5-hydroxymethylcytosine has been researched along with 5-formylcytosine in 83 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 70 (84.34) | 24.3611 |
2020's | 13 (15.66) | 2.80 |
Authors | Studies |
---|---|
Carell, T; Deiml, CA; Hackner, B; Hagemeier, C; Müller, M; Münzel, M; Pfaffeneder, T; Truss, M | 1 |
Collins, LB; Dai, Q; He, C; Ito, S; Shen, L; Swenberg, JA; Wu, SC; Zhang, Y | 1 |
Kohli, RM; Nabel, CS | 1 |
Dai, Q; He, C; Inoue, A; Shen, L; Zhang, Y | 1 |
Balasubramanian, S; Booth, MJ; Branco, MR; Ficz, G; Krueger, F; Oxley, D; Reik, W | 1 |
Balasubramanian, S; Beraldi, D; Booth, MJ; Branco, MR; Burgess, HE; Ficz, G; Murat, P; Oxley, D; Raiber, EA; Reik, W | 1 |
Fu, Y; He, C | 1 |
Bapat, B; Olkhov-Mitsel, E | 1 |
Chen, X; Hong, T; Hu, J; Mao, W; Wang, S; Xing, X; Zhou, X | 1 |
Jin, P; Yao, B | 1 |
Carell, T; Hackner, B; Höfner, G; Kashiwazaki, G; Ochsenfeld, C; Pfaffeneder, T; Sadeghian, K; Schiesser, S; Schröder, AS; Steigenberger, B; Steinbacher, J; Wanner, KT | 1 |
Cadet, J; Wagner, JR | 1 |
Feng, YQ; Liu, YL; Vargas, M; Wang, Y; Xing, XW; Yuan, BF; Zhou, X | 1 |
An, R; Ming, GL; Shin, J; Song, H; Weng, YL | 1 |
Fronhoffs, F; Grewe, MJ; Haas, N; Heukamp, LC; Honecker, F; Kristiansen, G; Nettersheim, D; Schorle, H; Waha, A | 1 |
Cheng, X; Corrêa, IR; Dai, N; Fu, ZQ; Hashimoto, H; Pais, JE; Saleh, L; Zhang, X; Zheng, Y | 1 |
Rao, A; Tsagaratou, A | 1 |
Aravind, L; Chen, W; Dai, Q; Fu, Y; He, C; Hu, J; Iyer, LM; Wang, G; Yu, M; Zhang, L | 1 |
Chouliaras, L; Condliffe, D; Cooper, J; Fernandes, C; Lovestone, S; Lunnon, K; Mill, J; Patel, Y; Proitsi, P; Schalkwyk, L; Troakes, C; Wong, A | 1 |
Aluru, N; Ci, W; Duan, J; Gao, X; He, C; Huang, X; Li, G; Li, W; Liu, J; Lu, X; Tang, F; Wang, L; Yang, L; Zhang, J; Zhou, Q; Zhu, W | 1 |
Delatte, B; Deplus, R; Fuks, F | 1 |
Brandmayr, C; Carell, T; Eisen, D; Hackner, B; Kashiwazaki, G; Kosmatchev, O; Kotljarova, O; Laube, SK; Leonhardt, H; Michalakis, S; Müller, M; Müller, U; Pfaffeneder, T; Raddaoui, N; Schär, P; Schiesser, S; Schuermann, D; Spada, F; Spruijt, CG; Steigenberger, B; Steinbacher, J; Truss, M; Vermeulen, M; Wagner, M | 1 |
Collins, LB; Hanaoka, F; Ito, S; Iwai, S; Kanao, R; Koseki, H; Kuraoka, I; Masuda, Y; Masutani, C; Shibata, M; Shibutani, T; Swenberg, JA; Toda, M; Urabe, M | 1 |
Huang, Y; Rao, A | 1 |
Hahn, MA; Pfeifer, GP; Szabó, PE | 1 |
Shen, L; Wu, H; Wu, X; Zhang, Y | 1 |
Lu, M; Mo, J; Wang, H; Yin, R | 1 |
Banerjee, S; Brooks, S; Egli, M; Eichman, BF; Joachimiak, A; Nocek, B; Pallan, PS; Stone, MP; Szulik, MW; Voehler, M | 1 |
Cui, L; Shao, F; Wu, Q; Xuan, S; Zhang, D | 1 |
Golla, JP; Sathyanarayana, BK; Sayeed, SK; Vinson, C; Zhao, J | 1 |
Chevassut, T; Cho, IH; Choudhury, SR; Chowdhury, B; Cooper, B; Cui, Y; Irudayaraj, J; Lossie, AC; McGovern, A | 1 |
Ito, S; Kuraoka, I | 1 |
Chan, WY; Chung, JP; Kong, GW; Lee, TL; Qian, Y; Tang, NL; Tu, J | 1 |
Bachman, M; Balasubramanian, S; Burgess, HE; Iurlaro, M; Murrell, A; Reik, W; Uribe-Lewis, S; Yang, X | 1 |
Chen, L; Chong, J; Fu, XD; He, C; Li, H; Lu, X; Wang, D; Wang, L; Xiao, R; Xu, L; Zhou, Y | 1 |
Carell, T; Giese, A; Hackner, B; Kraus, TF; Kretzschmar, HA; Michalakis, S; Müller, M; Perera, A; Pfaffeneder, T; Steinbacher, J; Wagner, M | 1 |
Wu, H; Zhang, Y | 1 |
Han, D; He, C; Jiang, X; Liu, M; Lu, X; Sun, Z; Xia, B; Xie, W; Yi, C; Yin, Q; Zeng, H; Zhou, A | 1 |
Cheng, J; Cui, Q; Fang, D; Gong, W; He, C; Hou, H; Hu, L; Jiang, H; Li, J; Li, W; Li, Z; Liu, M; Lou, Z; Lu, J; Luo, C; Rao, Q; Sun, C; Tan, X; Wang, P; Wang, Y; Xu, Y; Yang, P; Yin, X; Zhang, L | 1 |
Feng, YQ; Qi, BL; Xiong, J; Yuan, BF; Zhang, HY | 1 |
Gackowski, D; Modrzejewska, M; Olinski, R; Starczak, M; Zarakowska, E | 1 |
Aksimentiev, A; Dai, Q; Ha, T; He, C; Ngo, TT; Yoo, J; Zhang, Q | 1 |
He, Y; Jin, P; Tang, B; Wang, Z | 1 |
Incarnato, D; Krepelova, A; Neri, F; Oliviero, S; Parlato, C | 1 |
Abbes, S; Bernard, OA; Cabagnols, X; Della Valle, V; Ishchenko, AA; Mahfoudhi, E; Plo, I; Rameau, P; Saparbaev, M; Secardin, L; Talhaoui, I; Vainchenker, W | 1 |
Fukuzawa, S; Suetake, I; Tachibana, K; Tajima, S; Takahashi, S | 1 |
Chang, PM; Chou, NH; Kang, CH; Lam, HC; Li, GC; Liu, SI; Tsai, CY; Tsai, KW; Tu, YT; Wang, KC | 1 |
Pfeifer, GP; Song, J | 1 |
Li, Y; Ma, S; Qi, H; Sun, H; Zheng, J | 1 |
Han, YW; Harada, Y; Kizaki, S; Li, Y; Sugiyama, H; Suzuki, Y; Zou, T | 1 |
Shimbo, T; Wade, PA | 1 |
Cheng, X; Hong, S | 1 |
Foksinski, M; Gackowski, D; Gawronski, M; Modrzejewska, M; Olinski, R; Rzeszowska-Wolny, J; Skonieczna, M; Starczak, M; Zarakowska, E | 1 |
Klungland, A; Robertson, AB | 1 |
Chen, Z; Guo, L; He, J; Li, Y; Luo, M; Shi, X | 1 |
Bronner, C; Dimitrov, S; Gras, SL; Hamiche, A; Ibrahim, A; Jost, B; Menoni, H; Papin, C; Stoll, I; Velt, A | 1 |
Bieńkiewicz, A; Bryś, M; Ciesielski, P; Cwonda, Ł; Forma, E; Jóźwiak, P; Krześlak, A; Szczepaniec, S; Wójcik-Krowiranda, K | 1 |
Allgayer, J; Carell, T; Geier, N; Khobta, A; Kitsera, N; Parsa, E; Rossa, M | 1 |
Banerjee, M; Nair, C; Nair, IV; Saradalekshmi, KR; Swathy, B | 1 |
Brown, T; Hardwick, JS; Lane, AN | 1 |
Giehr, P; Kyriakopoulos, C; Lepikhov, K; Wallner, S; Walter, J; Wolf, V | 1 |
Cao, D; He, Y; Jiang, J; Liu, D; Liu, J; Mo, J; Wang, H | 1 |
Borre, M; Høyer, S; Lynnerup, AS; Storebjerg, TM; Strand, SH; Sørensen, KD; Ørntoft, TF | 1 |
Cao, Z; Chen, Z; Gao, D; Khan, IM; Luo, L; Tong, X; Wang, Y; Xu, T; Zhang, D; Zhang, L; Zhang, M; Zhang, Y | 1 |
Wang, P; Yan, Y; Yu, W; Zhang, H | 1 |
Bian, K; Chen, F; Drennan, CL; Essigmann, JM; Jost, M; Lenz, SAP; Li, D; Qi, R; Tang, Q; Wetmore, SD | 1 |
Daumann, LJ; Jonasson, NSW | 1 |
Cao, LL; Jia, M; Liu, H; Pei, L; Wang, H; Yue, Z | 1 |
Cai, C; Chen, D; Chen, J; Dai, Z; Liu, SY; Ma, Y; Mo, M; Wang, Y; Xu, Y; Zhang, J; Zhang, L; Zhang, Y; Zou, X | 1 |
Abdelhamid, MAS; Ehiabor, MO; Grigg, MC; Irving, K; Smith, NM; Waller, ZAE; Wright, EP | 1 |
Abakir, A; Fossdal, CG; Gackowski, D; Krutovsky, KV; Olinski, R; Ruzov, A; Starczak, M; Viejo, M; Yakovlev, IA | 1 |
Gackowski, D; Gawronski, M; Olinski, R; Starczak, M | 1 |
Gering, M; Jessop, P | 1 |
Fossdal, CG; Viejo, M; Yakovlev, I | 1 |
Celik-Uzuner, S | 1 |
Abakir, A; Alenezi, F; Ruzov, A | 1 |
Assad, N; Durell, S; Ray, S; Tillo, D; Ufot, A; Vinson, C | 1 |
Bai, M; Cao, X; Chen, F; Fan, C; Su, L; Xue, J; Zhao, Y | 1 |
DeNizio, JE; Dow, BJ; Drohat, AC; Ghanty, U; Kohli, RM; Serrano, JC | 1 |
Eden, HE; Huang, Z; Robertson, KD; Rothbart, SB; Tiedemann, RL | 1 |
Chen, D; Dai, Z; Li, Y; Liu, SY; Xu, Y; Yu, Z; Zhang, Y; Zou, X | 1 |
Bellacosa, A; Georges, RO; González-Avalos, E; Lio, CJ; Nakayama, T; Onodera, A; Rao, A | 1 |
Bai, L; Ding, C; Feng, J; Gong, T; Li, J; Li, X; Li, Z; Liu, M; Lyu, J; Qin, J; Qin, Z; Wang, Y; Yang, G; Yang, W | 1 |
17 review(s) available for 5-hydroxymethylcytosine and 5-formylcytosine
Article | Year |
---|---|
Nucleic acid modifications with epigenetic significance.
Topics: 5-Methylcytosine; Adenosine; Animals; Cytosine; DNA; Epigenesis, Genetic; Humans; Methylation; RNA | 2012 |
Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; Disease; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genetic Markers; Humans; Restriction Mapping; Sequence Analysis, DNA | 2012 |
Cytosine modifications in neurodevelopment and diseases.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; DNA-Cytosine Methylases; Humans; Models, Molecular; Nervous System Diseases; Neurogenesis | 2014 |
TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA Repair; Humans; Models, Biological; Mutagenesis; Neoplasms; Oxidation-Reduction | 2014 |
DNA modifications and neurological disorders.
Topics: 5-Methylcytosine; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Nervous System Diseases; Neurons | 2013 |
Playing TETris with DNA modifications.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Humans; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; Signal Transduction | 2014 |
Connections between TET proteins and aberrant DNA modification in cancer.
Topics: 5-Methylcytosine; Azacitidine; Cytosine; Decitabine; Dioxygenases; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Hematologic Neoplasms; Humans; Isocitrate Dehydrogenase; Mixed Function Oxygenases; Molecular Targeted Therapy; Mutation; Neoplasms; Proto-Oncogene Proteins; Small Molecule Libraries | 2014 |
5-Hydroxymethylcytosine: a stable or transient DNA modification?
Topics: 5-Methylcytosine; Animals; Brain; Cytosine; DNA Methylation; DNA Replication; DNA-Binding Proteins; Humans | 2014 |
Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword.
Topics: 5-Methylcytosine; Base Pair Mismatch; CpG Islands; Cytosine; Deamination; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Gene Expression; Humans; Molecular Mimicry; Oxidation-Reduction; Thymine DNA Glycosylase | 2015 |
DNA methylation dynamics in neurogenesis.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Stem Cells; Epigenesis, Genetic; Histones; Humans; Mammals; Neurogenesis | 2016 |
Are there specific readers of oxidized 5-methylcytosine bases?
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA-Binding Proteins; Humans | 2016 |
Proteins That Read DNA Methylation.
Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Protein Domains | 2016 |
DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications.
Topics: 5-Methylcytosine; Adenine; Cytosine; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Eukaryota; Prokaryotic Cells; Protein Domains | 2016 |
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.
Topics: 5-Methylcytosine; Animals; Carcinogenesis; Cell Self Renewal; Cytosine; DNA; DNA Methylation; DNA Repair; Humans; Oxidation-Reduction; Transcription, Genetic | 2017 |
Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Humans; Lymphatic Metastasis; Neoplasms; Prognosis | 2017 |
Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.
Topics: 5-Methylcytosine; Animals; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Mammals; Models, Molecular; Nucleic Acid Conformation | 2018 |
Role of ten-eleven translocation proteins and 5-hydroxymethylcytosine in hepatocellular carcinoma.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Humans; Liver Neoplasms; MicroRNAs; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA Processing, Post-Transcriptional; Transcription, Genetic | 2019 |
66 other study(ies) available for 5-hydroxymethylcytosine and 5-formylcytosine
Article | Year |
---|---|
The discovery of 5-formylcytosine in embryonic stem cell DNA.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; Embryonic Stem Cells; Mass Spectrometry; Mice | 2011 |
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
Topics: 5-Methylcytosine; Animals; Cell Line; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Humans; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Recombinant Fusion Proteins | 2011 |
Molecular biology. Demystifying DNA demethylation.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase | 2011 |
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.
Topics: 5-Methylcytosine; Animals; Antibodies; Cytosine; DNA Replication; DNA-Directed DNA Polymerase; Embryonic Development; Immunohistochemistry; Male; Mice | 2011 |
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Genes, Intracisternal A-Particle; High-Throughput Nucleotide Sequencing; Long Interspersed Nucleotide Elements; Mice; Oxidation-Reduction; Rhenium; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Uracil | 2012 |
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Line; Chromosome Mapping; Computational Biology; CpG Islands; Cytosine; Dioxygenases; DNA Repair; DNA-Binding Proteins; Down-Regulation; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genome; High-Throughput Nucleotide Sequencing; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Transcription, Genetic | 2012 |
A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences.
Topics: 5-Methylcytosine; Base Sequence; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Cytosine; Electrophoresis, Gel, Two-Dimensional; Sequence Analysis, DNA | 2013 |
Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine.
Topics: 5-Methylcytosine; Carboxylic Acids; Cytosine; Deamination; Oxidation-Reduction; Sulfhydryl Compounds | 2013 |
Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Escherichia coli; High-Throughput Nucleotide Sequencing; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.
Topics: 5-Methylcytosine; Carcinoma; Cell Line, Tumor; Cytosine; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Germ Cells; Humans; Immunohistochemistry; Male; Mixed Function Oxygenases; Neoplasms, Germ Cell and Embryonal; Oxidation-Reduction; Proto-Oncogene Proteins; Spermatogenesis; Testis | 2013 |
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Escherichia coli Proteins; HEK293 Cells; Humans; Hydrogen Bonding; Mice; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Naegleria; Proto-Oncogene Proteins; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity | 2014 |
TET proteins and 5-methylcytosine oxidation in the immune system.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Profiling; Humans; Immunoprecipitation; Mice; Mixed Function Oxygenases; Oxidoreductases; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins | 2013 |
A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine.
Topics: 5-Methylcytosine; Agaricales; Cytosine; Dioxygenases; Fungal Proteins | 2014 |
Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cytosine; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Humans; Ivermectin; Male; Methylation | 2014 |
Programming and inheritance of parental DNA methylomes in mammals.
Topics: 5-Methylcytosine; Animals; CpG Islands; Cytosine; DNA Methylation; Embryo, Mammalian; Embryonic Development; Female; Gene Expression Regulation, Developmental; Genomic Imprinting; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Promoter Regions, Genetic | 2014 |
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
Topics: 5-Methylcytosine; Animals; Base Sequence; Carbon Isotopes; Chromatin Assembly and Disassembly; Chromatography, Liquid; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression; Mice; Molecular Sequence Data; Oxidation-Reduction; Pentoxyl; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine; Transcription Factors | 2014 |
Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication.
Topics: 5-Methylcytosine; Base Pairing; Cell Proliferation; Cytosine; DNA; DNA Mismatch Repair; DNA Replication; Epigenesis, Genetic; Guanine; Humans; Thymine DNA Glycosylase | 2014 |
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing.
Topics: 5-Methylcytosine; Animals; Base Sequence; Chromatin; Cytosine; DNA Methylation; DNA Repair; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Methyltransferases; Mice; Thymine DNA Glycosylase | 2014 |
Detection of human urinary 5-hydroxymethylcytosine by stable isotope dilution HPLC-MS/MS analysis.
Topics: 5-Methylcytosine; Adult; Bicarbonates; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Female; Humans; Indicator Dilution Techniques; Isotopes; Male; Solid Phase Extraction; Tandem Mass Spectrometry; Young Adult | 2015 |
Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Topics: 5-Methylcytosine; Cytosine; DNA; Oligonucleotides; Thymine DNA Glycosylase | 2015 |
5-Hydroxymethylcytosine and 5-formylcytosine containing deoxyoligonucleotides: facile syntheses and melting temperature studies.
Topics: 5-Methylcytosine; Catalysis; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Copper; Cytosine; Oligonucleotides; Oxidation-Reduction; Transition Temperature | 2015 |
C/EBPβ (CEBPB) protein binding to the C/EBP|CRE DNA 8-mer TTGC|GTCA is inhibited by 5hmC and enhanced by 5mC, 5fC, and 5caC in the CG dinucleotide.
Topics: 5-Methylcytosine; Animals; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Crystallography, X-Ray; Cytosine; Cytosine Nucleotides; DNA; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Nucleotide Motifs; Transcription Factors | 2015 |
The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells.
Topics: 5-Methylcytosine; Azacitidine; Catalytic Domain; Chromatography, High Pressure Liquid; CpG Islands; Cytosine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; HL-60 Cells; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; MCF-7 Cells; Microscopy, Fluorescence; Mixed Function Oxygenases; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Fluorescence; Tandem Mass Spectrometry | 2015 |
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Histones; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Oocytes; Ovary; Protein Isoforms; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Vinyl Compounds | 2015 |
5-Formylcytosine can be a stable DNA modification in mammals.
Topics: 5-Methylcytosine; Aging; Animals; Animals, Newborn; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Developmental; Half-Life; Liver; Mice; Mice, Inbred C57BL; Myocardium | 2015 |
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
Topics: 5-Methylcytosine; Crystallography, X-Ray; Cytosine; DNA Methylation; DNA Repair; Epigenesis, Genetic; Hydrogen Bonding; Kinetics; RNA Polymerase II; Saccharomyces cerevisiae; Substrate Specificity; Templates, Genetic; Thymine DNA Glycosylase; Transcription Elongation, Genetic | 2015 |
Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.
Topics: 5-Methylcytosine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Animals; Brain; Child; Child, Preschool; Cytosine; Humans; Infant; Mice; Middle Aged; Young Adult | 2015 |
Charting oxidized methylcytosines at base resolution.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; DNA; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mammals; Oxidation-Reduction | 2015 |
Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale.
Topics: 5-Methylcytosine; Animals; Cell Line; CpG Islands; Cytosine; DNA Methylation; DNA Primers; Epigenomics; Gene Expression Regulation; Genome; Mice; Mice, Transgenic; Oligonucleotides; Oxygen; Polymerase Chain Reaction; Sequence Analysis, DNA; Stem Cells; Sulfites | 2015 |
Structural insight into substrate preference for TET-mediated oxidation.
Topics: 5-Methylcytosine; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Humans; Hydrogen Bonding; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Protein Binding; Proto-Oncogene Proteins; Substrate Specificity | 2015 |
The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Mammals; Mass Spectrometry; Oxidation-Reduction; RNA | 2016 |
Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression; Kidney; Liver; Lung; Male; Myocardium; Organ Specificity; Pentoxyl; Rats; Rats, Wistar; Swine; Tandem Mass Spectrometry; Thymus Gland | 2015 |
Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability.
Topics: 5-Methylcytosine; Biomechanical Phenomena; Cytosine; DNA; DNA Methylation; Molecular Dynamics Simulation; Nucleosomes; Oxidation-Reduction | 2016 |
Methylation-assisted bisulfite sequencing to simultaneously map 5fC and 5caC on a genome-wide scale for DNA demethylation analysis.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Line; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Mice; Sequence Analysis, DNA; Sulfites | 2016 |
TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.
Topics: 5-Methylcytosine; Animals; B-Lymphocytes; Base Sequence; Cell Line; Cytosine; Dioxygenases; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Fibroblasts; Genomic Instability; Humans; Hydroxylation; Megakaryocyte Progenitor Cells; Mice; Mutagenesis; Proto-Oncogene Proteins; S Phase; Thymine DNA Glycosylase; Tumor Suppressor Protein p53 | 2016 |
Simple and accurate single base resolution analysis of 5-hydroxymethylcytosine by catalytic oxidative bisulfite sequencing using micelle incarcerated oxidants.
Topics: 5-Methylcytosine; Adamantane; Animals; Cyclic N-Oxides; Cytosine; DNA, Single-Stranded; Embryonic Stem Cells; Iodobenzenes; Mice; Micelles; Onium Compounds; Oxidants; Oxidation-Reduction; Sequence Analysis, DNA; Sodium Dodecyl Sulfate; Sulfites; Temperature | 2016 |
Isocitrate Dehydrogenase 2 Dysfunction Contributes to 5-hydroxymethylcytosine Depletion in Gastric Cancer Cells.
Topics: 5-Methylcytosine; Cytosine; DNA Methylation; Female; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Male; Stomach Neoplasms | 2016 |
Discrimination between 5-Hydroxymethylcytosine and 5-Methylcytosine in DNA via Selective Electrogenerated Chemiluminescence (ECL) Labeling.
Topics: 5-Methylcytosine; Biosensing Techniques; Cytosine; DNA; DNA Probes; Humans; Limit of Detection; Luminescence; Luminol; Nucleic Acid Hybridization; Oxidation-Reduction; Ruthenium | 2016 |
Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA Methylation; Nucleosomes; Oxidation-Reduction | 2016 |
Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA.
Topics: 5-Methylcytosine; Ascorbic Acid; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Pentoxyl; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine | 2016 |
Combinatorial DNA methylation codes at repetitive elements.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cytosine; DNA Methylation; DNA Transposable Elements; Epigenesis, Genetic; Fibroblasts; Genome; Mice; Mouse Embryonic Stem Cells; Primary Cell Culture; Repetitive Sequences, Nucleic Acid; Thymine DNA Glycosylase | 2017 |
Differential expression of ten-eleven translocation genes in endometrial cancers.
Topics: 5-Methylcytosine; Aged; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Endometrial Neoplasms; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Middle Aged; Mixed Function Oxygenases; Prognosis; Proto-Oncogene Proteins | 2017 |
Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.
Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cyclic AMP Response Element-Binding Protein; Cytosine; DNA; DNA Methylation; Gene Expression Regulation; Humans; Promoter Regions, Genetic; Protein Binding; Thymine DNA Glycosylase | 2017 |
Understanding the influence of antipsychotic drugs on global methylation events and its relevance in treatment response.
Topics: 5-Methylcytosine; Adult; Antipsychotic Agents; Case-Control Studies; Clozapine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Female; Haloperidol; Hep G2 Cells; Humans; Male; MicroRNAs; Olanzapine; Pharmacogenetics; Schizophrenia; Treatment Outcome | 2018 |
Two are better than one: HPoxBS - hairpin oxidative bisulfite sequencing.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Mice; Oxidation-Reduction; Proto-Oncogene Proteins; Sulfites | 2018 |
Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cytosine; DNA, Neoplasm; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging | 2019 |
Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer.
Topics: 5-Methylcytosine; Adult; Aged; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Prognosis; Prostatic Neoplasms; Receptors, Estrogen; Tissue Array Analysis | 2018 |
Vitrification of murine mature metaphase II oocytes perturbs DNA methylation reprogramming during preimplantation embryo development.
Topics: 5-Methylcytosine; Animals; Blastocyst; Cryopreservation; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryonic Development; Female; Fertilization in Vitro; Metaphase; Mice; Morula; Oocytes; Oogenesis; Pregnancy; Proto-Oncogene Proteins; Vitrification | 2019 |
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
Topics: 5-Methylcytosine; AlkB Enzymes; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Animals; Computational Biology; CpG Islands; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Molecular Structure; Oxidation-Reduction | 2019 |
5-Methylcytosine is Oxidized to the Natural Metabolites of TET Enzymes by a Biomimetic Iron(IV)-Oxo Complex.
Topics: 5-Methylcytosine; Biomimetic Materials; Cerium; Coordination Complexes; Cytosine; Dioxygenases; Epigenesis, Genetic; Iron; Kinetics; Oxidation-Reduction; Thermodynamics | 2019 |
The clinical values of dysregulated DNA methylation and demethylation intermediates in acute lymphoblastic leukemia.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Area Under Curve; Biomarkers, Tumor; Cell Lineage; Child; Cytosine; Demethylation; DNA Methylation; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; ROC Curve; Young Adult | 2019 |
Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; DNA-Directed DNA Polymerase; Epigenomics; Genome; Humans; Mice; Oxides; Polymerase Chain Reaction; Polymerization; Rats | 2019 |
Epigenetic modification of cytosines fine tunes the stability of i-motif DNA.
Topics: 5-Methylcytosine; Cell Line; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Hydrogen-Ion Concentration; MCF-7 Cells; Nucleotide Motifs | 2020 |
Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome.
Topics: 5-Methylcytosine; Chromatography, High Pressure Liquid; Cytosine; DNA Methylation; Epigenesis, Genetic; Genome, Plant; Mass Spectrometry; Norway; Picea | 2019 |
Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS).
Topics: 5-Methylcytosine; Animals; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Hydrolysis; Tandem Mass Spectrometry; Zebrafish | 2021 |
Immunohistochemical Detection of 5-Hydroxymethylcytosine and 5-Carboxylcytosine in Sections of Zebrafish Embryos.
Topics: 5-Methylcytosine; Animals; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Embryo, Nonmammalian; Immunohistochemistry; Zebrafish | 2021 |
Immunochemical Detection of Modified Species of Cytosine in Plant Tissues.
Topics: 5-Methylcytosine; Antibodies; Cell Nucleus; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Dyes; Immunohistochemistry; Plants | 2021 |
Antigen Retrieval for Immunostaining of Modified Cytosine Species.
Topics: 5-Methylcytosine; Animals; Antibodies; Antigens; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Fluorescent Antibody Technique; Humans | 2021 |
Analysis of 5-Carboxylcytosine Distribution Using DNA Immunoprecipitation.
Topics: 5-Methylcytosine; Animals; Chromatin Immunoprecipitation; Cytosine; DNA; DNA Methylation; Humans; Immunoprecipitation | 2021 |
bZIP Dimers CREB1, ATF2, Zta, ATF3|cJun, and cFos|cJun Prefer to Bind to Some Double-Stranded DNA Sequences Containing 5-Formylcytosine and 5-Carboxylcytosine.
Topics: 5-Methylcytosine; Amino Acid Sequence; Animals; Basic-Leucine Zipper Transcription Factors; Cytosine; DNA; Mice; Protein Array Analysis; Protein Binding | 2020 |
Pairwise Proximity-Differentiated Visualization of Single-Cell DNA Epigenetic Marks.
Topics: 5-Methylcytosine; Cell Line; Chromatin; Cytosine; DNA; Humans; Molecular Structure; Single-Cell Analysis | 2021 |
TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.
Topics: 5-Methylcytosine; CpG Islands; Cytosine; Dioxygenases; DNA Demethylation; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Oxidation-Reduction; Proto-Oncogene Proteins; Thymine DNA Glycosylase | 2021 |
Distinguishing Active Versus Passive DNA Demethylation Using Illumina MethylationEPIC BeadChip Microarrays.
Topics: 5-Methylcytosine; Computational Biology; Cytosine; DNA; DNA Demethylation; DNA Methylation; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Microarray Analysis; Oxidation-Reduction; Sulfites | 2021 |
Pearl Necklacelike Strategy Enables Quantification of Global 5-Hydroxymethylcytosine and 5-Formylcytosine by Inductively Coupled Plasma-Atomic Emission Spectrometry.
Topics: 5-Methylcytosine; Cytosine; Spectrum Analysis | 2021 |
Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; Cell Proliferation; Cytosine; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression; Genetic Loci; Hematopoiesis; Interleukin-4; Isoenzymes; Lipopolysaccharides; Longevity; Macrophages; Mice; Mice, Knockout; T-Lymphocytes; Thymine DNA Glycosylase | 2021 |
Proteome-Wide Profiling of Readers for DNA Modification.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Humans; Mice; Mice, Inbred C57BL; Models, Animal; Proteome; Transcription Factors | 2021 |