gene Silencing; Genome; Hematopoiesis; Humans; Mice; Mice, Knockout; Mixed Function Oxygenases; Proto-Oncogene Proteins; Tissue Distribution | 2011 |
Novel DNA binding domain-based assays for detection of methylated and nonmethylated DNA.
Topics: 5-Methylcytosine; Biomarkers; CpG Islands; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; Humans; Immunoprecipitation; Polymerase Chain Reaction; Protein Interaction Domains and Motifs; Sensitivity and Specificity; Sulfites | 2011 |
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Models, Biological; Oxidation-Reduction | 2011 |
DNA methylation: TET proteins-guardians of CpG islands?
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; Humans; Mice; Proto-Oncogene Proteins; Transcription, Genetic | 2011 |
Hydroxylation mediates chromatin demethylation.
Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; DNA Methylation; Humans; Hydroxylation; Methylation | 2012 |
Dynamics of DNA methylation in aging and Alzheimer's disease.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; DNA; DNA Methylation; Humans; Neurodegenerative Diseases | 2012 |
Tet family proteins and 5-hydroxymethylcytosine in development and disease.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Epigenesis, Genetic; Humans; Mice; Mice, Knockout; Molecular Structure; Multigene Family; Neoplasms; Oxidation-Reduction; Protein Structure, Tertiary; Proto-Oncogene Proteins | 2012 |
Epigenetic features of the mouse trophoblast.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Fetal Growth Retardation; Gene Expression Regulation, Developmental; Histones; Mice; Models, Animal; Pregnancy; Pregnancy Complications; Trophoblasts | 2012 |
[Progress of research on 5-hydroxymethylcytosine].
Topics: 5-Methylcytosine; Animals; Cytosine; Epigenesis, Genetic; Humans | 2012 |
[Oxidation and deamination of nucleobases as an epigenetic tool].
Topics: 5-Methylcytosine; Animals; Base Composition; Chromatin Assembly and Disassembly; Cytosine; Deamination; DNA; DNA Methylation; DNA-Binding Proteins; Epigenomics; Gene Expression Regulation; Guanine; Mutation; Neoplasms; Oxidation-Reduction; Sequence Analysis, DNA; Transcription, Genetic | 2012 |
5-Hydroxymethylcytosine--the elusive epigenetic mark in mammalian DNA.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Epigenesis, Genetic; Humans; Mammals | 2012 |
Ten eleven translocation enzymes and 5-hydroxymethylation in mammalian development and cancer.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Humans; Neoplasms; Proto-Oncogene Proteins | 2013 |
[Recent advance in DNA epigenetic modifications-the sixth base in the genome].
Topics: 5-Methylcytosine; Animals; Biomarkers; Cell Differentiation; Cytosine; DNA; Epigenesis, Genetic; Gene Expression Regulation; Genome; Humans; Methylation | 2012 |
Nucleic acid modifications with epigenetic significance.
Topics: 5-Methylcytosine; Adenosine; Animals; Cytosine; DNA; Epigenesis, Genetic; Humans; Methylation; RNA | 2012 |
Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; Disease; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genetic Markers; Humans; Restriction Mapping; Sequence Analysis, DNA | 2012 |
Epigenetic medicine and fetal alcohol spectrum disorders.
Topics: 5-Methylcytosine; Cell Differentiation; Cytosine; DNA Methylation; Embryonic Development; Epigenesis, Genetic; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Gene Expression Regulation; Histones; Humans; Pregnancy | 2013 |
5-Hydroxymethylcytosine: generation, fate, and genomic distribution.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Genome; Genome-Wide Association Study; Humans | 2013 |
DNA methylation and methylcytosine oxidation in cell fate decisions.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Chromatin Assembly and Disassembly; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome; Histones; Humans; Oxidation-Reduction; Transcription Factors | 2013 |
Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Isocitrate Dehydrogenase; Mutation; Proto-Oncogene Proteins | 2013 |
Functions of DNA methylation and hydroxymethylation in mammalian development.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Embryonic Development; Gene Expression Regulation, Developmental; Genome; Humans; Mammals | 2013 |
Tet family of 5-methylcytosine dioxygenases in mammalian development.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Genome; Germ Cells; Humans; Proto-Oncogene Proteins | 2013 |
[Role of 5-hydroxymethylcytosine and TET proteins in epigenetic regulation of gene expression].
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Hematopoiesis; Humans; Mixed Function Oxygenases; Neoplasms; Proto-Oncogene Proteins | 2013 |
Cytosine modifications in neurodevelopment and diseases.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA-Cytosine Methylases; Humans; Models, Molecular; Nervous System Diseases; Neurogenesis | 2014 |
Epigenetic profiles as defined signatures of xenobiotic exposure.
Topics: 5-Methylcytosine; Animals; Carcinogens; Chemical Safety; Chromatin; Cytosine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Epigenomics; Genetic Markers; Genome; Humans; Transcriptome; Xenobiotics | 2014 |
TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA Repair; Humans; Models, Biological; Mutagenesis; Neoplasms; Oxidation-Reduction | 2014 |
DNA modifications and neurological disorders.
Topics: 5-Methylcytosine; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Nervous System Diseases; Neurons | 2013 |
TET enzymes, TDG and the dynamics of DNA demethylation.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cellular Reprogramming; Cytosine; DNA Methylation; DNA Repair; DNA Replication; Humans; Neoplasms; Oxidation-Reduction; Thymine DNA Glycosylase | 2013 |
Investigating 5-hydroxymethylcytosine (5hmC): the state of the art.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cytosine; DNA Methylation; Genetic Loci; Mammals; Molecular Biology; Molecular Sequence Data | 2014 |
5-hydroxymethylcytosine: a new insight into epigenetics in cancer.
Topics: 5-Methylcytosine; Animals; Brain Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Leukemia; Mixed Function Oxygenases; Neoplasms; Proto-Oncogene Proteins | 2014 |
5-hydroxymethylcytosine profiling as an indicator of cellular state.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Models, Genetic; Neoplasms; Organ Specificity; Signal Transduction | 2013 |
Recent advances in the bioanalysis of modified nucleotides in epigenetic studies.
Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Nucleotides | 2013 |
[The world of double helix--"it did not escape our notice"].
Topics: 5-Methylcytosine; Base Sequence; Chromatin; Cytosine; DNA; DNA Repair; DNA, Catalytic; Epigenomics; Forecasting; Humans; Molecular Biology; Nanotechnology | 2013 |
Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders.
Topics: 5-Methylcytosine; Animals; Biological Evolution; Brain; Cytosine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mental Disorders; Models, Biological; Nerve Tissue Proteins; Neurogenesis; Neurons; Up-Regulation | 2014 |
5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Humans; Stem Cells | 2014 |
Epigenetic modifications in the nervous system and their impact upon cognitive impairments.
Topics: 5-Methylcytosine; Acetylation; Animals; Central Nervous System; Cognition; Cognition Disorders; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histone Deacetylases; Histones; Humans; Learning; Memory; Models, Biological; Nerve Tissue Proteins; Neurons; Protein Processing, Post-Translational; Rett Syndrome; Rubinstein-Taybi Syndrome | 2014 |
The role of TET family proteins and 5-hydroxymethylcytosine in human tumors.
Topics: 5-Methylcytosine; Cell Transformation, Neoplastic; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Neoplasms | 2014 |
The role of 5-hydroxymethylcytosine in human cancer.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA, Neoplasm; Humans; Neoplasms; Oxidation-Reduction | 2014 |
Playing TETris with DNA modifications.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Humans; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; Signal Transduction | 2014 |
5-Hydroxymethylcytosine: A new player in brain disorders?
Topics: 5-Methylcytosine; Brain Diseases; Cytosine; Humans | 2015 |
Mitoepigenetics and drug addiction.
Topics: 5-Methylcytosine; Amphetamines; Animals; Cocaine; Cytosine; DNA, Mitochondrial; Dose-Response Relationship, Drug; Epigenesis, Genetic; Ethanol; Gene Expression; Humans; Mitochondria; Morphine; Oxidative Stress; Substance-Related Disorders | 2014 |
New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enhancer Elements, Genetic; Hematopoiesis; Hematopoietic Stem Cells; Mice; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid | 2014 |
Connections between TET proteins and aberrant DNA modification in cancer.
Topics: 5-Methylcytosine; Azacitidine; Cytosine; Decitabine; Dioxygenases; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Hematologic Neoplasms; Humans; Isocitrate Dehydrogenase; Mixed Function Oxygenases; Molecular Targeted Therapy; Mutation; Neoplasms; Proto-Oncogene Proteins; Small Molecule Libraries | 2014 |
DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: an emerging complex story.
Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Induced Pluripotent Stem Cells; Models, Biological; Oxidation-Reduction | 2014 |
Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Humans; Mixed Function Oxygenases; Neoplasms; Oxidation-Reduction; Proto-Oncogene Proteins | 2014 |
5-Hydroxymethylcytosine: a stable or transient DNA modification?
Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; DNA Replication; DNA-Binding Proteins; Humans | 2014 |
TET enzymes and DNA hydroxymethylation in neural development and function - how critical are they?
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Neurogenesis; Neurons; Oxidation-Reduction | 2014 |
From development to diseases: the role of 5hmC in brain.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Nervous System Diseases; Neurons | 2014 |
Genomic distribution and possible functions of DNA hydroxymethylation in the brain.
Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Genome; Humans; Oxidation-Reduction | 2014 |
Expanding the epigenetic landscape: novel modifications of cytosine in genomic DNA.
Topics: 5-Methylcytosine; Cytosine; DNA; Epigenesis, Genetic; Models, Genetic; Oxidation-Reduction | 2014 |
Determinants of valid measurements of global changes in 5'-methylcytosine and 5'-hydroxymethylcytosine by immunolocalisation in the early embryo.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Embryo, Mammalian; Embryonic Development; Immunohistochemistry | 2015 |
Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization.
Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; Decidua; DNA Methylation; Embryo Implantation; Epigenesis, Genetic; Female; Gene Expression Regulation; Histones; Humans; Pregnancy; Protein Processing, Post-Translational | 2014 |
5-hydroxymethylcytosine: a potential therapeutic target in cancer.
Topics: 5-Methylcytosine; Animals; Antineoplastic Agents; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms | 2014 |
New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cytosine; Diet; DNA Methylation; Folic Acid; Hematologic Neoplasms; Humans; MicroRNAs; Promoter Regions, Genetic; Structure-Activity Relationship; Transcription Factors | 2015 |
5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Isocitrate Dehydrogenase; Mutation; Neoplasms; Proto-Oncogene Proteins | 2015 |
DNA methylation and hydroxymethylation in stem cells.
Topics: 5-Methylcytosine; Adult; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Stem Cells | 2015 |
Hydroxymethylation and its potential implication in DNA repair system: A review and future perspectives.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Repair; Humans; Mental Disorders; Neoplasms; Neurodegenerative Diseases | 2015 |
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy.
Topics: 5-Methylcytosine; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Humans; Isocitrate Dehydrogenase; Neoplasms; Proto-Oncogene Proteins | 2015 |
Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword.
Topics: 5-Methylcytosine; Base Pair Mismatch; CpG Islands; Cytosine; Deamination; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Gene Expression; Humans; Molecular Mimicry; Oxidation-Reduction; Thymine DNA Glycosylase | 2015 |
The TET2 interactors and their links to hematological malignancies.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Genes, Tumor Suppressor; Hematologic Neoplasms; Hematopoiesis; Humans; Mice; Mutation; Protein Interaction Maps; Proto-Oncogene Proteins | 2015 |
Role of 5-hydroxymethylcytosine in neurodegeneration.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Neurodegenerative Diseases | 2015 |
Functions of TET Proteins in Hematopoietic Transformation.
Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Genes, Tumor Suppressor; Hematologic Neoplasms; Hematopoiesis; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mice; Oxidation-Reduction | 2015 |
Practical guidelines and consideration of using RRHP for 5hmC detection.
Topics: 5-Methylcytosine; Animals; Computational Biology; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Library; Guidelines as Topic; High-Throughput Nucleotide Sequencing; Humans | 2016 |
Hydroxymethyl cytosine marks in the human mitochondrial genome are dynamic in nature.
Topics: 5-Methylcytosine; Cytosine; DNA, Mitochondrial; Epigenesis, Genetic; Gene Expression Regulation; Genome, Mitochondrial; Humans | 2016 |
DNA methylation dynamics in neurogenesis.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Stem Cells; Epigenesis, Genetic; Histones; Humans; Mammals; Neurogenesis | 2016 |
[Advances on the profiling of 5-hydroxymethylcytosine].
Topics: 5-Methylcytosine; Animals; Cytosine; Epigenomics; High-Throughput Screening Assays; Humans | 2016 |
Physiological and pathological implications of 5-hydroxymethylcytosine in diseases.
Topics: 5-Methylcytosine; CpG Islands; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Demethylation; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Enzyme Inhibitors; Epigenesis, Genetic; Humans; Mixed Function Oxygenases; Neoplasms; Nervous System Diseases; Promoter Regions, Genetic; Proto-Oncogene Proteins | 2016 |
High-throughput sequencing offers new insights into 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Humans; Organ Specificity | 2016 |
New hope: the emerging role of 5-hydroxymethylcytosine in mental health and disease.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenesis, Genetic; Gene Expression; Humans; Mental Disorders; Mental Health | 2016 |
Uncovering the Role of the Methylome in Dementia and Neurodegeneration.
Topics: 5-Methylcytosine; Aging; Animals; Brain; Dementia; DNA Methylation; Epigenesis, Genetic; Epigenomics; Humans; Neurodegenerative Diseases | 2016 |
Are there specific readers of oxidized 5-methylcytosine bases?
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA-Binding Proteins; Humans | 2016 |
The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Nerve Tissue Proteins; Neurogenesis; Neurons; Protein Conformation; Signal Transduction; Structure-Activity Relationship | 2016 |
DNA methylation: conducting the orchestra from exposure to phenotype?
Topics: 5-Methylcytosine; 5' Untranslated Regions; CpG Islands; DNA Methylation; Environmental Exposure; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation; Humans; Phenotype; Protein Isoforms; Receptors, Glucocorticoid | 2016 |
The elusive role of 5'-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Oxidation-Reduction | 2016 |
Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies.
Topics: 5-Methylcytosine; Dioxygenases; DNA-Binding Proteins; Hematologic Neoplasms; Humans; Mutation; Proto-Oncogene Proteins | 2016 |
Proteins That Read DNA Methylation.
Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Protein Domains | 2016 |
DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications.
Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Eukaryota; Prokaryotic Cells; Protein Domains | 2016 |
Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.
Topics: 5-Methylcytosine; DNA; DNA Methylation; Epigenesis, Genetic; Genome; High-Throughput Nucleotide Sequencing; Humans; Sequence Analysis, DNA | 2016 |
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.
Topics: 5-Methylcytosine; Animals; Carcinogenesis; Cell Self Renewal; Cytosine; DNA; DNA Methylation; DNA Repair; Humans; Oxidation-Reduction; Transcription, Genetic | 2017 |
Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Humans; Lymphatic Metastasis; Neoplasms; Prognosis | 2017 |
The application of genome-wide 5-hydroxymethylcytosine studies in cancer research.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms; Sequence Analysis, DNA | 2017 |
The role of 5-hydroxymethylcytosine in melanoma.
Topics: 5-Methylcytosine; DNA Methylation; Epigenesis, Genetic; Humans; Melanoma | 2017 |
Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Antibody Specificity; Base Sequence; Chromatography, High Pressure Liquid; Chromosome Mapping; DNA; DNA Restriction Enzymes; Epigenesis, Genetic; Fluorescence Resonance Energy Transfer; Genetic Markers; Glycosylation; Humans; Mass Spectrometry; Sequence Analysis, DNA; Single Molecule Imaging | 2017 |
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
Topics: 5-Methylcytosine; Aging; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms; Oxidation-Reduction | 2017 |
DNA Modifications and Alzheimer's Disease.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Causality; Disease Models, Animal; DNA Methylation; DNA-Cytosine Methylases; Epigenesis, Genetic; Forecasting; Gene Expression Regulation; Genome-Wide Association Study; Humans; Mice; Mice, Transgenic; Nerve Tissue Proteins; Tissue Array Analysis | 2017 |
Technologies for Deciphering Epigenomic DNA Patterns.
Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA Methylation; Epigenomics; Formaldehyde; Humans; Microarray Analysis; Paraffin Embedding; Sulfites; Tissue Fixation; Uracil | 2017 |
The role of TET-mediated DNA hydroxymethylation in prostate cancer.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenesis, Genetic; Humans; Male; Models, Biological; Prostatic Neoplasms; Proto-Oncogene Proteins | 2018 |
Research progress on 5hmC and TET dioxygenases in neurodevelopment and neurological diseases.
Topics: 5-Methylcytosine; Animals; Dioxygenases; Humans; Mixed Function Oxygenases; Nervous System; Nervous System Diseases; Neurogenesis; Proto-Oncogene Proteins | 2017 |
Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.
Topics: 5-Methylcytosine; Animals; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Mammals; Models, Molecular; Nucleic Acid Conformation | 2018 |
TET Enzymes and 5hmC in Adaptive and Innate Immune Systems.
Topics: 5-Methylcytosine; Adaptive Immunity; Animals; Biomarkers; Cell Differentiation; DNA Methylation; DNA-Binding Proteins; Enzymes; Epigenesis, Genetic; Gene Expression Regulation; Humans; Immunity, Innate; Lymphocyte Subsets; Proto-Oncogene Proteins | 2019 |
Towards precision medicine: advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cell-Free Nucleic Acids; Epigenomics; Humans; Liquid Biopsy; Neoplasms; Precision Medicine | 2019 |
Role of ten-eleven translocation proteins and 5-hydroxymethylcytosine in hepatocellular carcinoma.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Humans; Liver Neoplasms; MicroRNAs; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA Processing, Post-Transcriptional; Transcription, Genetic | 2019 |
Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies.
Topics: 5-Methylcytosine; Animals; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Mixed Function Oxygenases; Mutation; Proto-Oncogene Proteins | 2019 |
TET enzymes in neurophysiology and brain function.
Topics: 5-Methylcytosine; Animals; Brain; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Humans; Mixed Function Oxygenases; Neuronal Plasticity | 2019 |
The DNA methylation landscape in cancer.
Topics: 5-Methylcytosine; Animals; DNA; DNA Methylation; Epigenomics; Humans; Neoplasms | 2019 |
The Impact of Environmental Factors on 5-Hydroxymethylcytosine in the Brain.
Topics: 5-Methylcytosine; Brain; Environmental Biomarkers; Environmental Exposure; Humans | 2020 |
Environmental Epigenetics and Genome Flexibility: Focus on 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Benzhydryl Compounds; DNA Methylation; Environmental Exposure; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Developmental; Genome; Humans; Phenols | 2020 |
Hydroxymethylation and tumors: can 5-hydroxymethylation be used as a marker for tumor diagnosis and treatment?
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms | 2020 |
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation.
Topics: 5-Methylcytosine; Animals; DNA; DNA Damage; DNA Glycosylases; DNA Repair; Epigenesis, Genetic; Gene Expression Regulation; Guanine; Humans | 2021 |
TETology: Epigenetic Mastermind in Action.
Topics: 5-Methylcytosine; Animals; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Humans | 2021 |
RNA modifications act as regulators of cell death.
Topics: 5-Methylcytosine; Adenosine; Animals; Cell Death; Humans; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Signal Transduction | 2021 |
2 trial(s) available for 5-hydroxymethylcytosine and 5-methylcytosine
| Article | Year |
|---|---|
Characterization of acute myeloid leukemia based on levels of global hydroxymethylation.
Topics: 5-Methylcytosine; Acute Disease; Adolescent; Adult; Aged; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Mutational Analysis; DNA-Binding Proteins; Humans; Isocitrate Dehydrogenase; Leukemia, Myeloid; Middle Aged; Mutation; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins; Survival Analysis; Young Adult | 2014 |
DNA hydroxymethylation combined with carotid plaques as a novel biomarker for coronary atherosclerosis.
Topics: 5-Methylcytosine; Aged; Biomarkers; Carotid Intima-Media Thickness; Case-Control Studies; Coronary Artery Disease; DNA Methylation; Female; Humans; Leukocytes, Mononuclear; Male; Plaque, Atherosclerotic | 2019 |
981 other study(ies) available for 5-hydroxymethylcytosine and 5-methylcytosine
| Article | Year |
|---|---|
Reaction of bisulfite with the 5-hydroxymethyl group in pyrimidines and in phage DNAs.
Topics: 5-Methylcytosine; Chemical Phenomena; Chemistry; Coliphages; Cytosine; DNA, Viral; Pentoxyl; Pyrimidines; Spectrophotometry, Ultraviolet; Sulfites; Uracil | 1979 |
Evidence for a near UV-induced photoproduct of 5-hydroxymethylcytosine in bacteriophage T4 that can be recognized by endonuclease V.
Topics: 5-Methylcytosine; Coliphages; Cytosine; DNA, Viral; Endonucleases; Substrate Specificity; Ultraviolet Rays | 1978 |
Modification and restriction of T-even bacteriophages. In vitro degradation of deoxyribonucleic acid containing 5-hydroxymethylctosine.
Topics: 5-Methylcytosine; Coliphages; Cytosine; DNA Restriction Enzymes; DNA, Circular; DNA, Viral; Escherichia coli; Genetic Complementation Test; Kinetics; Mutation; Phenotype; Species Specificity; Templates, Genetic | 1976 |
[Bacteriophage T2 DNA modification by O-methylhydroxylamine].
Topics: 5-Methylcytosine; Chemical Phenomena; Chemistry; Coliphages; Cytosine; DNA, Viral; Hydroxylamines; Nucleic Acid Denaturation; Viral Proteins | 1976 |
Trace detection of modified DNA bases via moving-belt liquid chromatography-mass spectrometry using electrophoric derivatization and negative chemical ionization.
Topics: 5-Methylcytosine; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cytosine; DNA; Electrophoresis; Mass Spectrometry | 1989 |
5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue.
Topics: 5-Methylcytosine; Animals; Cattle; Chromatography, High Pressure Liquid; Cytosine; DNA Glycosylases; DNA, Viral; N-Glycosyl Hydrolases; T-Phages; Thymus Gland | 1988 |
Cloning and physical mapping of an early region of the bacteriophage T4 genome.
Topics: 5-Methylcytosine; Chromosome Deletion; Chromosome Mapping; Cloning, Molecular; Cytosine; DNA Restriction Enzymes; Genes, Viral; T-Phages | 1984 |
Formation of 5-hydroxymethylcytosine-containing pyrimidine dimers in UV-irradiated bacteriophage T4 DNA.
Topics: 5-Methylcytosine; Cytosine; DNA, Viral; Escherichia coli; Pyrimidine Dimers; T-Phages; Ultraviolet Rays | 1983 |
Region-specific recombination in phage T4. I. A special glucosyl-dependent recombination system.
Topics: 5-Methylcytosine; Capsid; Cytosine; DNA, Viral; Escherichia coli; Genes, Viral; Glucosyltransferases; Hot Temperature; Mutation; Recombination, Genetic; T-Phages | 1980 |
Shutoff of lambda gene expression by bacteriophage T4: role of the T4 alc gene.
Topics: 5-Methylcytosine; Bacteriophage lambda; Cytosine; DNA, Circular; Escherichia coli; Genes, Viral; Mutation; Nucleic Acid Conformation; Nucleic Acid Hybridization; Protein Biosynthesis; RNA, Viral; T-Phages; Time Factors; Transcription, Genetic; Viral Interference | 1980 |
Molecular cloning and expression of a novel hydroxymethylcytosine-specific restriction enzyme (PvuRts1I) modulated by glucosylation of DNA.
Topics: 5-Methylcytosine; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cytosine; DNA; DNA Restriction Enzymes; DNA, Viral; Genes, Bacterial; Glucose; Molecular Sequence Data; Substrate Specificity; T-Phages | 1994 |
The Northrop hypothesis and the origins of a virus-induced enzyme.
Topics: 5-Methylcytosine; Cytosine; DNA, Viral; Escherichia coli; History, 20th Century; Hydroxymethyl and Formyl Transferases; Models, Biological; T-Phages; Transferases; United States | 1994 |
5-Methylcytosine attack by hydroxyl free radicals and during carbon tetrachloride promoted liver microsomal lipid peroxidation: structure of reaction products.
Topics: 5-Methylcytosine; Animals; Carbon Tetrachloride; Cytosine; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydantoins; Hydrogen Peroxide; Hydroxyl Radical; Iron; Lipid Peroxidation; Male; Microsomes, Liver; Molecular Structure; Rats; Rats, Sprague-Dawley; Ultraviolet Rays | 1996 |
Solid phase synthesis and restriction endonuclease cleavage of oligodeoxynucleotides containing 5-(hydroxymethyl)-cytosine.
Topics: 5-Methylcytosine; Cytosine; Deoxyribonuclease HpaII; DNA Restriction Enzymes; DNA-Cytosine Methylases; Molecular Structure; Oligodeoxyribonucleotides | 1997 |
Nucleic acid economy in bacteria infected with bacteriophage T2. I. Purine and pyrimidine composition.
Topics: 5-Methylcytosine; Bacteria; Bacteriophage T4; Bacteriophages; Cytosine; Escherichia coli; Nucleic Acids; Purines | 1953 |
The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Bacteriophages; Cytosine; Nucleic Acids; Pyrimidines; Viruses | 1953 |
Some precursors of the 5-hydroxymethylcytosine of T6r+ bacteriophage.
Topics: 5-Methylcytosine; Bacteriophages; Cytosine; Pyrimidines | 1954 |
Structural evidence of a passive base-flipping mechanism for beta-glucosyltransferase.
Topics: 5-Methylcytosine; Adenine; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Cytosine; DNA; Glucosyltransferases; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Oligonucleotides; Plasmids; Protein Binding; Protein Conformation; Uridine Diphosphate | 2004 |
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).
Topics: 5-Methylcytosine; Base Sequence; Binding Sites; Chromosomal Proteins, Non-Histone; CpG Islands; Cytosine; DNA Damage; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Guanosine; Methyl-CpG-Binding Protein 2; Models, Molecular; Oligodeoxyribonucleotides; Oxidative Stress; Protein Structure, Tertiary; Repressor Proteins | 2004 |
A type IV modification dependent restriction nuclease that targets glucosylated hydroxymethyl cytosine modified DNAs.
Topics: 5-Methylcytosine; Capsid Proteins; Chromatography, Affinity; Coliphages; Cytosine; DNA Restriction Enzymes; DNA, Viral; Escherichia coli; Escherichia coli Proteins; Evolution, Molecular; Mutant Proteins; Myoviridae; Nucleic Acid Conformation; Nucleotides; Protein Binding; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity | 2007 |
Exclusion of glucosyl-hydroxymethylcytosine DNA containing bacteriophages is overcome by the injected protein inhibitor IPI*.
Topics: 5-Methylcytosine; Amino Acid Sequence; Bacteriophage T4; Bacteriophages; Base Sequence; Capsid Proteins; Clone Cells; Cytosine; DNA Restriction Enzymes; DNA, Viral; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Molecular Sequence Data; Prophages; Sequence Analysis, DNA; Substrate Specificity | 2007 |
The mildiomycin biosynthesis: initial steps for sequential generation of 5-hydroxymethylcytidine 5'-monophosphate and 5-hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119.
Topics: 5-Methylcytosine; Amino Acid Sequence; Chromatography, High Pressure Liquid; Cloning, Molecular; Cytidine Monophosphate; Cytosine; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multigene Family; Sequence Alignment; Streptomycetaceae; Substrate Specificity | 2008 |
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Cell Line; Cytosine; Dinucleoside Phosphates; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Hydroxylation; Mass Spectrometry; Mice; Mixed Function Oxygenases; Molecular Sequence Data; Proto-Oncogene Proteins; RNA Interference; Sequence Alignment; Transfection | 2009 |
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cell Line; Cerebellum; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytosine; Deoxycytidine; DNA; DNA Damage; Humans; Mass Spectrometry; Mice; Purkinje Cells | 2009 |
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing.
Topics: 5-Methylcytosine; Base Sequence; Chromatography, Liquid; Cytosine; Mass Spectrometry; Molecular Sequence Data; Polymerase Chain Reaction; Sulfites | 2010 |
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Antibodies; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Immunoprecipitation; Oligonucleotides; Sequence Analysis, DNA; Sulfites | 2010 |
Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA.
Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA; DNA Methylation; DNA Restriction Enzymes; Genes, BRCA1; Humans; Octamer Transcription Factor-3; Polymerase Chain Reaction; Sequence Analysis, DNA; Sulfites | 2010 |
Quantification of the sixth DNA base hydroxymethylcytosine in the brain.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cytosine; DNA; DNA Methylation; Mice | 2010 |
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.
Topics: 5-Methylcytosine; Alkaline Phosphatase; Animals; Blastocyst Inner Cell Mass; Cell Proliferation; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Homeodomain Proteins; Mice; Nanog Homeobox Protein; Proto-Oncogene Proteins | 2010 |
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Cytosine; DNA; Embryonic Stem Cells; Genetic Techniques; Genome; Glucosyltransferases; Mice | 2010 |
Chemical discrimination between dC and 5MedC via their hydroxylamine adducts.
Topics: 5-Methylcytosine; Base Pairing; Cytosine; DNA; DNA Adducts; DNA Methylation; Hydroxylamines; Isomerism; Models, Molecular; Oligodeoxyribonucleotides; Sequence Analysis, DNA | 2010 |
Identification of epigenetic DNA modifications with a protein nanopore.
Topics: 5-Methylcytosine; Cyclodextrins; Cytosine; DNA; Epigenesis, Genetic; Hemolysin Proteins; Nanopores | 2010 |
MIRA-SNuPE, a quantitative, multiplex method for measuring allele-specific DNA methylation.
Topics: 5-Methylcytosine; Alleles; Animals; Chromosome Duplication; CpG Islands; Cytosine; DNA Methylation; Genomic Imprinting; Kidney; Liver; Mice; Sensitivity and Specificity; Sequence Analysis, DNA | 2011 |
Efficient synthesis of 5-hydroxymethylcytosine containing DNA.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Genome; Molecular Structure | 2010 |
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Bacteriophage T4; Biotin; Cerebellum; Cytosine; DNA; Genome; Genome, Human; Glucosyltransferases; HEK293 Cells; HeLa Cells; Humans; Mice; Models, Molecular; Molecular Sequence Data; Sequence Analysis, DNA; Staining and Labeling | 2011 |
Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Molecular Dynamics Simulation; Nucleic Acid Conformation; Polymerase Chain Reaction | 2011 |
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.
Topics: 5-Methylcytosine; Animals; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytosine; DNA Methylation; Immunohistochemistry; Mass Spectrometry; Mice; Models, Chemical; Oxygen; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution | 2010 |
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Topics: 5-Methylcytosine; Amino Acid Substitution; Animals; Binding, Competitive; Biocatalysis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Catalytic Domain; Cell Line, Tumor; Cytosine; Dioxygenases; DNA-Binding Proteins; Endostatins; F-Box Proteins; Gene Expression; Glioma; Glutarates; Histone Demethylases; Histones; Homeodomain Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isocitrate Dehydrogenase; Jumonji Domain-Containing Histone Demethylases; Ketoglutaric Acids; Mixed Function Oxygenases; Models, Molecular; Oxalates; Oxidoreductases, N-Demethylating; Procollagen-Proline Dioxygenase; Proto-Oncogene Proteins | 2011 |
A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples.
Topics: 5-Methylcytosine; Animals; Catalytic Domain; Chromatography, Liquid; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Fibroblasts; Humans; Hydroxylation; Induced Pluripotent Stem Cells; Mass Spectrometry; Mice; Mixed Function Oxygenases; Proto-Oncogene Proteins; Reproducibility of Results | 2011 |
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Binding Sites; Cell Differentiation; Cell Lineage; Chromatin Immunoprecipitation; Computational Biology; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Mice; Octamer Transcription Factor-3; Proto-Oncogene Proteins; Teratoma | 2011 |
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Topics: 5-Methylcytosine; Carrier Proteins; Cytosine; DNA; Embryonic Stem Cells; Gene Expression Regulation; Genome, Human; Genomics; Glucosyltransferases; Humans; Promoter Regions, Genetic; Protozoan Proteins | 2011 |
High sensitivity 5-hydroxymethylcytosine detection in Balb/C brain tissue.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cytosine; DNA; DNA Methylation; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction | 2011 |
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Base Sequence; Cell Compartmentation; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Mitochondrial; Genes, Mitochondrial; HCT116 Cells; Humans; Mice; Mitochondria; Molecular Sequence Data; Oxidative Stress; Protein Binding; Protein Sorting Signals; Transcription, Genetic | 2011 |
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.
Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Chromosomal Proteins, Non-Histone; Cleavage Stage, Ovum; Cytosine; DNA-Binding Proteins; Embryo, Mammalian; Female; Fertilization; Gene Expression Regulation, Developmental; Genome; Male; Mice; Oocytes; Oxidation-Reduction; Repressor Proteins; Sequence Analysis, DNA; Sulfites; Zygote | 2011 |
Methyltransferase-directed derivatization of 5-hydroxymethylcytosine in DNA.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; S-Adenosylmethionine; Selenium Compounds; Sulfhydryl Compounds | 2011 |
Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Cleavage; DNA Restriction Enzymes; Genome; Mice | 2011 |
Genomic mapping of 5-hydroxymethylcytosine in the human brain.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cytosine; DNA; Gene Expression; Genomics; Humans; Mice; Promoter Regions, Genetic | 2011 |
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.
Topics: 5-Methylcytosine; Animals; Cattle; Cell Nucleus; Chromosomal Proteins, Non-Histone; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Epigenomics; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Mammals; Mice; Mice, Knockout; Nuclear Transfer Techniques; Oxidation-Reduction; Proto-Oncogene Proteins; Rabbits; Repressor Proteins; Sex Factors; Zygote | 2011 |
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cell Line; Chromatin; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Silencing; Genome; Mice; Polycomb-Group Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Repressor Proteins; Transcription, Genetic | 2011 |
Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; Cytosine Nucleotides; Dinucleoside Phosphates; DNA; DNA Methylation; Humans; Hydroxylation; Methylation; Molecular Sequence Data; Molecular Structure; Polymerase Chain Reaction | 2011 |
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cell Line; Chromatin; Cytosine; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Mice; Proto-Oncogene Proteins; Transcription Factors | 2011 |
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.
Topics: 5-Methylcytosine; Animals; Antibodies; Cell Differentiation; Cell Line; Cell Lineage; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Embryoid Bodies; Embryonic Stem Cells; Euchromatin; Exons; Gene Expression Regulation, Developmental; Gene Silencing; Genome; Mice; Pluripotent Stem Cells; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reproducibility of Results; Sequence Analysis, DNA; Transcription, Genetic | 2011 |
Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.
Topics: 5-Methylcytosine; Cytosine; DNA; Organophosphorus Compounds; Siloxanes; Styrenes | 2011 |
Enzymatic labeling of 5-hydroxymethylcytosine in DNA.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Glycosyltransferases; Humans; Isotope Labeling; Tritium | 2011 |
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
Topics: 5-Methylcytosine; Animals; Cell Line; CpG Islands; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Embryonic Stem Cells; Gene Knockdown Techniques; Mice; Protein Binding; Proto-Oncogene Proteins; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex; Transcription Initiation Site; Transcription, Genetic | 2011 |
Facile synthesis of hydroxymethylcytosine-containing oligonucleotides and their reactivity upon osmium oxidation.
Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; Models, Molecular; Molecular Structure; Oligonucleotides; Osmium; Oxidation-Reduction; Stereoisomerism; Transition Temperature | 2011 |
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Mice; Mixed Function Oxygenases; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins | 2011 |
Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(α)I.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA; DNA-Directed RNA Polymerases; Glycosylation | 2011 |
Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.
Topics: 5-Methylcytosine; Animals; Azides; Biotin; Cell Line; Click Chemistry; Cross-Linking Reagents; Cytosine; Diazomethane; DNA; DNA Probes; Genome; Glucosyltransferases; Humans; Mice; Streptavidin; Ultraviolet Rays | 2011 |
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Biotinylation; Cell Line; Cytosine; DNA Methylation; Embryonic Stem Cells; Exons; Gene Expression Regulation, Developmental; Genome; Glucose; Mice; Periodic Acid; Promoter Regions, Genetic; Sequence Analysis, DNA; Transcription Initiation Site; Transcription, Genetic | 2011 |
Epigenetics: Tet proteins in the limelight.
Topics: 5-Methylcytosine; Animals; Chromatin; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genome; Mice; Polycomb-Group Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex; Transcription, Genetic | 2011 |
Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes.
Topics: 5-Methylcytosine; Animals; Brain; CpG Islands; Cytosine; DNA Methylation; Embryonic Stem Cells; Genome, Human; HeLa Cells; Humans; Mice; Myocardium; NIH 3T3 Cells; Organ Specificity | 2011 |
Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia.
Topics: 5-Methylcytosine; Cytosine; Dioxygenases; DNA-Binding Proteins; Gene Expression Profiling; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myeloid, Acute; Mutation; Proto-Oncogene Proteins | 2011 |
Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
Topics: 5-Methylcytosine; Cytosine; Deoxycytidine; DNA; Methylation; Molecular Structure; Oligonucleotides; Oxidation-Reduction | 2011 |
Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage β-glucosyltransferase.
Topics: 5-Methylcytosine; Bacteriophage T4; Cytosine; DNA; Glucose; Glucosyltransferases; Humans | 2011 |
5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells.
Topics: 5-Methylcytosine; Base Composition; Binding Sites; Cytosine; Embryonic Stem Cells; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Humans; Transcription Factors | 2011 |
Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide.
Topics: 5-Methylcytosine; Cytosine; DNA; Electrophoretic Mobility Shift Assay; Oxidation-Reduction; Phosphopeptides; Phosphotyrosine; Protein Kinases; Zinc Fingers | 2011 |
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.
Topics: 5-Methylcytosine; Cytosine; Gene Expression Regulation; HeLa Cells; Humans; Promoter Regions, Genetic; Repressor Proteins; RNA Polymerase II; Transcription, Genetic | 2011 |
The discovery of 5-formylcytosine in embryonic stem cell DNA.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Embryonic Stem Cells; Mass Spectrometry; Mice | 2011 |
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
Topics: 5-Methylcytosine; Animals; Cell Cycle Proteins; Cytidine Deaminase; Cytosine; DNA Methylation; Embryonic Development; Female; Gene Expression Regulation, Developmental; Gene Knock-In Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins; Promoter Regions, Genetic; Thymine DNA Glycosylase; Transcription, Genetic | 2011 |
Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells.
Topics: 5-Methylcytosine; Binding Sites; Cell Line; Chromosome Mapping; Cytosine; DNA Methylation; Embryonic Stem Cells; Epigenomics; Gene Expression Regulation; Gene Library; Genome, Human; Heterochromatin; Histones; Humans; Immunoblotting; Metaphase; Promoter Regions, Genetic; Sequence Alignment; Transcription Factors | 2011 |
Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.
Topics: 5-Methylcytosine; Binding Sites; CCAAT-Enhancer-Binding Proteins; CpG Islands; Cytosine; DNA; HEK293 Cells; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Protein Binding; Protein Structure, Tertiary; Thermodynamics | 2011 |
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Lineage; Colony-Forming Units Assay; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Erythropoiesis; Fetal Blood; Genetic Vectors; Granulocytes; Hematopoietic Stem Cells; Humans; Lentivirus; Monocytes; Mutation; Myelopoiesis; Proto-Oncogene Proteins; RNA Interference; RNA, Small Interfering | 2011 |
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.
Topics: 5-Methylcytosine; Animals; Antibodies; Bone Marrow; Cell Differentiation; Cell Lineage; Cells, Cultured; CpG Islands; Cytosine; DNA Methylation; Embryonic Development; Embryonic Stem Cells; Genome, Human; Humans; Induced Pluripotent Stem Cells; Intermediate Filament Proteins; Mice; Nerve Tissue Proteins; Nestin; Neurons; Zygote | 2011 |
Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Profiling; Genome; Mice; Proto-Oncogene Proteins; Transcription, Genetic | 2011 |
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Recombinant Fusion Proteins | 2011 |
Comparative characterization of the PvuRts1I family of restriction enzymes and their application in mapping genomic 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Chromosome Mapping; Conserved Sequence; Cytosine; DNA Cleavage; DNA Restriction Enzymes; Genomics; Molecular Sequence Data; Rats; Substrate Specificity | 2011 |
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Body Size; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Embryonic Stem Cells; Female; Fertility; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Genetic Complementation Test; Mice; Mice, Inbred C57BL; Pluripotent Stem Cells; Proto-Oncogene Proteins; Tetraploidy | 2011 |
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; RNA, Small Interfering; Thymine DNA Glycosylase; Transfection | 2011 |
Gene expression profiling: identification of genes with altered expression in Ayu17-449 knockout mice.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Gene Expression Profiling; Gene Expression Regulation; Genes, Tumor Suppressor; Genome; Mice; Mice, Knockout; NF-kappa B; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2011 |
Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.
Topics: 5-Methylcytosine; Cytosine; DNA; Histone Demethylases; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Structure-Activity Relationship | 2011 |
Molecular biology. Demystifying DNA demethylation.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase | 2011 |
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.
Topics: 5-Methylcytosine; Alleles; Animals; Cellular Reprogramming; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Fertility; Gene Expression Regulation, Developmental; Germ Cells; Male; Mice; Octamer Transcription Factor-3; Oocytes; Oxidation-Reduction; Proto-Oncogene Proteins; Zygote | 2011 |
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.
Topics: 5-Methylcytosine; Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Differentiation; Colonic Neoplasms; Cytosine; Down-Regulation; Embryo, Mammalian; Female; Gestational Age; HEK293 Cells; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Prostatic Neoplasms; Stem Cells | 2011 |
5-Hydroxymethylcytosine-selective oxidation with peroxotungstate.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA, Single-Stranded; Oxidation-Reduction; Substrate Specificity; Tungsten Compounds | 2011 |
Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos.
Topics: 5-Methylcytosine; Animals; Blastocyst; Chromatids; Chromosomes, Mammalian; Cytosine; Dioxygenases; DNA Replication; DNA-Binding Proteins; Embryonic Development; Mice; Mitosis; Proto-Oncogene Proteins; Sister Chromatid Exchange; Zygote | 2011 |
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
Topics: 5-Methylcytosine; Aging; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Chromosome Deletion; Chromosome Mapping; Cytosine; Disease Models, Animal; DNA Methylation; Epigenomics; Gene Expression Regulation, Developmental; Hippocampus; Humans; Immunoprecipitation; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Organ Specificity; Phosphopyruvate Hydratase; Rett Syndrome; X Chromosome | 2011 |
Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis.
Topics: 5-Methylcytosine; Adult; Antigens, Differentiation; Brain-Derived Neurotrophic Factor; Case-Control Studies; Cytosine; DNA Methylation; Female; Gene Expression; Humans; Male; Middle Aged; Parietal Lobe; Prefrontal Cortex; Promoter Regions, Genetic; Psychotic Disorders | 2012 |
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.
Topics: 5-Methylcytosine; Animals; Base Sequence; Brain; Brain Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; Chromatography, Liquid; Cytosine; DNA-Binding Proteins; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Lung Neoplasms; Male; Mice; Mixed Function Oxygenases; Molecular Structure; Mutation; Neoplasms; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Improved synthesis and mutagenicity of oligonucleotides containing 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine.
Topics: 5-Methylcytosine; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Molecular Structure; Mutagens; Oligonucleotides; Organophosphorus Compounds; Spectrometry, Mass, Electrospray Ionization | 2011 |
Epigenetic regulation of motor neuron cell death through DNA methylation.
Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation | 2011 |
Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA; Sensitivity and Specificity; Sequence Analysis, DNA | 2011 |
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.
Topics: 5-Methylcytosine; Animals; Cell Line; Cells, Cultured; Chromosome Mapping; Cluster Analysis; Cytosine; DNA; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Genetic Loci; Humans; Mice; Nuclear Proteins; Organ Specificity; Promoter Regions, Genetic; RNA-Binding Proteins; Transcription, Genetic | 2012 |
Methylation on the mind.
Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cytosine; Epigenomics; Gene Expression Regulation, Developmental; Hippocampus; Humans | 2011 |
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.
Topics: 5-Methylcytosine; Animals; Antibodies; Cytosine; DNA Replication; DNA-Directed DNA Polymerase; Embryonic Development; Immunohistochemistry; Male; Mice | 2011 |
The hunt for 5-hydroxymethylcytosine: the sixth base.
Topics: 5-Methylcytosine; Cytosine; Dioxygenases; Epigenesis, Genetic; Sequence Analysis, DNA | 2011 |
5-Hydroxymethylcytosine: a new kid on the epigenetic block?
Topics: 5-Methylcytosine; Animals; Cell Line; Chromatin; Cluster Analysis; Cytosine; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mice; Oxygenases; Transcription, Genetic; Translocation, Genetic | 2011 |
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Chromatin Assembly and Disassembly; Cytosine; DNA Helicases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Knockdown Techniques; Humans; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Mice; Nuclear Proteins; Proto-Oncogene Proteins; RNA Polymerase II; Transcription Factors | 2011 |
Tracking genomic hydroxymethylation by the base.
Topics: 5-Methylcytosine; Cytosine; DNA; Sequence Analysis, DNA | 2011 |
Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation; Homeodomain Proteins; Leukemia Inhibitory Factor; MAP Kinase Signaling System; Mice; Nanog Homeobox Protein; Proto-Oncogene Proteins; RNA Interference; Signal Transduction; STAT3 Transcription Factor | 2012 |
Biochemical characterization of recombinant β-glucosyltransferase and analysis of global 5-hydroxymethylcytosine in unique genomes.
Topics: 5-Methylcytosine; Animals; Arabidopsis Proteins; Bacteriophage T4; Cattle; Cytosine; Deoxyribonucleases, Type II Site-Specific; Escherichia coli; Escherichia coli Proteins; Female; Genome, Plant; Genome, Viral; Glucosyltransferases; HCT116 Cells; HEK293 Cells; Humans; Male; Mice; NIH 3T3 Cells; Rats; Recombinant Proteins; Substrate Specificity | 2012 |
Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Anaplasia; Astrocytoma; Brain; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Cytosine; DNA; Epigenesis, Genetic; Female; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Young Adult | 2012 |
The involvement of 5-hydroxymethylcytosine in active DNA demethylation in mice.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cytosine; DNA; DNA Methylation; Embryo, Mammalian; Gene Expression Regulation, Developmental; Metaphase; Mice; Oocytes; Plasmids | 2012 |
Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction.
Topics: 5-Methylcytosine; Age Factors; Animals; Caloric Restriction; Cytosine; DNA Methyltransferase 3A; Gene Expression Regulation; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1; Tissue Distribution | 2012 |
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Humans; Translocation, Genetic | 2012 |
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Glucosyltransferases; Magnetic Phenomena; Microspheres | 2012 |
Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.
Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cytosine; DNA Methylation; DNA-Binding Proteins; Gene Knockdown Techniques; Humans; Mixed Function Oxygenases; Mutation; Neoplasms; Proto-Oncogene Proteins; Stomach Neoplasms | 2012 |
TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia.
Topics: 5-Methylcytosine; Computational Biology; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Humans; Isocitrate Dehydrogenase; Janus Kinase 2; Leukemia, Myelomonocytic, Chronic; Mutation; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Proto-Oncogene Proteins; Transcription Factors | 2012 |
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.
Topics: 5-Methylcytosine; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; DNA-Binding Proteins; Humans; Pentoxyl; Thymine DNA Glycosylase | 2012 |
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cytosine; Dioxygenases; DNA-Binding Proteins; Down-Regulation; Humans; Hydroxylation; Mice; Mixed Function Oxygenases; Neoplasms; Proto-Oncogene Proteins | 2013 |
Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals.
Topics: 5-Methylcytosine; Ambystoma mexicanum; Amphibians; Animals; Chickens; Cytosine; DNA-Binding Proteins; Humans; Immunohistochemistry; Mammals; Mice; Phylogeny; Tissue Distribution; Xenopus; Zebrafish | 2012 |
5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cell Differentiation; Chick Embryo; Culture Media, Conditioned; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryo, Nonmammalian; Embryonic Development; Embryonic Stem Cells; Female; Gene Expression Regulation, Developmental; Immunohistochemistry; Male; Mice; Organogenesis; Proto-Oncogene Proteins; Time Factors; Vertebrates; Zebrafish | 2012 |
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Arachidonate 5-Lipoxygenase; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Hippocampus; Male; Mice; Mice, Inbred C57BL; Up-Regulation | 2012 |
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.
Topics: 5-Methylcytosine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, Cultured; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; DNA, Mitochondrial; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Developmental; Laser Capture Microdissection; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Proto-Oncogene Proteins | 2012 |
Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: in vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA.
Topics: 5-Methylcytosine; Arabidopsis Proteins; Cytosine; DNA Methylation; DNA-Binding Proteins; DNA, Plant; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Escherichia coli; Models, Molecular; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Substrate Specificity | 2012 |
DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cells.
Topics: 5-Methylcytosine; Animals; Cell Cycle Proteins; Cell Line; Cytosine; Dimethyl Sulfoxide; DNA (Cytosine-5-)-Methyltransferases; DNA Helicases; DNA Methylation; DNA Methyltransferase 3B; DNA-Binding Proteins; Homeodomain Proteins; Mice; Nuclear Proteins; Osteoblasts; Proto-Oncogene Proteins; Repressor Proteins; Stem Cells; Transcription, Genetic | 2012 |
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Genes, Intracisternal A-Particle; High-Throughput Nucleotide Sequencing; Long Interspersed Nucleotide Elements; Mice; Oxidation-Reduction; Rhenium; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Uracil | 2012 |
Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Line; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Homeodomain Proteins; Humans; Hydroxylation; Mice; Mice, Knockout; Proto-Oncogene Proteins | 2012 |
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Topics: 5-Methylcytosine; Animals; Cytosine; Embryonic Stem Cells; Epigenomics; Gene Expression Regulation; Genome-Wide Association Study; Genome, Human; Humans; Mice; Sequence Analysis, DNA | 2012 |
Reduction of DNA hydroxymethylation in the mouse kidney insulted by ischemia reperfusion.
Topics: 5-Methylcytosine; Animals; Chemokine CXCL10; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Kidney; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Receptors, Interferon; Reperfusion Injury | 2012 |
Simultaneous determination of global DNA methylation and hydroxymethylation levels by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Topics: 5-Methylcytosine; Animals; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Tandem Mass Spectrometry | 2012 |
Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas.
Topics: 5-Methylcytosine; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cytosine; Dioxygenases; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Dual-Specificity Phosphatases; Female; Gene Expression Regulation, Enzymologic; Glioblastoma; Glioma; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Male; Mitogen-Activated Protein Kinase Phosphatases; Mixed Function Oxygenases; Mutation; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Subcellular Fractions; Tumor Suppressor Proteins | 2012 |
5-Methylcytosine and 5-hydroxymethylcytosine spatiotemporal profiles in the mouse zygote.
Topics: 5-Methylcytosine; Animals; Cell Cycle; Cytosine; DNA Methylation; DNA Replication; Female; Heterochromatin; Male; Mice; Time Factors; Zygote | 2012 |
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.
Topics: 5-Methylcytosine; Animals; Chromatin; Chromosomal Proteins, Non-Histone; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Female; Genomic Imprinting; Histones; Lysine; Male; Methylation; Mice; Protein Binding; Proto-Oncogene Proteins; ras-GRF1; Repressor Proteins; RNA, Long Noncoding; RNA, Untranslated; Spermatozoa | 2012 |
Effect of valproic acid on mitochondrial epigenetics.
Topics: 3T3-L1 Cells; 5-Methylcytosine; Animals; Anticonvulsants; Base Sequence; Benzamides; Cell Nucleus; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA, Mitochondrial; Epigenesis, Genetic; Mice; Mitochondria; Molecular Sequence Data; Pyridines; RNA, Messenger; Valproic Acid | 2012 |
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers.
Topics: 3T3-L1 Cells; 5-Methylcytosine; Animals; Binding Sites; Cell Differentiation; Cell Line, Tumor; Chromatin; Cytosine; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Homeodomain Proteins; Mice; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Neurogenesis; Proto-Oncogene Proteins; Transcription Factors | 2012 |
Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice.
Topics: 5-Methylcytosine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavioral Symptoms; Benzofurans; Cognition Disorders; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Female; Hippocampus; Humans; Male; Memory Disorders; Mice; Mice, Transgenic; Pregnancy; Prenatal Exposure Delayed Effects; Presenilin-1; Quinolines; Space Perception; Stress, Psychological | 2013 |
Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma.
Topics: 5-Methylcytosine; Brain; Cell Differentiation; Cytosine; Glioma; Humans; Immunohistochemistry; Neurons; Stem Cells | 2012 |
Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Topics: 5-Methylcytosine; Bacteria; Catalytic Domain; Cytosine; DNA; Endodeoxyribonucleases; Humans; Models, Molecular; Pentoxyl; Protein Structure, Tertiary; Substrate Specificity; Thymine; Thymine DNA Glycosylase | 2012 |
New sequencing technique produces high-resolution map of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA; Embryonic Stem Cells; Epigenesis, Genetic; Mice; Nucleotide Mapping; Rhenium; Sequence Analysis, DNA | 2012 |
Differential effect of three base modifications on DNA thermostability revealed by high resolution melting.
Topics: 5-Methylcytosine; Adenine; Cluster Analysis; Cytosine; DNA; Nucleic Acid Denaturation; Phase Transition; Principal Component Analysis; Transition Temperature | 2012 |
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Line; Chromosome Mapping; Computational Biology; CpG Islands; Cytosine; Dioxygenases; DNA Repair; DNA-Binding Proteins; Down-Regulation; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genome; High-Throughput Nucleotide Sequencing; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Transcription, Genetic | 2012 |
CpG site-specific alteration of hydroxymethylcytosine to methylcytosine beyond DNA replication.
Topics: 5-Methylcytosine; Base Sequence; CpG Islands; Cytosine; DNA Methylation; DNA Replication; Genetic Vectors; HEK293 Cells; Humans; Polymerase Chain Reaction | 2012 |
[Analysis of global deoxyribonucleic acid 5-hydroxymethylcytosine in tissue by liquid chromatography-tandem mass spectrometry].
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; Rats; Tandem Mass Spectrometry | 2012 |
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.
Topics: 5-Methylcytosine; Alternative Splicing; Animals; Brain; Cell Line; Cytosine; Glucosyltransferases; Humans; Introns; Male; Mice; Mice, Inbred C57BL; Microarray Analysis; Organ Specificity; Reproducibility of Results; RNA Splicing; Synapses | 2012 |
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.
Topics: 5-Methylcytosine; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Humans; Isocitrate Dehydrogenase; Melanocytes; Melanoma; Nevus; Proto-Oncogene Proteins | 2012 |
Sequencing the sixth base (5-hydroxymethylcytosine): selective DNA oxidation enables base-pair resolution.
Topics: 5-Methylcytosine; Base Pairing; Cytosine; Deamination; DNA; Oxidation-Reduction; Sequence Analysis, DNA; Sulfites | 2012 |
The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Antibodies; Base Sequence; Cytosine; DNA Primers; Genomics; Immunoprecipitation; Molecular Sequence Data; Sulfites | 2012 |
The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Base Sequence; Biotinylation; Cytosine; Genomics; Glucose; Molecular Sequence Data; Oxidation-Reduction; Periodic Acid | 2012 |
Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenomics; Gene Expression Profiling; Gene Expression Regulation; Histones; Liver; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phenobarbital; Promoter Regions, Genetic | 2012 |
Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum.
Topics: 5-Methylcytosine; Adult; Cerebellum; CpG Islands; Cytosine; DNA; DNA Methylation; DNA, Intergenic; Epigenesis, Genetic; Female; Fragile X Mental Retardation Protein; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Genome, Human; Genomics; Humans; Male; RNA, Messenger; Sequence Alignment | 2012 |
Selective capture of 5-hydroxymethylcytosine from genomic DNA.
Topics: 5-Methylcytosine; Cytosine; DNA; Genome, Human; Humans | 2012 |
Balance of DNA methylation and demethylation in cancer development.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Liver; Male; Phenobarbital | 2012 |
Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells.
Topics: 5-Methylcytosine; Animals; Bromodeoxyuridine; Cell Line; Chromosomes, Human, X; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Euchromatin; Female; Gene Deletion; Gene Expression Regulation; Gene Silencing; Genetic Markers; Genomic Imprinting; Heterochromatin; Histones; Humans; In Situ Hybridization, Fluorescence; Male; Mice; Retroelements; Sequence Analysis, DNA | 2012 |
Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin.
Topics: 5-Methylcytosine; Animals; Chromatin; Chromosomes; Cytosine; DNA; DNA Methylation; Gene Expression Regulation; Humans; Immunoblotting; Methyl-CpG-Binding Protein 2; Mutation; Oocytes; RNA Polymerase II; Sequence Analysis, DNA; Transcription, Genetic; Xenopus laevis | 2012 |
Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA-Binding Proteins; Glucosyltransferases; Mice; Polymerase Chain Reaction; Proto-Oncogene Proteins; Sequence Analysis, DNA; Sulfites | 2012 |
Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Genomic Imprinting; Germ Cells; Germ Layers; Male; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA-Binding Proteins | 2013 |
Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Line; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Mice; Octamer Transcription Factor-3; Proto-Oncogene Proteins; Pyrazoles; Pyrimidines | 2013 |
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.
Topics: 5-Methylcytosine; Animals; Cerebellum; Chromatin; Cytosine; Epigenesis, Genetic; Humans; Methyl-CpG-Binding Protein 2; Mice; Mice, Knockout; Neuroglia; Neurons; Purkinje Cells; Rett Syndrome | 2012 |
Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4.
Topics: 5-Methylcytosine; Animals; Crystallography, X-Ray; Cytosine; DNA Methylation; Endodeoxyribonucleases; Humans; Mice; Protein Structure, Tertiary; Structure-Activity Relationship | 2013 |
Quantification of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry.
Topics: 5-Methylcytosine; Biomarkers; Carcinoma, Hepatocellular; Chromatography, Liquid; Cytosine; DNA Methylation; DNA, Neoplasm; Humans; Limit of Detection; Liver Neoplasms; Sequence Analysis, DNA; Tandem Mass Spectrometry | 2013 |
High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cell Line; Chromosome Mapping; Computational Biology; CpG Islands; Cytosine; DNA Methylation; DNA Restriction Enzymes; Embryonic Stem Cells; Genomics; Histones; Hydroxylation; Mice; Sequence Analysis, DNA | 2013 |
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Embryonic Stem Cells; Epigenesis, Genetic; Female; Fertility; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Genomic Imprinting; Humans; Hydroxylation; Male; Mice; Proto-Oncogene Proteins | 2013 |
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Glycosylation; Histone-Lysine N-Methyltransferase; Histones; Host Cell Factor C1; Humans; Immunoprecipitation; Mice; Mice, Knockout; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Transcription, Genetic | 2013 |
Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease.
Topics: 5-Methylcytosine; 5' Untranslated Regions; Adult; Aged; Aged, 80 and over; Animals; Corpus Striatum; Cytosine; Disease Models, Animal; Disease Progression; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Transgenic; Middle Aged; Nerve Tissue Proteins; Putamen; Receptor, Adenosine A2A | 2013 |
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Germ Cells; Heterochromatin; Male; Mice | 2013 |
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Chromatin; Cytosine; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Histones; Mice; Neurogenesis; Neurons; Oxidation-Reduction; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; RNA, Small Interfering | 2013 |
A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mixed Function Oxygenases; N-Acetylglucosaminyltransferases; Proto-Oncogene Proteins; Transcription, Genetic | 2013 |
Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method.
Topics: 5-Methylcytosine; Animals; Cell Lineage; Cells, Cultured; Cytosine; DNA Methylation; Embryonic Stem Cells; Gene Expression; Genome; High-Throughput Nucleotide Sequencing; Immunoprecipitation; Mice; Neural Stem Cells; Sequence Analysis, DNA | 2013 |
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Genome; Germ Cells; Green Fluorescent Proteins; Mice; Proto-Oncogene Proteins | 2013 |
Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Myosins; Case-Control Studies; CCCTC-Binding Factor; Cell Lineage; Child; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Homeobox; Genome, Human; Guanine Nucleotide Exchange Factors; Histones; Humans; Infant, Newborn; Male; Middle Aged; Mixed Function Oxygenases; Muscle Development; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Dystrophy, Facioscapulohumeral; Myoblasts; Myosin Heavy Chains; Paired Box Transcription Factors; PAX3 Transcription Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Repressor Proteins; Rho Guanine Nucleotide Exchange Factors; T-Box Domain Proteins; Transcription, Genetic | 2013 |
Decreased 5-hydroxymethylcytosine levels are associated with TET2 mutation and unfavorable overall survival in myelodysplastic syndromes.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Prognosis; Proto-Oncogene Proteins; Young Adult | 2013 |
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.
Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Glycosylases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Kruppel-Like Factor 4; Mass Spectrometry; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Regulatory Factor X Transcription Factors; Stem Cells; Transcription Factors; Ubiquitin-Protein Ligases | 2013 |
Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder.
Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Bipolar Disorder; Cytosine; Deoxyguanosine; DNA; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Multivariate Analysis; Oxidation-Reduction; Oxidative Stress; Young Adult | 2013 |
Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion.
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Fusion; Cell Line; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression; Genomic Imprinting; Germ Cells; Green Fluorescent Proteins; Humans; Insulin-Like Growth Factor II; Mice; Molecular Sequence Data; Octamer Transcription Factor-3; Polymorphism, Single Nucleotide; Proteins; Proto-Oncogene Proteins; RNA, Long Noncoding; Sequence Analysis, DNA | 2013 |
Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Cytosine; Dioxygenases; Disease Progression; DNA-Binding Proteins; Epigenomics; Humans; Melanoma; Paraffin Embedding; Proto-Oncogene Proteins; Skin Neoplasms; Translocation, Genetic | 2013 |
Characterization of the 5-hydroxymethylcytosine-specific DNA restriction endonucleases.
Topics: 5-Methylcytosine; Bacteriophage T4; Cytosine; DNA Cleavage; DNA Restriction Enzymes; DNA, Viral; Glucosyltransferases; Sequence Homology, Amino Acid; Substrate Specificity | 2013 |
Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming.
Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Models, Biological; Octamer Transcription Factor-3; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; SOXB1 Transcription Factors; Transcription, Genetic; Transcriptome | 2013 |
Integrated detection of both 5-mC and 5-hmC by high-throughput tag sequencing technology highlights methylation reprogramming of bivalent genes during cellular differentiation.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cells, Cultured; Cytosine; DNA Methylation; Embryoid Bodies; Embryonic Stem Cells; High-Throughput Screening Assays; Humans; Mice; Sequence Analysis, DNA | 2013 |
Quantification of the sixth DNA base 5-hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line.
Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatography, Liquid; Colorectal Neoplasms; Cytosine; DNA Methylation; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Tandem Mass Spectrometry | 2013 |
Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cells, Cultured; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Knockdown Techniques; Hydroxylation; Mice; Mice, Inbred C57BL; Phloretin; Proto-Oncogene Proteins; RNA, Small Interfering | 2013 |
Single-molecule detection of 5-hydroxymethylcytosine in DNA through chemical modification and nanopore analysis.
Topics: 5-Methylcytosine; Cytosine; DNA; Molecular Structure; Nanopores | 2013 |
GSE is a maternal factor involved in active DNA demethylation in zygotes.
Topics: 5-Methylcytosine; Animals; Blastocyst; Chromatin; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Homeodomain Proteins; Long Interspersed Nucleotide Elements; Male; Mice; Nanog Homeobox Protein; Octamer Transcription Factor-3; Protein Binding; Proteins; RNA, Small Interfering; Sex Factors; Zygote | 2013 |
Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.
Topics: 5-Methylcytosine; Animals; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Cytosine; DNA Methylation; Epigenesis, Genetic; Genetic Markers; Liver; Male; Mice; Oligonucleotide Array Sequence Analysis; Phenobarbital; Promoter Regions, Genetic; Transcriptome | 2013 |
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA Repair; Embryonic Stem Cells; Epigenesis, Genetic; Genetic Techniques; Genome-Wide Association Study; Heterochromatin; Mice; Oxidation-Reduction; Regulatory Elements, Transcriptional; Thymine DNA Glycosylase | 2013 |
A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences.
Topics: 5-Methylcytosine; Base Sequence; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Cytosine; Electrophoresis, Gel, Two-Dimensional; Sequence Analysis, DNA | 2013 |
First evidence of DNA methylation in insect Tribolium castaneum: environmental regulation of DNA methylation within heterochromatin.
Topics: 5-Methylcytosine; Animals; Base Sequence; Blotting, Southern; Cytosine; DNA Methylation; DNA, Satellite; Electrophoresis, Agar Gel; Environment; Genome, Insect; Heterochromatin; Molecular Sequence Data; Tribolium | 2013 |
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.
Topics: 5-Methylcytosine; Animals; Brain; Corpus Striatum; Cytosine; Disease Models, Animal; DNA Methylation; Epigenomics; Humans; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Sequence Alignment; Sequence Analysis, DNA | 2013 |
Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.
Topics: 5-Methylcytosine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine; Diethylnitrosamine; Dioxygenases; Disease Progression; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Middle Aged; Mixed Function Oxygenases; Prognosis; Proto-Oncogene Proteins; Rats, Wistar | 2013 |
Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease.
Topics: 5-Methylcytosine; Cell Differentiation; Cell Line, Tumor; Cytosine; DNA Methylation; Epigenomics; Female; Histones; Humans; In Vitro Techniques; Male; Neoplasms; Polycomb-Group Proteins | 2013 |
Formation of cyclobutane pyrimidine dimers at dipyrimidines containing 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Base Sequence; Cells, Cultured; Cytosine; DNA; Fibroblasts; Humans; Keratinocytes; Melanocytes; Pyrimidine Dimers; Ultraviolet Rays | 2013 |
Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection.
Topics: 5-Methylcytosine; Chromatography, Liquid; Cytosine; HEK293 Cells; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Jurkat Cells; Tandem Mass Spectrometry | 2013 |
Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency.
Topics: 5-Methylcytosine; Cell Differentiation; Cell Line; Cellular Reprogramming; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Enzyme Activation; Epigenesis, Genetic; Fibroblasts; Humans; Induced Pluripotent Stem Cells; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA Interference; RNA, Small Interfering; Sequence Alignment; Transcription Factors | 2013 |
5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote.
Topics: 5-Methylcytosine; Animals; Cell Nucleus; Cytosine; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Male; Mice; Solvents; Temperature; Zygote | 2013 |
Maternal low-protein diet affects epigenetic regulation of hepatic mitochondrial DNA transcription in a sex-specific manner in newborn piglets associated with GR binding to its promoter.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Cytosine; Dietary Proteins; DNA Methylation; DNA, Mitochondrial; Electron Transport Complex IV; Epigenesis, Genetic; Female; Liver; Male; Mothers; Promoter Regions, Genetic; Protein Binding; Receptors, Glucocorticoid; RNA, Messenger; Sex Characteristics; Swine; Transcription, Genetic | 2013 |
5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes.
Topics: 5-Methylcytosine; Cell Differentiation; Cytosine; Dendritic Cells; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Knockdown Techniques; Humans; Mass Spectrometry; Monocytes; Proto-Oncogene Proteins | 2013 |
5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni.
Topics: 5-Methylcytosine; Animals; Biomphalaria; Chemistry Techniques, Analytical; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic | 2013 |
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cytosine; DNA Mutational Analysis; Down-Regulation; Electron Transport Complex II; Exons; Gastrointestinal Stromal Tumors; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Membrane Proteins; Mutation; Phenotype; Proto-Oncogene Proteins c-kit; Receptor, Platelet-Derived Growth Factor alpha; Succinate Dehydrogenase | 2013 |
Optical detection of epigenetic marks: sensitive quantification and direct imaging of individual hydroxymethylcytosine bases.
Topics: 5-Methylcytosine; Animals; Bacteriophage lambda; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Dyes; Mice; Models, Molecular; Optical Imaging | 2013 |
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis.
Topics: 5-Methylcytosine; Animals; Cell Separation; Cell Shape; Chromatin; Chromosomes, Mammalian; Cytosine; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Profiling; Genome; Male; Mice; Microscopy, Phase-Contrast; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Sex Chromosomes; Spermatogenesis; Spermatozoa; Transcriptome; Up-Regulation | 2013 |
Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA, Single-Stranded; Nanopores; Sequence Analysis, DNA | 2013 |
Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
Topics: 5-Methylcytosine; Adult; Age Factors; Aging; Cytosine; DNA; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Humans; Male; Middle Aged; Paternal Age; Prospective Studies; Risk Factors; Spermatozoa; Up-Regulation | 2013 |
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
Topics: 5-Methylcytosine; Animals; Antioxidants; Ascorbic Acid; Blastocyst; Cell Line; Culture Media; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Mice; Protein Binding; Proto-Oncogene Proteins; Recombinant Proteins | 2013 |
TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Topics: 5-Methylcytosine; Chromatin Immunoprecipitation; Chromatography, Liquid; Cytosine; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Homeodomain Proteins; Humans; Immunoblotting; Leukemia, Myeloid, Acute; Microarray Analysis; Mixed Function Oxygenases; Myeloid Ecotropic Viral Integration Site 1 Protein; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins; Signal Transduction; Tandem Mass Spectrometry | 2013 |
Global epigenomic reconfiguration during mammalian brain development.
Topics: 5-Methylcytosine; Adult; Animals; Base Sequence; Conserved Sequence; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Frontal Lobe; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Humans; Longevity; Mice; Mice, Inbred C57BL; X Chromosome Inactivation | 2013 |
Paternal age and sperm methylation status.
Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa | 2013 |
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.
Topics: 5-Methylcytosine; Animals; Breast Neoplasms; Chromatin Assembly and Disassembly; Cytosine; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; MicroRNAs; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Proto-Oncogene Proteins; RNA Interference; Transplantation, Heterologous | 2013 |
Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytosine; DNA, Neoplasm; Gene Expression; Genome, Human; Genomics; Glycosyltransferases; Humans; Mice; Pancreatic Neoplasms; Polymerase Chain Reaction | 2013 |
Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin.
Topics: 5-Methylcytosine; Animal Fins; Animals; Animals, Genetically Modified; Cell Dedifferentiation; Cytosine; DNA Methylation; DNA Repair; Embryo, Nonmammalian; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Regeneration; Zebrafish | 2013 |
PPARγ-induced PARylation promotes local DNA demethylation by production of 5-hydroxymethylcytosine.
Topics: 3T3-L1 Cells; 5-Methylcytosine; Adipocytes; Adipose Tissue; Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Cytosine; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; HEK293 Cells; Humans; Hydroxylation; Mice; Molecular Sequence Data; Phenanthrenes; Poly Adenosine Diphosphate Ribose; PPAR gamma; Protein Binding; Proto-Oncogene Proteins; Response Elements | 2013 |
Genetics. The maturing brain methylome.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Frontal Lobe; Gene Expression Regulation, Developmental; Humans | 2013 |
Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase.
Topics: 5-Methylcytosine; Cell Cycle; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Genome, Human; HEK293 Cells; Humans; Hydroquinones; Mixed Function Oxygenases; Proto-Oncogene Proteins; Reactive Oxygen Species | 2013 |
Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function.
Topics: 5-Methylcytosine; Adult; Age Factors; Carbohydrate Metabolism; Cytosine; DNA Methylation; Epigenesis, Genetic; Fetus; Gene Expression Regulation, Developmental; Genome, Human; Hepatocytes; Humans; Inactivation, Metabolic; Lipid Metabolism; Liver; Molecular Sequence Annotation; Protein Biosynthesis | 2013 |
Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine.
Topics: 5-Methylcytosine; Cations; Crystallography, X-Ray; Cytosine; DNA, B-Form; Epigenesis, Genetic; Models, Molecular; Thermodynamics; Water | 2013 |
MLML: consistent simultaneous estimates of DNA methylation and hydroxymethylation.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; High-Throughput Nucleotide Sequencing; Sequence Analysis, DNA; Software | 2013 |
Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Fluorescent Antibody Technique; Gene Expression Profiling; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Olfactory Bulb; Olfactory Mucosa; Olfactory Receptor Neurons; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2013 |
Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy.
Topics: 5-Methylcytosine; Azacitidine; Cell Hypoxia; Cytosine; Decitabine; DNA; DNA Modification Methylases; DNA-Binding Proteins; HeLa Cells; Humans; Single-Cell Analysis; Spectrometry, Fluorescence | 2013 |
Decreased 5-hydroxymethylcytosine (5-hmC) is an independent poor prognostic factor in gastric cancer patients.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; China; Cytosine; Female; Humans; Incidence; Male; Middle Aged; Prognosis; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Stomach Neoplasms; Survival Analysis; Survival Rate | 2013 |
Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine.
Topics: 5-Methylcytosine; Carboxylic Acids; Cytosine; Deamination; Oxidation-Reduction; Sulfhydryl Compounds | 2013 |
Reactivation of Х chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation.
Topics: 5-Methylcytosine; Animals; Cell Line; Cellular Reprogramming; Chromosomes, Human, X; Cytosine; DNA Replication; DNA Replication Timing; Female; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Mice; X Chromosome Inactivation | 2014 |
Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Adult Stem Cells; Animals; Cell Differentiation; Chromatin; Cytosine; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; Genome; Histones; Mice; Pluripotent Stem Cells; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Proto-Oncogene Proteins; Repressor Proteins; RNA, Small Interfering; Sin3 Histone Deacetylase and Corepressor Complex; Transcription, Genetic | 2013 |
Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Nucleus; Cells, Cultured; Chromosomes, Mammalian; Cytosine; DNA Methylation; DNA, Satellite; Embryonic Stem Cells; Humans; In Situ Hybridization, Fluorescence; Male; Mice; Spermatozoa | 2013 |
Fluorescent strategy based on cationic conjugated polymer fluorescence resonance energy transfer for the quantification of 5-(hydroxymethyl)cytosine in genomic DNA.
Topics: 5-Methylcytosine; Animals; Cations; Chromatography, High Pressure Liquid; Cytosine; DNA; Embryonic Stem Cells; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; HEK293 Cells; HeLa Cells; Humans; Mice; Oxidation-Reduction; Polymers; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Static Electricity | 2013 |
DNA methylation: an identity card for brain cells.
Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome; Humans; Mice; Neuroglia; Neurons; Organ Specificity | 2013 |
Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Oxidation-Reduction; Sequence Analysis, DNA | 2013 |
Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Fibroblasts; Iron; Isocitrate Dehydrogenase; Ketoglutaric Acids; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Sodium-Coupled Vitamin C Transporters | 2013 |
Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus.
Topics: 5-Methylcytosine; 5' Untranslated Regions; Adolescent; Adult; CCCTC-Binding Factor; Cerebellum; Cytosine; DNA Methylation; Frataxin; Friedreich Ataxia; Genetic Loci; Humans; Iron-Binding Proteins; Microsatellite Repeats; Middle Aged; Myocardium; Protein Binding; Repressor Proteins; Young Adult | 2013 |
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation.
Topics: 5-Methylcytosine; Binding Sites; Cell Differentiation; CpG Islands; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Monocytes; NF-kappa B; Osteoclasts; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins; RNA, Small Interfering; Trans-Activators; Transcription Factor AP-1 | 2013 |
Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Escherichia coli; High-Throughput Nucleotide Sequencing; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Intronic non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees.
Topics: 5-Methylcytosine; Africa; Alternative Splicing; Animals; Bees; Behavior, Animal; CpG Islands; Cytosine; DNA Methylation; Europe; Exons; Gene Expression Regulation; Genes, Insect; Honey; Introns; Reproducibility of Results; RNA Splice Sites; RNA, Messenger; Sequence Analysis, DNA; Sulfites | 2013 |
Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.
Topics: 5-Methylcytosine; Cell Differentiation; Cell Lineage; Cells, Cultured; Cytosine; DNA Methylation; Embryonic Stem Cells; Gene Expression Regulation; Gene Silencing; GPI-Linked Proteins; Homeodomain Proteins; Humans; Mesoderm; Nerve Tissue Proteins; Neurogenesis; Neurons; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor, Notch1; Transcription Factors | 2014 |
Evaluation of UDP-GlcN derivatives for selective labeling of 5-(hydroxymethyl)cytosine.
Topics: 5-Methylcytosine; Animals; Antibodies; Bacteriophage T4; Cytosine; DNA; Embryonic Stem Cells; Fluorescent Dyes; Glucosamine; Glucosyltransferases; Glycosylation; Mice; Oligonucleotides; Staining and Labeling; Substrate Specificity; Uracil Nucleotides | 2013 |
Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome.
Topics: 5-Methylcytosine; Animals; Ataxia; Base Sequence; Cerebellum; Consensus Sequence; Cytosine; Disease Models, Animal; DNA Methylation; Fragile X Syndrome; Humans; Mice; Mice, Transgenic; Terminator Regions, Genetic; Transcription Initiation Site; Tremor | 2014 |
MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Flow Cytometry; Gene Expression Regulation, Developmental; Islets of Langerhans; Luciferases; Mice; Mice, Transgenic; Microfluidics; MicroRNAs; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Thymine DNA Glycosylase | 2013 |
An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.
Topics: 3' Untranslated Regions; 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA-Binding Proteins; Down-Regulation; Hematologic Neoplasms; Hematopoiesis; Humans; Mice; MicroRNAs; Phenotype; Proto-Oncogene Proteins | 2013 |
Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Squamous Cell; Case-Control Studies; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Mouth Mucosa; Mouth Neoplasms; Proto-Oncogene Proteins | 2013 |
Association of 5-methylcytosine and 5-hydroxymethylcytosine with mitochondrial DNA content and clinical and biochemical parameters in hepatocellular carcinoma.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Cytosine; DNA, Mitochondrial; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Risk Factors; Tumor Burden; Young Adult | 2013 |
Hydroxymethylated DNA immunoprecipitation (hmeDIP).
Topics: 5-Methylcytosine; Antibody Specificity; Brain; Breast; Cytosine; DNA; DNA Fragmentation; Epitopes; Female; Humans; Immunoprecipitation; Sonication | 2014 |
Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA.
Topics: 5-Methylcytosine; Bayes Theorem; Cytosine; DNA Methylation; Epigenomics; Models, Molecular; Molecular Structure; Nanopores; Porins | 2013 |
Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Epigenomics; Nanopores; Research Design | 2013 |
5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Humans; Keratinocytes; Male; Melanoma; Middle Aged; Nevus, Epithelioid and Spindle Cell; Nevus, Pigmented; Skin Neoplasms | 2014 |
Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques.
Topics: 5-Methylcytosine; Animals; Antibodies; Chromatin; CpG Islands; Cytosine; DNA; DNA-Binding Proteins; Genetic Loci; Genomic Imprinting; Immunoassay; Liver; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Tandem Repeat Sequences | 2013 |
Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.
Topics: 5-Methylcytosine; Animals; Apoferritins; Cell Line; Cell Line, Tumor; Chloranil; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Genome; Humans; Iron; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Quinones | 2014 |
Large conserved domains of low DNA methylation maintained by Dnmt3a.
Topics: 5-Methylcytosine; Animals; Base Sequence; Conserved Sequence; CpG Islands; Cytosine; Databases, Genetic; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Gene Expression Regulation; Hematopoietic Stem Cells; Histones; Humans; Leukemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains | 2014 |
Structural insights into how 5-hydroxymethylation influences transcription factor binding.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Models, Molecular; Nucleic Acid Conformation; Oxidation-Reduction; Protein Binding; Transcription Factors | 2014 |
Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling.
Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA; Models, Molecular; Molecular Structure | 2014 |
Dynamic reprogramming of 5-hydroxymethylcytosine during early porcine embryogenesis.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Embryonic Development; Nuclear Transfer Techniques; Swine | 2014 |
Understanding variation in transcription factor binding by modeling transcription factor genome-epigenome interactions.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Embryonic Stem Cells; Epigenomics; Genome; Histones; Mice; Models, Biological; Protein Binding; Transcription Factors | 2013 |
Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Proteins; Cell Cycle; Cell Proliferation; Cell Separation; CpG Islands; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Replication; Embryonic Stem Cells; Flow Cytometry; Mice; Mice, Knockout; Multigene Family; Nuclear Proteins; Promoter Regions, Genetic; Protein Structure, Tertiary; Ubiquitin-Protein Ligases | 2013 |
Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor.
Topics: 5-Methylcytosine; Algorithms; Biological Transport; Biosensing Techniques; Cytosine; DNA; DNA Damage; DNA, Single-Stranded; Escherichia coli; Ions; Lipid Bilayers; Molecular Dynamics Simulation; Nanopores; Nanotechnology; Nanotubes, Carbon; Thermodynamics | 2013 |
Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions.
Topics: 5-Methylcytosine; Animals; Binding Sites; CCCTC-Binding Factor; Cell Differentiation; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; Genome; Mice; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Repressor Proteins; Transcription Factors; Transcription, Genetic | 2013 |
Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells.
Topics: 5-Methylcytosine; Cell Culture Techniques; Cell Cycle Checkpoints; Cell Differentiation; Cytosine; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Pluripotent Stem Cells; Signal Transduction; Transcription Factors | 2013 |
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Topics: 5-Methylcytosine; Antigens, CD34; Cells, Cultured; Cytosine; Dioxygenases; DNA Methylation; Erythroid Cells; Erythropoiesis; Histones; Humans; Mutation; Regulatory Sequences, Nucleic Acid; Transcription Factors | 2014 |
Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.
Topics: 5-Methylcytosine; Carcinoma; Cell Line, Tumor; Cytosine; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Germ Cells; Humans; Immunohistochemistry; Male; Mixed Function Oxygenases; Neoplasms, Germ Cell and Embryonal; Oxidation-Reduction; Proto-Oncogene Proteins; Spermatogenesis; Testis | 2013 |
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Cytosine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Genetic Markers; Humans; Male; Microglia; Middle Aged; Neurons; Parahippocampal Gyrus | 2014 |
Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cytosine; DNA Methylation; Female; Humans; Male; Melanoma; Middle Aged; Nevus; Precancerous Conditions; Skin Neoplasms; Young Adult | 2014 |
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Escherichia coli Proteins; HEK293 Cells; Humans; Hydrogen Bonding; Mice; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Naegleria; Proto-Oncogene Proteins; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity | 2014 |
Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).
Topics: 5-Methylcytosine; Active Transport, Cell Nucleus; Cell Nucleus; Cytosine; Dioxygenases; DNA Methylation; Glucose; HeLa Cells; Humans; N-Acetylglucosaminyltransferases | 2014 |
Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence.
Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cytosine; Disease Models, Animal; Epigenomics; Genome-Wide Association Study; Hypertension; Kidney Medulla; Male; Phenotype; Rats; Rats, Inbred Dahl; RNA, Messenger; Sodium Chloride, Dietary; Transcriptome | 2014 |
Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum.
Topics: 5-Methylcytosine; Cell Adhesion Molecules, Neuronal; Cerebellar Cortex; Child Development Disorders, Pervasive; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Extracellular Matrix Proteins; Glutamate Decarboxylase; Humans; Methyl-CpG-Binding Protein 2; Mixed Function Oxygenases; Nerve Tissue Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reelin Protein; Serine Endopeptidases; Tissue Banks | 2014 |
A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes.
Topics: 5-Methylcytosine; ADAM Proteins; ADAMTS5 Protein; Adolescent; Adult; Aged; Aged, 80 and over; Anterior Cruciate Ligament Reconstruction; Arthroplasty, Replacement, Knee; Biomarkers; Cartilage, Articular; Case-Control Studies; Child; Child, Preschool; Chondrocytes; CpG Islands; Cytokines; Cytosine; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Female; Gene Expression; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Middle Aged; Mixed Function Oxygenases; Osteoarthritis, Knee; Promoter Regions, Genetic; Proto-Oncogene Proteins; Young Adult | 2014 |
Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process.
Topics: 5-Methylcytosine; Animals; Carcinoma, Hepatocellular; Cell Dedifferentiation; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cytosine; DNA Methylation; ELAV Proteins; ELAV-Like Protein 2; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genetic Vectors; HEK293 Cells; Homeodomain Proteins; Humans; Lentivirus; Liver; Liver Neoplasms; Metabolomics; Mice; MicroRNAs; Nanog Homeobox Protein; Neoplasm Transplantation; Neoplastic Stem Cells; Octamer Transcription Factor-3; Pluripotent Stem Cells; Proto-Oncogene Proteins c-myc; RNA Interference; RNA, Small Interfering; Serum Albumin; Serum Albumin, Human; Telomerase; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2014 |
Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, α-Ketoglutarate (α-KG), and DNA hydroxymethylation levels by interleukin-1β in primary human chondrocytes.
Topics: 5-Methylcytosine; Chondrocytes; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Interleukin-1beta; Isocitrate Dehydrogenase; Ketoglutaric Acids; Mixed Function Oxygenases; Primary Cell Culture; Proto-Oncogene Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha | 2014 |
Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice.
Topics: 5-Methylcytosine; Animals; Brain; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Genetic Loci; Genome; Genome, Human; Humans; Macaca mulatta; Mice; Oligonucleotide Array Sequence Analysis | 2014 |
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain.
Topics: 5-Methylcytosine; Adult; Brain; CpG Islands; Cytosine; DNA Methylation; DNA, Antisense; Exons; Female; Gene Expression Regulation, Developmental; Genome, Human; Histones; Humans; Introns; Male; Transcription, Genetic | 2014 |
DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.
Topics: 5-Methylcytosine; Cell Line, Tumor; CpG Islands; Cyclin-Dependent Kinase Inhibitor p21; Cytosine; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; HeLa Cells; Humans; Protein Binding; Repressor Proteins | 2014 |
Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Animals, Newborn; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Humans; Mice; Mixed Function Oxygenases; Molecular Sequence Data; Oligodendroglia; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley | 2014 |
TET proteins and 5-methylcytosine oxidation in the immune system.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Profiling; Humans; Immunoprecipitation; Mice; Mixed Function Oxygenases; Oxidoreductases; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins | 2013 |
DNA counterstaining for methylation and hydroxymethylation immunostaining in bovine zygotes.
Topics: 5-Methylcytosine; Animals; Cattle; Cytosine; DNA Methylation; Staining and Labeling; Zygote | 2014 |
Crystal structure of the 5hmC specific endonuclease PvuRts1I.
Topics: 5-Methylcytosine; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Bacteriophage T4; Catalytic Domain; Crystallography, X-Ray; Cytosine; DNA Restriction Enzymes; DNA, Viral; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Secondary; Proteus vulgaris; Substrate Specificity | 2014 |
A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine.
Topics: 5-Methylcytosine; Agaricales; Cytosine; Dioxygenases; Fungal Proteins | 2014 |
Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation.
Topics: 5-Methylcytosine; Animals; Cytosine; Databases, Genetic; DNA Methylation; Epigenesis, Genetic; Frontal Lobe; Gene Expression; Macaca mulatta; Maternal Deprivation; Methylation; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Prefrontal Cortex; Promoter Regions, Genetic | 2014 |
Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases.
Topics: 5-Methylcytosine; Animals; Arabidopsis; Arabidopsis Proteins; Cytosine; DNA Glycosylases; DNA Methylation; Mice; N-Glycosyl Hydrolases; Nuclear Proteins; Signal Transduction; Trans-Activators | 2014 |
Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Cerebellum; Chromatin; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Histones; Humans; Male; Mixed Function Oxygenases; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; Myocardium; Organ Specificity; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptors, Notch | 2014 |
Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cytosine; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Humans; Ivermectin; Male; Methylation | 2014 |
Boronic acid-mediated polymerase chain reaction for gene- and fragment-specific detection of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Base Sequence; Boronic Acids; Cells, Cultured; Cytosine; Embryonic Stem Cells; Introns; Mice; PAX5 Transcription Factor; Polymerase Chain Reaction; Sequence Analysis, DNA | 2014 |
Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.
Topics: 5-Methylcytosine; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Cytosine; Disease Models, Animal; Gene Expression Regulation; Genotype; Humans; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1; tau Proteins | 2014 |
Genome-wide analysis of DNA 5-hmC in peripheral blood of uremia by hMeDIP-chip.
Topics: 5-Methylcytosine; Case-Control Studies; CpG Islands; Cytosine; DNA Methylation; Genome-Wide Association Study; Humans; Promoter Regions, Genetic; Uremia | 2014 |
High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cytosine; DNA Methylation; Female; Hepatectomy; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Retrospective Studies; Treatment Outcome | 2014 |
TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells.
Topics: 5-Methylcytosine; Adult; Case-Control Studies; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression; Humans; Leukocytes, Mononuclear; Male; Multiple Sclerosis; Promoter Regions, Genetic; Proto-Oncogene Proteins | 2014 |
Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation.
Topics: 5-Methylcytosine; Adaptation, Physiological; Animals; Behavior, Animal; Conditioning, Psychological; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Extinction, Psychological; Fear; Genome-Wide Association Study; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neocortex; Neurons; Proto-Oncogene Proteins | 2014 |
Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples.
Topics: 5-Methylcytosine; Aged; Arsenic; Cadmium; Cross-Sectional Studies; Cytosine; DNA; DNA Methylation; Environmental Exposure; Epigenesis, Genetic; Female; Humans; Longitudinal Studies; Male; Metals; Middle Aged | 2014 |
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cytosine; Dioxygenases; DNA-Activated Protein Kinase; DNA-Binding Proteins; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Gastric Mucosa; Humans; Ki-67 Antigen; Mice; Mixed Function Oxygenases; Nuclear Proteins; Phosphorylation; Phosphoserine; Polycomb Repressive Complex 2; Protein Binding; Proto-Oncogene Proteins; Signal Transduction; Stomach Neoplasms; Tissue Array Analysis; Tumor Suppressor Protein p53; Up-Regulation | 2014 |
PRIMA-1 selectively induces global DNA demethylation in p53 mutant-type thyroid cancer cells.
Topics: 5-Methylcytosine; Aza Compounds; bcl-2-Associated X Protein; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Mixed Function Oxygenases; Models, Biological; Mutation; Nuclear Proteins; Proto-Oncogene Proteins; Thyroid Neoplasms; Tumor Suppressor Protein p53; Up-Regulation | 2014 |
Programming and inheritance of parental DNA methylomes in mammals.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Development; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Promoter Regions, Genetic | 2014 |
Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2.
Topics: 5-Methylcytosine; Binding Sites; Crystallography, X-Ray; Cytosine; Humans; Hydrogen Bonding; Models, Molecular; Oligonucleotides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Ubiquitin-Protein Ligases | 2014 |
TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
Topics: 5-Methylcytosine; Cell Hypoxia; Cell Line, Tumor; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mixed Function Oxygenases; Neuroblastoma; Proto-Oncogene Proteins; Response Elements; Up-Regulation | 2014 |
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
Topics: 5-Methylcytosine; Animals; Base Sequence; Carbon Isotopes; Chromatin Assembly and Disassembly; Chromatography, Liquid; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression; Mice; Molecular Sequence Data; Oxidation-Reduction; Pentoxyl; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine; Transcription Factors | 2014 |
Deamination features of 5-hydroxymethylcytosine, a radical and enzymatic DNA oxidation product.
Topics: 5-Methylcytosine; Computer Simulation; Cytosine; Deamination; DNA; Energy Transfer; Hydrolysis; Models, Chemical; Models, Molecular; Molecular Structure; Oxidation-Reduction; Quantum Theory; Structure-Activity Relationship; Water | 2014 |
TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.
Topics: 5-Methylcytosine; Catalytic Domain; Cell Differentiation; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; HEK293 Cells; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins; Transcription, Genetic | 2014 |
High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Bone Marrow; Cytosine; DNA; DNA Methylation; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Survival Analysis | 2014 |
CRISPR/Cas9-mediated phage resistance is not impeded by the DNA modifications of phage T4.
Topics: 5-Methylcytosine; Bacteriophage T4; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR-Associated Proteins; CRISPR-Cas Systems; Cytosine; DNA, Bacterial; Endonucleases; Escherichia coli; Streptococcus pyogenes | 2014 |
Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma.
Topics: 5-Methylcytosine; Age Factors; Brain Stem Neoplasms; Child; Child, Preschool; Cytosine; DNA Methylation; Epigenomics; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Statistics, Nonparametric; Tissue Array Analysis | 2014 |
Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA.
Topics: 5-Methylcytosine; CCAAT-Enhancer-Binding Proteins; Cytosine; Dimerization; DNA; DNA Cleavage; DNA Restriction Enzymes; Endodeoxyribonucleases; Models, Molecular; Nuclear Proteins; Protein Structure, Tertiary; Ubiquitin-Protein Ligases | 2014 |
Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication.
Topics: 5-Methylcytosine; Base Pairing; Cell Proliferation; Cytosine; DNA; DNA Mismatch Repair; DNA Replication; Epigenesis, Genetic; Guanine; Humans; Thymine DNA Glycosylase | 2014 |
Distinct global DNA methylation status in B-cell lymphomas: immunohistochemical study of 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Humans; Immunohistochemistry; Lymphoma, B-Cell; Male; Middle Aged; Young Adult | 2014 |
Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.
Topics: 5-Methylcytosine; Cell Differentiation; Cell Line, Tumor; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sequence Analysis, DNA | 2014 |
Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial.
Topics: 5-Methylcytosine; Adolescent; Adult; Animals; Chlorocebus aethiops; Clinical Trials as Topic; COS Cells; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA-Binding Proteins; Female; Gene Expression Regulation, Leukemic; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Multicenter Studies as Topic; Mutation; Neoplasm Proteins; Prognosis; Prospective Studies; Proto-Oncogene Proteins; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Transfection; Young Adult | 2014 |
Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Female; Genome; Mice, Inbred C57BL; Oocytes; Proto-Oncogene Proteins; Zygote | 2014 |
5-Hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: a biological link to a new epigenetic modification in benign tumors.
Topics: 5-Methylcytosine; Adult; Cell Proliferation; Cytosine; Epigenesis, Genetic; Female; Humans; Leiomyoma; Middle Aged; Uterine Neoplasms | 2014 |
Comparison of the absolute level of epigenetic marks 5-methylcytosine, 5-hydroxymethylcytosine, and 5-hydroxymethyluracil between human leukocytes and sperm.
Topics: 5-Methylcytosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Leukocytes; Male; Pentoxyl; Poland; Spectrometry, Mass, Electrospray Ionization; Spermatozoa; Tandem Mass Spectrometry; Thymidine; Up-Regulation | 2014 |
Epigenetically modified nucleotides in chronic heroin and cocaine treated mice.
Topics: 5-Methylcytosine; Animals; Brain; Brain Chemistry; Cocaine; Cytosine; Dose-Response Relationship, Drug; Epigenesis, Genetic; Heroin; Liver; Male; Mice; Mice, Inbred C57BL | 2014 |
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Lineage; Cytosine; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Developmental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins; T-Lymphocyte Subsets; T-Lymphocytes | 2014 |
Spectroscopic quantification of 5-hydroxymethylcytosine in genomic DNA.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cytosine; DNA; DNA Methylation; DNA, Fungal; Equipment Design; Genomics; Limit of Detection; Mice; Molecular Sequence Data; Saccharomyces cerevisiae; Spectrometry, Fluorescence | 2014 |
Tet-mediated formation of 5-hydroxymethylcytosine in RNA.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; HEK293 Cells; Humans; Mice; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA | 2014 |
5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cytosine; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Nevus; Sentinel Lymph Node Biopsy; Skin Neoplasms | 2015 |
Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.
Topics: 5-Methylcytosine; Basic Helix-Loop-Helix Transcription Factors; Cell Cycle Proteins; Cell Line, Tumor; CpG Islands; Cytosine; DNA Methylation; DNA Repair; Gene Expression Regulation, Neoplastic; Genome, Human; HEK293 Cells; Humans; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Promoter Regions, Genetic; RNA, Long Noncoding; Thymine DNA Glycosylase | 2014 |
5-Hydroxymethylcytosine is a useful marker to differentiate between dermatofibrosarcoma protuberans and dermatofibroma.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Cytosine; Dermatofibrosarcoma; Humans; Skin Neoplasms | 2016 |
Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer.
Topics: 5-Methylcytosine; Aged; Chromatography, Liquid; Cytosine; Deoxycytidine; Dioxygenases; DNA-Binding Proteins; Enzymes; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mixed Function Oxygenases; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins; Stomach Neoplasms; Tandem Mass Spectrometry | 2015 |
Insights into DNA hydroxymethylation in the honeybee from in-depth analyses of TET dioxygenase.
Topics: 5-Methylcytosine; Alternative Splicing; Amino Acid Sequence; Animals; Bees; Brain; Catalytic Domain; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Insect Proteins; Male; Molecular Sequence Data; Organ Specificity; Ovary; Sequence Alignment; Testis; Transgenes | 2014 |
5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation.
Topics: 5-Methylcytosine; Animals; Binding Sites; Cell Lineage; Cytosine; Embryonic Stem Cells; Enhancer Elements, Genetic; Epigenesis, Genetic; Histones; Mice; RNA, Messenger; Transcription Factors | 2014 |
Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.
Topics: 5-Methylcytosine; Animals; Aristolochic Acids; Carcinogenesis; Carcinogens; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Liver; Mutation; Neoplasms; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Rats, Transgenic | 2015 |
Application of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells.
Topics: 5-Methylcytosine; Cell Differentiation; Cells, Cultured; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Molecular Sequence Data; Myoblasts, Cardiac; Neural Stem Cells; Pluripotent Stem Cells; Sequence Analysis, DNA | 2014 |
5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels.
Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Embryonic Stem Cells; Enzyme Inhibitors; Gene Expression Regulation; Gene Knockout Techniques; Genomic Imprinting; Germ Cells; Humans; Mice; Neurons; NIH 3T3 Cells; Sequence Analysis, DNA; Transcription, Genetic | 2014 |
Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cytosine; DNA Methylation; Entorhinal Cortex; Epigenesis, Genetic; Female; Humans; Male; Middle Aged | 2015 |
Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; Gene Expression Regulation; Gene-Environment Interaction; Hippocampus; Learning; Mice | 2014 |
Hydroxymethylated cytosines are associated with elevated C to G transversion rates.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; Humans; Mice; Mutation | 2014 |
JBP1-seq: a fast and efficient method for genome-wide profiling of 5hmC.
Topics: 5-Methylcytosine; Brain; Cytosine; DNA Methylation; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Magnetic Phenomena; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Sequence Analysis, DNA | 2014 |
RRHP: a tag-based approach for 5-hydroxymethylcytosine mapping at single-site resolution.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Gene Library; High-Throughput Nucleotide Sequencing; Humans; Liver Neoplasms; Molecular Sequence Annotation; Sequence Analysis, DNA | 2014 |
[Simultaneous analysis of global DNA methylation and hydroxymethylation in tissues by liquid chromatography-tandem mass spectrometry].
Topics: 5-Methylcytosine; Animals; Chromatography, Liquid; Cytidine; Cytosine; Deoxyguanosine; DNA; DNA Methylation; Rats; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Exposure to arsenic via drinking water induces 5-hydroxymethylcytosine alteration in rat.
Topics: 5-Methylcytosine; Animals; Arsenic; Cytosine; DNA Methylation; Drinking Water; Epigenesis, Genetic; Gene Expression Regulation; Male; Rats; Rats, Sprague-Dawley; Water Pollutants, Chemical | 2014 |
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Differentiation; Cell Line; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Mice; Mice, Knockout; Oxidation-Reduction; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sequence Analysis, DNA; Transcriptome; Zinc Fingers | 2014 |
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Topics: 5-Methylcytosine; Acetylation; Brain Neoplasms; Carcinogenesis; Chromatin; Cytosine; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glioblastoma; HEK293 Cells; Histones; Humans; Methylation; Mixed Function Oxygenases; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins; Repressor Proteins; Transcription Factors; Transcription, Genetic | 2014 |
Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.
Topics: 5-Methylcytosine; Adolescent; Autistic Disorder; Cerebellum; Cytosine; Female; Gene Expression; Homeodomain Proteins; Humans; Male; Methyl-CpG-Binding Protein 2; Nerve Tissue Proteins; Promoter Regions, Genetic | 2014 |
Trace analysis of methylated and hydroxymethylated cytosines in DNA by isotope-dilution LC-MS/MS: first evidence of DNA methylation in Caenorhabditis elegans.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cadmium; Caenorhabditis elegans; Chromatography, Liquid; Cytosine; Decitabine; Deoxycytidine; DNA; DNA Methylation; Isotope Labeling; Online Systems; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2015 |
White matter tract and glial-associated changes in 5-hydroxymethylcytosine following chronic cerebral hypoperfusion.
Topics: 5-Methylcytosine; Animals; Autophagy-Related Proteins; Calcium-Binding Proteins; Cerebrovascular Disorders; Chronic Disease; Corpus Callosum; Cytosine; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Gray Matter; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Microfilament Proteins; Neural Stem Cells; Neuroglia; Oxidative Stress; Pilot Projects; Proto-Oncogene Proteins; Random Allocation; White Matter | 2014 |
A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels.
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Birnaviridae Infections; Bursa of Fabricius; Chickens; Cytosine; DNA Methylation; Genome; Infectious bursal disease virus; Poultry Diseases | 2014 |
Loss of expression of 5-hydroxymethylcytosine in CD30-positive cutaneous lymphoproliferative disorders.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Case-Control Studies; Child; Cytosine; Epigenesis, Genetic; Female; Humans; Immunohistochemistry; Ki-1 Antigen; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphomatoid Papulosis; Male; Middle Aged; Retrospective Studies; Skin Neoplasms; Young Adult | 2014 |
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.
Topics: 5-Methylcytosine; Animals; Catalytic Domain; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Cleavage; Endodeoxyribonucleases; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Recombination, Genetic; Tumor Suppressor p53-Binding Protein 1 | 2014 |
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing.
Topics: 5-Methylcytosine; Animals; Base Sequence; Chromatin; Cytosine; DNA Methylation; DNA Repair; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Methyltransferases; Mice; Thymine DNA Glycosylase | 2014 |
HTS for SMFS, organohalide respiration, new epigenetic mark, and a decoy receptor.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Epigenomics; High-Throughput Screening Assays; Hydrocarbons, Halogenated; Hydrolases; Microfluidic Analytical Techniques; Oligonucleotide Array Sequence Analysis; Tumor Necrosis Factor Decoy Receptors | 2014 |
5-hydroxymethylcytosine is not present in appreciable quantities in Arabidopsis DNA.
Topics: 5-Methylcytosine; Arabidopsis; Chromatography, Thin Layer; Cytosine; DNA, Plant; Enzyme-Linked Immunosorbent Assay; Immunoprecipitation; Mass Spectrometry; Real-Time Polymerase Chain Reaction | 2014 |
DNA modifications: Another stable base in DNA.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Humans | 2014 |
5-Hydroxymethylcytosine is a predominantly stable DNA modification.
Topics: 5-Methylcytosine; Animals; Cell Cycle; Cell Proliferation; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; MCF-7 Cells; Mice; Mice, Inbred C57BL | 2014 |
Single base resolution analysis of 5-methylcytosine and 5-hydroxymethylcytosine by RRBS and TAB-RRBS.
Topics: 5-Methylcytosine; Cytosine; Deoxyribonuclease HpaII; Glycosylation; Humans; Oxidation-Reduction; Sequence Analysis, DNA; Sulfites | 2015 |
Quantification of 5-methylcytosine, 5-hydroxymethylcytosine and 5-carboxylcytosine from the blood of cancer patients by an enzyme-based immunoassay.
Topics: 5-Methylcytosine; Cytosine; DNA; Epigenesis, Genetic; Humans; Immunoenzyme Techniques; Limit of Detection; Neoplasms | 2014 |
Genomics special issue on 5-hydroxymethylation.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Humans | 2014 |
Label free detection of 5'hydroxymethylcytosine within CpG islands using optical sensors.
Topics: 5-Methylcytosine; Animals; Antibodies, Immobilized; Biosensing Techniques; CpG Islands; Cytosine; DNA Methylation; Optics and Photonics | 2015 |
5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cytosine; Female; Fetus; Gestational Age; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Phosphopyruvate Hydratase; Young Adult | 2015 |
Role of 5-hydroxymethylcytosine level in diagnosis and prognosis prediction of intrahepatic cholangiocarcinoma.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Cytosine; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis | 2015 |
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Mice, Knockout; Mutation; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Sequence Analysis, DNA; WT1 Proteins | 2014 |
Chemical display of pyrimidine bases flipped out by modification-dependent restriction endonucleases of MspJI and PvuRts1I families.
Topics: 5-Methylcytosine; Bacterial Proteins; Catalytic Domain; Cytosine; DNA Restriction Enzymes; DNA, Bacterial; Models, Molecular; Protein Binding | 2014 |
Chromosome hydroxymethylation patterns in human zygotes and cleavage-stage embryos.
Topics: 5-Methylcytosine; Blastocyst; Cytosine; DNA Methylation; Female; Genome, Human; Humans; Zygote | 2015 |
Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma.
Topics: 5-Methylcytosine; Activating Transcription Factors; Carcinoma, Hepatocellular; Cell Line, Tumor; Comparative Genomic Hybridization; Cytosine; DNA Methylation; Epigenesis, Genetic; Extracellular Matrix Proteins; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Molecular Sequence Data; Promoter Regions, Genetic; Sequence Analysis, DNA; T-Box Domain Proteins | 2014 |
DNA cytosine methylation and hydroxymethylation at the borders.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Promoter Regions, Genetic | 2014 |
Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.
Topics: 5-Methylcytosine; Animals; CD4-Positive T-Lymphocytes; Culture Media; Cytosine; DNA Methylation; Epigenesis, Genetic; Immunotherapy; Mice; Mice, Inbred C57BL; Peptides; Programmed Cell Death 1 Receptor; Promoter Regions, Genetic | 2014 |
Detection of human urinary 5-hydroxymethylcytosine by stable isotope dilution HPLC-MS/MS analysis.
Topics: 5-Methylcytosine; Adult; Bicarbonates; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Female; Humans; Indicator Dilution Techniques; Isotopes; Male; Solid Phase Extraction; Tandem Mass Spectrometry; Young Adult | 2015 |
Programmable sensors of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Cytosine; DNA; Epigenesis, Genetic; Genetic Engineering; Models, Molecular; Molecular Structure; Tandem Repeat Sequences; Trans-Activators | 2015 |
Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice.
Topics: 5-Methylcytosine; Animals; Chromosomal Instability; Cytosine; DNA Methylation; Dose-Response Relationship, Radiation; Epigenesis, Genetic; Hematopoietic Stem Cells; Inflammation; Interleukin-1beta; Interleukin-6; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred CBA; NF-kappa B; Oxidative Stress; Time Factors; Titanium; Tumor Necrosis Factor-alpha | 2015 |
Ethanol deregulates Mecp2/MeCP2 in differentiating neural stem cells via interplay between 5-methylcytosine and 5-hydroxymethylcytosine at the Mecp2 regulatory elements.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cells, Cultured; Cytosine; Ethanol; Methyl-CpG-Binding Protein 2; Mice; Neural Stem Cells; Regulatory Elements, Transcriptional | 2015 |
Understanding the structural and dynamic consequences of DNA epigenetic modifications: computational insights into cytosine methylation and hydroxymethylation.
Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Models, Molecular; Molecular Dynamics Simulation; Nucleic Acid Conformation; Protein Binding | 2014 |
Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Topics: 5-Methylcytosine; Cytosine; DNA; Oligonucleotides; Thymine DNA Glycosylase | 2015 |
A sensitive approach to map genome-wide 5-hydroxymethylcytosine and 5-formylcytosine at single-base resolution.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cytosine; DNA Restriction Enzymes; Embryonic Stem Cells; Epigenesis, Genetic; Gene Library; Histones; Mice; Restriction Mapping | 2015 |
Spatial distribution of 5-hydroxymethyl cytosine in rat brain and temporal distribution in striatum.
Topics: 5-Methylcytosine; Animals; Brain; Corpus Striatum; Cytosine; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley | 2015 |
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.
Topics: 5-Methylcytosine; Adaptation, Biological; Animals; Cell Culture Techniques; Cells, Cultured; Cellular Reprogramming; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Genetic Loci; Mammals; Mice, Inbred C57BL; Transcriptome | 2015 |
Analysis of nanopore data using hidden Markov models.
Topics: 5-Methylcytosine; Algorithms; Cytosine; DNA Methylation; Epigenomics; High-Throughput Nucleotide Sequencing; Humans; Markov Chains; Nanopores; Sequence Alignment; Sequence Analysis, DNA | 2015 |
The Tet1 and histone methylation expression pattern in dairy goat testis.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Cytosine; Dairying; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression; Goats; Histones; Male; Methylation; Spermatogenesis; Spermatogonia; Testis | 2015 |
Formation and abundance of 5-hydroxymethylcytosine in RNA.
Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; Mice; Mice, Inbred C57BL; Molecular Structure; Oxidation-Reduction; RNA; Tandem Mass Spectrometry | 2015 |
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways.
Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Cytosine; Deoxyguanosine; DNA Methylation; Fatty Liver; Gene Expression Regulation, Enzymologic; Liver; Male; Methionine; Mice, Inbred C57BL; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation.
Topics: 5-Methylcytosine; Animals; Cell Division; Cell Line; Cells, Cultured; Chromosomal Instability; Chromosomal Proteins, Non-Histone; Chromosome Aberrations; Chromosome Segregation; Cytosine; Dioxygenases; DNA Methylation; DNA Replication; DNA-Binding Proteins; Embryo, Mammalian; Epigenesis, Genetic; Female; Gene Knockout Techniques; Histones; Male; Mice; Protein Transport; Proto-Oncogene Proteins; Repressor Proteins; Zygote | 2015 |
5-Hydroxymethylcytosine and 5-formylcytosine containing deoxyoligonucleotides: facile syntheses and melting temperature studies.
Topics: 5-Methylcytosine; Catalysis; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Copper; Cytosine; Oligonucleotides; Oxidation-Reduction; Transition Temperature | 2015 |
Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).
Topics: 5-Methylcytosine; Adult; Cerebellum; Cytosine; DNA; DNA Methylation; Humans; Male; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Reproducibility of Results; Sulfites | 2015 |
Neighboring Genes Show Correlated Evolution in Gene Expression.
Topics: 5-Methylcytosine; Animals; Cerebellum; Chromosomes, Human, Pair 2; Computer Simulation; Cytosine; Evolution, Molecular; Female; Gene Expression Regulation; Genes; Histones; Humans; Lysine; Male; Methylation; Monte Carlo Method; Organ Specificity; Primates; Statistics, Nonparametric; Up-Regulation | 2015 |
Hippocampal increase of 5-hmC in the glucocorticoid receptor gene following acute stress.
Topics: 3' Untranslated Regions; 5-Methylcytosine; Acute Disease; Animals; Cytosine; Disease Models, Animal; Hippocampus; Mice; Neurons; Random Allocation; Receptors, Glucocorticoid; Restraint, Physical; Stress, Psychological | 2015 |
Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia.
Topics: 5-Methylcytosine; Case-Control Studies; Cell Shape; Cytosine; DNA; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomic Imprinting; Humans; Infertility, Male; Male; Phenotype; Sperm Motility; Spermatogenesis; Spermatozoa | 2015 |
Role of Tet1 and 5-hydroxymethylcytosine in cocaine action.
Topics: 5-Methylcytosine; Animals; Behavior, Animal; Cocaine; Cytosine; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Gene Expression; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Proto-Oncogene Proteins | 2015 |
C/EBPβ (CEBPB) protein binding to the C/EBP|CRE DNA 8-mer TTGC|GTCA is inhibited by 5hmC and enhanced by 5mC, 5fC, and 5caC in the CG dinucleotide.
Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Crystallography, X-Ray; Cytosine; Cytosine Nucleotides; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Nucleotide Motifs; Transcription Factors | 2015 |
Cocaine shapes chromatin landscapes via Tet1.
Topics: 5-Methylcytosine; Animals; Cocaine; Cytosine; DNA-Binding Proteins; Gene Expression; Male; Nucleus Accumbens; Proto-Oncogene Proteins | 2015 |
Post-conversion targeted capture of modified cytosines in mammalian and plant genomes.
Topics: 5-Methylcytosine; Alleles; Animals; Cell Line; Cytosine; DNA Methylation; Genome, Plant; Genomics; High-Throughput Nucleotide Sequencing; Humans; Mice; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Sulfites | 2015 |
Genome-wide analysis of 5-hmC in the peripheral blood of systemic lupus erythematosus patients using an hMeDIP-chip.
Topics: 5-Methylcytosine; Case-Control Studies; Chromosome Mapping; Computational Biology; CpG Islands; Cytosine; DNA Methylation; Gene Expression Profiling; Gene Ontology; Genome-Wide Association Study; Humans; Lupus Erythematosus, Systemic; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Signal Transduction | 2015 |
Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer.
Topics: 5-Methylcytosine; Adult; Aged; Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Case-Control Studies; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Middle Aged; Neoplasm Grading; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Prognosis; Proto-Oncogene Proteins; Survival Analysis | 2015 |
TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Mice; Neurons; Proto-Oncogene Proteins; Repressor Proteins; Retina; Transcriptional Activation | 2015 |
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer.
Topics: 5-Methylcytosine; Cell Proliferation; Colonic Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Proto-Oncogene Proteins | 2015 |
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytokines; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; E1A-Associated p300 Protein; Epigenesis, Genetic; Gene Expression Regulation; Genome; Humans; Mice; Mice, Transgenic; Proto-Oncogene Proteins; STAT4 Transcription Factor; T-Box Domain Proteins; Th1 Cells; Th17 Cells | 2015 |
TET1 is a tumor suppressor of hematopoietic malignancy.
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Cell Differentiation; Cell Lineage; Chromosomal Instability; Cytosine; DNA Methylation; DNA Repair; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Exome; Gene Expression Profiling; Humans; Lymphoma, B-Cell; Mice; Mutation; Proto-Oncogene Proteins; Tumor Suppressor Proteins | 2015 |
Regulation of telomeric i-motif stability by 5-methylcytosine and 5-hydroxymethylcytosine modification.
Topics: 5-Methylcytosine; Circular Dichroism; Cytosine; DNA; DNA Methylation; Humans; Nucleotide Motifs; Protein Structure, Tertiary; Telomere; Temperature | 2015 |
The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells.
Topics: 5-Methylcytosine; Azacitidine; Catalytic Domain; Chromatography, High Pressure Liquid; CpG Islands; Cytosine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; HL-60 Cells; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; MCF-7 Cells; Microscopy, Fluorescence; Mixed Function Oxygenases; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Fluorescence; Tandem Mass Spectrometry | 2015 |
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Acetylation; Animals; Cell Differentiation; Cell Lineage; Cells, Cultured; Chromatin Assembly and Disassembly; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Genotype; Histones; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Nanog Homeobox Protein; Neurogenesis; Octamer Transcription Factor-3; Phenotype; Proto-Oncogene Proteins; RNA Interference; Signal Transduction; Sirtuins; SOXB1 Transcription Factors; Teratoma; Transfection | 2015 |
Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Antineoplastic Agents; Ascorbic Acid; Azacitidine; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cytosine; Decitabine; Dioxygenases; DNA Methylation; Erythroid Cells; gamma-Globins; Histone Demethylases; Humans; Hydroxyurea; Liver; Papio anubis; Promoter Regions, Genetic; Tranylcypromine | 2015 |
Short-term memory of danger signals or environmental stimuli in mesenchymal stem cells: implications for therapeutic potential.
Topics: 5-Methylcytosine; Adipose Tissue; Animals; Cell Differentiation; Cell Proliferation; Cell Shape; Chemokine CCL2; Diabetes Mellitus, Experimental; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Immunologic Memory; Immunophenotyping; Interleukin-6; Interleukin-8; Lipopolysaccharides; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Rats, Wistar; Real-Time Polymerase Chain Reaction; Signal Transduction; Surgical Flaps; Tissue Survival; Tumor Necrosis Factor-alpha | 2016 |
Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study.
Topics: 5-Methylcytosine; Adolescent; Adult; Air Pollution; Beijing; Cytosine; Environmental Exposure; Female; Humans; Male; Middle Aged; Particulate Matter; Young Adult | 2015 |
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Histones; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Oocytes; Ovary; Protein Isoforms; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Vinyl Compounds | 2015 |
Direct conjugation of peptides and 5-hydroxymethylcytosine in DNA.
Topics: 5-Methylcytosine; Amino Acid Sequence; Cytosine; DNA; DNA-Cytosine Methylases; Models, Molecular; Peptides; Spiroplasma | 2015 |
Oxygen concentration controls epigenetic effects in models of familial paraganglioma.
Topics: 5-Methylcytosine; Animals; Case-Control Studies; Cytosine; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Gene Knockdown Techniques; HEK293 Cells; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids; Mice, Inbred C57BL; Models, Biological; Oxygen; Paraganglioma; Succinate Dehydrogenase; Succinic Acid | 2015 |
Structure-guided sequence specificity engineering of the modification-dependent restriction endonuclease LpnPI.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA; DNA Restriction Enzymes; DNA-Binding Proteins; Models, Molecular; Protein Binding; Protein Engineering; Protein Structure, Tertiary | 2015 |
Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cytosine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epigenesis, Genetic; Female; Glioblastoma; Histones; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Loss of Heterozygosity; Male; Middle Aged; Mutation; Prognosis; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2015 |
Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood.
Topics: 5-Methylcytosine; Cell Line; CpG Islands; Cytosine; DNA Methylation; Environmental Exposure; Fetal Blood; Human Embryonic Stem Cells; Humans; Lead; Mexico; Sequence Analysis, DNA; Sex Factors; Umbilical Cord | 2015 |
Cell Fate by SIRT6 and TETs.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins; Sirtuins; Transcription Factors | 2015 |
Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth.
Topics: 5-Methylcytosine; Birth Weight; Cyclin-Dependent Kinase Inhibitor p57; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Placenta; Pregnancy | 2015 |
TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma.
Topics: 5-Methylcytosine; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Cell Survival; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Markers; Humans; Immunohistochemistry; Intestinal Mucosa; Kaplan-Meier Estimate; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prognosis; Proto-Oncogene Proteins; RNA, Messenger; Sequence Analysis, DNA | 2015 |
5-Formylcytosine can be a stable DNA modification in mammals.
Topics: 5-Methylcytosine; Aging; Animals; Animals, Newborn; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Developmental; Half-Life; Liver; Mice; Mice, Inbred C57BL; Myocardium | 2015 |
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA Methylation; DNA Repair; Epigenesis, Genetic; Hydrogen Bonding; Kinetics; RNA Polymerase II; Saccharomyces cerevisiae; Substrate Specificity; Templates, Genetic; Thymine DNA Glycosylase; Transcription Elongation, Genetic | 2015 |
5-Hydroxymethylcytosine Profiling in Human DNA.
Topics: 5-Methylcytosine; DNA; DNA Fingerprinting; Epigenomics; Genome, Human; Humans; Immunoprecipitation; Sequence Analysis, DNA | 2017 |
MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cells, Cultured; Cytosine; Dioxygenases; DNA-Binding Proteins; Ectoderm; Embryoid Bodies; Endoderm; Epigenesis, Genetic; HEK293 Cells; Humans; Left-Right Determination Factors; Mesoderm; Mice; MicroRNAs; Mouse Embryonic Stem Cells; Proto-Oncogene Proteins; Thymine DNA Glycosylase | 2015 |
5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme.
Topics: 5-Methylcytosine; Amino Acid Sequence; Catalytic Domain; Cytosine; DNA Damage; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glutathione Transferase; HEK293 Cells; Humans; Immunoprecipitation; Mixed Function Oxygenases; Molecular Sequence Data; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Recombinant Proteins; Sequence Homology, Amino Acid | 2015 |
Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.
Topics: 5-Methylcytosine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Animals; Brain; Child; Child, Preschool; Cytosine; Humans; Infant; Mice; Middle Aged; Young Adult | 2015 |
A Cell Electrofusion Chip for Somatic Cells Reprogramming.
Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; Cytosine; DNA; DNA Methylation; Electroporation; Homeodomain Proteins; Karyotyping; Mice; Mice, Nude; Microfluidic Analytical Techniques; Mouse Embryonic Stem Cells; Nanog Homeobox Protein; NIH 3T3 Cells; Octamer Transcription Factor-3; Real-Time Polymerase Chain Reaction | 2015 |
Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells.
Topics: 5-Methylcytosine; CpG Islands; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Knockdown Techniques; HEK293 Cells; Humans; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Up-Regulation | 2015 |
The dynamics of DNA methylation and hydroxymethylation during amelogenesis.
Topics: 5-Methylcytosine; Amelogenesis; Animals; Cytosine; DNA Methylation; Incisor; Mandible; Mice; Mice, Inbred ICR | 2015 |
Genome-Wide Mapping of 5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study.
Topics: 5-Methylcytosine; Adult; Cytosine; DNA Methylation; Epigenesis, Genetic; ErbB Receptors; Female; Genome-Wide Association Study; Genome, Human; Humans; Pilot Projects; Pre-Eclampsia; Pregnancy; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Signal Transduction | 2015 |
Altering 5-hydroxymethylcytosine modification impacts ischemic brain injury.
Topics: 5-Methylcytosine; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Male; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reperfusion Injury | 2015 |
Diagnostic utility of 5-hydroxymethylcytosine immunohistochemistry in melanocytic proliferations.
Topics: 5-Methylcytosine; Cytosine; Diagnosis, Differential; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; Melanocytes; Melanoma; Nevus, Pigmented; Skin Neoplasms; Tissue Array Analysis | 2015 |
Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype.
Topics: 5-Methylcytosine; Adult; Aged; Breast Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression; Humans; Immunohistochemistry; Middle Aged; Mixed Function Oxygenases; Neoplasm Grading; Neoplasm Staging; Prognosis; Protein Transport; Proto-Oncogene Proteins; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Survival Analysis; Young Adult | 2015 |
Increased DNA methylation in the livers of patients with alcoholic hepatitis.
Topics: 5-Methylcytosine; Biomarkers; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Hepatitis, Alcoholic; Hepatocytes; Humans; Immunoenzyme Techniques; Liver | 2015 |
Genome-wide mapping of 5-hydroxymethylcytosine in three rice cultivars reveals its preferential localization in transcriptionally silent transposable element genes.
Topics: 5-Methylcytosine; Chromatography, Liquid; Chromosome Mapping; Cytosine; DNA Transposable Elements; DNA, Plant; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Oryza; Sequence Analysis, DNA; Tandem Mass Spectrometry | 2015 |
TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cytopenia of childhood.
Topics: 5-Methylcytosine; Adolescent; Case-Control Studies; Child; Child, Preschool; Cytosine; Dioxygenases; DNA Mutational Analysis; DNA-Binding Proteins; Female; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Humans; Infant; Male; MicroRNAs; Mutation; Myelodysplastic Syndromes; Polymerase Chain Reaction; Proto-Oncogene Proteins; Transcriptome | 2015 |
A novel electrochemical immunosensor for the quantitative detection of 5-hydroxymethylcytosine in genomic DNA of breast cancer tissue.
Topics: 5-Methylcytosine; Biosensing Techniques; Breast Neoplasms; Cytosine; DNA, Neoplasm; Female; Humans | 2015 |
Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis.
Topics: 5-Methylcytosine; Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Chromatin Immunoprecipitation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Mixed Function Oxygenases; Molecular Sequence Data; Neoplasm Proteins; Neoplastic Stem Cells; p38 Mitogen-Activated Protein Kinases; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Retrospective Studies; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Epigenetic regulation of human adipose-derived stem cells differentiation.
Topics: 5-Methylcytosine; Adipose Tissue; Adult Stem Cells; Cell Differentiation; Cell Line; Cell Lineage; Cytosine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Homeodomain Proteins; Humans; Mixed Function Oxygenases; Nanog Homeobox Protein; Octamer Transcription Factor-3; Oligonucleotide Array Sequence Analysis; Osteoblasts; Osteogenesis; Phenotype; Pluripotent Stem Cells; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; SOXB1 Transcription Factors | 2015 |
Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.
Topics: 5-Methylcytosine; Amino Acid Substitution; Catalytic Domain; Cytosine; Dioxygenases; DNA; Models, Molecular; Naegleria; Thymine | 2015 |
Charting oxidized methylcytosines at base resolution.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mammals; Oxidation-Reduction | 2015 |
Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution.
Topics: 5-Methylcytosine; Adult; Base Pairing; Binding Sites; Chromosomes, Human; Cluster Analysis; Cytosine; Epigenesis, Genetic; Exons; Female; Gene Ontology; Genome, Human; Humans; Introns; Male; Prefrontal Cortex; Protein Processing, Post-Translational; Sequence Analysis, DNA; Sex Characteristics; X Chromosome Inactivation | 2015 |
Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale.
Topics: 5-Methylcytosine; Animals; Cell Line; CpG Islands; Cytosine; DNA Methylation; DNA Primers; Epigenomics; Gene Expression Regulation; Genome; Mice; Mice, Transgenic; Oligonucleotides; Oxygen; Polymerase Chain Reaction; Sequence Analysis, DNA; Stem Cells; Sulfites | 2015 |
A Strategy for Accurate Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine at CpG Sites Within Gene Promoter.
Topics: 5-Methylcytosine; CpG Islands; Cytosine; DNA Methylation; Female; Humans; Oxidation-Reduction; Promoter Regions, Genetic; Reproducibility of Results; Sequence Analysis, DNA; Tumor Cells, Cultured | 2015 |
Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine.
Topics: 5-Methylcytosine; Animals; Arsenites; Chromatography, Liquid; Cytosine; DNA; DNA-Binding Proteins; HEK293 Cells; Humans; Hydroxylation; Mice; Mouse Embryonic Stem Cells; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Zinc Fingers | 2015 |
Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins.
Topics: 5-Methylcytosine; Adult; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Genetic Predisposition to Disease; Heat-Shock Proteins; Humans; Liver; Male; Middle Aged; Mitochondria, Liver; Mixed Function Oxygenases; Non-alcoholic Fatty Liver Disease; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Proto-Oncogene Proteins; Transcription Factors | 2015 |
Stable 5-Hydroxymethylcytosine (5hmC) Acquisition Marks Gene Activation During Chondrogenic Differentiation.
Topics: 5-Methylcytosine; Animals; Cartilage; Cell Differentiation; Chondrocytes; Chondrogenesis; Cytosine; DNA-Binding Proteins; DNA, Intergenic; Embryonic Development; Extremities; Gene Expression Regulation, Developmental; Mice; Proto-Oncogene Proteins; Stem Cells; Transcriptional Activation | 2016 |
Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: results from two studies in Bangladesh.
Topics: 5-Methylcytosine; Adult; Aged; Arsenic; Bangladesh; Cytosine; DNA Methylation; Drinking Water; Environmental Exposure; Female; Homocysteine; Humans; Leukocytes; Male; Middle Aged; Sex Factors; Young Adult | 2015 |
Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
Topics: 5-Methylcytosine; Bacterial Infections; CpG Islands; Cytosine; Dendritic Cells; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Mycobacterium tuberculosis; Transcription Factors; Tuberculosis | 2015 |
Diagnosis of abnormal human fertilization status based on pronuclear origin and/or centrosome number.
Topics: 5-Methylcytosine; Aneuploidy; Case-Control Studies; Cell Nucleus; Centrosome; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Fertilization in Vitro; Fluorescent Antibody Technique; Genetic Techniques; Humans; Male; Sperm Injections, Intracytoplasmic; Spermatozoa; Zygote | 2015 |
TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression.
Topics: 5-Methylcytosine; Aged; Androgens; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Cytosine; Dioxygenases; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hepatocyte Nuclear Factor 3-alpha; Humans; Hydroxylation; Immunohistochemistry; Male; Mice, Inbred BALB C; MicroRNAs; Middle Aged; Neoplasm Transplantation; Prostatic Neoplasms; Proto-Oncogene Proteins; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, RNA; TOR Serine-Threonine Kinases | 2015 |
Water-bridged hydrogen bond formation between 5-hydroxylmethylcytosine (5-hmC) and its 3'-neighbouring bases in A- and B-form DNA duplexes.
Topics: 5-Methylcytosine; Base Pairing; Crystallography, X-Ray; Cytosine; DNA, A-Form; DNA, B-Form; Hydrogen Bonding; Molecular Dynamics Simulation; Water | 2015 |
DNA 5-hydroxymethylation in human adipose tissue differs between subcutaneous and visceral adipose tissue depots.
Topics: 5-Methylcytosine; Adipocytes; Adiposity; Aged; Biomarkers; Cell Size; Cytosine; DNA Methylation; Female; Humans; Intra-Abdominal Fat; Male; Middle Aged; Sex Factors; Subcutaneous Fat; Tomography, X-Ray Computed | 2015 |
Genome-wide disruption of 5-hydroxymethylcytosine in a mouse model of autism.
Topics: 5-Methylcytosine; Animals; Autistic Disorder; Corpus Striatum; Cytosine; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Annotation; Nerve Tissue Proteins; Reelin Protein | 2015 |
Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Small Cell; Cytosine; Epigenomics; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Neoplasm Staging; Nevus, Pigmented; Prognosis; Skin Neoplasms; Young Adult | 2015 |
Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3'-shore.
Topics: 3' Untranslated Regions; 5-Methylcytosine; Chromatin Immunoprecipitation; CpG Islands; Cytosine; DNA Methylation; Female; Gene Silencing; Histone Code; Humans; Immunoenzyme Techniques; Male; Middle Aged; Mixed Function Oxygenases; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured | 2015 |
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors.
Topics: 5-Methylcytosine; Adrenal Gland Neoplasms; Cell Nucleus; Cytosine; Fumarate Hydratase; Gene Silencing; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Immunohistochemistry; Mixed Function Oxygenases; Paraganglioma; Pheochromocytoma; Proto-Oncogene Proteins; Smooth Muscle Tumor; Succinate Dehydrogenase | 2015 |
Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Aging; Animals; Caloric Restriction; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression; Immunohistochemistry; Mice, Inbred C57BL; Purkinje Cells; Superoxide Dismutase; Superoxide Dismutase-1 | 2015 |
Profiling of methylation and demethylation pathways during brain development and ageing.
Topics: 5-Methylcytosine; Aging; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Transcriptome | 2016 |
Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency.
Topics: 5-Methylcytosine; Animals; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Behavior, Animal; Cells, Cultured; Cerebellum; Cytosine; DNA Damage; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Mice; Mice, Knockout; Proto-Oncogene Proteins; Purkinje Cells | 2015 |
Structural insight into substrate preference for TET-mediated oxidation.
Topics: 5-Methylcytosine; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Humans; Hydrogen Bonding; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Protein Binding; Proto-Oncogene Proteins; Substrate Specificity | 2015 |
MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy.
Topics: 5-Methylcytosine; Alternative Splicing; Animals; Cell Line, Tumor; Cytosine; Epigenesis, Genetic; Gene Amplification; Humans; Methyl-CpG-Binding Protein 2; Mice; Neoplasm Transplantation; Neoplasms; Protein Isoforms; ras Proteins; Signal Transduction | 2016 |
The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Mammals; Mass Spectrometry; Oxidation-Reduction; RNA | 2016 |
Single Site Discrimination of Cytosine, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Target DNA Using Anthracene-Tagged Fluorescent Probes.
Topics: 5-Methylcytosine; Anthracenes; Cytosine; DNA; Fluorescent Dyes; Nucleic Acid Conformation | 2016 |
Selective oxidation of 5-hydroxymethylcytosine with micelle incarcerated oxidants to determine it at single base resolution.
Topics: 5-Methylcytosine; Base Sequence; Catalysis; Cytosine; Mass Spectrometry; Micelles; Oxidation-Reduction; Sulfites | 2015 |
Genome-wide alterations in hippocampal 5-hydroxymethylcytosine links plasticity genes to acute stress.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Stress, Psychological | 2016 |
TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.
Topics: 5-Methylcytosine; Adenocarcinoma; Binding Sites; Cell Differentiation; Cell Line, Tumor; Colon; Colonic Neoplasms; Cytosine; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins; Transcription Factors | 2015 |
Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression; Kidney; Liver; Lung; Male; Myocardium; Organ Specificity; Pentoxyl; Rats; Rats, Wistar; Swine; Tandem Mass Spectrometry; Thymus Gland | 2015 |
Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer.
Topics: 5-Methylcytosine; Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Cytosine; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Isocitrate Dehydrogenase; Kidney; Kidney Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude | 2016 |
Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution.
Topics: 5-Methylcytosine; Adolescent; Air Pollution; Alleles; Asthma; Case-Control Studies; Child; CpG Islands; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Epithelial Cells; Female; Gene Expression; Humans; Male; Mixed Function Oxygenases; Nasal Mucosa; Promoter Regions, Genetic; Proto-Oncogene Proteins; Risk Factors; RNA, Messenger; Vehicle Emissions | 2016 |
5-Hydroxymethylcytosine as a putative marker for erosive adenomatosis of the nipple.
Topics: 5-Methylcytosine; Adenoma; Adult; Biomarkers, Tumor; Biopsy, Needle; Breast Neoplasms; Female; Humans; Image-Guided Biopsy; Immunohistochemistry; Magnetic Resonance Imaging; Middle Aged; Nipples | 2016 |
Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.
Topics: 5-Methylcytosine; Allergens; Animals; Cytosine; Dinitrochlorobenzene; DNA Fragmentation; DNA Methylation; Epigenesis, Genetic; Female; Immunoprecipitation; Local Lymph Node Assay; Lymph Nodes; Mice, Inbred BALB C; Phthalic Anhydrides; Polymerase Chain Reaction; Promoter Regions, Genetic | 2016 |
C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.
Topics: 5-Methylcytosine; Amyotrophic Lateral Sclerosis; Brain; C9orf72 Protein; Coculture Techniques; CpG Islands; Cytosine; DNA Methylation; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Lymphocytes; Motor Neurons; Mutation; Nanog Homeobox Protein; Nestin; Promoter Regions, Genetic; Proteins; RNA, Messenger; SOXB1 Transcription Factors; Time Factors | 2016 |
De novo DNA methylation drives 5hmC accumulation in mouse zygotes.
Topics: 5-Methylcytosine; Animals; Biomarkers; Cellular Reprogramming; Chromatography, Liquid; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Embryo Culture Techniques; Epigenesis, Genetic; Fertilization in Vitro; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Kinetics; Mass Spectrometry; Mice; Mice, Knockout; Proto-Oncogene Proteins; Zygote | 2016 |
Ultrasensitive determination of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA by sheathless interfaced capillary electrophoresis-mass spectrometry.
Topics: 5-Methylcytosine; Cytosine; DNA; Electrophoresis, Capillary; Genomics; Limit of Detection; Spectrometry, Mass, Electrospray Ionization | 2016 |
Enhanced MAPK signaling drives ETS1-mediated induction of miR-29b leading to downregulation of TET1 and changes in epigenetic modifications in a subset of lung SCC.
Topics: 5-Methylcytosine; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Computational Biology; Down-Regulation; Epigenesis, Genetic; Humans; Lung Neoplasms; MAP Kinase Signaling System; MicroRNAs; Mixed Function Oxygenases; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Tumor Escape | 2016 |
Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cytosine; DNA Methylation; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Urogenital Neoplasms | 2016 |
RNA biochemistry. Transcriptome-wide distribution and function of RNA hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Brain; Cell Line; Cytosine; Dioxygenases; Drosophila melanogaster; Methylation; RNA, Messenger; Transcriptome | 2016 |
Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs.
Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; Epigenesis, Genetic; Evolution, Molecular; Mice; Mouse Embryonic Stem Cells; Multiprotein Complexes; Signal Transduction | 2016 |
Mechanistic insights into the recognition of 5-methylcytosine oxidation derivatives by the SUVH5 SRA domain.
Topics: 5-Methylcytosine; Base Sequence; Binding Sites; Calorimetry; Crystallography, X-Ray; Cytosine; DNA; Histidine; Methyltransferases; Molecular Dynamics Simulation; Oligopeptides; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2016 |
5-Hydroxymethylcytosine expression is associated with poor survival in cervical squamous cell carcinoma.
Topics: 5-Methylcytosine; Adult; Carcinoma, Squamous Cell; Cervix Uteri; Dioxygenases; Disease-Free Survival; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Mixed Function Oxygenases; Multivariate Analysis; Prognosis; Proto-Oncogene Proteins; Uterine Cervical Neoplasms | 2016 |
5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability.
Topics: 5-Methylcytosine; Animals; Aphidicolin; Cell Line; CRISPR-Cas Systems; Cytosine; Dioxygenases; DNA Damage; DNA Methylation; DNA Repair; DNA Replication; DNA-Binding Proteins; Epigenesis, Genetic; Genome; Genomic Instability; HeLa Cells; Histones; Human Embryonic Stem Cells; Humans; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Rad51 Recombinase; Tumor Suppressor p53-Binding Protein 1 | 2016 |
5-hydroxymethylcytosine loss is associated with poor prognosis for patients with WHO grade II diffuse astrocytomas.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Antibodies; Astrocytoma; Biomarkers, Tumor; Brain; Central Nervous System Neoplasms; Cytosine; Female; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Ki-67 Antigen; Male; Middle Aged; Mutation; Neoplasm Grading; Prognosis; Spinal Cord; Survival Analysis | 2016 |
Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation.
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Differentiation; Cytosine; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genome-Wide Association Study; Germinal Center; Interleukin-4; Interleukins; Macrophages; Mice; Mice, Transgenic; Molecular Sequence Data; Proto-Oncogene Proteins c-bcl-6; Receptors, Interleukin-7; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes, Helper-Inducer | 2016 |
Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.
Topics: 5-Methylcytosine; Cerebellar Cortex; Cerebellum; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Genome, Human; Humans; Sequence Analysis, DNA; Sulfites | 2016 |
TET1 contributes to neurogenesis onset time during fetal brain development in mice.
Topics: 5-Methylcytosine; Animals; Biomarkers; Brain; Cytosine; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genetic Vectors; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Neurons; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction | 2016 |
Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability.
Topics: 5-Methylcytosine; Biomechanical Phenomena; Cytosine; DNA; DNA Methylation; Molecular Dynamics Simulation; Nucleosomes; Oxidation-Reduction | 2016 |
Methylation profiling by bisulfite sequencing analysis of the mtDNA Non-Coding Region in replicative and senescent Endothelial Cells.
Topics: 5-Methylcytosine; Cytosine; DNA, Intergenic; DNA, Mitochondrial; Endothelial Cells; Humans; Mitochondria; Sequence Analysis, DNA; Sulfites | 2016 |
Ten-Eleven Translocation Genes are Downregulated in Endometriosis.
Topics: 5-Methylcytosine; Adult; Aged; Case-Control Studies; Cytosine; Dioxygenases; DNA-Binding Proteins; Endometriosis; Endometrium; Epigenesis, Genetic; Female; Fibroblasts; Humans; Hysterectomy; Menstrual Cycle; Middle Aged; Mixed Function Oxygenases; Primary Cell Culture; Proto-Oncogene Proteins; Signal Transduction; Stromal Cells | 2016 |
[Expression and clinical significance of 5hmC in bladder urothelial carcinoma].
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Transitional Cell; Cytosine; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Prognosis; Urinary Bladder Neoplasms | 2016 |
Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Formaldehyde; Gene Expression Regulation; HEK293 Cells; Humans; Male; Mice; Mice, Inbred Strains; MicroRNAs; Pain; Phosphopyruvate Hydratase; Promoter Regions, Genetic; Proto-Oncogene Proteins; Spinal Cord; Time Factors | 2016 |
Analysis of Ferrous on Ten-Eleven Translocation Activity and Epigenetic Modifications of Early Mouse Embryos by Fluorescence Microscopy.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cytosine; Dioxygenases; DNA-Binding Proteins; Embryo, Mammalian; Epigenesis, Genetic; Ferrous Compounds; Mice; Microscopy, Fluorescence; Octamer Transcription Factor-3; Proto-Oncogene Proteins | 2016 |
5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma.
Topics: 5-Methylcytosine; Adenoma; Adolescent; Adult; Aged; Blotting, Western; Case-Control Studies; Cytosine; DNA-Binding Proteins; Humans; Middle Aged; Mixed Function Oxygenases; Parathyroid Glands; Parathyroid Neoplasms; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Young Adult | 2016 |
Increased 5-hydroxymethylcytosine in CD4(+) T cells in systemic lupus erythematosus.
Topics: 5-Methylcytosine; Adult; Autoimmunity; Case-Control Studies; CD4-Positive T-Lymphocytes; Chromatin Immunoprecipitation; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Humans; Lupus Erythematosus, Systemic; Male; Promoter Regions, Genetic; Protein Binding; Receptors, Interleukin-15; Receptors, Steroid; Repressor Proteins; RNA, Messenger; Severity of Illness Index; Suppressor of Cytokine Signaling 1 Protein; Young Adult | 2016 |
5-Hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human.
Topics: 5-Methylcytosine; Adult; Ascorbic Acid; Diabetes, Gestational; Dioxygenases; DNA Methylation; DNA Transposable Elements; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Humans; Pre-Eclampsia; Pregnancy; Proto-Oncogene Proteins | 2016 |
Single-CpG resolution mapping of 5-hydroxymethylcytosine by chemical labeling and exonuclease digestion identifies evolutionarily unconserved CpGs as TET targets.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; CpG Islands; Cytosine; DNA; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Epigenomics; Exonucleases; Mice; Sequence Analysis, DNA; Staining and Labeling | 2016 |
Spontaneous Oligomerization of Nucleotide Alternatives in Aqueous Solutions.
Topics: 5-Methylcytosine; Evolution, Chemical; Hot Temperature; Origin of Life; Pentoxyl; Polymerization; Water | 2017 |
Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Mice; Molecular Imaging | 2016 |
Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Heart Ventricles; Hippocampus; Male; Mice; Mice, Inbred C57BL; Protons | 2016 |
Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Squamous Cell; Cytosine; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Prognosis | 2016 |
TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cytosine; DNA Methylation; Female; Genome-Wide Association Study; Hippocampus; Humans; Male; Membrane Glycoproteins; Middle Aged; Receptors, Immunologic; Up-Regulation | 2016 |
5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Autopsy; Disease Models, Animal; DNA Methylation; Drosophila melanogaster; Epigenesis, Genetic; Female; Gene Expression Regulation; Genome, Human; Humans; Male; Neurogenesis; Neurons; Polymorphism, Single Nucleotide; Prefrontal Cortex; Protein Interaction Mapping; tau Proteins | 2016 |
Genomic distribution of 5-Hydroxymethylcytosine in mouse kidney and its relationship with gene expression.
Topics: 5-Methylcytosine; Acute Kidney Injury; Animals; DNA Methylation; Epigenesis, Genetic; Gene Expression; Kidney; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury | 2016 |
5-hydroxymethylcytosine is detected in RNA from mouse brain tissues.
Topics: 5-Methylcytosine; Animals; Brain; DNA; Hot Temperature; Immunoblotting; Male; Mice, Inbred ICR; Motor Activity; MPTP Poisoning; Nucleic Acid Denaturation; Random Allocation; RNA; Time Factors | 2016 |
TET1 inhibits gastric cancer growth and metastasis by PTEN demethylation and re-expression.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; CpG Islands; Demethylation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mixed Function Oxygenases; Neoplasm Metastasis; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; PTEN Phosphohydrolase; RNA Interference; Stomach Neoplasms; Transplantation, Heterologous | 2016 |
Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Asbestos, Crocidolite; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Epithelial Cells; Epithelium; Humans; Karyotype; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mixed Function Oxygenases; Precancerous Conditions; Proto-Oncogene Proteins; Rats; Rats, Inbred F344 | 2016 |
Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.
Topics: 5-Methylcytosine; CCAAT-Enhancer-Binding Proteins; Chromatin; Cytosine; DNA-Binding Proteins; HEK293 Cells; Humans; Ubiquitin-Protein Ligases | 2016 |
Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression.
Topics: 5-Methylcytosine; Adult; Base Pairing; Base Sequence; Chromatography, Liquid; CpG Islands; DNA; Gene Expression Regulation; Genes; Humans; Liver; Mass Spectrometry; Reproducibility of Results; Sequence Analysis, DNA; Sulfites | 2016 |
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.
Topics: 5-Methylcytosine; Ascorbic Acid; Biocatalysis; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cell Proliferation; Cytokines; Dioxygenases; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation; Gene Knockdown Techniques; Genome; HEK293 Cells; Humans; Male; Mast Cells; Proto-Oncogene Proteins; Sequence Analysis, RNA; Transcription, Genetic | 2016 |
Similar kinetics for 5-methylcytosine and 5-hydroxymethylcytosine during human preimplantation development in vitro.
Topics: 5-Methylcytosine; Animals; Blastocyst; DNA Methylation; Embryonic Development; Humans; Mice | 2016 |
DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes.
Topics: 5-Methylcytosine; B-Lymphocytes; Cell Separation; DNA Methylation; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Humans; T-Lymphocytes | 2016 |
Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; Adipocytes; Animals; Base Sequence; Biomarkers; Cell Cycle; Cell Nucleus; Chromatin; DNA; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Profiling; Intra-Abdominal Fat; Pluripotent Stem Cells; PPAR gamma; RNA, Messenger; Sus scrofa | 2016 |
5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA.
Topics: 5-Methylcytosine; Brain Neoplasms; CpG Islands; Databases, Genetic; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Exome Sequencing; Humans; Kidney Neoplasms; Mutation Rate; Myelodysplastic Syndromes; Myeloid Cells | 2016 |
Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.
Topics: 5-Methylcytosine; Animals; Carcinoma, Hepatocellular; Cell Differentiation; CpG Islands; DNA Methylation; DNA-Binding Proteins; Histones; Liver Neoplasms, Experimental; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2016 |
Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Genome-Wide Association Study; Humans; Mice; Mice, Transgenic | 2016 |
DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on Leanness and Obesity of the Offspring.
Topics: 5-Methylcytosine; Animals; Brain; CpG Islands; Diet, High-Fat; DNA Methylation; Histones; Hypothalamus; Obesity; Pro-Opiomelanocortin; Promoter Regions, Genetic; Rats; Rats, Wistar; Sulfites; Thinness | 2016 |
Whole-genome DNA methylation and hydroxymethylation profiling for HBV-related hepatocellular carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; DNA Methylation; Genome-Wide Association Study; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Promoter Regions, Genetic | 2016 |
The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach.
Topics: 5-Methylcytosine; Animals; Cell Division; Computational Biology; CpG Islands; DNA Methylation; DNA Replication; Embryonic Stem Cells; Hydroxylation; Markov Chains; Mice; Models, Biological; Stochastic Processes; Sulfites | 2016 |
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Cellular Reprogramming; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Mice; Models, Genetic; Mutation; Nuclear Proteins; Proto-Oncogene Proteins; Time Factors; Transfection; Ubiquitin-Protein Ligases | 2016 |
Pitfalls in mitochondrial epigenetics.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenesis, Genetic; Genome, Mitochondrial; Mice; Mitochondria | 2017 |
Methylation-assisted bisulfite sequencing to simultaneously map 5fC and 5caC on a genome-wide scale for DNA demethylation analysis.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Line; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Mice; Sequence Analysis, DNA; Sulfites | 2016 |
TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Line; Cytosine; Dioxygenases; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Fibroblasts; Genomic Instability; Humans; Hydroxylation; Megakaryocyte Progenitor Cells; Mice; Mutagenesis; Proto-Oncogene Proteins; S Phase; Thymine DNA Glycosylase; Tumor Suppressor Protein p53 | 2016 |
Expression of TET2 enzyme indicates enhanced epigenetic modification of cells in periodontitis.
Topics: 5-Methylcytosine; Adult; Case-Control Studies; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Humans; Male; Periodontitis; Proto-Oncogene Proteins | 2016 |
5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells.
Topics: 5-Methylcytosine; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Lineage; Cells, Cultured; DNA Methylation; Gene Expression Regulation; Humans | 2016 |
Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Lineage; Chromosome Mapping; Chromosomes; Computer Simulation; Embryonic Development; Epigenesis, Genetic; Genetic Variation; Male; Mice; Models, Chemical; Models, Genetic; Sequence Analysis, DNA | 2016 |
Quantification of Oxidized 5-Methylcytosine Bases and TET Enzyme Activity.
Topics: 5-Methylcytosine; Animals; Cell Line; Chromatography, High Pressure Liquid; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Enzyme Assays; Humans; Immunoblotting; Insecta; Mixed Function Oxygenases; Nucleosides; Oligonucleotides; Oxidation-Reduction; Proto-Oncogene Proteins; Recombinant Proteins; Tandem Mass Spectrometry | 2016 |
Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores.
Topics: 5-Methylcytosine; Animals; Biotinylation; DNA; Epigenesis, Genetic; Genomics; Mice; Nanopores; Oligonucleotides; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Ultrasonics | 2016 |
Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Bone Marrow Cells; Child; Child, Preschool; Chromatin; CpG Islands; DNA Methylation; Genome, Human; Genomics; Humans; Mesenchymal Stem Cells; Middle Aged; Young Adult | 2016 |
5-hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system.
Topics: 5-Methylcytosine; Animals; Animals, Genetically Modified; Brain; Dermoscopy; Green Fluorescent Proteins; Immunohistochemistry; In Situ Hybridization; Male; Mice; Microscopy, Confocal; Neural Stem Cells; Neurogenesis; Neuroglia; Neurons; Olfactory Mucosa; Real-Time Polymerase Chain Reaction; Xenopus; Zebrafish | 2017 |
Isolation of Human Genomic DNA Sequences with Expanded Nucleobase Selectivity.
Topics: 5-Methylcytosine; Animals; Antibodies; Biomarkers; Borohydrides; DNA; DNA Methylation; Epigenesis, Genetic; Escherichia coli; Genome, Human; Genomics; Humans; Male; Protein Binding; Xanthomonas axonopodis; Zebrafish | 2016 |
5-Hydroxymethylcytosine Expression in Proliferative Nodules Arising within Congenital Nevi Allows Differentiation from Malignant Melanoma.
Topics: 5-Methylcytosine; Adult; Analysis of Variance; Biopsy, Needle; Cohort Studies; Diagnosis, Differential; Disease Progression; Dysplastic Nevus Syndrome; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Melanoma; Melanoma, Cutaneous Malignant; Nevus, Pigmented; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Retrospective Studies; Skin Neoplasms | 2016 |
Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; DNA Mutational Analysis; Epigenesis, Genetic; Female; High-Throughput Nucleotide Sequencing; History, 17th Century; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation | 2016 |
Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Biomarkers; DNA Methylation; Female; Humans; Immunohistochemistry; Intermediate Filaments; Male; Middle Aged; Neurofibrillary Tangles; Pyramidal Cells | 2016 |
Simple and accurate single base resolution analysis of 5-hydroxymethylcytosine by catalytic oxidative bisulfite sequencing using micelle incarcerated oxidants.
Topics: 5-Methylcytosine; Adamantane; Animals; Cyclic N-Oxides; Cytosine; DNA, Single-Stranded; Embryonic Stem Cells; Iodobenzenes; Mice; Micelles; Onium Compounds; Oxidants; Oxidation-Reduction; Sequence Analysis, DNA; Sodium Dodecyl Sulfate; Sulfites; Temperature | 2016 |
Isocitrate Dehydrogenase 2 Dysfunction Contributes to 5-hydroxymethylcytosine Depletion in Gastric Cancer Cells.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Female; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Male; Stomach Neoplasms | 2016 |
Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2.
Topics: 5-Methylcytosine; Age Factors; Aged; Aged, 80 and over; Biomarkers; Blood Cells; Chromatography, Liquid; Dioxygenases; DNA-Binding Proteins; Humans; Leukemia, Myeloid; Mass Spectrometry; Metabolomics; Mutation; Proto-Oncogene Proteins | 2016 |
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.
Topics: 5-Methylcytosine; Base Sequence; Cell Differentiation; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA-Binding Proteins; Enhancer Elements, Genetic; Epidermal Cells; Histones; Homeostasis; Humans; Keratinocytes; Lysine; Protein Binding; Proto-Oncogene Proteins; Stem Cells; Transcription Factors; Tumor Suppressor Proteins | 2016 |
A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Computational Biology; Databases, Genetic; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Library; Genome-Wide Association Study; Hematopoiesis; Hematopoietic Stem Cells; High-Throughput Nucleotide Sequencing; Leukemia, Promyelocytic, Acute; Mice; Mutation; Nanotechnology; Proto-Oncogene Proteins; Time Factors | 2016 |
5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4.
Topics: 5-Methylcytosine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Binding Sites; DNA; DNA-Binding Proteins; E-Box Elements; Protein Array Analysis; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Transcription Factor 4 | 2016 |
Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells.
Topics: 5-Methylcytosine; Animals; Calcium-Binding Proteins; DNA Demethylation; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Female; Genome; Genomic Imprinting; Germ Cells; High-Throughput Nucleotide Sequencing; Intercellular Signaling Peptides and Proteins; Iodide Peroxidase; Male; Mice; Mutation; Pluripotent Stem Cells; RNA, Long Noncoding | 2016 |
DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy.
Topics: 5-Methylcytosine; Animals; Cardiomegaly; Cell Differentiation; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Genome; Mice, Inbred C57BL; Myocytes, Cardiac; Proto-Oncogene Proteins; Repetitive Sequences, Nucleic Acid; Transcription, Genetic | 2016 |
Maternal Methyl-Group Donor Intake and Global DNA (Hydroxy)Methylation before and during Pregnancy.
Topics: 5-Methylcytosine; Adult; Belgium; Betaine; Biomarkers; Choline; Cohort Studies; Cytosine; Diet; Dietary Supplements; DNA Methylation; Feeding Behavior; Female; Folic Acid; Humans; Hydroxylation; Leukocytes; Longitudinal Studies; Maternal Nutritional Physiological Phenomena; Methionine; Pregnancy; Prospective Studies; Self Report | 2016 |
oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA.
Topics: 5-Methylcytosine; Computational Biology; CpG Islands; DNA; DNA Methylation; Models, Theoretical; Sequence Analysis, DNA | 2016 |
Immune Regulator MCPIP1 Modulates TET Expression during Early Neocortical Development.
Topics: 5-Methylcytosine; Animals; Base Sequence; Binding Sites; Cell Differentiation; Cell Self Renewal; DNA Methylation; Gene Expression Regulation, Developmental; Mice; Neocortex; Neural Stem Cells; Neurogenesis; Nucleotide Motifs; Organogenesis; Protein Binding; Protein Interaction Domains and Motifs; Ribonucleases | 2016 |
Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue.
Topics: 5-Methylcytosine; Arachidonate 15-Lipoxygenase; Colorectal Neoplasms; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glycoproteins; Humans; Sequence Analysis, DNA; Transketolase | 2016 |
IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC.
Topics: 5-Methylcytosine; Cell Line, Tumor; Dioxygenases; DNA; DNA-Binding Proteins; Gene Expression Regulation; HEK293 Cells; Humans; Isocitrate Dehydrogenase; Mixed Function Oxygenases; Mutation; Osteoblasts; Oxidation-Reduction; Plasmids; Proto-Oncogene Proteins; RNA; Signal Transduction; Transfection | 2016 |
Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress.
Topics: 5-Methylcytosine; Animals; Chromatin Immunoprecipitation; Disease Models, Animal; Epigenesis, Genetic; Female; Gene Ontology; Hippocampus; Male; Methylation; Mice; Mice, Inbred C57BL; Sex Factors; Stress, Psychological | 2016 |
Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryo, Mammalian; Female; Gene Deletion; Germ Cells; Male; Meiosis; Mice, Knockout; Promoter Regions, Genetic; RNA-Binding Proteins | 2016 |
Discrimination between 5-Hydroxymethylcytosine and 5-Methylcytosine in DNA via Selective Electrogenerated Chemiluminescence (ECL) Labeling.
Topics: 5-Methylcytosine; Biosensing Techniques; Cytosine; DNA; DNA Probes; Humans; Limit of Detection; Luminescence; Luminol; Nucleic Acid Hybridization; Oxidation-Reduction; Ruthenium | 2016 |
TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt pathway in Steroid-Associated Osteonecrosis.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Animals; Apoptosis; Dexamethasone; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Femur Head; Gene Knockdown Techniques; Humans; Mice; Middle Aged; Models, Biological; Osteocytes; Osteonecrosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Steroids; Up-Regulation | 2017 |
Chiral Antioxidant-based Gold Nanoclusters Reprogram DNA Epigenetic Patterns.
Topics: 5-Methylcytosine; Antioxidants; Biocatalysis; Cell Death; Cell Line, Tumor; DNA; DNA-Binding Proteins; Epigenesis, Genetic; Glutathione; Gold; HEK293 Cells; Humans; Metal Nanoparticles; Reactive Oxygen Species; Stereoisomerism | 2016 |
Glucosylation Mediated Rolling Circle Amplification Combined with a qPCR Assay for the Detection of 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; DNA; Glucose; Glycosylation; Polymerase Chain Reaction | 2016 |
Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Nucleosomes; Oxidation-Reduction | 2016 |
5-Hydroxymethylcytosine is an independent predictor of survival in malignant melanoma.
Topics: 5-Methylcytosine; Age Factors; Aged; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Staging; Prognosis; Retrospective Studies; Skin; Skin Neoplasms; Survival Rate | 2017 |
Whole-genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liver.
Topics: 5-Methylcytosine; CpG Islands; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Liver; Lung; Neoplasms; Organ Specificity; Promoter Regions, Genetic; Whole Genome Sequencing | 2016 |
Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Lymphocytes; Lymphoid Progenitor Cells; Neoplasm Grading; Neoplasms; Promoter Regions, Genetic; Protein Transport; Ubiquitin-Protein Ligases | 2016 |
Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate.
Topics: 5-Methylcytosine; Base Pairing; Base Sequence; DNA; Selenium Radioisotopes; Sulfites; Tungsten Compounds | 2016 |
Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.
Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Proteins; Cell Survival; Cerebral Cortex; DNA Methylation; Gene Deletion; Genes, Intracisternal A-Particle; Mice; Mice, Knockout; Neural Stem Cells; Neurogenesis; Nuclear Proteins; Ubiquitin-Protein Ligases; Virus Activation | 2016 |
Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice.
Topics: 5-Methylcytosine; Animals; Apolipoproteins E; Atherosclerosis; Autophagy; Cytokines; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Gene Expression; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Inflammation Mediators; Lipoproteins, LDL; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic; Proto-Oncogene Proteins | 2016 |
A reusable laser wrapped graphene-Ag array based SERS sensor for trace detection of genomic DNA methylation.
Topics: 5-Methylcytosine; Antibodies, Immobilized; Biosensing Techniques; Cell Line, Tumor; Cytosine; DNA; DNA Methylation; Equipment Design; Gold; Graphite; Humans; Metal Nanoparticles; Reproducibility of Results; Silver; Spectrum Analysis, Raman | 2017 |
Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA.
Topics: 5-Methylcytosine; Ascorbic Acid; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Pentoxyl; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine | 2016 |
Regulatory landscape and clinical implication of MBD3 in human malignant glioma.
Topics: 5-Methylcytosine; Brain Neoplasms; Cell Line, Tumor; Disease-Free Survival; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; High-Throughput Nucleotide Sequencing; HLA-D Antigens; Humans; MicroRNAs; Oligonucleotide Array Sequence Analysis; Pilot Projects; RNA Interference; RNA, Long Noncoding; RNA, Untranslated; Signal Transduction; Time Factors; Transcription, Genetic; Transfection | 2016 |
Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma.
Topics: 3' Untranslated Regions; 5-Methylcytosine; A549 Cells; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; HeLa Cells; Humans; Lung Neoplasms; Male; Middle Aged; Mixed Function Oxygenases; Neoplasm Invasiveness; Proto-Oncogene Proteins; RNA Interference; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Time Factors; Tongue Neoplasms; Transfection; Up-Regulation | 2016 |
5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Cell Differentiation; Cell Nucleus; CpG Islands; DNA Methylation; DNA, Intergenic; Enhancer Elements, Genetic; Flow Cytometry; Genetic Loci; Genome; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Sequence Analysis, DNA; Transcription, Genetic; Transcriptional Activation | 2016 |
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Dioxygenases; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Demethylation; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Small Interfering; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays | 2017 |
The Yin-Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling.
Topics: 5-Methylcytosine; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Azacitidine; Cell Dedifferentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Decitabine; Diet, High-Fat; Dioxygenases; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme Inhibitors; Epigenesis, Genetic; Genetic Predisposition to Disease; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Proto-Oncogene Proteins; Rats; Signal Transduction; Time Factors; Trans-Activators; Vascular Remodeling | 2017 |
Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron.
Topics: 5-Methylcytosine; Animals; Biomarkers; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Electrophysiological Phenomena; Embryo, Mammalian; Fibroblasts; Mice, Inbred C57BL; Mice, Inbred ICR; Neurons; Oxidation-Reduction; Proto-Oncogene Proteins; Transcription, Genetic | 2016 |
5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Brain Neoplasms; DNA Methylation; DNA, Neoplasm; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Prefrontal Cortex; Survival Analysis; Transcription Factors | 2016 |
Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Disease Progression; Epigenesis, Genetic; Female; Gas Chromatography-Mass Spectrometry; Humans; Male | 2017 |
Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression.
Topics: 5-Methylcytosine; Adult; Aged; Brain; Cadherins; Child, Preschool; DNA Methylation; Female; Homeodomain Proteins; Humans; Male; Muscle, Skeletal; Myoblasts; Myocardium; Organ Specificity; Promoter Regions, Genetic; Transcription Factors | 2017 |
Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration.
Topics: 5-Methylcytosine; Activating Transcription Factor 3; Animals; Brain-Derived Neurotrophic Factor; DNA Methylation; Epigenesis, Genetic; Female; Ganglia, Spinal; Mice; Nerve Regeneration; Neuronal Outgrowth; Neurons; Smad1 Protein | 2017 |
Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Catalytic Domain; Dioxygenases; DNA-Binding Proteins; HEK293 Cells; Humans; Molecular Dynamics Simulation; Mutation; Oxidation-Reduction; Proto-Oncogene Proteins | 2017 |
Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; DNA; DNA-Binding Proteins; DNA, Satellite; Humans; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oxidation-Reduction; Proto-Oncogene Proteins; Rats; Rett Syndrome; Transcription, Genetic | 2017 |
Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Lineage; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Genome-Wide Association Study; Mesoderm; Mice; Mice, Knockout; Myocardium; Neural Plate; Proto-Oncogene Proteins; Wnt Signaling Pathway | 2016 |
5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA.
Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Proteins; Cyclic AMP Response Element-Binding Protein; DNA; Mice; Promoter Regions, Genetic | 2016 |
DNA demethylation mediated by down-regulated TETs in the testes of rare minnow Gobiocypris rarus under bisphenol A exposure.
Topics: 5-Methylcytosine; Animals; Benzhydryl Compounds; Cyprinidae; DNA Methylation; Dose-Response Relationship, Drug; Down-Regulation; Environmental Pollutants; Fish Proteins; Glutathione; Male; Phenols; Testis | 2017 |
5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cohort Studies; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Male; Melanoma; Middle Aged; Nevus, Pigmented; Retrospective Studies; Skin Neoplasms; Young Adult | 2017 |
5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Dioxygenases; Disease Progression; Disease-Free Survival; DNA Mutational Analysis; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Female; Genetic Predisposition to Disease; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Karyotype; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Phenotype; Predictive Value of Tests; Proportional Hazards Models; Proto-Oncogene Proteins; Recurrence; Time Factors; Treatment Outcome; Young Adult | 2017 |
Spectroscopic quantification of 5-hydroxymethylcytosine in genomic DNA using boric acid-functionalized nano-microsphere fluorescent probes.
Topics: 5-Methylcytosine; Animals; Boric Acids; Brain Chemistry; DNA; Fluorescent Dyes; Liver; Mice; Myocardium; Polymethacrylic Acids; Quinolines; Spectrometry, Fluorescence | 2017 |
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Topics: 5-Methylcytosine; Cell Proliferation; Collagen; Connective Tissue Diseases; DNA Damage; DNA Methylation; Endodeoxyribonucleases; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Heart Failure; Heart-Assist Devices; Humans; Leukocytes; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; Myofibroblasts; N-Glycosyl Hydrolases; Oxidation-Reduction; Phenotype; Sequence Analysis, RNA; Survival Analysis; Time Factors | 2017 |
Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Adult; DNA Methylation; Humans; Male; Oxidation-Reduction; Sequence Analysis, DNA; Sulfites | 2017 |
TET-mediated hydroxymethylcytosine at the Pparγ locus is required for initiation of adipogenic differentiation.
Topics: 3T3-L1 Cells; 5-Methylcytosine; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Cells, Cultured; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression; Gene Knockdown Techniques; Mice; Mice, Inbred C57BL; PPAR gamma; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Up-Regulation | 2017 |
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.
Topics: 5-Methylcytosine; Acetylation; Chromatin; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; E1A-Associated p300 Protein; HCT116 Cells; Histone Deacetylase 1; Histone Deacetylase 2; Humans; Neoplasms; Oxidative Stress; Protein Binding; Protein Processing, Post-Translational; Protein Stability; Proto-Oncogene Proteins; RNA Interference; Time Factors; Transfection; Ubiquitination | 2017 |
Elevated 5-hydroxymethycytosine and cell apoptosis induced by tetrachloro-1,4-benzoquinone in mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Apoptosis; Chloranil; Cytosine; Fungicides, Industrial; Mice; Mouse Embryonic Stem Cells; Toxicity Tests | 2017 |
Tetrachloro-1,4-benzoquinone induces apoptosis of mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Apoptosis; Chloranil; Cytosine; Fungicides, Industrial; Mice; Mouse Embryonic Stem Cells; Toxicity Tests | 2017 |
The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory.
Topics: 5-Methylcytosine; Animals; Brain; Brain Chemistry; Cell Line; DNA Methylation; Female; Humans; Locomotion; Male; Memory; Mice; Mice, Knockout; Spatial Learning; Ubiquitin-Protein Ligases | 2017 |
From the Cover: Zinc oxide Nanoparticles-Induced Reactive Oxygen Species Promotes Multimodal Cyto- and Epigenetic Toxicity.
Topics: 5-Methylcytosine; Actin Cytoskeleton; Carcinogens, Environmental; Cell Membrane; Cell Nucleus Size; Cell Survival; DNA Demethylation; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; HEK293 Cells; Hepatocytes; Humans; Metal Nanoparticles; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Oxidative Stress; Oxidoreductases; Promoter Regions, Genetic; Reactive Oxygen Species; Repetitive Sequences, Nucleic Acid; Zinc Oxide | 2017 |
Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver.
Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cerebral Cortex; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Essential; Genome; Hippocampus; Hypothalamus; Liver; Male; Mice; Mitochondrial Proteins; Organ Specificity; Ribosomal Proteins; Sequence Analysis, RNA; Sex Chromosomes; Thalamus; Transcriptome | 2017 |
Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors.
Topics: 5-Methylcytosine; Animals; Anxiety; Female; Male; Mice; Stress, Physiological | 2017 |
H(O)TA: estimation of DNA methylation and hydroxylation levels and efficiencies from time course data.
Topics: 5-Methylcytosine; CpG Islands; DNA; DNA Methylation; Epigenesis, Genetic; Hydroxylation; Models, Statistical; Sequence Analysis, DNA; Software | 2017 |
Epigenomic landscape of 5-hydroxymethylcytosine reveals its transcriptional regulation of lncRNAs in colorectal cancer.
Topics: 5-Methylcytosine; Colorectal Neoplasms; DNA Methylation; Epigenomics; Gene Expression Regulation, Neoplastic; Humans; Prognosis; RNA, Long Noncoding; Survival Analysis | 2017 |
Accurate, Direct, and High-Throughput Analyses of a Broad Spectrum of Endogenously Generated DNA Base Modifications with Isotope-Dilution Two-Dimensional Ultraperformance Liquid Chromatography with Tandem Mass Spectrometry: Possible Clinical Implication.
Topics: 5-Methylcytosine; Animals; Biomarkers; Brain; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; DNA; Humans; Isotope Labeling; Mixed Function Oxygenases; Nucleotidases; Reproducibility of Results; Swine; Tandem Mass Spectrometry; Thymus Gland | 2016 |
A Novel method for the simultaneous identification of methylcytosine and hydroxymethylcytosine at a single base resolution.
Topics: 5-Methylcytosine; Animals; DNA (Cytosine-5-)-Methyltransferase 1; Genome; Genomics; Humans; Mice; Mice, Inbred C57BL; RNA, Long Noncoding; Sequence Analysis, DNA | 2017 |
Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain.
Topics: 5-Methylcytosine; Alternative Splicing; Animals; Brain; Cells, Cultured; Epigenesis, Genetic; HEK293 Cells; Histone Code; Humans; Methyl-CpG-Binding Protein 2; Mice; Neurons; Rats | 2017 |
Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.
Topics: 5-Methylcytosine; Adult; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Male; Mixed Function Oxygenases; Proto-Oncogene Proteins; Seminoma; Testicular Neoplasms; Testis; Up-Regulation | 2017 |
Epigenetic determinants of space radiation-induced cognitive dysfunction.
Topics: 5-Methylcytosine; Adenosine Kinase; Animals; Behavior, Animal; Brain; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigenomics; Hippocampus; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Tubercidin; Whole-Body Irradiation | 2017 |
Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects.
Topics: 5-Methylcytosine; Adolescent; Adult; Analysis of Variance; Autism Spectrum Disorder; Cell Adhesion Molecules, Neuronal; Chromatin Immunoprecipitation; Cohort Studies; DNA (Cytosine-5-)-Methyltransferase 1; Epigenesis, Genetic; Extracellular Matrix Proteins; Female; Frontal Lobe; Glutamate Decarboxylase; Humans; Male; Methyl-CpG-Binding Protein 2; Nerve Tissue Proteins; Promoter Regions, Genetic; Protein Binding; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Young Adult | 2017 |
Increased 5-hydroxymethylcytosine and Ten-eleven Translocation Protein Expression in Ultraviolet B-irradiated HaCaT Cells.
Topics: 5-Methylcytosine; Cell Line; DNA Methylation; Gene Expression; Humans; Proto-Oncogene Proteins; Ultraviolet Rays | 2017 |
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells.
Topics: 5-Methylcytosine; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Mixed Function Oxygenases; Monoterpenes; Neoplasm Proteins; Proto-Oncogene Proteins; RNA, Messenger; Time Factors; Tropolone; Ubiquitin-Protein Ligases | 2017 |
Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cell Differentiation; Cell Line; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Mice; Muscle Development; Myoblasts, Skeletal; Promoter Regions, Genetic; Proto-Oncogene Proteins | 2017 |
A Knockin Reporter Allows Purification and Characterization of mDA Neurons from Heterogeneous Populations.
Topics: 5-Methylcytosine; Base Sequence; Cell Differentiation; Cell Line; Cell Separation; Dopaminergic Neurons; Enhancer Elements, Genetic; Gene Expression Profiling; Gene Knock-In Techniques; Genes, Reporter; Human Embryonic Stem Cells; Humans; Luminescent Proteins; Mesencephalon; Red Fluorescent Protein; Sequence Analysis, RNA; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2017 |
5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.
Topics: 5-Methylcytosine; Animals; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Ganglia, Spinal; Male; Mice; Mice, Inbred C57BL; Neuralgia; Proto-Oncogene Proteins | 2017 |
Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity.
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Birnaviridae Infections; Chickens; DNA Methylation; Infectious bursal disease virus; Poultry Diseases | 2017 |
TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response.
Topics: 5-Methylcytosine; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Death; Dioxygenases; DNA; DNA Damage; DNA Methylation; DNA Repair; DNA-Binding Proteins; Genome; Mice; Oxidation-Reduction; Proto-Oncogene Proteins | 2017 |
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI.
Topics: 5-Methylcytosine; Animals; Cell Nucleus; DNA; DNA Methylation; Histones; Horses; Microscopy, Fluorescence; Oocytes; Sperm Injections, Intracytoplasmic; Zygote | 2017 |
Combinatorial DNA methylation codes at repetitive elements.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; DNA Transposable Elements; Epigenesis, Genetic; Fibroblasts; Genome; Mice; Mouse Embryonic Stem Cells; Primary Cell Culture; Repetitive Sequences, Nucleic Acid; Thymine DNA Glycosylase | 2017 |
Detection of 5-Methylcytosine in Specific Poly(A) RNAs by Bisulfite Sequencing.
Topics: 5-Methylcytosine; Computational Biology; Methylation; Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, RNA; Software | 2017 |
Automated Chemical Solid-Phase Synthesis and Deprotection of 5-Hydroxymethylcytosine-Containing RNA.
Topics: 5-Methylcytosine; Epigenesis, Genetic; Methylation; RNA; Solid-Phase Synthesis Techniques | 2017 |
Differential expression of ten-eleven translocation genes in endometrial cancers.
Topics: 5-Methylcytosine; Aged; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Endometrial Neoplasms; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Middle Aged; Mixed Function Oxygenases; Prognosis; Proto-Oncogene Proteins | 2017 |
Epigenetic Status of H19-Igf2 Imprinted Genes and Loss of 5-Hydroxymethylcytosine in the Brain of Cloned Goats.
Topics: 5-Methylcytosine; Animals; Brain; Cloning, Organism; DNA Methylation; Female; Genomic Imprinting; Goats; Histones; Insulin-Like Growth Factor II; Male | 2017 |
Ten-eleven translocation 1 functions as a mediator of SOD3 expression in human lung cancer A549 cells.
Topics: 5-Methylcytosine; A549 Cells; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mixed Function Oxygenases; Oxidation-Reduction; Proto-Oncogene Proteins; Superoxide Dismutase | 2017 |
Aberrant gene-specific DNA methylation signature analysis in cervical cancer.
Topics: 5-Methylcytosine; Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; DNA Methylation; Female; Genotype; High-Throughput Nucleotide Sequencing; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Humans; Middle Aged; Neoplasm Proteins; Nuclear Proteins; Papillomaviridae; Promoter Regions, Genetic; Transcription Factors; Uterine Cervical Neoplasms | 2017 |
Cytosine modifications modulate the chromatin architecture of transcriptional enhancers.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Chromatin; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; Embryonal Carcinoma Stem Cells; Enhancer Elements, Genetic; Epigenesis, Genetic; Hepatocyte Nuclear Factor 3-alpha; Histones; Mice; Myeloid Ecotropic Viral Integration Site 1 Protein; Neural Stem Cells; Pre-B-Cell Leukemia Transcription Factor 1; Protein Binding; Proto-Oncogene Proteins; RNA, Small Interfering; Transcription, Genetic; Tumor Cells, Cultured | 2017 |
Increased 5-hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self-administration.
Topics: 5-Methylcytosine; Animals; Cocaine-Related Disorders; Dioxygenases; DNA Methylation; Extinction, Psychological; Gene Expression Regulation; Hippocampus; Male; Rats; Rats, Wistar | 2017 |
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.
Topics: 5-Methylcytosine; Animals; Axons; Epigenesis, Genetic; Ganglia, Spinal; Mice, Inbred C57BL; Nerve Regeneration; Peripheral Nerve Injuries | 2017 |
Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA.
Topics: 5-Methylcytosine; Brain; Cell Line, Tumor; CpG Islands; DNA; DNA Methylation; Gene Expression Profiling; Genome, Human; Humans; Immunoprecipitation; Mixed Function Oxygenases; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Proto-Oncogene Proteins; Sequence Analysis, DNA; Sulfites; Whole Genome Sequencing | 2017 |
DNA Methylation program in normal and alcohol-induced thinning cortex.
Topics: 5-Methylcytosine; Alcohol Drinking; Animals; DNA Methylation; Epigenesis, Genetic; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Genotype; Gestational Age; Maternal Exposure; Mice, Inbred C57BL; Neocortex; Neurogenesis; Phenotype; Pregnancy | 2017 |
Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
Topics: 5-Methylcytosine; Animals; Cell Line; CpG Islands; Dioxygenases; DNA; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; HEK293 Cells; Heterochromatin; Humans; Luminescent Proteins; Mice; Mixed Function Oxygenases; Mouse Embryonic Stem Cells; Myoblasts; Oxidation-Reduction; Protein Domains; Proto-Oncogene Proteins; Red Fluorescent Protein; Signal Transduction; Transcription Factors | 2017 |
Gene-body 5-hydroxymethylation is associated with gene expression changes in the prefrontal cortex of depressed individuals.
Topics: 5-Methylcytosine; Adult; Autopsy; Depressive Disorder, Major; DNA Methylation; Epigenesis, Genetic; Gene Expression; Genome; Humans; Male; Middle Aged; Myosin Heavy Chains; Phenotype; Prefrontal Cortex; Suicide | 2017 |
Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas.
Topics: 5-Methylcytosine; Animals; Cadmium; Cytosine; Hepatopancreas; Humans; Snails; Water Pollutants, Chemical | 2017 |
A sensitive signal-off electrogenerated chemiluminescence biosensing method for the discrimination of DNA hydroxymethylation based on glycosylation modification and signal quenching from ferroceneboronic acid.
Topics: 5-Methylcytosine; Biosensing Techniques; Boronic Acids; DNA; DNA Methylation; Electrochemical Techniques; Equipment Design; Ferrous Compounds; Fluorocarbon Polymers; Glycosylation; Gold; Humans; Limit of Detection; Luminescent Measurements; Metal Nanoparticles; Metallocenes | 2017 |
DIRECTION: a machine learning framework for predicting and characterizing DNA methylation and hydroxymethylation in mammalian genomes.
Topics: 5-Methylcytosine; Algorithms; Animals; CpG Islands; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Machine Learning; Mammals; Software | 2017 |
Immunofluorescence Imaging Strategy for Evaluation of the Accessibility of DNA 5-Hydroxymethylcytosine in Chromatins.
Topics: 5-Methylcytosine; Animals; Antibodies; Chromatin; DNA; Embryonic Stem Cells; Fluorescent Antibody Technique; Humans; MCF-7 Cells; Mice; Mixed Function Oxygenases; Molecular Imaging; Proto-Oncogene Proteins | 2017 |
The level and clinical significance of 5-hydroxymethylcytosine in oral squamous cell carcinoma: An immunohistochemical study in 95 patients.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Disease-Free Survival; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Mouth Neoplasms; Proportional Hazards Models; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck | 2017 |
Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men.
Topics: 5-Methylcytosine; Adult; Air Pollutants, Occupational; Benzhydryl Compounds; DNA Methylation; DNA-Binding Proteins; Environmental Exposure; Epigenesis, Genetic; Estrogens, Non-Steroidal; Genome, Human; Histones; Homeodomain Proteins; Humans; Hydroxylation; Male; Middle Aged; MutL Protein Homolog 1; Phenols; Promoter Regions, Genetic; Protein Isoforms; Sperm Count; Spermatogenesis; Spermatozoa | 2017 |
Molecular cloning of chicken TET family genes and role of chicken TET1 in erythropoiesis.
Topics: 5-Methylcytosine; Animals; beta-Globins; Cell Line; Chickens; Cloning, Molecular; Dioxygenases; DNA Methylation; Erythropoiesis; HeLa Cells; Humans; Multigene Family; Promoter Regions, Genetic | 2017 |
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.
Topics: 5-Methylcytosine; Animals; Cell Proliferation; Cells, Cultured; Dioxygenases; DNA-Binding Proteins; Forkhead Box Protein O3; Gene Expression Regulation; Male; Mice, Knockout; Neural Stem Cells; Neurogenesis; Protein Binding; Proto-Oncogene Proteins | 2017 |
MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET-SOCS1-MMP9 signaling axis.
Topics: 5-Methylcytosine; Adult; Aged; Animals; Carcinoma, Hepatocellular; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Matrix Metalloproteinase 9; Mice; MicroRNAs; Middle Aged; Mixed Function Oxygenases; Neoplasm Metastasis; Proto-Oncogene Proteins; Signal Transduction; Suppressor of Cytokine Signaling 1 Protein; Xenograft Model Antitumor Assays | 2017 |
Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci.
Topics: 5-Methylcytosine; Brain; DNA Methylation; Female; Genetic Loci; Genomic Imprinting; Humans; Placenta; Pregnancy; snRNP Core Proteins; Ubiquitin-Protein Ligases | 2018 |
The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis.
Topics: 5-Methylcytosine; Animals; Cation Transport Proteins; Cytokines; Dioxygenases; DNA Demethylation; DNA-Binding Proteins; Erythroid Cells; Erythropoiesis; Hepcidins; Homeostasis; Humans; Iron; K562 Cells; Male; Mice, Inbred C57BL; Muscle Proteins; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins; Stress, Physiological; Transcription, Genetic | 2017 |
Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; Carbohydrate Conformation; Crystallography, X-Ray; Models, Molecular; Oligonucleotides; RNA; Thermodynamics | 2017 |
Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers.
Topics: 5-Methylcytosine; Colonic Neoplasms; DNA, Neoplasm; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Microscopy, Fluorescence; Sensitivity and Specificity; Single Molecule Imaging | 2017 |
Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cells, Cultured; Disease Models, Animal; DNA Methylation; Early Diagnosis; Fibroma; Humans; Immunoblotting; Immunoenzyme Techniques; Keratinocytes; Lichen Planus, Oral; Mice; Mouth Neoplasms; Precancerous Conditions; Prognosis | 2018 |
5-hydroxymethylcytosine in DNA repair: A new player or a red herring?
Topics: 5-Methylcytosine; Animals; DNA Damage; DNA Demethylation; DNA Repair; Humans | 2017 |
Altered Global 5-Hydroxymethylation Status in Hidradenitis Suppurativa: Support for an Epigenetic Background.
Topics: 5-Methylcytosine; Case-Control Studies; DNA Methylation; Epigenesis, Genetic; Female; Hidradenitis Suppurativa; Humans; Immunohistochemistry; Male; Skin | 2017 |
5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages.
Topics: 5-Methylcytosine; Adult; Aged; Animals; Cell-Free Nucleic Acids; Circulating Tumor DNA; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Humans; Male; Middle Aged; Neoplasm Staging; Neoplasms | 2017 |
Evaluation of Post-Mortem Effects on Global Brain DNA Methylation and Hydroxymethylation.
Topics: 5-Methylcytosine; Age Factors; Animals; Animals, Newborn; Autopsy; Cerebellum; DNA Damage; DNA Methylation; Humans; Oxidative Stress; Postmortem Changes; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors | 2018 |
Variation in global DNA hydroxymethylation with age associated with schizophrenia.
Topics: 5-Methylcytosine; Adult; Age Factors; Case-Control Studies; DNA; DNA Methylation; Female; Humans; Male; Schizophrenia; Sex Factors | 2017 |
5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes.
Topics: 5-Methylcytosine; Animals; Cytosine; Demethylation; DNA Methylation; Epigenesis, Genetic; Gene Expression; Methyl-CpG-Binding Protein 2; Mice; Mitosis; Neurons; Promoter Regions, Genetic | 2017 |
Ultrasensitive electrochemiluminescence immunosensor for 5-hydroxymethylcytosine detection based on Fe
Topics: 5-Methylcytosine; Biosensing Techniques; Dendrimers; Ferric Compounds; Humans; Metal Nanoparticles; Silicon Dioxide | 2018 |
Bi-directional and shared epigenomic signatures following proton and
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenomics; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Hippocampus; Male; Maze Learning; Mice; Protons; Sequence Analysis, RNA; Spatial Learning; Time Factors; Whole-Body Irradiation | 2017 |
Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects.
Topics: 5-Methylcytosine; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; DNA Methylation; Epigenesis, Genetic; Female; Hippocampus; Humans; Male | 2017 |
5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
Topics: 5-Methylcytosine; Brain; Fetus; Humans; Quantitative Trait Loci; Sex Characteristics; Time Factors | 2017 |
5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Biomarkers, Tumor; Cell-Free Nucleic Acids; Circulating Tumor DNA; DNA Methylation; Epigenomics; Female; Gene Expression Regulation, Neoplastic; Humans; Liquid Biopsy; Male; Middle Aged; Neoplasms; Young Adult | 2017 |
Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways.
Topics: 5-Methylcytosine; Animals; Axons; Cell Differentiation; Dioxygenases; DNA Methylation; Neurogenesis; Neurons; Receptors, Notch; Retina; Transcriptome; Wnt Signaling Pathway; Zebrafish; Zebrafish Proteins | 2017 |
Mouse olfactory bulb methylome and hydroxymethylome maps reveal noncanonical active turnover of DNA methylation.
Topics: 5-Methylcytosine; Animals; CpG Islands; DNA Methylation; Female; Genome; Mice; Mice, Inbred C57BL; Olfactory Bulb; Whole Genome Sequencing | 2017 |
TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells.
Topics: 5-Methylcytosine; Cell Differentiation; Cell Lineage; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Profiling; Histone-Lysine N-Methyltransferase; Histones; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Osteoclasts; Primary Cell Culture; Proto-Oncogene Proteins; RANK Ligand; Thymine DNA Glycosylase; Transcriptome | 2017 |
Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.
Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cyclic AMP Response Element-Binding Protein; Cytosine; DNA; DNA Methylation; Gene Expression Regulation; Humans; Promoter Regions, Genetic; Protein Binding; Thymine DNA Glycosylase | 2017 |
Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genome-Wide Association Study; Histones; Humans; Mice; Neoplasm Transplantation; Pancreatic Neoplasms; Patient-Specific Modeling; Regulatory Sequences, Nucleic Acid; Sequence Analysis, RNA | 2017 |
Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Female; Male; Mice; Mice, Inbred C57BL; Protein Binding | 2017 |
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition.
Topics: 5-Methylcytosine; Base Sequence; DNA; Epigenesis, Genetic; HEK293 Cells; HeLa Cells; Humans; Molecular Structure; Protein Binding; Repetitive Sequences, Amino Acid; Transcription Activator-Like Effectors | 2017 |
Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation.
Topics: 5-Methylcytosine; Adiposity; Body Mass Index; DNA Methylation; Epigenesis, Genetic; Female; Genome, Human; Humans; Metabolome; Multigene Family; Obesity; Placenta; Pregnancy; Thinness | 2017 |
DNA methylation and hydroxymethylation analyses of the active LINE-1 subfamilies in mice.
Topics: 5-Methylcytosine; 5' Untranslated Regions; Animals; Base Sequence; Brain; DNA Methylation; Female; Long Interspersed Nucleotide Elements; Male; Mice; Mice, Inbred C57BL; Myocardium; Ovary; Sequence Analysis, DNA; Testis | 2017 |
DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress.
Topics: 5-Methylcytosine; Adenine; Animals; Brain; Computational Biology; Depression; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genome; Humans; Long Interspersed Nucleotide Elements; Male; Mental Disorders; Mice; Mice, Inbred C57BL; Neurons; Prefrontal Cortex; Stress, Physiological; Swimming; Transcriptome | 2017 |
DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project.
Topics: 5-Methylcytosine; Adult; Aged; Aging; Cross-Sectional Studies; DNA Methylation; Down Syndrome; Epigenesis, Genetic; Europe; Female; Humans; Immunoblotting; Italy; Leukocytes, Mononuclear; Male; Middle Aged; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA, Messenger | 2018 |
Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Cisplatin; Dioxygenases; DNA Helicases; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genomic Instability; Heterochromatin; Humans; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Protein Binding; Proto-Oncogene Proteins | 2017 |
Clinical Significance of Measuring Global Hydroxymethylation of White Blood Cell DNA in Prostate Cancer: Comparison to PSA in a Pilot Exploratory Study.
Topics: 5-Methylcytosine; Aged; Biomarkers, Tumor; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Humans; Leukocytes; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms | 2017 |
Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells.
Topics: 5-Methylcytosine; Arsenic; CCCTC-Binding Factor; Cell Transformation, Neoplastic; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Humans; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins | 2018 |
Oxygen gradients can determine epigenetic asymmetry and cellular differentiation via differential regulation of Tet activity in embryonic stem cells.
Topics: 5-Methylcytosine; Amino Acids, Dicarboxylic; Animals; Cell Differentiation; Cell Hypoxia; Cell Line; Demethylation; Dioxygenases; Embryoid Bodies; Epigenesis, Genetic; Gene Expression Regulation, Developmental; HEK293 Cells; Histones; Humans; Hydroxylation; Mice; Mixed Function Oxygenases; Models, Biological; Mouse Embryonic Stem Cells; Oxygen; Promoter Regions, Genetic; Protein Isoforms; Proto-Oncogene Proteins | 2018 |
Integrating 5hmC and gene expression data to infer regulatory mechanisms.
Topics: 5-Methylcytosine; Cell Line, Tumor; Computational Biology; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Sequence Analysis, DNA; Sequence Analysis, RNA; Triple Negative Breast Neoplasms | 2018 |
Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water.
Topics: 5-Methylcytosine; Animals; Arsenic; Arsenic Trioxide; Arsenicals; Cerebral Cortex; DNA Methylation; DNA Modification Methylases; Drinking Water; Epigenesis, Genetic; Hippocampus; Learning; Male; Oxidative Stress; Oxides; Rats, Sprague-Dawley; Water Pollutants, Chemical | 2018 |
Quantification of Global DNA Methylation Levels by Mass Spectrometry.
Topics: 5-Methylcytosine; Animals; Chromatography, Liquid; DNA Methylation; Epigenesis, Genetic; Humans; Nanotechnology; Plants; Tandem Mass Spectrometry | 2018 |
Tet-Assisted Bisulfite Sequencing (TAB-seq).
Topics: 5-Methylcytosine; Animals; Cells, Cultured; DNA-Binding Proteins; Epigenomics; Glucosyltransferases; Humans; Mice; Proto-Oncogene Proteins; Recombinant Proteins; Sequence Analysis, DNA; Sulfites | 2018 |
Multiplexing for Oxidative Bisulfite Sequencing (oxBS-seq).
Topics: 5-Methylcytosine; DNA Methylation; Genomic Library; Humans; Organ Specificity; Sequence Analysis, DNA; Sulfites; Workflow | 2018 |
Affinity-Based Enrichment Techniques for the Genome-Wide Analysis of 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; CpG Islands; DNA Methylation; Epigenesis, Genetic; Humans; Vertebrates; Whole Genome Sequencing | 2018 |
cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Cyclic AMP; DNA; Gene Expression Regulation; Iron; Methylation; Rats; Schwann Cells; Signal Transduction | 2017 |
Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas.
Topics: 5-Methylcytosine; Epigenesis, Genetic; Humans; Lymphoma, T-Cell, Peripheral; Methylation | 2018 |
Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR-Cas effector complexes.
Topics: 5-Methylcytosine; Bacteriophage T4; Base Sequence; CRISPR-Associated Protein 9; CRISPR-Cas Systems; DNA, Viral; Escherichia coli; Protein Binding; T-Phages | 2018 |
Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer.
Topics: 5-Methylcytosine; Animals; Cell Survival; Cellular Reprogramming; Combined Modality Therapy; Cystadenocarcinoma, Serous; Dioxygenases; Disease Models, Animal; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Grading; Ovarian Neoplasms; Prognosis; Proto-Oncogene Proteins; Recurrence; Survival Analysis; Xenograft Model Antitumor Assays | 2018 |
Understanding the influence of antipsychotic drugs on global methylation events and its relevance in treatment response.
Topics: 5-Methylcytosine; Adult; Antipsychotic Agents; Case-Control Studies; Clozapine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Female; Haloperidol; Hep G2 Cells; Humans; Male; MicroRNAs; Olanzapine; Pharmacogenetics; Schizophrenia; Treatment Outcome | 2018 |
Copper induces expression and methylation changes of early development genes in Crassostrea gigas embryos.
Topics: 5-Methylcytosine; Animals; Comet Assay; Copper; Crassostrea; DNA Methylation; Embryo, Nonmammalian; Gene Expression; Homeodomain Proteins; Larva; Principal Component Analysis; Real-Time Polymerase Chain Reaction; RNA; Water Pollutants, Chemical | 2018 |
Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus.
Topics: 5-Methylcytosine; Animals; Brain; DNA Methylation; Gene Regulatory Networks; Humans; Macaca mulatta; Species Specificity | 2018 |
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation.
Topics: 3' Untranslated Regions; 5-Methylcytosine; Adenosine Deaminase; Animals; Bone Marrow Cells; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation; Immunity, Innate; Mice; Myelopoiesis; Nucleic Acid Conformation; Oxidation-Reduction; Proto-Oncogene Proteins; RNA, Double-Stranded; RNA, Messenger; Sepsis; Suppressor of Cytokine Signaling 3 Protein; Transcriptome | 2018 |
Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Cannabidiol; Creatine Kinase; Disease Models, Animal; DNA Methylation; DNA, Mitochondrial; Female; Gene Expression Regulation; Hippocampus; Iron Carbonyl Compounds; Male; Mitochondria; Mitochondrial Proteins; Muscle Proteins; NADH Dehydrogenase; Neurodegenerative Diseases; Pregnancy; Rats; Rats, Wistar | 2018 |
Sulfinate Based Selective Labeling of 5-Hydroxymethylcytosine: Application to Biotin Pull Down Assay.
Topics: 5-Methylcytosine; Biotin; Biotinylation; DNA; Sulfinic Acids; Sulfites | 2018 |
Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC.
Topics: 5-Methylcytosine; Cell Differentiation; Cell Line; Cell Lineage; DNA Methylation; Endoderm; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Developmental; Human Embryonic Stem Cells; Humans; Pancreas | 2018 |
DNA redox modulations and global DNA methylation in bipolar disorder: Effects of sex, smoking and illness state.
Topics: 5-Methylcytosine; Adult; Bipolar Disorder; DNA Methylation; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Sex Factors; Smoking | 2018 |
Genomic 5-mC contents in peripheral blood leukocytes were independent protective factors for coronary artery disease with a specific profile in different leukocyte subtypes.
Topics: 5-Methylcytosine; Aged; Case-Control Studies; Cholesterol; Chromatography, Liquid; Coronary Artery Disease; Cross-Sectional Studies; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Down-Regulation; Female; Genome-Wide Association Study; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Protective Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; THP-1 Cells; Tissue Distribution | 2018 |
Impaired fear extinction in serotonin transporter knockout rats is associated with increased 5-hydroxymethylcytosine in the amygdala.
Topics: 5-Methylcytosine; Amygdala; Animals; DNA Methylation; Extinction, Psychological; Fear; Male; Rats; Rats, Wistar; Serotonin Plasma Membrane Transport Proteins | 2018 |
5-Hydroxymethylcytosine preferentially targets genes upregulated in isocitrate dehydrogenase 1 mutant high-grade glioma.
Topics: 5-Methylcytosine; Adult; Aged; Brain Neoplasms; Cohort Studies; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Neoplasm Grading; RNA, Messenger; Up-Regulation | 2018 |
A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases.
Topics: 5-Methylcytosine; Animals; Gene Expression Regulation; Gene Regulatory Networks; Genomics; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; Metabolome; Microarray Analysis; Oxidative Stress; Protein Kinases; RNA; tert-Butylhydroperoxide | 2018 |
Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.
Topics: 5-Methylcytosine; Aging; Animals; Brain; Cognition; Dentate Gyrus; Dioxygenases; DNA-Binding Proteins; Male; Mice, Inbred C57BL; Models, Animal; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Parabiosis; Proto-Oncogene Proteins | 2018 |
Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Circulating Tumor DNA; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Staging | 2018 |
Peroxiredoxin as a functional endogenous antioxidant enzyme in pronuclei of mouse zygotes.
Topics: 5-Methylcytosine; Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cells, Cultured; Cumulus Cells; DNA Methylation; Ectogenesis; Epigenesis, Genetic; Female; Fertilization in Vitro; Hydrogen Peroxide; Male; Mice, Inbred ICR; Microscopy, Confocal; Oxidants; Oxidative Stress; Peroxiredoxins; Proteomics; Reactive Oxygen Species; Zygote | 2018 |
Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer.
Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Epigenomics; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Male; Mitochondrial Trifunctional Protein, beta Subunit; Sequence Analysis, DNA; Sequence Analysis, RNA | 2018 |
Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte.
Topics: 5-Methylcytosine; Animals; Cellular Reprogramming; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gametogenesis; Germ Cells; Male; Meiosis; Mice; Proto-Oncogene Proteins | 2018 |
DNA hydroxymethylation of colorectal primary carcinoma and its association with survival.
Topics: 5-Methylcytosine; Adenocarcinoma; Adenocarcinoma, Mucinous; Biomarkers, Tumor; Colorectal Neoplasms; DNA Methylation; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Middle Aged; Prognosis; Survival Rate | 2018 |
Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice.
Topics: 5-Methylcytosine; Aminoquinolines; Animals; Case-Control Studies; Cell Differentiation; Cell Proliferation; Chemokine CXCL1; Dioxygenases; Disease Models, Animal; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Humans; Imiquimod; Interferon-gamma; Interleukin-17; Mice, Inbred BALB C; Proto-Oncogene Proteins; Psoriasis; Skin; Time Factors | 2018 |
Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression.
Topics: 5-Methylcytosine; Apoptosis; Ascorbic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sodium-Coupled Vitamin C Transporters; TNF-Related Apoptosis-Inducing Ligand | 2018 |
Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury.
Topics: 5-Methylcytosine; Adult; Aged; Allografts; Cold Ischemia; CpG Islands; Cross-Sectional Studies; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Fibrosis; Gene Expression; Glomerulosclerosis, Focal Segmental; Humans; Ischemia; Kidney Transplantation; Longitudinal Studies; Male; Middle Aged; Mixed Function Oxygenases; Postoperative Period; Predictive Value of Tests; Preoperative Period; Proto-Oncogene Proteins | 2018 |
Electrochemical signal-amplified detection of 5-methylcytosine and 5-hydroxymethylcytosine in DNA using glucose modification coupled with restriction endonucleases.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; DNA Restriction Enzymes; Electrochemical Techniques; Electrodes; Glucose; Gold; Humans; Nucleic Acid Hybridization | 2018 |
Ten-eleven translocation 1 regulates methylation of autophagy-related genes in human glioma.
Topics: 5-Methylcytosine; Autophagy; Brain; Brain Neoplasms; Cell Line, Tumor; DNA Methylation; Glioma; Humans; Mixed Function Oxygenases; Neoplasm Grading; Proto-Oncogene Proteins | 2018 |
Quantification of DNA methylation and hydroxymethylation in Alzheimer's disease mouse model using LC-MS/MS.
Topics: 5-Methylcytosine; Alzheimer Disease; Animals; Biomarkers; Chromatography, High Pressure Liquid; DNA; DNA Methylation; Mice, Inbred C57BL; Tandem Mass Spectrometry | 2018 |
PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent.
Topics: 5-Methylcytosine; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Proliferation; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Doxorubicin; Drug Resistance, Neoplasm; Head and Neck Neoplasms; HEK293 Cells; Humans; Leukemia, Promyelocytic, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Promyelocytic Leukemia Protein; Proto-Oncogene Proteins; Retinoic Acid Receptor alpha; RNA Interference; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2018 |
Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice.
Topics: 5-Methylcytosine; Animals; Cell Lineage; Demethylation; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Female; Genes, Essential; Genetic Linkage; Liver; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Transcription, Genetic | 2018 |
5-Hydroxymethylcytosine alterations in the human postmortem brains of autism spectrum disorder.
Topics: 5-Methylcytosine; Adolescent; Adult; Autism Spectrum Disorder; Autopsy; Case-Control Studies; DNA Methylation; Epigenesis, Genetic; Female; Humans; Male; Young Adult | 2018 |
Overexpression of Tet3 in donor cells enhances goat somatic cell nuclear transfer efficiency.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cellular Reprogramming; Cloning, Organism; Dioxygenases; DNA Demethylation; Embryonic Development; Female; Gene Expression Regulation, Developmental; Goats; Male; Nanog Homeobox Protein; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Pregnancy | 2018 |
Loss of 5-Hydroxymethylcytosine Is an Epigenetic Biomarker in Cutaneous T-Cell Lymphoma.
Topics: 5-Methylcytosine; Apoptosis; Biomarkers, Tumor; Carcinogenesis; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Disease Progression; Epigenesis, Genetic; Female; Humans; Keratinocytes; Lymphoma, T-Cell, Cutaneous; Male; Mycosis Fungoides; Neoplasm Staging; Prognosis; Skin Neoplasms; Survival Analysis | 2018 |
Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Case-Control Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genome, Human; Glioma; Humans | 2018 |
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients.
Topics: 5-Methylcytosine; Adult; Aged; Cytidine Deaminase; Cytokines; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression; Gene Expression Regulation; Humans; Inflammation; Lip; Male; Methyl-CpG-Binding Protein 2; Middle Aged; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Salivary Glands, Minor; Sjogren's Syndrome; Young Adult | 2018 |
Protected 2'-deoxyribonucleoside triphosphate building blocks for the photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA.
Topics: 5-Methylcytosine; Deoxyribonucleosides; DNA; Light; Photochemical Processes; Polyphosphates; Ultraviolet Rays | 2018 |
Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC).
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cells, Cultured; Core Binding Factor Alpha 2 Subunit; Dioxygenases; DNA-Binding Proteins; Genome; Genomics; Mice; Mice, Knockout; Osteoclasts; Proto-Oncogene Proteins | 2018 |
Two are better than one: HPoxBS - hairpin oxidative bisulfite sequencing.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Sulfites | 2018 |
Epigenetic Optical Mapping of 5-Hydroxymethylcytosine in Nanochannel Arrays.
Topics: 5-Methylcytosine; DNA; Epigenesis, Genetic; Humans; Nanotechnology; Optics and Photonics | 2018 |
TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Survival; Dioxygenases; DNA-Binding Proteins; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Knockdown Techniques; Humans; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasms; Proto-Oncogene Proteins; Recurrence; Xenograft Model Antitumor Assays | 2018 |
Restoration of 5-hydroxymethylcytosine by ascorbate blocks kidney tumour growth.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Dioxygenases; DNA-Binding Proteins; Enhancer Elements, Genetic; Humans; Kidney Neoplasms; Mice; Proto-Oncogene Proteins; Transcriptome; Xenograft Model Antitumor Assays | 2018 |
Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer.
Topics: 5-Methylcytosine; Aged; Animals; Ascorbic Acid; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Male; Mice; Middle Aged; Prognosis; Sequence Analysis, DNA; Sequence Analysis, RNA; Survival Analysis; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2018 |
5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Circulating Tumor DNA; DNA Methylation; Epigenomics; Female; Humans; Lung Neoplasms; Male; Middle Aged | 2018 |
Sensitive and label-free discrimination of 5-hydroxymethylcytosine and 5-methylcytosine in DNA by ligation-mediated rolling circle amplification.
Topics: 5-Methylcytosine; DNA; Fluorescence; Humans; Molecular Structure; Nucleic Acid Amplification Techniques; Oxidation-Reduction; Uracil | 2018 |
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
Topics: 5-Methylcytosine; Adenylate Kinase; Animals; Diabetes Mellitus; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Enzyme Stability; Epigenesis, Genetic; Glucose; Glycated Hemoglobin; Humans; Hyperglycemia; Metformin; Mice; Mice, Nude; Neoplasms; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins; Substrate Specificity; Xenograft Model Antitumor Assays | 2018 |
The role of 5-hydroxymethylcytosine in mitochondria after ischemic stroke.
Topics: 5-Methylcytosine; Adenosine Triphosphate; Animals; Brain Ischemia; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; DNA, Mitochondrial; Epigenesis, Genetic; Female; Infarction, Middle Cerebral Artery; Male; Mice, Inbred ICR; Mitochondria; Mitochondrial Proteins; NADH Dehydrogenase; Proto-Oncogene Proteins; Pyrazoles; Pyrimidines; RNA, Messenger; Sex Factors; Stroke; Up-Regulation | 2018 |
Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood.
Topics: 5-Methylcytosine; Animals; Benzhydryl Compounds; Environmental Pollutants; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Male; Mice; Phenols | 2018 |
Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.
Topics: 5-Methylcytosine; Adult; Aged; Cell Nucleus; Dioxygenases; DNA-Binding Proteins; Humans; Intestinal Neoplasms; Intestine, Small; Middle Aged; Mixed Function Oxygenases; Neuroendocrine Tumors; Proto-Oncogene Proteins | 2018 |
Gene body profiles of 5-hydroxymethylcytosine: potential origin, function and use as a cancer biomarker.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Genome; Humans; Neoplasms | 2018 |
Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cytosine; DNA, Neoplasm; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging | 2019 |
Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.
Topics: 5-Methylcytosine; Abortion, Spontaneous; Adult; Dioxygenases; DNA; DNA-Binding Proteins; Female; Humans; Mixed Function Oxygenases; Pregnancy; Proto-Oncogene Proteins; RNA, Messenger; Trophoblasts | 2018 |
Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood.
Topics: 5-Methylcytosine; Aging; Animals; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Gene Expression Regulation; Genome; Male; Mice | 2018 |
Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer.
Topics: 5-Methylcytosine; Adult; Aged; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Prognosis; Prostatic Neoplasms; Receptors, Estrogen; Tissue Array Analysis | 2018 |
Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen.
Topics: 5-Methylcytosine; Adult; Benzhydryl Compounds; China; Cohort Studies; DNA Methylation; Endocrine Disruptors; Humans; Male; Occupational Exposure; Phenols; Semen | 2018 |
Chronic ethanol-mediated hepatocyte apoptosis links to decreased TET1 and 5-hydroxymethylcytosine formation.
Topics: 5-Methylcytosine; Apoptosis; Cell Cycle Proteins; Cell Line; Deferoxamine; DNA Damage; Down-Regulation; Epigenesis, Genetic; Ethanol; Gene Knockdown Techniques; Hepatocytes; Humans; Liver Diseases, Alcoholic; Mixed Function Oxygenases; Nuclear Proteins; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 2019 |
Recognition of modified cytosine variants by the DNA-binding domain of methyl-directed endonuclease McrBC.
Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA; DNA Restriction Enzymes; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Molecular Structure; Protein Binding; Protein Domains | 2018 |
Crystal structure of the modification-dependent SRA-HNH endonuclease TagI.
Topics: 5-Methylcytosine; Amino Acid Sequence; Bacterial Proteins; Base Sequence; Binding Sites; Binding, Competitive; Crystallography, X-Ray; DNA; DNA Restriction Enzymes; Models, Molecular; Nucleic Acid Conformation; Protein Binding; Protein Domains; Sequence Homology, Amino Acid | 2018 |
Epigenetic markers in basal cell carcinoma: universal themes in oncogenesis and tumor stratification? - a short report.
Topics: 5-Methylcytosine; Carcinogenesis; Carcinoma, Basal Cell; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Skin Neoplasms | 2018 |
Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina.
Topics: 5-Methylcytosine; Animals; Humans; Immunohistochemistry; Mice; Retina | 2018 |
Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation.
Topics: 5-Methylcytosine; Catalysis; CpG Islands; DNA (Cytosine-5-)-Methyltransferase 1; DNA Demethylation; Humans; Oxidation-Reduction | 2018 |
MicroRNA-26b promotes transition from Kit
Topics: 5-Methylcytosine; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dioxygenases; DNA-Binding Proteins; Male; Mice; MicroRNAs; Promyelocytic Leukemia Zinc Finger Protein; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Spermatogenesis; Spermatogonia; Tretinoin | 2018 |
Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution.
Topics: 5-Methylcytosine; Cell-Free Nucleic Acids; Embryonic Stem Cells; Genome; Genomics; Humans; Nucleic Acid Amplification Techniques; Oxidation-Reduction; Sequence Analysis, DNA | 2018 |
Hypersensitive quantification of global 5-hydroxymethylcytosine by chemoenzymatic tagging.
Topics: 5-Methylcytosine; Animals; Chromatography, Liquid; Humans; Leukemia; Mice; Tandem Mass Spectrometry | 2018 |
Effects of ten-eleven translocation 1 (Tet1) on DNA methylation and gene expression in chicken primordial germ cells.
Topics: 5-Methylcytosine; Amino Acid Transport System y+L; Animals; Cell Proliferation; Cell Survival; Chickens; Deleted in Azoospermia 1 Protein; DNA Methylation; Gene Knockdown Techniques; Genomic Imprinting; Germ Cells; Mixed Function Oxygenases; Nanog Homeobox Protein; Proto-Oncogene Proteins; SOXB1 Transcription Factors | 2019 |
OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.
Topics: 5-Methylcytosine; Animals; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenomics; Gene Expression Regulation, Developmental; Hematopoiesis; Humans; Mice; Mouse Embryonic Stem Cells; Mutation; N-Acetylglucosaminyltransferases; Protein Binding; Protein Domains; Proto-Oncogene Proteins; Zebrafish; Zebrafish Proteins | 2018 |
Mirror Bisulfite Sequencing: A Method for Single-Base Resolution of Hydroxymethylcytosine.
Topics: 5-Methylcytosine; Base Sequence; DNA; DNA-Cytosine Methylases; Gene Library; Glucosyltransferases; Humans; Reproducibility of Results; Sensitivity and Specificity; Sequence Analysis, DNA; Sulfites | 2018 |
Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; DNA Methylation; Endothelial Cells; Epigenomics; Female; Gene Expression Regulation; Glucose; Humans; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; rac1 GTP-Binding Protein; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Retinal Vessels; RNA, Small Interfering; Signal Transduction; Transfection | 2018 |
Computational Study on the Excited-State Decay of 5-Methylcytosine and 5-Hydroxymethylcytosine: The Common Form of DNA Methylation and Its Oxidation Product.
Topics: 5-Methylcytosine; Models, Chemical; Molecular Conformation; Thermodynamics | 2018 |
TET2-Mediated Spatiotemporal Changes of 5-Hydroxymethylcytosine During Organogenesis in the Late Mouse Fetus.
Topics: 5-Methylcytosine; Animals; Brain; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenomics; Female; Fetus; Heart; Mice; Organogenesis; Pregnancy; Proto-Oncogene Proteins; Spatio-Temporal Analysis | 2019 |
Development of the Bioluminescent Immunoassay for the Detection of 5-Hydroxymethylcytosine in Dinoflagellate.
Topics: 5-Methylcytosine; Antibodies, Immobilized; Biotinylation; Dinoflagellida; DNA; Epigenesis, Genetic; Immunoenzyme Techniques; Luciferases; Luminescent Measurements; Streptavidin | 2019 |
Failure to convert.
Topics: 5-Methylcytosine; DNA | 2018 |
Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats.
Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Deoxyguanosine; Dioxygenases; Female; Fetal Weight; Maternal-Fetal Exchange; Oxidative Stress; Placenta; Pregnancy; Rats, Wistar; Solvents; Trichloroethylene | 2019 |
Inter-Cell and Inter-Chromosome Variability of 5-Hydroxymethylcytosine Patterns in Noncultured Human Embryonic and Extraembryonic Cells.
Topics: 5-Methylcytosine; Cell Communication; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 9; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Humans; Pregnancy; Pregnancy Trimester, First | 2018 |
Versatile Electroanalytical Bioplatforms for Simultaneous Determination of Cancer-Related DNA 5-Methyl- and 5-Hydroxymethyl-Cytosines at Global and Gene-Specific Levels in Human Serum and Tissues.
Topics: 5-Methylcytosine; Antibodies, Monoclonal; Armoracia; Biomarkers, Tumor; Biosensing Techniques; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Electrochemical Techniques; Fluorescent Dyes; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Immunomagnetic Separation; Limit of Detection; Tumor Suppressor Proteins | 2019 |
Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: a useful immunohistochemical approach for identification of neoplastic plasma cells.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Diagnosis, Differential; Female; Humans; Hyperplasia; Immunohistochemistry; Male; Middle Aged; Multiple Myeloma; Plasma Cells | 2019 |
TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression.
Topics: 5-Methylcytosine; Animals; Dioxygenases; Disease Progression; DNA-Binding Proteins; DNA, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Monomeric GTP-Binding Proteins; Proto-Oncogene Proteins; Rats; Skin Neoplasms | 2019 |
Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice.
Topics: 5-Methylcytosine; Animals; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Environment; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Prefrontal Cortex; Protein Binding; Proto-Oncogene Proteins; Restraint, Physical; Stress, Physiological | 2018 |
TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation.
Topics: 5-Methylcytosine; Adenocarcinoma; Aged; Aged, 80 and over; Ataxia Telangiectasia Mutated Proteins; Biomarkers, Tumor; Cell Differentiation; DNA Methylation; Female; Gene Silencing; Humans; Loss of Heterozygosity; Lymphatic Metastasis; Male; Middle Aged; Mixed Function Oxygenases; Mutation; Neoplasm Staging; Promoter Regions, Genetic; Proto-Oncogene Proteins; Stomach Neoplasms; Treatment Outcome; Tumor Suppressor Protein p53 | 2019 |
HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA.
Topics: 5-Methylcytosine; Apurinic Acid; DNA; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Endonucleases; Escherichia coli; Polynucleotides; Proliferating Cell Nuclear Antigen | 2019 |
5-methylcytosine and 5-hydroxymethylcytosine in brains of patients with multiple system atrophy and patients with Parkinson's disease.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Brain; Female; Humans; Male; Middle Aged; Multiple System Atrophy; Parkinson Disease | 2019 |
The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.
Topics: 5-Methylcytosine; Animals; Bone Neoplasms; Brain Neoplasms; Cell Line, Tumor; DNA Copy Number Variations; DNA Methylation; DNA, Mitochondrial; Genotype; Glioblastoma; Humans; Immunoprecipitation; Mice; Mitochondria; Neoplasm Transplantation; Osteosarcoma; Whole Genome Sequencing | 2018 |
Ascorbic acid improves parthenogenetic embryo development through TET proteins in mice.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Blastocyst; Dioxygenases; DNA-Binding Proteins; Embryonic Development; Female; Gene Expression Regulation, Developmental; Glycine; Male; Mice; Mice, Inbred C57BL; Parthenogenesis; Proto-Oncogene Proteins; Signal Transduction | 2019 |
Label-Free and Immobilization-Free Electrochemical Magnetobiosensor for Sensitive Detection of 5-Hydroxymethylcytosine in Genomic DNA.
Topics: 5-Methylcytosine; Biosensing Techniques; Carbon; DNA; DNA Nucleotidylexotransferase; Electrochemical Techniques; Electrodes; Ferricyanides; HEK293 Cells; HeLa Cells; Humans; Limit of Detection; Magnetic Phenomena; Oxidation-Reduction; Ruthenium Compounds | 2019 |
Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain.
Topics: 5-Methylcytosine; Animals; Brain; Cerebellar Cortex; Cerebellum; Chromosome Mapping; CpG Islands; Cytosine; DNA Methylation; Female; Genome; Haplotypes; Mice; Mice, Inbred C57BL; Olfactory Bulb; Regulatory Sequences, Nucleic Acid; Sequence Analysis, DNA | 2018 |
Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination.
Topics: 5-Methylcytosine; Adipogenesis; Animals; Cell Differentiation; Cells, Cultured; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Osteogenesis; Protein Binding; Proto-Oncogene Proteins; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex | 2019 |
Global distribution of DNA hydroxymethylation and DNA methylation in chronic lymphocytic leukemia.
Topics: 5-Methylcytosine; B-Lymphocytes; Case-Control Studies; Cell Line, Tumor; DNA Methylation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell | 2019 |
Simultaneous Targeted Methylation Sequencing (sTM-Seq).
Topics: 5-Methylcytosine; DNA; DNA Methylation; DNA Primers; Epigenesis, Genetic; Genome; Genomics; High-Throughput Nucleotide Sequencing; Humans; Sequence Analysis, DNA; Software | 2019 |
Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men.
Topics: 5-Methylcytosine; Acetylcholinesterase; Adult; Air Pollutants, Occupational; Benzhydryl Compounds; DNA Methylation; Epigenesis, Genetic; Humans; Hydroxylation; Male; Middle Aged; Phenols; Spermatozoa | 2019 |
Diagnostic utility of dual 5-hydroxymethylcytosine/Melan-A immunohistochemistry in differentiating nodal nevus from metastatic melanoma: An effective first-line test for the workup of sentinel lymph node specimen.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Diagnosis, Differential; Humans; Immunohistochemistry; Lymphatic Metastasis; MART-1 Antigen; Melanoma; Melanoma, Cutaneous Malignant; Nevus, Pigmented; Sentinel Lymph Node; Sentinel Lymph Node Biopsy; Skin Neoplasms; Staining and Labeling | 2019 |
ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; Brain; Databases, Genetic; Datasets as Topic; Genes; Genome; Humans; Machine Learning; Methylation; Mice; Organ Specificity; Promoter Regions, Genetic; Sequence Analysis, RNA; Sulfites | 2019 |
X-ray irradiation induces subtle changes in the genome-wide distribution of DNA hydroxymethylation with opposing trends in genic and intergenic regions.
Topics: 5-Methylcytosine; Cells, Cultured; CpG Islands; DNA Methylation; DNA, Intergenic; Fibroblasts; Genome, Human; Humans; X-Rays | 2019 |
The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent.
Topics: 5-Methylcytosine; Biomarkers; Cell Differentiation; DNA Methylation; Humans; Immunophenotyping; Lymphocyte Activation; Receptors, Antigen, T-Cell; T-Lymphocytes | 2019 |
Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.
Topics: 5-Methylcytosine; Adult; Alcohol Oxidoreductases; Animals; Ascorbic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Female; Gene Deletion; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Male; Mice | 2019 |
Decreased 5-hydroxymethylcytosine immunoreactivity in primary Merkel cell carcinoma is a strong predictor for disease-specific death.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Merkel Cell; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Follow-Up Studies; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Male; Merkel cell polyomavirus; Neoplasm Recurrence, Local; Neoplasm Staging; Pilot Projects; Prognosis; Proto-Oncogene Proteins; Sex Factors; Skin; Skin Neoplasms; Viral Load | 2019 |
Vitrification of murine mature metaphase II oocytes perturbs DNA methylation reprogramming during preimplantation embryo development.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cryopreservation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Female; Fertilization in Vitro; Metaphase; Mice; Morula; Oocytes; Oogenesis; Pregnancy; Proto-Oncogene Proteins; Vitrification | 2019 |
Differential distribution of the epigenetic marker 5-hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation.
Topics: 5-Methylcytosine; Animals; Biomarkers; Cell Differentiation; Cell Proliferation; Epigenesis, Genetic; Hair Follicle; Humans; Keratin-15; Mice; Stem Cells | 2019 |
Epigenetic modulation of β cells by interferon-α via PNPT1/mir-26a/TET2 triggers autoimmune diabetes.
Topics: 5-Methylcytosine; Animals; Cell Line; Cytokines; Diabetes Mellitus, Type 1; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Exoribonucleases; Female; Gene Expression Regulation; Humans; Insulin-Secreting Cells; Interferon-alpha; Mice; Mice, Inbred NOD; Mice, Transgenic; MicroRNAs; Microtubule-Associated Proteins; Proto-Oncogene Proteins; T-Lymphocytes; Up-Regulation | 2019 |
Sensitive detection of hydroxymethylcytosine levels in normal and neoplastic cells and tissues.
Topics: 5-Methylcytosine; Animals; Cell Dedifferentiation; DNA Methylation; Electrophoresis, Capillary; Fluorescence; Glioma; Humans; Lung Neoplasms; Mice; Neoplasms | 2019 |
The global DNA and RNA methylation and their reversal in lung under different concentration exposure of ambient air particulate matter in mice.
Topics: 5-Methylcytosine; Air Pollution; Animals; DNA Methylation; Gene Expression; Lung; Male; Mice; Mice, Inbred C57BL; Particulate Matter | 2019 |
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; CpG Islands; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Methylation; Mice, Inbred C57BL; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Neoplasms; Promoter Regions, Genetic | 2019 |
TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; HeLa Cells; Heterografts; Humans; Mice; Mixed Function Oxygenases; Neoplastic Stem Cells; Precancerous Conditions; Proto-Oncogene Proteins; Squamous Intraepithelial Lesions of the Cervix; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vimentin; Zinc Finger E-box-Binding Homeobox 1 | 2019 |
New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation.
Topics: 5-Methylcytosine; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Practice Guidelines as Topic; RNA, Messenger; Whole Genome Sequencing | 2019 |
Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution.
Topics: 5-Methylcytosine; Animals; Base Sequence; Biotechnology; CpG Islands; DNA; DNA Methylation; Humans; Mice; Sequence Analysis, DNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfites; Whole Genome Sequencing | 2019 |
Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis.
Topics: 5-Methylcytosine; Animals; Cadherins; Cell Differentiation; Cell Lineage; CRISPR-Associated Protein 9; Cytosine; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Oncogene Proteins, Fusion; Pregnancy; Proto-Oncogene Proteins; Transcription Factors; Transcriptome | 2019 |
5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors.
Topics: 5-Methylcytosine; Aged; Cohort Studies; Humans; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Prostatectomy; Prostatic Neoplasms; ROC Curve; Transcriptional Regulator ERG | 2019 |
The expression of TET3 regulated cell proliferation in HepG2 cells.
Topics: 5-Methylcytosine; Ascorbic Acid; Cell Proliferation; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Hep G2 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Proto-Oncogene Proteins; Transcriptome | 2019 |
Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid.
Topics: 5-Methylcytosine; Ascorbic Acid; Cell Hypoxia; Cells, Cultured; Cicatrix; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit | 2019 |
DNA methylation and hydroxymethylation are associated with the degree of coronary atherosclerosis in elderly patients with coronary heart disease.
Topics: 5-Methylcytosine; Aged; Atherosclerosis; Case-Control Studies; Coronary Disease; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Male; Proto-Oncogene Proteins; Up-Regulation | 2019 |
5-Hydroxymethylcytosine profiling from genomic and cell-free DNA for colorectal cancers patients.
Topics: 5-Methylcytosine; Cell-Free Nucleic Acids; Colorectal Neoplasms; DNA Methylation; DNA, Neoplasm; Epigenomics; Gene Expression Regulation, Neoplastic; Gene Ontology; Genomics; Humans; Precancerous Conditions; Sequence Analysis, DNA | 2019 |
Bisulfite-free epigenetic sequencing.
Topics: 5-Methylcytosine; Sequence Analysis, DNA; Sulfites | 2019 |
Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs.
Topics: 5-Methylcytosine; Aged; Animals; Case-Control Studies; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dioxygenases; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Leukocytes; Male; Middle Aged; Proto-Oncogene Proteins; Rats; Sirtuins; Up-Regulation | 2019 |
Hydroxyurea promotes TET1 expression and induces apoptosis in osteosarcoma cells.
Topics: 5-Methylcytosine; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxyurea; Mixed Function Oxygenases; Osteosarcoma; Proto-Oncogene Proteins; Up-Regulation | 2019 |
Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy.
Topics: 5-Methylcytosine; Animals; Cardiomyopathy, Dilated; Carrier Proteins; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Regulatory Networks; Genetic Predisposition to Disease; Hydroxylation; Introns; Male; Mice, Mutant Strains; Mutation; Phenotype; Promoter Regions, Genetic; Transcriptome; Ventricular Function, Left | 2019 |
TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Basic-Leucine Zipper Transcription Factors; Cell Differentiation; Cells, Cultured; Cytidine Deaminase; Dioxygenases; DNA Demethylation; DNA-Binding Proteins; Gene Expression Regulation; Genetic Loci; Immunoglobulin Class Switching; Lymphocyte Activation; Mice; Mice, Transgenic; Primary Cell Culture; Proto-Oncogene Proteins; Response Elements | 2019 |
Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation.
Topics: 5-Methylcytosine; Abortion, Legal; Adult; DNA Methylation; Epigenesis, Genetic; Female; Humans; Placenta; Placentation; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Trophoblasts | 2019 |
Loss of 5-hydroxymethylcytosine immunohistochemical expression is a useful diagnostic aid for distinguishing hepatocellular carcinoma in cytology fine needle aspiration specimens.
Topics: 5-Methylcytosine; Biopsy, Fine-Needle; Carcinoma, Hepatocellular; Cytodiagnosis; Diagnosis, Differential; Hepatocytes; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity | 2019 |
EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation.
Topics: 5-Methylcytosine; Animals; Female; Histone-Lysine N-Methyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Oocytes; Oxidation-Reduction; Zygote | 2019 |
Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis.
Topics: 5-Methylcytosine; Animals; Apoptosis; Cerebral Cortex; DNA Methylation; DNA Methyltransferase 3A; Gene Expression Regulation; Neural Stem Cells; Neurons; Oxygen; Proto-Oncogene Proteins; Transcriptome; Triiodothyronine | 2019 |
A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids.
Topics: 5-Methylcytosine; Biotechnology; Breast Neoplasms; Carcinogenesis; Cell Line; Cells, Cultured; Female; Humans; Mammary Glands, Human; MCF-7 Cells; Organoids; Printing, Three-Dimensional; Tumor Microenvironment | 2019 |
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
Topics: 5-Methylcytosine; AlkB Enzymes; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Animals; Computational Biology; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Molecular Structure; Oxidation-Reduction | 2019 |
Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites.
Topics: 5-Methylcytosine; DNA; Genomics; Nucleic Acid Amplification Techniques | 2019 |
Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cadaver; Case-Control Studies; Cyclic AMP Response Element-Binding Protein; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Multiple Sclerosis; Neurons; Phosphorylation; Sequence Analysis, DNA; Signal Transduction; White Matter | 2019 |
Decreased global DNA hydroxymethylation in neural tube defects: Association with polycyclic aromatic hydrocarbons.
Topics: 5-Methylcytosine; Animals; Case-Control Studies; Disease Models, Animal; Embryo Culture Techniques; Female; Humans; Linear Models; Liver; Male; Maternal Exposure; Mice; Neural Tube Defects; Polycyclic Aromatic Hydrocarbons; Pregnancy; Superoxide Dismutase | 2019 |
Statistical methods for classification of 5hmC levels based on the Illumina Inifinium HumanMethylation450 (450k) array data, under the paired bisulfite (BS) and oxidative bisulfite (oxBS) treatment.
Topics: 5-Methylcytosine; Case-Control Studies; DNA Methylation; Humans; Neoplasms; Oxidation-Reduction; Sulfites | 2019 |
Certain and uncertain malignant potential in melanocytic skin neoplasms.
Topics: 5-Methylcytosine; Biomarkers; Humans; Nevus, Pigmented; Skin Neoplasms | 2019 |
5-Hydroxymethylcytosine as a clinical biomarker: Fluorescence-based assay for high-throughput epigenetic quantification in human tissues.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Cost-Benefit Analysis; Epigenesis, Genetic; Fluorescence; High-Throughput Screening Assays; Humans; Mice; Neoplasms; Proof of Concept Study | 2020 |
Epigenetic downregulation of TET3 reduces genome-wide 5hmC levels and promotes glioblastoma tumorigenesis.
Topics: 5-Methylcytosine; Animals; Biopsy; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Dioxygenases; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Code; Humans; Mice; Prognosis; RNA, Messenger; Survival Analysis; Xenograft Model Antitumor Assays | 2020 |
5-Methylcytosine is Oxidized to the Natural Metabolites of TET Enzymes by a Biomimetic Iron(IV)-Oxo Complex.
Topics: 5-Methylcytosine; Biomimetic Materials; Cerium; Coordination Complexes; Cytosine; Dioxygenases; Epigenesis, Genetic; Iron; Kinetics; Oxidation-Reduction; Thermodynamics | 2019 |
Altered expression of epigenetic regulators and imprinted genes in human placenta and fetal tissues from second trimester spontaneous pregnancy losses.
Topics: 5-Methylcytosine; Aborted Fetus; Abortion, Spontaneous; Adult; Cyclin-Dependent Kinase Inhibitor p57; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Placenta; Pregnancy; Pregnancy Trimester, Second; Proto-Oncogene Proteins; RNA, Long Noncoding | 2019 |
Library Preparation for Multiplexed Reduced Representation Bisulfite Sequencing with a Universal Adapter.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; DNA Primers; Gene Library; Rats; Sequence Analysis, DNA; Sulfites | 2019 |
MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Leukemic; Humans; Mice; Mice, Transgenic; Mixed Function Oxygenases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc | 2019 |
Crosslink and shield: protecting abasic sites from error-prone repair.
Topics: 5-Methylcytosine; DNA Repair; DNA-Binding Proteins; DNA, Single-Stranded; Escherichia coli; Escherichia coli Proteins; Humans; Models, Molecular | 2019 |
Characterization of DNA hydroxymethylation profile in cervical cancer.
Topics: 5-Methylcytosine; Adult; DNA Methylation; Female; Genomics; Humans; Transcription, Genetic; Uterine Cervical Neoplasms | 2019 |
Testes and duct deferens of mice during space flight: cytoskeleton structure, sperm-specific proteins and epigenetic events.
Topics: 5-Methylcytosine; Animals; Cytoskeletal Proteins; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Histone Deacetylase 1; Histone Deacetylases; Male; Mice; Organ Specificity; Proto-Oncogene Proteins; Space Flight; Testis; Vas Deferens | 2019 |
Regulation of DNA methylation levels in the process of oral mucosal regeneration in a rat oral ulcer model.
Topics: 5-Methylcytosine; Animals; Cell Proliferation; Disease Models, Animal; DNA Methylation; Epithelial Cells; Gene Expression Regulation; Immunohistochemistry; Ligands; Male; Mouth Mucosa; Oral Ulcer; Rats; Rats, Wistar; Regeneration; Wnt-5a Protein | 2020 |
The clinical values of dysregulated DNA methylation and demethylation intermediates in acute lymphoblastic leukemia.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Area Under Curve; Biomarkers, Tumor; Cell Lineage; Child; Cytosine; Demethylation; DNA Methylation; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; ROC Curve; Young Adult | 2019 |
Induction of DNA Hydroxymethylation Protects the Brain After Stroke.
Topics: 5-Methylcytosine; Age Factors; Animals; Brain; DNA; DNA-Binding Proteins; Epigenesis, Genetic; Infarction, Middle Cerebral Artery; Male; Mice; Proto-Oncogene Proteins; Stroke | 2019 |
Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell-Free Nucleic Acids; DNA, Neoplasm; Early Detection of Cancer; Female; Genome-Wide Association Study; Humans; Liver Neoplasms; Male; Middle Aged; Prospective Studies; ROC Curve | 2019 |
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication.
Topics: 5-Methylcytosine; Cell Cycle; Cell Division; Cell Proliferation; DNA Replication; HeLa Cells; Humans; Replication Origin | 2019 |
Vitamin C effects on 5-hydroxymethylcytosine and gene expression in osteoblasts and chondrocytes: Potential involvement of PHD2.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Cell Differentiation; Cells, Cultured; Chondrocytes; Gene Expression; Hypoxia-Inducible Factor-Proline Dioxygenases; Mice; Osteoblasts | 2019 |
New warning signs on the road: 5-hydroxymethylcytosine-based liquid biopsy for the early detection of hepatocellular carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cell-Free Nucleic Acids; Humans; Liquid Biopsy; Liver Neoplasms | 2019 |
Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; DNA-Directed DNA Polymerase; Epigenomics; Genome; Humans; Mice; Oxides; Polymerase Chain Reaction; Polymerization; Rats | 2019 |
The effects of TETs on DNA methylation and hydroxymethylation of mouse oocytes after vitrification and warming.
Topics: 5-Methylcytosine; Amino Acids, Dicarboxylic; Animals; Ascorbic Acid; Cryopreservation; Cryoprotective Agents; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo Research; Female; Gene Expression; Mice; Oocytes; Proto-Oncogene Proteins; Vitrification | 2019 |
TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.
Topics: 5-Methylcytosine; Animals; Dioxygenases; DNA Demethylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Developmental; Gonads; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sex Determination Processes; Sex-Determining Region Y Protein; Steroidogenic Factor 1 | 2019 |
Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cell-Free Nucleic Acids; Humans; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Prognosis; Prospective Studies; Young Adult | 2019 |
5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers; Cell-Free Nucleic Acids; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Male; Middle Aged; Risk Factors | 2019 |
5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns.
Topics: 5-Methylcytosine; Biomarkers; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Fetal Blood; Humans; Infant, Newborn; Male; Sex Factors | 2019 |
Co-Localization of DNA i-Motif-Forming Sequences and 5-Hydroxymethyl-cytosines in Human Embryonic Stem Cells.
Topics: 5-Methylcytosine; Base Composition; Cell Differentiation; Cell Proliferation; CpG Islands; DNA Methylation; Epigenesis, Genetic; G-Quadruplexes; Human Embryonic Stem Cells; Humans; Nanostructures; Nucleic Acid Conformation; Nucleotide Motifs; Transcription Initiation Site | 2019 |
Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice.
Topics: 5-Methylcytosine; Amyotrophic Lateral Sclerosis; Animals; Bacteria; Brain; Disease Progression; Epigenome; Feces; Female; Gastrointestinal Microbiome; Immune System; Inflammation; Leukocytes; Male; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells; Phenotype; Phylogeny; Superoxide Dismutase-1; Time Factors | 2019 |
The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice.
Topics: 5-Methylcytosine; Age Factors; Animals; Brain; Brain Chemistry; Cell Line; Cells, Cultured; DNA Methylation; Epigenesis, Genetic; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Neural Stem Cells | 2019 |
Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells.
Topics: 5-Methylcytosine; Benzhydryl Compounds; Cell Line, Tumor; Cyclin D2; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylation; Down-Regulation; Endocrine Disruptors; Epigenesis, Genetic; Gene Expression; Histone Code; Humans; Male; PC-3 Cells; Phenols; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Processing, Post-Translational; Tissue Inhibitor of Metalloproteinase-3; Tumor Suppressor Proteins | 2019 |
Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis.
Topics: 5-Methylcytosine; Adult; Allergens; Antigens, Dermatophagoides; Cell Differentiation; Dendritic Cells; Female; Humans; Leukocytes, Mononuclear; Male; Mixed Function Oxygenases; Monocytes; Proto-Oncogene Proteins; Rhinitis, Allergic | 2019 |
Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences.
Topics: 5-Methylcytosine; Animals; Calcium-Binding Proteins; CpG Islands; Cyclin-Dependent Kinase Inhibitor p57; DNA Methylation; Embryo, Mammalian; Genetic Loci; Genomic Imprinting; Liver; Mice; Mice, Inbred C57BL; RNA, Long Noncoding; snRNP Core Proteins | 2019 |
Tet3 regulates cellular identity and DNA methylation in neural progenitor cells.
Topics: 5-Methylcytosine; Animals; Apoptosis Regulatory Proteins; Brain; Cell Differentiation; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Knockdown Techniques; Genomic Imprinting; Humans; Mice; Mouse Embryonic Stem Cells; Neural Stem Cells; Neurogenesis; Neurons; Promoter Regions, Genetic; RNA-Binding Proteins | 2020 |
Are the 5-hydroxymethylcytosine-based wd-scores really superior over α-fetoprotein for the early diagnosis of hepatocellular carcinoma?
Topics: 5-Methylcytosine; alpha-Fetoproteins; Carcinoma, Hepatocellular; Cell-Free Nucleic Acids; Early Diagnosis; Humans; Liver Cirrhosis; Liver Neoplasms | 2020 |
Altered 5-Hydroxymethylcytosine Landscape in Primary Gastric Adenocarcinoma.
Topics: 5-Methylcytosine; Adenocarcinoma; Case-Control Studies; DNA Methylation; Epigenesis, Genetic; Genome, Human; Humans; Stomach Neoplasms | 2019 |
Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Cerebellum; CpG Islands; D-Amino-Acid Oxidase; D-Aspartic Acid; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Developmental; High-Throughput Nucleotide Sequencing; Male; Mice; Sequence Analysis, DNA; Serine; Single Molecule Imaging; Transcriptional Activation | 2019 |
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Topics: 5-Methylcytosine; Animals; Cancer-Associated Fibroblasts; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Reprogramming; DNA Methylation; Epigenesis, Genetic; Humans; Ketoglutaric Acids; Lactic Acid; Mesenchymal Stem Cells; Mice; Neoplasm Invasiveness; Pancreatic Neoplasms; Receptors, CXCR4; Stromal Cells; Transcriptome | 2019 |
Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells.
Topics: 5-Methylcytosine; Ascorbic Acid; Cell Line; Epigenesis, Genetic; Genes, Reporter; Germ Cells; Human Embryonic Stem Cells; Humans; Positive Regulatory Domain I-Binding Factor 1 | 2019 |
Highly sensitive quantification of site-specific 5-hydroxymethylcytosine at single-base resolution by HpaII-mediated ligation PCR.
Topics: 5-Methylcytosine; DNA; Humans; Polymerase Chain Reaction | 2019 |
Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood.
Topics: 5-Methylcytosine; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Brain Chemistry; Disease Progression; DNA Methylation; Epigenesis, Genetic; Female; Humans; Intracellular Signaling Peptides and Proteins; Male; Oxytocin; Receptors, Nicotinic; Temporal Lobe | 2019 |
Epigenetic modification of cytosines fine tunes the stability of i-motif DNA.
Topics: 5-Methylcytosine; Cell Line; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Hydrogen-Ion Concentration; MCF-7 Cells; Nucleotide Motifs | 2020 |
Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA, Protozoan; Epigenesis, Genetic; Erythrocytes; Genome, Protozoan; High-Throughput Nucleotide Sequencing; Humans; Hydroxylation; Plasmodium falciparum; RNA, Messenger | 2020 |
Electrochemiluminescence biosensor for DNA hydroxymethylation detection based on enzyme-catalytic covalent bonding reaction of -CH
Topics: 5-Methylcytosine; Animals; Biosensing Techniques; Cell Line; Chick Embryo; DNA Methylation; Electrochemical Techniques; Luminescent Measurements; Magnetite Nanoparticles; Oryza; Sulfhydryl Compounds | 2020 |
Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cyclin-Dependent Kinase 5; Cytidine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Histones; Mice; Mice, Knockout; Mouse Embryonic Stem Cells; Nerve Tissue Proteins; Neurogenesis; Neurons; Phosphorylation; POU Domain Factors; Promoter Regions, Genetic | 2020 |
Ethnicity-specific and overlapping alterations of brain hydroxymethylome in Alzheimer's disease.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Basic Helix-Loop-Helix Transcription Factors; Brain; Computational Biology; DNA Methylation; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; RNA-Seq | 2020 |
5hmC-MIQuant: Ultrasensitive Quantitative Detection of 5-Hydroxymethylcytosine in Low-Input Cell-Free DNA Samples.
Topics: 5-Methylcytosine; Animals; Cell Line; Cell-Free Nucleic Acids; Humans; Male; Mice; Rats | 2020 |
Vitamin C treatment of embryos, but not donor cells, improves the cloned embryonic development in sheep.
Topics: 5-Methylcytosine; Animals; Antioxidants; Ascorbic Acid; Blastocyst; Cloning, Organism; Culture Media; DNA Methylation; Embryonic Development; Fibroblasts; Male; Nuclear Transfer Techniques; Sheep | 2020 |
Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Genetic Loci; Humans; Mammary Glands, Human; Middle Aged; Transcriptome | 2020 |
Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome.
Topics: 5-Methylcytosine; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome, Plant; Mass Spectrometry; Norway; Picea | 2019 |
5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Topics: 5-Methylcytosine; Adolescent; Adult; Biomarkers, Tumor; Cell-Free Nucleic Acids; Child; Child, Preschool; DNA Methylation; Epigenomics; Female; Humans; Infant; Infant, Newborn; Male; Neoplasm Metastasis; Neuroblastoma; Prognosis; Young Adult | 2020 |
Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors.
Topics: 5-Methylcytosine; Amino Acid Sequence; Crystallography, X-Ray; DNA; Protein Binding; Protein Structure, Secondary; Repetitive Sequences, Amino Acid; Transcription Activator-Like Effectors | 2020 |
Values of 5mC, 5hmC, and TET2 for identifying the presence and progression of breast precancerous lesion.
Topics: 5-Methylcytosine; Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Dioxygenases; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Middle Aged; Precancerous Conditions; Proto-Oncogene Proteins; Receptor, ErbB-2 | 2020 |
Reply to 'Are the 5-hydroxymethylcytosine-based wd-scores really superior over α-fetoprotein for the early diagnosis of hepatocellular carcinoma?'
Topics: 5-Methylcytosine; alpha-Fetoproteins; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell-Free Nucleic Acids; Early Diagnosis; Humans; Liver Neoplasms | 2020 |
Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver.
Topics: 5-Methylcytosine; Adenosine; AlkB Homolog 5, RNA Demethylase; Animals; Animals, Newborn; Embryo, Mammalian; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Guanosine; Liver; Male; Methyltransferases; Mice; Pseudouridine; RNA Helicases; RNA Processing, Post-Transcriptional; RNA-Seq; RNA, Messenger | 2019 |
Downregulation of the DNA 5-hydroxymethylcytosine is involved in mitochondrial dysfunction and neuronal impairment in high fat diet-induced diabetic mice.
Topics: 5-Methylcytosine; Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; DNA; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Mice; Mitochondria; Proto-Oncogene Proteins | 2020 |
High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
Topics: 5-Methylcytosine; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Ascorbic Acid; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Drug Synergism; Female; Granzymes; Immunotherapy; Lymphoma; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Tumor Microenvironment | 2020 |
Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.
Topics: 5-Methylcytosine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Differentiation; Cognitive Dysfunction; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Gene Expression Regulation; Hippocampus; Histone Deacetylase 1; Humans; Learning; Mice; Mice, Transgenic; Neural Stem Cells; Proto-Oncogene Proteins; RNA-Seq | 2020 |
5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation.
Topics: 5-Methylcytosine; Adult Stem Cells; Animals; Cell Differentiation; Intestines; Mice | 2020 |
5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease.
Topics: 5-Methylcytosine; Adult; Aged; Biomarkers; Cell-Free Nucleic Acids; Coronary Artery Disease; DNA; Female; Humans; Male; Middle Aged; Myocardial Infarction | 2020 |
Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding.
Topics: 5-Methylcytosine; Breast Neoplasms; Cell Line, Tumor; DNA; Epigenesis, Genetic; Female; Humans; Hydrogels; Microfluidics; Neoplasm Invasiveness; Pentoxyl; Single-Cell Analysis | 2020 |
Characterization of global 5-hydroxymethylcytosine in pediatric posterior fossa ependymoma.
Topics: 5-Methylcytosine; Adolescent; Brain Neoplasms; Carcinogenesis; Case-Control Studies; Cell Proliferation; Child; Child, Preschool; DNA Methylation; Ependymoma; Epigenomics; Female; Humans; Infant; Infratentorial Neoplasms; Ki-67 Antigen; Male; Prognosis; Proportional Hazards Models | 2020 |
Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers.
Topics: 5-Methylcytosine; Adult; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Female; Humans; Long Interspersed Nucleotide Elements; Male; Middle Aged; Tobacco Smoking; Vaping | 2020 |
Genome-wide characterization of 5-hydoxymethylcytosine in melanoma reveals major differences with nevus.
Topics: 5-Methylcytosine; 5' Untranslated Regions; Adult; Biomarkers, Tumor; CpG Islands; DNA Methylation; Female; Humans; Male; Melanoma; Middle Aged; Nevus | 2020 |
Selective targeting of TET catalytic domain promotes somatic cell reprogramming.
Topics: 5-Methylcytosine; Catalytic Domain; Cell Line; Cellular Reprogramming; Dioxygenases; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins | 2020 |
Alterations in 5hmC level and genomic distribution in aging-related epigenetic drift in human adipose stem cells.
Topics: 5-Methylcytosine; Adipose Tissue; Aging; Binding Sites; Cellular Senescence; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation; Genetic Drift; Humans; Protein Binding; Stem Cells | 2020 |
TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson's disease.
Topics: 5-Methylcytosine; Animals; Cyclin-Dependent Kinase Inhibitor p16; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Dopaminergic Neurons; Epigenesis, Genetic; Humans; Male; Mesencephalon; Mice; Parkinson Disease; Proto-Oncogene Proteins | 2020 |
Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Topics: 5-Methylcytosine; Adipocytes; Animals; Antineoplastic Agents; Biphenyl Compounds; Carboplatin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clustered Regularly Interspaced Short Palindromic Repeats; Coculture Techniques; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Fatty Acid-Binding Proteins; Female; Gene Knockdown Techniques; Heterografts; Humans; Lipid Metabolism; Lipidomics; Mass Spectrometry; Metabolomics; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Proteins; Omentum; Ovarian Neoplasms; Protein Array Analysis; Proteomics; Pyrazoles; Tumor Burden; Up-Regulation | 2020 |
Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Computational Biology; CpG Islands; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Genetic Loci; Genetic Predisposition to Disease; Humans; Lung Neoplasms | 2020 |
UHRF1-repressed 5'-hydroxymethylcytosine is essential for the male meiotic prophase I.
Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Proteins; Cell Line; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Fertility; Infertility, Male; Male; Meiotic Prophase I; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; RNA Polymerase II; Signal Transduction; Spermatocytes; Spermatogenesis; Testis; Transcriptional Activation; Ubiquitin-Protein Ligases | 2020 |
Peroxotungstate oxidation-mediated two-phase amplification system (POM-TPAS) for bisulfite-free quantification of locus-specific 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; DNA; Epoxy Compounds; Humans; Oxidation-Reduction; Tungsten Compounds | 2020 |
Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function.
Topics: 5-Methylcytosine; Animals; Binding Sites; DNA; DNA Cleavage; DNA, Cruciform; Endodeoxyribonucleases; Mice; Models, Molecular; Substrate Specificity | 2020 |
Aberrant hydroxymethylation of
Topics: 5-Methylcytosine; Adult; Angiopoietin-Like Protein 4; Apoptosis; Cell Hypoxia; Cell Line; Cell Movement; DNA Methylation; Female; Fetal Growth Retardation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Placenta; Pregnancy; Pregnancy, Twin; Promoter Regions, Genetic; Trophoblasts | 2020 |
Accurate targeted long-read DNA methylation and hydroxymethylation sequencing with TAPS.
Topics: 5-Methylcytosine; Animals; Boron Compounds; Cells, Cultured; DNA; DNA Methylation; Hep G2 Cells; Humans; Mice; Mixed Function Oxygenases; Nanopore Sequencing; Oxidation-Reduction; Proto-Oncogene Proteins; Pyridines; Sequence Analysis, DNA | 2020 |
Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Brain; Case-Control Studies; DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Flow Cytometry; HLA Antigens; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Male; Middle Aged; Monocytes; Multiple System Atrophy; Prefrontal Cortex; T-Lymphocytes; Transcriptome; Ubiquitin-Protein Ligases | 2020 |
Induction of DEAD Box helicase 5 in early adipogenesis is regulated by Ten-eleven translocation 2.
Topics: 3T3-L1 Cells; 5-Methylcytosine; Adipogenesis; Animals; DEAD-box RNA Helicases; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Mice; Proto-Oncogene Proteins | 2020 |
Combined 5-hydroxymethylcytosine content of human leucocyte antigen-B and human leucocyte antigen-DQB1 as novel biomarker for anti-tuberculosis drug-induced liver injury.
Topics: 5-Methylcytosine; Adult; Antitubercular Agents; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver Injury; DNA Methylation; Female; Genetic Predisposition to Disease; HLA-B Antigens; HLA-DQ beta-Chains; Humans; Male; Middle Aged; Tuberculosis | 2020 |
Demethylation Status of Somatic DNA Extracted From Pituitary Neuroendocrine Tumors Indicates Proliferative Behavior.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Case-Control Studies; Cell Proliferation; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Epigenesis, Genetic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroendocrine Tumors; Pituitary Neoplasms; Prognosis; Proto-Oncogene Proteins; Ubiquitin-Protein Ligases; Young Adult | 2020 |
TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.
Topics: 5-Methylcytosine; Adult; Aged; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line; Cell Line, Tumor; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genome, Human; Humans; Male; Mesoderm; Mice, Nude; Middle Aged; Mutation; Neoplasm Metastasis; Phenotype; Polycomb Repressive Complex 2; Proto-Oncogene Proteins; Succinate Dehydrogenase | 2020 |
Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Domestication; Epigenesis, Genetic; Fish Proteins; Muscle, Skeletal; Selective Breeding; Tilapia | 2020 |
Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing.
Topics: 5-Methylcytosine; Acetylation; Animals; Bacteriophage lambda; Cell Line; DNA Methylation; Embryonic Stem Cells; Genome; Histones; Lysine; Mice; Oligonucleotides; Reproducibility of Results; Sequence Analysis, DNA; Sulfites | 2020 |
Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Chromatin; DNA-Binding Proteins; Gene Expression Regulation; Gene Knockout Techniques; Mice; Mouse Embryonic Stem Cells; Neurogenesis; Proto-Oncogene Proteins; RNA-Binding Proteins; RNA-Seq; Transcription, Genetic | 2020 |
DNA demethylation is a driver for chick retina regeneration.
Topics: 5-Methylcytosine; Animals; Avian Proteins; Chick Embryo; Chromatin; Cytosine; Dioxygenases; DNA Methylation; Fibroblast Growth Factor 2; Histone Code; Regeneration; Retinal Pigment Epithelium | 2020 |
PHLPP2 is a novel biomarker and epigenetic target for the treatment of vitamin C in pancreatic cancer.
Topics: 5-Methylcytosine; Ascorbic Acid; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Phosphoprotein Phosphatases; Prognosis; Promoter Regions, Genetic; Sodium-Coupled Vitamin C Transporters; Survival Analysis; Up-Regulation | 2020 |
TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes.
Topics: 5-Methylcytosine; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p16; Cytokines; Dioxygenases; DNA Methylation; DNA-Binding Proteins; HaCaT Cells; Humans; Inflammation; Inflammation Mediators; Keratinocytes; Proto-Oncogene Proteins; RNA, Messenger | 2020 |
Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons.
Topics: 5-Methylcytosine; Adult; Aged; Ascorbic Acid; Cell Differentiation; Cell Line; Cell Lineage; Chromatin Assembly and Disassembly; Dioxygenases; DNA-Binding Proteins; Dopamine; Dopaminergic Neurons; Epigenesis, Genetic; Humans; Induced Pluripotent Stem Cells; Mesencephalon; Middle Aged; Models, Biological; Proto-Oncogene Proteins | 2020 |
TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia.
Topics: 5-Methylcytosine; Animals; Dioxygenases; DNA Methylation; Female; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Ischemia; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering | 2021 |
Genome-wide 5-hydroxymethylcytosine (5hmC) emerges at early stage of in vitro differentiation of a putative hepatocyte progenitor.
Topics: 5-Methylcytosine; Cell Differentiation; DNA Demethylation; DNA Methylation; Gene Expression Regulation, Developmental; Genome; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Stem Cells | 2020 |
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Dioxygenases; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Jumonji Domain-Containing Histone Demethylases; Mice, Inbred C57BL; Neurogenesis; Promoter Regions, Genetic; Up-Regulation | 2021 |
Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation.
Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Axons; Contusions; Dioxygenases; Epigenesis, Genetic; Female; Motor Cortex; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries | 2020 |
HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation.
Topics: 5-Methylcytosine; Cell Line; Cell Nucleus; Chromatin; Cytidine Deaminase; Deamination; DNA Breaks, Double-Stranded; DNA Replication; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; DNA-Directed DNA Polymerase; DNA, Single-Stranded; Endonucleases; Humans; Multifunctional Enzymes; Proteins; RNA Interference; RNA, Small Interfering; Uracil; Uracil-DNA Glycosidase | 2020 |
Characteristics of iron status, oxidation response, and DNA methylation profile in response to occupational iron oxide nanoparticles exposure.
Topics: 5-Methylcytosine; Adult; Cross-Sectional Studies; DNA Methylation; Female; Ferric Compounds; Humans; Iron; Male; Metal Nanoparticles; Middle Aged; Occupational Exposure | 2020 |
Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells.
Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Movement; DNA Methylation; HEK293 Cells; Humans; Male; Mixed Function Oxygenases; Neoplasm Invasiveness; PC-3 Cells; Prostatic Neoplasms; Proto-Oncogene Proteins; Resveratrol; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Up-Regulation | 2020 |
DNA methylation and hydroxymethylation have distinct genome-wide profiles related to axonal regeneration.
Topics: 5-Methylcytosine; Animals; Axons; DNA Methylation; Epigenesis, Genetic; Female; Male; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Transcriptome | 2021 |
MicroRNA22-5p targets ten-eleven translocation and regulates estrogen receptor 2 expression in infertile women with minimal/mild endometriosis during implantation window.
Topics: 3' Untranslated Regions; 5-Methylcytosine; Adult; Cells, Cultured; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo Implantation; Endometriosis; Endometrium; Estrogen Receptor beta; Female; Gene Expression Regulation; Genes, Reporter; Humans; Infertility, Female; Luteal Phase; MicroRNAs; Promoter Regions, Genetic; Protein Transport; Proto-Oncogene Proteins; Stromal Cells; Young Adult | 2020 |
Diminished expression of 5hmc in Reed-Sternberg cells in classical Hodgkin lymphoma is a common epigenetic marker.
Topics: 5-Methylcytosine; Biomarkers; DNA Methylation; Epigenesis, Genetic; Hodgkin Disease; Humans; Reed-Sternberg Cells | 2020 |
Integrated epigenetic biomarkers in circulating cell-free DNA as a robust classifier for pancreatic cancer.
Topics: 5-Methylcytosine; Adenocarcinoma; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell-Free Nucleic Acids; Epigenesis, Genetic; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms; Reproducibility of Results; Sensitivity and Specificity | 2020 |
Epigenetic marker expression is of limited diagnostic utility in spitzoid melanocytic neoplasms.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Diagnosis, Differential; Epigenesis, Genetic; Female; Humans; Male; Melanoma; Nevus, Epithelioid and Spindle Cell; Skin Neoplasms | 2020 |
In silico structural analysis of sequences containing 5-hydroxymethylcytosine reveals its potential as binding regulator for development, ageing and cancer-related transcription factors.
Topics: 5-Methylcytosine; Aging; DNA Methylation; G-Quadruplexes; Humans; Neoplasms; Transcription Factors | 2021 |
Quantitative analysis of global 5-methyl- and 5-hydroxymethylcytosine in TET1 expressed HEK293T cells.
Topics: 5-Methylcytosine; Animals; Biosensing Techniques; Cytosine; DNA Methylation; HEK293 Cells; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins | 2020 |
Changes in DNA 5-Hydroxymethylcytosine Levels and the Underlying Mechanism in Non-functioning Pituitary Adenomas.
Topics: 5-Methylcytosine; Adenoma; Dioxygenases; DNA; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Pituitary Neoplasms; Proto-Oncogene Proteins | 2020 |
A Comparative Study on 5hmC Targeting Regulation of Neurons in AD Mice by Several Natural Compounds.
Topics: 5-Methylcytosine; Alzheimer Disease; Animals; Cell Line, Tumor; Deoxyadenosines; Disease Models, Animal; Humans; Mice; Mice, Mutant Strains; Neurons; Resveratrol | 2020 |
Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS).
Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Hydrolysis; Tandem Mass Spectrometry; Zebrafish | 2021 |
Immunohistochemical Detection of Modified Cytosine Bases in Rodent Brain.
Topics: 5-Methylcytosine; Animals; Antibodies; Brain; Cell Nucleus; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Immunohistochemistry; Mice; Peroxidase; Rats; Rodentia | 2021 |
Immunohistochemical Detection of 5-Hydroxymethylcytosine and 5-Carboxylcytosine in Sections of Zebrafish Embryos.
Topics: 5-Methylcytosine; Animals; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Embryo, Nonmammalian; Immunohistochemistry; Zebrafish | 2021 |
Immunochemical Detection of Modified Species of Cytosine in Plant Tissues.
Topics: 5-Methylcytosine; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Dyes; Immunohistochemistry; Plants | 2021 |
Antigen Retrieval for Immunostaining of Modified Cytosine Species.
Topics: 5-Methylcytosine; Animals; Antibodies; Antigens; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Antibody Technique; Humans | 2021 |
Analysis of 5-Hydroxymethyluracil Levels Using Flow Cytometry.
Topics: 5-Methylcytosine; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Flow Cytometry; Humans; Oxidation-Reduction; Pentoxyl; Single-Cell Analysis; Tandem Mass Spectrometry; Thymine | 2021 |
Analysis of 5-Carboxylcytosine Distribution Using DNA Immunoprecipitation.
Topics: 5-Methylcytosine; Animals; Chromatin Immunoprecipitation; Cytosine; DNA; DNA Methylation; Humans; Immunoprecipitation | 2021 |
High-Resolution Analysis of 5-Hydroxymethylcytosine by TET-Assisted Bisulfite Sequencing.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Genome; Humans; Oxidation-Reduction; Sequence Analysis, DNA; Sulfites | 2021 |
Oxidative Bisulfite Sequencing: An Experimental and Computational Protocol.
Topics: 5-Methylcytosine; Animals; Computational Biology; Cytosine; Dioxygenases; DNA; DNA Methylation; High-Throughput Nucleotide Sequencing; Humans; Oxidation-Reduction; Oxidative Stress; Sequence Analysis, DNA; Sulfites | 2021 |
Bisulfite-Free Sequencing of 5-Hydroxymethylcytosine with APOBEC-Coupled Epigenetic Sequencing (ACE-Seq).
Topics: 5-Methylcytosine; Animals; Computational Biology; Cytidine Deaminase; Cytosine; DNA; DNA Methylation; Epigenomics; Humans; Proteins; Sequence Analysis, DNA; Single Molecule Imaging; Sulfites | 2021 |
Analyzing DNA-Immunoprecipitation Sequencing Data.
Topics: 5-Methylcytosine; Animals; Computational Biology; CpG Islands; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Genome; High-Throughput Nucleotide Sequencing; Humans; Immunoprecipitation; Reproducibility of Results; Sequence Analysis, DNA | 2021 |
Integrated Analysis of DNA Methylation, Hydroxymethylation, and Gene Expression Data Using ME-Class2.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression; Gene Silencing; Genome; Genomics; Humans; Machine Learning; Sequence Analysis, DNA | 2021 |
bZIP Dimers CREB1, ATF2, Zta, ATF3|cJun, and cFos|cJun Prefer to Bind to Some Double-Stranded DNA Sequences Containing 5-Formylcytosine and 5-Carboxylcytosine.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Basic-Leucine Zipper Transcription Factors; Cytosine; DNA; Mice; Protein Array Analysis; Protein Binding | 2020 |
Role of TET1 and 5hmC in an Obesity-Linked Pathway Driving Cancer Stem Cells in Triple-Negative Breast Cancer.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Diet, High-Fat; Disease Models, Animal; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Mice; Mixed Function Oxygenases; Neoplastic Stem Cells; Obesity; Proto-Oncogene Proteins; Serine-Arginine Splicing Factors; Triple Negative Breast Neoplasms | 2020 |
Mapping 5-Hydroxymethylcytosine (5hmC) Modifications in Skeletal Tissues Using High-Throughput Sequencing.
Topics: 5-Methylcytosine; Animals; DNA; DNA Methylation; High-Throughput Nucleotide Sequencing; Humans; Muscle, Skeletal | 2021 |
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation.
Topics: 5-Methylcytosine; Animals; Antibody Specificity; Base Sequence; Cell Differentiation; Dioxygenases; DNA-Binding Proteins; Embryoid Bodies; Mice; Models, Biological; Mouse Embryonic Stem Cells; Pluripotent Stem Cells; Protein Binding; Proto-Oncogene Proteins; RNA; RNA Stability; RNA, Messenger; Transcriptome | 2020 |
PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
Topics: 5-Methylcytosine; Animals; Binding Sites; DNA Breaks, Double-Stranded; DNA Helicases; Endodeoxyribonucleases; HeLa Cells; Histone-Lysine N-Methyltransferase; Homologous Recombination; Humans; Male; Mice; Mice, Knockout; Proteomics; Spermatocytes; Testis | 2020 |
Neonatal Sevoflurane Exposure Impairs Learning and Memory by the Hypermethylation of Hippocampal Synaptic Genes.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Cognition; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Hippocampus; Memory; Models, Biological; Rats, Sprague-Dawley; Sevoflurane; Spatial Memory; Synapses | 2021 |
Loss of 5-Hydroxymethylcytosine is an Epigenetic Hallmark of Thyroid Carcinomas with TERT Promoter Mutations.
Topics: 5-Methylcytosine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Mutation; Promoter Regions, Genetic; Telomerase; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2020 |
Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease.
Topics: 5-Methylcytosine; Alzheimer Disease; Animals; Astrocytes; Brain; Cell Line; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epigenomics; Genome; HEK293 Cells; Humans; Mice; Neurodegenerative Diseases; Neurons | 2020 |
Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA.
Topics: 5-Methylcytosine; Adult; Biomarkers, Tumor; Cell-Free Nucleic Acids; Cohort Studies; DNA-Binding Proteins; Female; GATA4 Transcription Factor; Homeodomain Proteins; Humans; Male; Middle Aged; Neoplasm Staging; Nuclear Proteins; Pancreatic Neoplasms; TEA Domain Transcription Factors; Transcription Factors; Tumor Suppressor Proteins | 2020 |
Identification of fetal unmodified and 5-hydroxymethylated CG sites in maternal cell-free DNA for non-invasive prenatal testing.
Topics: 5-Methylcytosine; Adult; Cell-Free Nucleic Acids; DNA Methylation; Down Syndrome; Epigenomics; Female; Fetal Diseases; Fetus; Genetic Testing; High-Throughput Nucleotide Sequencing; Humans; Male; Placenta; Pregnancy; Prenatal Diagnosis; Sensitivity and Specificity; Sequence Analysis, DNA; Trisomy | 2020 |
5-Hydroxymethylcytosine signature in circulating cell-free DNA as a potential diagnostic factor for early-stage colorectal cancer and precancerous adenoma.
Topics: 5-Methylcytosine; Adenoma; Adult; Aged; Cell-Free Nucleic Acids; Cluster Analysis; Colorectal Neoplasms; DNA, Neoplasm; Female; Genome, Human; Humans; Male; Middle Aged; Molecular Sequence Annotation; Neoplasm Staging; Precancerous Conditions | 2021 |
Pairwise Proximity-Differentiated Visualization of Single-Cell DNA Epigenetic Marks.
Topics: 5-Methylcytosine; Cell Line; Chromatin; Cytosine; DNA; Humans; Molecular Structure; Single-Cell Analysis | 2021 |
DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma.
Topics: 5-Methylcytosine; Chromatin; Cyclin D1; Cyclin D2; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Gene Expression Regulation, Neoplastic; Genome; Histone-Lysine N-Methyltransferase; Humans; Male; Middle Aged; Multiple Myeloma; Phenotype; Proto-Oncogene Proteins c-myc; Regulatory Sequences, Nucleic Acid; Repressor Proteins; Severity of Illness Index | 2020 |
Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia.
Topics: 5-Methylcytosine; Animals; Cytidine Deaminase; DNA (Cytosine-5-)-Methyltransferase 1; Down-Regulation; Female; Humans; Mice, Inbred C57BL; Minor Histocompatibility Antigens; Mixed Function Oxygenases; Proto-Oncogene Proteins; Tumor Suppressor Protein p53; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2020 |
Photocaged 5-(Hydroxymethyl)pyrimidine Nucleoside Phosphoramidites for Specific Photoactivatable Epigenetic Labeling of DNA.
Topics: 5-Methylcytosine; Deoxycytidine; DNA; Epigenesis, Genetic; Epigenomics; Molecular Structure; Oligonucleotides; Organophosphorus Compounds; Pyrimidine Nucleosides; Uracil; Uridine | 2020 |
Perinatal protein malnutrition results in genome-wide disruptions of 5-hydroxymethylcytosine at regions that can be restored to control levels by an enriched environment.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenesis, Genetic; Female; Male; Malnutrition; Mice | 2021 |
Effects of caffeic acid on epigenetics in the brain of rats with chronic unpredictable mild stress.
Topics: 5-Methylcytosine; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Caffeic Acids; Catechol O-Methyltransferase; Depression; Depressive Disorder, Major; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epigenomics; Hippocampus; Male; Prefrontal Cortex; Rats; Rats, Wistar; Stress, Psychological | 2020 |
5-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers.
Topics: 5-Methylcytosine; Cell Movement; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Head and Neck Neoplasms; Humans; Intercellular Junctions; Keratinocytes; Male; Middle Aged; Papillomaviridae; Papillomavirus Infections; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck | 2020 |
Alterations of 5-hydroxymethylcytosines in circulating cell-free DNA reflect retinopathy in type 2 diabetes.
Topics: 5-Methylcytosine; Adult; Aged; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell-Free Nucleic Acids; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans; Immunoglobulins; Male; Middle Aged; RNA, Long Noncoding | 2021 |
TET2 chemically modifies tRNAs and regulates tRNA fragment levels.
Topics: 5-Methylcytosine; Animals; Cell Line; Dioxygenases; DNA-Binding Proteins; Embryonic Stem Cells; Gene Knock-In Techniques; Gene Knockout Techniques; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; RNA-Binding Proteins; RNA, Small Untranslated; RNA, Transfer | 2021 |
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Topics: 5-Methylcytosine; Chromosome Mapping; CpG Islands; Cytosine; DNA; DNA Methylation; Enhancer Elements, Genetic; Epigenesis, Genetic; Genome, Human; Histones; Humans; Organ Specificity; Transcription Factors; Transcriptional Activation | 2020 |
5-Hydroxymethylcytosine Glucosylation-Triggered Helicase-Dependent Amplification-Based Fluorescent Biosensor for Sensitive Detection of β-Glucosyltransferase with Zero Background Signal.
Topics: 5-Methylcytosine; Biocatalysis; Biosensing Techniques; Exodeoxyribonucleases; Fluorescence; Glucosyltransferases; Glycosylation; Kinetics; Limit of Detection | 2020 |
TROP-2, 5hmC, and IDH1 Expression in Anaplastic Thyroid Carcinoma.
Topics: 5-Methylcytosine; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; Biomarkers, Tumor; Camptothecin; Cell Adhesion Molecules; Feasibility Studies; Humans; Immunoconjugates; Immunohistochemistry; Isocitrate Dehydrogenase; Molecular Targeted Therapy; Mutation; Patient Selection; Predictive Value of Tests; Prognosis; Thyroid Carcinoma, Anaplastic; Thyroid Gland; Thyroid Neoplasms | 2021 |
Relative DNA Methylation and Demethylation Efficiencies during Postnatal Liver Development Regulate Hepatitis B Virus Biosynthesis.
Topics: 5-Methylcytosine; Animals; Animals, Newborn; Demethylation; Dioxygenases; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Replication; DNA, Viral; Gene Expression Regulation, Developmental; Gene Expression Regulation, Viral; Hepatitis B virus; Hepatitis B, Chronic; Hepatocyte Nuclear Factors; Liver; Mice; Mice, Transgenic; RNA, Viral; Virus Replication | 2021 |
Alterations in the Genomic Distribution of 5hmC in In Vivo Aged Human Skin Fibroblasts.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; CCCTC-Binding Factor; DNA Methylation; DNA-Directed RNA Polymerases; Female; Fibroblasts; Gene Expression Regulation, Developmental; Histones; Humans; Male; Mitochondrial Proteins; Neoplasm Proteins; Promoter Regions, Genetic; Skin Aging | 2020 |
One-pot intramolecular cyclization of 5-hydroxymethylcytosine for sequencing DNA hydroxymethylation at single-base resolution.
Topics: 5-Methylcytosine; Cyclization; Cytosine; DNA; DNA Methylation; Prospective Studies; Sequence Analysis, DNA | 2021 |
Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes.
Topics: 5-Methylcytosine; Acetylation; Animals; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Evolution, Molecular; Exons; Histones; Introns; Male; Mammals; Mice, Inbred C57BL; Nuclear Proteins; Organ Specificity; Pachytene Stage; Promoter Regions, Genetic; RNA Splicing; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Testis; Transcription, Genetic | 2021 |
Label-Free and Template-Free Chemiluminescent Biosensor for Sensitive Detection of 5-Hydroxymethylcytosine in Genomic DNA.
Topics: 5-Methylcytosine; Biosensing Techniques; Cell Line, Tumor; DNA; Humans; Luminescent Measurements | 2021 |
Exercise Ameliorates Spinal Cord Injury by Changing DNA Methylation.
Topics: 5-Methylcytosine; Animals; Axons; Cell Polarity; DNA Methylation; Epigenesis, Genetic; Female; Hydroxylation; Inflammation; Macrophages; Motor Cortex; Nerve Regeneration; Physical Conditioning, Animal; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Urinary Bladder, Neurogenic | 2021 |
Crystal structures of the EVE-HNH endonuclease VcaM4I in the presence and absence of DNA.
Topics: 5-Methylcytosine; Catalytic Domain; Crystallography, X-Ray; DNA; DNA Restriction Enzymes; DNA, Single-Stranded; Models, Molecular; Nucleotide Motifs; Protein Domains; Scattering, Small Angle; Vibrio; X-Ray Diffraction | 2021 |
Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution.
Topics: 5-Methylcytosine; Animals; Base Sequence; Mice; Mouse Embryonic Stem Cells; Oxidation-Reduction; Pyridines; Sequence Analysis, DNA; Sulfites | 2021 |
Liquid biopsy by combining 5-hydroxymethylcytosine signatures of plasma cell-free DNA and protein biomarkers for diagnosis and prognosis of hepatocellular carcinoma.
Topics: 5-Methylcytosine; Biomarkers; Carcinoma, Hepatocellular; Cell-Free Nucleic Acids; Humans; Liquid Biopsy; Liver Neoplasms; Neoplasm Recurrence, Local; Prognosis | 2021 |
Experimental eye research / short communication format characterization of DNA hydroxymethylation in the ocular choroid.
Topics: 5-Methylcytosine; Aged; Blotting, Western; Choroid; Chromatography, Liquid; Dioxygenases; DNA Methylation; Female; Fluorescent Antibody Technique; Gene Expression; Humans; Isocitrate Dehydrogenase; Male; Melanocytes; Real-Time Polymerase Chain Reaction; Tandem Mass Spectrometry; Tissue Donors | 2021 |
An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine.
Topics: 5-Methylcytosine; Cell Line; CpG Islands; DNA; Enhancer Elements, Genetic; Epigenesis, Genetic; Epigenomics; Gene Library; Human Embryonic Stem Cells; Humans; Recombinant Proteins; Upstream Stimulatory Factors | 2021 |
Reduced hepatic global hydroxymethylation in mice treated with non-genotoxic carcinogens is transiently reversible with a methyl supplemented diet.
Topics: 5-Methylcytosine; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Carcinogenesis; Carcinogens; Clofibrate; Dietary Supplements; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Liver; Male; Methionine; Mice, Transgenic; Phenobarbital; Time Factors; Transcriptome | 2021 |
TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.
Topics: 5-Methylcytosine; CpG Islands; Cytosine; Dioxygenases; DNA Demethylation; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase | 2021 |
5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients.
Topics: 5-Methylcytosine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Cell-Free Nucleic Acids; Cohort Studies; Cyclophosphamide; DNA Demethylation; Doxorubicin; Female; Humans; Logistic Models; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Predictive Value of Tests; Prednisone; Rituximab; Sensitivity and Specificity; Vincristine | 2021 |
Oxytocin prevents cue-induced reinstatement of oxycodone seeking: Involvement of DNA methylation in the hippocampus.
Topics: 5-Methylcytosine; Animals; Conditioning, Classical; Cues; DNA Methylation; Dose-Response Relationship, Drug; Hippocampus; Learning; Male; Memory; Narcotic-Related Disorders; Oxycodone; Oxytocin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2021 |
TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions.
Topics: 5-Methylcytosine; Animals; Breast Neoplasms; Chromatin Assembly and Disassembly; Databases, Genetic; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Estrogen Receptor alpha; Estrogen Receptor Antagonists; Female; Fulvestrant; GATA3 Transcription Factor; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice, Inbred NOD; Mice, SCID; Xenograft Model Antitumor Assays | 2021 |
Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer.
Topics: 5-Methylcytosine; Breast Neoplasms; Epigenomics; Female; Humans; Lymphatic Metastasis; Microtubule-Associated Proteins; Mixed Function Oxygenases; Proto-Oncogene Proteins | 2021 |
Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.
Topics: 5-Methylcytosine; Animals; Cardiomegaly; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Fibrosis; Gene Expression Regulation; Heart; HSP70 Heat-Shock Proteins; Humans; MAP Kinase Signaling System; Mice; Myocytes, Cardiac; Phosphorylation; Transcriptome | 2021 |
Aberrant Epigenetic Reprogramming in the First Cell Cycle of Bovine Somatic Cell Nuclear Transfer Embryos.
Topics: 5-Methylcytosine; Animals; Cattle; Cell Cycle; Cell Nucleus; Cellular Reprogramming; DNA Methylation; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Fertilization in Vitro; Gene Expression Regulation, Developmental; Histones; Nuclear Transfer Techniques; Zygote | 2021 |
Downregulation of 5-hydroxymethylcytosine is an early event in pancreatic tumorigenesis.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Carcinogenesis; Carcinoma, Pancreatic Ductal; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Mixed Function Oxygenases; Pancreatic Neoplasms; Proto-Oncogene Proteins | 2021 |
[Roles of ten eleven translocation proteins family and 5-hydroxymethylcytosine in epigenetic regulation of stem cells and regenerative medicine].
Topics: 5-Methylcytosine; Animals; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Mixed Function Oxygenases; Prospective Studies; Proto-Oncogene Proteins; Regenerative Medicine; Stem Cells | 2021 |
Solid-state nanopore analysis of human genomic DNA shows unaltered global 5-hydroxymethylcytosine content associated with early-stage breast cancer.
Topics: 5-Methylcytosine; Breast Neoplasms; DNA, Neoplasm; Female; Genome, Human; Humans; MCF-7 Cells; Nanopore Sequencing; Neoplasm Staging | 2021 |
5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.
Topics: 5-Methylcytosine; Alzheimer Disease; Animals; Humans; Mice; Neurogenesis; Organoids; Prosencephalon | 2021 |
TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.
Topics: 5-Methylcytosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Differentiation; Cell Line, Tumor; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Epigenome; Epigenomics; GATA6 Transcription Factor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice, Nude; Mice, Transgenic; Pancreatic Neoplasms; Retrospective Studies; Smad4 Protein; Transcription, Genetic; Transcriptome; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2021 |
DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.
Topics: 5-Methylcytosine; Adult; Air; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Female; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophenotyping; Male; Mesenchymal Stem Cells; Middle Aged; Mixed Function Oxygenases; Nanog Homeobox Protein; Octamer Transcription Factor-3; Oxygen; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Messenger; SOXB1 Transcription Factors; Up-Regulation | 2021 |
Ten-eleven translocation protein 1 modulates medulloblastoma progression.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Computational Biology; CpG Islands; Databases, Nucleic Acid; Disease Models, Animal; Disease Progression; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Medulloblastoma; Mice; Mice, Transgenic; Mixed Function Oxygenases; Nucleotide Motifs; Prognosis; Proto-Oncogene Proteins | 2021 |
Bisulphite miRNA-seq reveals widespread CpG and non-CpG 5-(hydroxy)methyl-Cytosine in human microRNAs.
Topics: 5-Methylcytosine; CpG Islands; DNA Methyltransferase 3A; HEK293 Cells; HeLa Cells; High-Throughput Nucleotide Sequencing; Humans; Leukocytes, Mononuclear; MicroRNAs; Sequence Analysis, RNA | 2021 |
Aba-Seq: High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; Animals; DNA Methylation; DNA Restriction Enzymes; Genome; Genomics; Mice; Mouse Embryonic Stem Cells; Sequence Analysis, DNA | 2021 |
ELISA-Based Quantitation of Global 5hmC Levels.
Topics: 5-Methylcytosine; Antibodies; DNA; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Genomics; Humans | 2021 |
Avidin-Biotin ELISA-Based Detection of 5hmC.
Topics: 5-Methylcytosine; Antibodies; Avidin; Biotin; DNA; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Genomics; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins | 2021 |
Distinguishing Active Versus Passive DNA Demethylation Using Illumina MethylationEPIC BeadChip Microarrays.
Topics: 5-Methylcytosine; Computational Biology; Cytosine; DNA; DNA Demethylation; DNA Methylation; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Microarray Analysis; Oxidation-Reduction; Sulfites | 2021 |
Bioinformatic Estimation of DNA Methylation and Hydroxymethylation Proportions.
Topics: 5-Methylcytosine; Computational Biology; DNA; DNA Methylation; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Oxidation-Reduction; Sulfites | 2021 |
TAB-seq and ACE-seq Data Processing for Genome-Wide DNA hydroxymethylation Profiling.
Topics: 5-Methylcytosine; Computational Biology; DNA; DNA Methylation; Epigenesis, Genetic; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Proto-Oncogene Proteins; Sulfites | 2021 |
High-Fidelity CRISPR/Cas9-Based Gene-Specific Hydroxymethylation.
Topics: 5-Methylcytosine; Chromatin; Computational Biology; CRISPR-Cas Systems; DNA; DNA Methylation; Epigenesis, Genetic; Gene Editing; High-Throughput Nucleotide Sequencing; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sulfites | 2021 |
Identifying Protein-(Hydroxy)Methylated DNA Interactions Using Quantitative Interaction Proteomics.
Topics: 5-Methylcytosine; Computational Biology; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Isotope Labeling; Oxidation-Reduction; Proteome | 2021 |
Purification of TET Proteins.
Topics: 5-Methylcytosine; DNA; DNA Methylation; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Proto-Oncogene Proteins; Substrate Specificity | 2021 |
Pearl Necklacelike Strategy Enables Quantification of Global 5-Hydroxymethylcytosine and 5-Formylcytosine by Inductively Coupled Plasma-Atomic Emission Spectrometry.
Topics: 5-Methylcytosine; Cytosine; Spectrum Analysis | 2021 |
UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.
Topics: 5-Methylcytosine; Allosteric Regulation; Animals; Cell Line; Cell Line, Tumor; DNA Demethylation; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; HEK293 Cells; Humans; MCF-7 Cells; Mice; Mice, Knockout; Promoter Regions, Genetic; Protein Binding; Ubiquitin-Protein Ligases; Ubiquitination; X-ray Repair Cross Complementing Protein 1 | 2021 |
Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Proliferation; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression; Genetic Loci; Hematopoiesis; Interleukin-4; Isoenzymes; Lipopolysaccharides; Longevity; Macrophages; Mice; Mice, Knockout; T-Lymphocytes; Thymine DNA Glycosylase | 2021 |
Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways.
Topics: 5-Methylcytosine; Animals; Biomarkers; Dioxygenases; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Gene Expression Regulation; Hypersensitivity; Immunomodulation; Mice; Mice, Knockout; Proto-Oncogene Proteins; Signal Transduction | 2021 |
Tet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells.
Topics: 5-Methylcytosine; Animals; Cell Line; Centromere; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Heterochromatin; Histones; Meiosis; Mice; Mouse Embryonic Stem Cells; Ovum; Polycomb Repressive Complex 1; Protein Isoforms; Proto-Oncogene Proteins; Ubiquitin-Protein Ligases | 2021 |
Telomere Length in Chromosomally Normal and Abnormal Miscarriages and Ongoing Pregnancies and Its Association with 5-hydroxymethylcytosine Patterns.
Topics: 5-Methylcytosine; Abortion, Spontaneous; Case-Control Studies; Chorion; DNA Methylation; Female; Humans; Lymphocytes; Pregnancy; Pregnancy Trimester, First; Telomere; Telomere Homeostasis; Trophoblasts | 2021 |
Stress modulates Ahi1-dependent nuclear localization of ten-eleven translocation protein 2.
Topics: 5-Methylcytosine; Adaptor Proteins, Vesicular Transport; Animals; Cell Nucleus; Depression; Dioxygenases; DNA-Binding Proteins; Hippocampus; Mice; Mice, Knockout; Phenotype; Protein Binding; Protein Transport; Stress, Physiological | 2021 |
Regulation of Rac1 transcription by histone and DNA methylation in diabetic retinopathy.
Topics: 5-Methylcytosine; Animals; Diabetic Retinopathy; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Gene Expression Regulation; Glucose; Histones; Humans; Methyltransferases; Mice, Inbred C57BL; Microvessels; Models, Biological; Promoter Regions, Genetic; Protein Processing, Post-Translational; rac1 GTP-Binding Protein; Repressor Proteins; Retinal Vessels; RNA, Messenger; Transcription, Genetic | 2021 |
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome.
Topics: 5-Methylcytosine; Base Sequence; Binding Sites; DNA Methylation; Gene Expression Regulation; Genome-Wide Association Study; Genome, Human; Humans; Organ Specificity; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Transcription Factors | 2021 |
MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion.
Topics: 5-Methylcytosine; Animals; Cells, Cultured; Chromatin; Cytosine; Dinucleotide Repeats; DNA Methylation; Embryonic Stem Cells; Fibroblasts; Frontal Lobe; Methyl-CpG-Binding Protein 2; Mice; Microsatellite Repeats; Neurons; Nucleic Acid Conformation; Nucleosomes; Oxidation-Reduction; Protein Binding; Protein Domains; Rett Syndrome; Transcription, Genetic | 2021 |
Proteome-Wide Profiling of Readers for DNA Modification.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Humans; Mice; Mice, Inbred C57BL; Models, Animal; Proteome; Transcription Factors | 2021 |
Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain.
Topics: 5-Methylcytosine; Animals; Brain; Cell Cycle; Cell Differentiation; DNA; DNA Methylation; DNA-Binding Proteins; Genome; Mice; Mice, Knockout; Mice, Neurologic Mutants; Oligodendroglia; Organogenesis; Proto-Oncogene Proteins; Remyelination | 2021 |
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker.
Topics: 5-Methylcytosine; Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Gene Expression Regulation; Humans; Male; Neoplasm Staging; Pediatrics | 2021 |
Rapid and Label-Free Detection of 5-Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure-Based Electrochemical Sensor.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; DNA; Genomics; Gold; Humans; Liver Neoplasms; Metal Nanoparticles; Nanotubes; Zinc Oxide | 2021 |
iR5hmcSC: Identifying RNA 5-hydroxymethylcytosine with multiple features based on stacking learning.
Topics: 5-Methylcytosine; Algorithms; Computational Biology | 2021 |
Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers.
Topics: 5-Methylcytosine; Cell-Free Nucleic Acids; Disease Progression; Early Detection of Cancer; Humans; Neoplasms; RNA, Long Noncoding | 2021 |
Regulation of 5-Hydroxymethylcytosine by TET2 Contributes to Squamous Cell Carcinoma Tumorigenesis.
Topics: 5-Methylcytosine; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Humans; Mice; Proto-Oncogene Proteins; Skin Neoplasms | 2022 |
Epigenetic Dysregulation of 5-hydroxymethylcytosine in Well-Differentiated Pancreatic Neuroendocrine Tumors.
Topics: 5-Methylcytosine; Epigenesis, Genetic; Female; Humans; Mitotic Index; Neuroendocrine Tumors; Pancreatic Neoplasms | 2022 |
Loss of ten-eleven translocation 1 (TET1) expression as a diagnostic and prognostic biomarker of endometrial carcinoma.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Case-Control Studies; DNA Methylation; Down-Regulation; Endometrial Hyperplasia; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Mixed Function Oxygenases; Neoplasm Grading; Prognosis; Proto-Oncogene Proteins; Retrospective Studies; Survival Analysis | 2021 |
The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function.
Topics: 5-Methylcytosine; Binding Sites; Biophysical Phenomena; Computational Biology; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Magnetic Resonance Spectroscopy; Models, Biological; Molecular Dynamics Simulation; Nucleic Acid Conformation | 2021 |
5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Diagnostic Biomarkers for Late-Onset Alzheimer's Disease.
Topics: 5-Methylcytosine; Aged; Alzheimer Disease; Biomarkers; Case-Control Studies; Cell-Free Nucleic Acids; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Female; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged | 2022 |
Loss of 5-hydroxymethylcytosine expression is near-universal in B-cell lymphomas with variable mutations in epigenetic regulators.
Topics: 5-Methylcytosine; Epigenesis, Genetic; Humans; Lymphoma, B-Cell; Mutation | 2022 |
5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Demethylation; Mice; Neurons | 2021 |
Epigenetic Quantification of DNA 5-Hydroxymethylcytosine Using DNA Hybridization-Based Single-Molecule Immunofluorescent Imaging.
Topics: 5-Methylcytosine; Antibodies; DNA; DNA Probes; Fluorescent Dyes; Nucleic Acid Hybridization; Single Molecule Imaging | 2021 |
Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Epigenesis, Genetic; Female; Gene-Environment Interaction; Membrane Proteins; Mice; Nerve Tissue Proteins; Neurodevelopmental Disorders; Pregnancy | 2022 |
Integrated single-cell sequencing of 5-hydroxymethylcytosine and genomic DNA using scH&G-seq.
Topics: 5-Methylcytosine; Cell Division; Cell Line; Computational Biology; DNA; Humans; Sequence Analysis, DNA; Single-Cell Analysis | 2021 |
Navigating the hydroxymethylome: experimental biases and quality control tools for the tandem bisulfite and oxidative bisulfite Illumina microarrays.
Topics: 5-Methylcytosine; Bias; Computational Biology; DNA Methylation; Humans; Oligonucleotide Array Sequence Analysis; Quality Control | 2022 |
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; China; DNA Fragmentation; DNA Methylation; Female; Humans; Lung Neoplasms; Male; Middle Aged | 2022 |
Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns.
Topics: 5-Methylcytosine; Animals; Base Sequence; Chromatography, High Pressure Liquid; Cloning, Molecular; Computational Biology; Dioxygenases; DNA-Binding Proteins; Gene Expression Regulation; Genomics; Mice; Proto-Oncogene Proteins; Tandem Mass Spectrometry | 2022 |
Epigenetic Quantification of 5-Hydroxymethylcytosine Signatures
Topics: 5-Methylcytosine; DNA; DNA, Catalytic; Epigenesis, Genetic | 2022 |
Evolved DNA Duplex Readers for Strand-Asymmetrically Modified 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads.
Topics: 5-Methylcytosine; Directed Molecular Evolution; DNA; DNA Methylation; HEK293 Cells; Humans; Methyl-CpG-Binding Protein 2; Peptide Fragments; Protein Domains | 2022 |
Loss of 5-hydroxymethylcytosine as a Poor Prognostic Factor for Primary Testicular Diffuse Large B-cell Lymphoma.
Topics: 5-Methylcytosine; Aged; Biomarkers, Tumor; Humans; Immunohistochemistry; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Testicular Neoplasms; Testis | 2022 |
N-3 polyunsaturated fatty acids prevent the D-galactose-induced cognitive impairment by up-regulating the levels of 5-hydroxymethylcytosine in the mouse brain.
Topics: 5-Methylcytosine; Animals; Brain; Cognitive Dysfunction; Fatty Acids, Omega-3; Galactose; Mice; Neurodegenerative Diseases | 2022 |
Punicalagin Attenuates Neuronal Apoptosis by Upregulating 5-Hydroxymethylcytosine in the Diabetic Mouse Brain.
Topics: 5-Methylcytosine; AMP-Activated Protein Kinases; Animals; Apoptosis; Brain; Diabetes Mellitus; Hydrolyzable Tannins; Mice; Mice, Inbred C57BL | 2022 |
5-Hydroxymethylcytosine (5hmC) at or near cancer mutation hot spots as potential targets for early cancer detection.
Topics: 5-Methylcytosine; DNA; DNA Methylation; Humans; Mutation; Neoplasms | 2022 |
Value of 5-Hydroxymethylcytosine in HBV-Carrying High-Risk Hepatocellular Carcinoma Population: An Evaluation Based on Differential Analysis.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms | 2022 |
Hydroxymethylation-Specific Ligation-Mediated Single Quantum Dot-Based Nanosensors for Sensitive Detection of 5-Hydroxymethylcytosine in Cancer Cells.
Topics: 5-Methylcytosine; Animals; Biotin; DNA; DNA Methylation; Mammals; Neoplasms; Quantum Dots | 2022 |
Magnetic multi-enzyme cascade combined with liquid chromatography tandem mass spectrometry for fast DNA digestion and quantitative analysis of 5-hydroxymethylcytosine in genome of human bladder cancer T24 cells induced by tetrachlorobenzoquinone.
Topics: 5-Methylcytosine; Benzoquinones; Chromatography, High Pressure Liquid; DNA; Humans; Hydrocarbons, Chlorinated; Magnetic Phenomena; Nucleosides; Tandem Mass Spectrometry; Urinary Bladder Neoplasms | 2022 |
Tight correlation of 5-hydroxymethylcytosine expression with the scarring damage of discoid lupus erythematosus.
Topics: 5-Methylcytosine; Cicatrix; Humans; Interferon Type I; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Skin | 2022 |
Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia.
Topics: 5-Methylcytosine; Cell-Free Nucleic Acids; Epigenomics; Humans; Leukemia, Myeloid, Acute | 2022 |
iRNA5hmC-HOC: High-order correlation information for identifying RNA 5-hydroxymethylcytosine modification.
Topics: 5-Methylcytosine; Algorithms; RNA; Software; Support Vector Machine | 2022 |
R5hmCFDV: computational identification of RNA 5-hydroxymethylcytosine based on deep feature fusion and deep voting.
Topics: 5-Methylcytosine; Machine Learning; Neural Networks, Computer; Nucleotides; RNA | 2022 |
5-Hydroxymethylcytosine profiles in plasma cell-free DNA reflect molecular characteristics of diabetic kidney disease.
Topics: 5-Methylcytosine; Animals; Cell-Free Nucleic Acids; Diabetes Mellitus; Diabetic Nephropathies; Humans; Mice; Myeloid Differentiation Factor 88 | 2022 |
Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma.
Topics: 5-Methylcytosine; Cell-Free Nucleic Acids; Humans; Monoclonal Gammopathy of Undetermined Significance; Multiple Myeloma | 2022 |
Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways.
Topics: 5-Methylcytosine; Ascorbic Acid; Carcinogenesis; DNA; DNA Methylation; Fibrin; Humans; Magnesium; Male; Phosphates; Prostatic Neoplasms; Urogenital Neoplasms | 2022 |
Locus-Specific Enrichment Analysis of 5-Hydroxymethylcytosine Reveals Novel Genes Associated with Breast Carcinogenesis.
Topics: 5-Methylcytosine; Breast Neoplasms; Cell Transformation, Neoplastic; Cytosine; DNA, Intergenic; Female; Humans; Untranslated Regions | 2022 |
The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
Topics: 5-Methylcytosine; Biopsy; Humans; Male; Prostate; Prostatic Neoplasms | 2022 |
Identifying 5-Hydroxymethylcytosine without Sequence Specificity Using MOF-Derived MnO
Topics: 5-Methylcytosine; Biosensing Techniques; DNA; Electrochemical Techniques; Limit of Detection; Luminescent Measurements; Metal-Organic Frameworks | 2022 |
Noninvasive detection of brain gliomas using plasma cell-free DNA 5-hydroxymethylcytosine sequencing.
Topics: 5-Methylcytosine; Brain; Brain Neoplasms; Glioma; Humans; Isocitrate Dehydrogenase; Mutation | 2023 |
Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Asthma; DNA Methylation; Humans; Immunity, Innate; Inflammation | 2023 |
5-hydroxymethylcytosine stabilizes transcription by preventing aberrant initiation in gene bodies.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation | 2023 |
5-Methylcytosine and 5-Hydroxymethylcytosine in Scrapie-Infected Sheep and Mouse Brain Tissues.
Topics: 5-Methylcytosine; Animals; Brain; DNA Methylation; DNA Methyltransferase 3B; Epigenesis, Genetic; Histone Deacetylase 2; Mice; Prion Diseases; Prions; Scrapie; Sheep | 2023 |
Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-akt | 2023 |
EBS-seq: enrichment-based method for accurate analysis of 5-hydroxymethylcytosine at single-base resolution.
Topics: 5-Methylcytosine; Colorectal Neoplasms; DNA Methylation; HEK293 Cells; Humans | 2023 |
Global DNA 5-hydroxymethylcytosine level and its chromosomal distribution in four rye species.
Topics: 5-Methylcytosine; Chromosomes; Cytosine; DNA; DNA Methylation; Secale | 2023 |
Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer's Disease.
Topics: 5-Methylcytosine; Alzheimer Disease; Cell-Free Nucleic Acids; Diabetes Mellitus; DNA Methylation; Humans | 2023 |
The link between 5-hydroxymethylcytosine and DNA demethylation in early embryos.
Topics: 5-Methylcytosine; DNA Demethylation; DNA Methylation; Embryonic Development; Humans | 2023 |
Decrease of 5-hydroxymethylcytosine in hepatitis B virus-related hepatocellular carcinoma: A cross-sectional study.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cross-Sectional Studies; Cytosine; DNA Methylation; Hepatitis B virus; Humans; Liver Neoplasms; Mixed Function Oxygenases; Proto-Oncogene Proteins | 2023 |
Classification of Acute Myeloid Leukemia by Cell-Free DNA 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; Humans; Leukemia, Myeloid, Acute; Proto-Oncogene Proteins | 2023 |
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Topics: 5-Methylcytosine; Biomedical Research; Cytosine; Databases, Factual; Humans | 2023 |
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Topics: 5-Methylcytosine; Biomedical Research; Cytosine; Databases, Factual; Humans | 2023 |
Chemo-Enzymatic Fluorescence Labeling Of Genomic DNA For Simultaneous Detection Of Global 5-Methylcytosine And 5-Hydroxymethylcytosine.
Topics: 5-Methylcytosine; DNA; DNA Methylation; Fluorescence; Genomics; Humans; Leukocytes, Mononuclear | 2023 |
Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia.
Topics: 5-Methylcytosine; Cell-Free Nucleic Acids; DNA Methylation; Humans; Leukemia, Myeloid, Acute | 2023 |