5-hydroxymethyl-2'-deoxyuridine has been researched along with thymidine in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (28.92) | 18.7374 |
| 1990's | 23 (27.71) | 18.2507 |
| 2000's | 15 (18.07) | 29.6817 |
| 2010's | 16 (19.28) | 24.3611 |
| 2020's | 5 (6.02) | 2.80 |
| Authors | Studies |
|---|---|
| Lewis, HL; Muhleman, DR; Ward, JF | 1 |
| Frenkel, K; Karkoszka, J; Khasak, D; Shupack, J; Stiller, M | 1 |
| Bhimani, R; Frenkel, K; Patel, U | 1 |
| Boorstein, RJ; Chiu, LN; Teebor, GW | 1 |
| Glauert, HP; Srinivasan, S | 1 |
| Cutler, RG; Hartman, PE; Kirsh, ME | 1 |
| Frenkel, K; Tofigh, S | 1 |
| Kaufman, ER | 3 |
| Lockshin, A; Meshcherikova, VV | 1 |
| Frenkel, K | 1 |
| Boorstein, RJ; Cannon, SV; Teebor, GW | 1 |
| Boorstein, RJ; Teebor, GW | 2 |
| Frenkel, K; Rossman, TG; Shirnamé-Moré, L; Teebor, GW; Troll, W | 1 |
| Vilpo, JA; Vilpo, LM | 1 |
| Bilimoria, MH; Gupta, SV | 1 |
| Rasi, S; Suvanto, E; Vilpo, JA; Vilpo, LM | 1 |
| Kangas, L; Suvanto, E; Vilpo, JA | 1 |
| Chrzan, K; Frenkel, K; Steinberg, JJ; Teebor, GW; Troll, W | 1 |
| Bergstrom, D; Kahilainen, L; Kangas, L; Vilpo, JA | 1 |
| Gupta, VS; Lowes, NR; Meldrum, JB; Paterson, AR | 1 |
| Bergstrom, DE; Kahilainen, LI; Vilpo, JA | 1 |
| Chen, MS; Prusoff, WH; Schinazi, RF; Shiau, GT | 1 |
| Frenkel, K; Goldstein, MS; Teebor, GW | 1 |
| Frenkel, K; Wei, H; Wei, L | 1 |
| Fujimoto, A; Lin, MS; Zhang, A | 1 |
| Bhimani, RS; Frenkel, K; Grunberger, D; Troll, W | 1 |
| Boorstein, RJ; Chiu, LN; Mahl, E; Mi, LJ | 1 |
| Boorstein, RJ; Haldar, J; Poirier, G; Putnam, D | 1 |
| de Jong, AP; Ferreira, MR; Teixeira, AJ; van de Werken, G; van Dijk, WJ | 1 |
| de Jong, AP; Gommers-Ampt, JH; Stavenuiter, JF; Teixeira, AJ; Van de Werken, G; Westra, JG | 1 |
| Frenkel, K; Karkoszka, J; Khasak, D; Sasson, M; Shupack, JL; Stiller, MJ | 1 |
| Frenkel, K; Karkoszka, J; Kim, E; Taioli, E | 1 |
| Djuric, Z; Everett, CK; Luongo, DA | 1 |
| Beland, FA; Culp, SJ; Djurić, Z; Luongo, DA; Potter, DW | 1 |
| Fazakerley, GV; Mellac, S; Sowers, LC | 1 |
| Djuric, Z; Heilbrun, LK; LoRusso, PM; Luongo, DA; Martino, S; Simon, MS; Smith, D | 1 |
| Bramham, J; Galeone, A; Jia, X; Kearns, DR; Mayol, L; Pasternack, LB | 1 |
| Boorstein, RJ; Chaung, W | 1 |
| Boorstein, RJ; Chaung, W; Mahl, E; Mi, LJ | 1 |
| Buison, AM; Djuric, Z; Guo, F; Jen, KL; Pellizzon, MA; Uhley, VE | 1 |
| Kearns, DR; Pasternack, LB; Silva, MV | 1 |
| Dubin, N; Frenkel, K; Glassman, T; Karkoszka, J; Kato, I; Mooney, LA; Taioli, E; Toniolo, P | 1 |
| Djuric, Z; Heilbrun, LK; Lababidi, S; Simon, MS; Stephens, D | 1 |
| Boorstein, RJ; Chaung, W; Horowitz, R; Mi, LJ; Teebor, GW | 1 |
| Berzinkas, E; Djuric, Z; Heilbrun, LK; Kosir, MA; Lababidi, S; Simon, MS | 1 |
| Djuric, Z; Potter, DW; Strasburg, GM; Taffe, BG | 1 |
| Blaner, WS; Cooper, TB; Covey, L; Frenkel, K; Hsu, Y; Karkoszka, J; Mooney, LA; Perera, FP; Van Bennekum, AM | 1 |
| Cooney, RV; Franke, AA; Frenkel, K; Karkoszka, J; Maskarinec, G; Okinaka, L; Wilkens, LR | 1 |
| Djuric, Z; Hart, RW; Lewis, SM; Lu, MH; Mayhugh, M; Tang, N | 1 |
| Djuric, Z; Hart, RW; Lewis, SM; Lu, MH; Mayhugh, M; Naegeli, L; Tang, N | 1 |
| Berglund, G; Frenkel, K; Gullberg, B; Janzon, L; Karkoszka, J; Seidegård, J; Wallström, P; Wirfält, E | 1 |
| Ahmed, A; Cutler, RG; Gucciardo, F; Harman, SM; Heward, CB; Liang, L; Ping, W; Reaven, PD; Tsitouras, PD | 1 |
| Berwick, M; Brady, MS; Coit, D; Frenkel, K; Karkoszka, J; Leibes, L; Mahabir, S | 1 |
| Beck, G; Bohr, VA; Imam, SZ; Muftuoglu, M; Wilson, DM; Wong, HK | 1 |
| Burdzy, A; Darwanto, A; Hadley, SR; Herring, JL; Neidigh, JW; Rogstad, DK; Rogstad, KN; Sowers, LC | 1 |
| Cho, SH; Choi, MH; Chung, BC; Kwon, OS; Lee, WY | 1 |
| Cho, SH; Choi, MH; Chung, BC; Lee, WY | 1 |
| Bahde, R; Guerrero, C; Gupta, S; Wang, J; Wang, Y; Yuan, B | 1 |
| Killen, MW; Pierce, AJ; Shelton, BJ; Stults, DM | 1 |
| Doseth, B; Kavli, B; Krokan, HE; Pettersen, HS; Slupphaug, G; Svaasand, EK; Vågbø, CB; Visnes, T | 1 |
| Craft, NE; Franco, EL; Frenkel, K; Giuliano, AR; Lee, JH; Lu, B; Nyitray, AG; Patel, N; Siegel, EM; Villa, LL | 1 |
| Dumke, CL; Henson, DA; McAnulty, LS; McAnulty, SR; Milne, G; Nieman, DC; Shooter, LA; Utter, AC | 1 |
| Dingler, FA; Kemmerich, K; Neuberger, MS; Rada, C | 1 |
| Frecer, V; Munier-Lehmann, H; Risseeuw, MD; Toti, KS; Van Calenbergh, S; Verbeke, F | 1 |
| Brooks, PJ; Fisher, DE; Guerrero, C; Liu, S; Mitra, D; Song, H; Su, Y; Wang, J; Wang, Y; Zeng, Y | 1 |
| Dunwell, JM; Dunwell, TL; Liu, S; Pfeifer, GP; Ullah, I; Wang, Y | 1 |
| Alizadeh, E; García, G; Madugundu, GS; Sanche, L; Sanz, AG; Wagner, JR | 1 |
| Foksinski, M; Gackowski, D; Guz, J; Olinski, R; Rozalski, R | 1 |
| Bucci, M; Esposito, V; Galeone, A; Mayol, L; Petraccone, L; Scuotto, M; Varra, M; Vellecco, V; Virgilio, A | 1 |
| El Safadi, Y; Isel, C; Laumond, G; Marquet, R; Moog, C; Paillart, JC; Smyth, RP; Vivet-Boudou, V | 1 |
| Esposito, V; Galeone, A; Giancola, C; Mayol, L; Petraccone, L; Virgilio, A | 1 |
| Javahishvili, T; Li, H; Mehta, AP; Reed, SA; Schultz, PG; Supekova, L | 1 |
| Amato, T; Esposito, F; Esposito, V; Galeone, A; Gomez-Monterrey, I; Grandi, N; Haider, S; Mayol, L; Novellino, E; Petraccone, L; Romero, R; Tramontano, E; Virgilio, A | 1 |
| Beijnen, JH; Heidebrecht, T; Perrakis, A; Roosendaal, J; Rosing, H | 1 |
| Bajrami, I; Boulton, SJ; Carell, T; Fugger, K; Goldstone, R; Hewitt, G; Kelly, G; Kunzelmann, S; MacRae, J; Patel, H; Silva Dos Santos, M; Taylor, IA; West, SC; Young, SJ | 1 |
| Peña-Gómez, MJ; Rosado, IV; Suárez-Pizarro, M | 1 |
| García-Calderón, CB; Klimašauskas, S; Moreno-Gordillo, P; Narmontė, M; Peña-Gómez, MJ; Rosado, IV; Rukšėnaitė, A | 1 |
| Jang, S; Raja, SJ; Roginskaya, V; Schaich, MA; Van Houten, B; Watkins, SC | 1 |
| Chou, TC; Gadler, H; Kalman, TI; Matulic-Adamic, J; Price, RW; Reddy, AR; Takahashi, K; Watanabe, KA | 1 |
| Meyer, RB; Nakayama, C; Saneyoshi, M; Santi, DV; Ueda, T; Wataya, Y | 1 |
1 review(s) available for 5-hydroxymethyl-2'-deoxyuridine and thymidine
| Article | Year |
|---|---|
Oxidation of DNA bases by tumor promoter-activated processes.
Topics: Animals; Carcinogens; DNA; Humans; Hydrogen Peroxide; Neutrophils; Oxidation-Reduction; Plasma; Thymidine | 1989 |
3 trial(s) available for 5-hydroxymethyl-2'-deoxyuridine and thymidine
| Article | Year |
|---|---|
Levels of 5-hydroxymethyl-2'-deoxyuridine in DNA from blood of women scheduled for breast biopsy.
Topics: Biomarkers, Tumor; Biopsy, Needle; Breast Neoplasms; DNA; Incidence; Mass Screening; Oxidative Stress; Risk Assessment; Sensitivity and Specificity; Thymidine | 2001 |
Randomized, placebo-controlled pilot trial of the effects of alpha-tocopherol supplementation on levels of autoantibodies against 5-hydroxymethyl-2-deoxyuridine in melanoma patients.
Topics: alpha-Tocopherol; Antineoplastic Agents; Antioxidants; Autoantibodies; Dietary Supplements; DNA Damage; DNA Repair; Double-Blind Method; Female; gamma-Tocopherol; Humans; Male; Melanoma; Middle Aged; Pilot Projects; Placebos; Skin Neoplasms; Thymidine; Vitamin E | 2004 |
Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Athletes; Biomarkers; Blueberry Plants; Exercise; F2-Isoprostanes; Fruit; Humans; Interleukin-10; Killer Cells, Natural; Lymphocyte Count; Myositis; Oxidative Stress; Physical Endurance; Running; Thymidine; Young Adult | 2011 |
79 other study(ies) available for 5-hydroxymethyl-2'-deoxyuridine and thymidine
| Article | Year |
|---|---|
Serologic assay of DNA base damage. I. 5-Hydroxymethyldeoxyuridine, a radiation product of thymidine.
Topics: Animals; Cobalt Radioisotopes; Coliphages; Cross Reactions; Deoxyuridine; DNA; Haptens; Immunoassay; Rabbits; Serum Albumin, Bovine; Thymidine; Viral Plaque Assay | 1978 |
Enhanced antibody titers to an oxidized DNA base in inflammatory and neoplastic diseases.
Topics: Adult; Aged; Antibodies; Antigen-Antibody Complex; Dermatitis; DNA; Female; Humans; Immune System Diseases; Male; Middle Aged; Neoplasms; Psoriasis; Reactive Oxygen Species; Thymidine; Varicose Ulcer | 1992 |
Mechanism of mutagenicity by 5-hydroperoxymethyl-2'-deoxyuridine, an intermediate product of ionizing radiation, in bacteria. HPMdU bacterial mutagenicity and oxidation of DNA bases.
Topics: Deoxyuridine; DNA Damage; DNA, Bacterial; Free Radicals; Iron; Iron Chelating Agents; Mutagenesis; Mutagenicity Tests; Mutagens; Oxidants; Oxidation-Reduction; Salmonella typhimurium; Thymidine; Thymine | 1992 |
A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine.
Topics: Animals; Cell Division; Cell Line; Colony-Forming Units Assay; Cricetinae; DNA Glycosylases; DNA Repair; Drug Resistance; N-Glycosyl Hydrolases; Nucleosides; Phenotype; Thymidine | 1992 |
Formation of 5-hydroxymethyl-2'-deoxyuridine in hepatic DNA of rats treated with gamma-irradiation, diethylnitrosamine, 2-acetylaminofluorene or the peroxisome proliferator ciprofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibric Acid; Diethylnitrosamine; DNA Damage; Female; Fibric Acids; Liver; Rats; Thymidine | 1990 |
Absence of deoxyuridine and 5-hydroxymethyldeoxyuridine in the DNA from three tissues of mice of various ages.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Deoxyuridine; DNA; Embryo, Mammalian; Intestinal Mucosa; Liver; Male; Mice; Mice, Inbred C57BL; RNA; Thymidine | 1986 |
Effect of metals on nucleoside hydroperoxide, a product of ionizing radiation in DNA.
Topics: Chromatography, High Pressure Liquid; Copper; Deferoxamine; Deoxyuridine; DNA; Edetic Acid; Formates; Iron; Pentetic Acid; Thymidine | 1989 |
Induction of sister chromatid exchanges by the thymidine analog 5-hydroxymethyl-2'-deoxyuridine.
Topics: Animals; Benzamides; Cells, Cultured; DNA; Mutagens; Pentoxyl; Sister Chromatid Exchange; Thymidine | 1989 |
[The selective toxicity of 5-hydroxymethyldeoxyuridine for the cells of human adenocarcinoma of the large intestine].
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Survival; Cells, Cultured; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Embryo, Mammalian; Humans; Intestinal Mucosa; Thymidine; Time Factors; Tumor Cells, Cultured | 1989 |
Enzymatic repair of oxidative DNA damage.
Topics: Animals; Cells, Cultured; Cricetinae; DNA Damage; DNA Repair; Mutation; Oxidation-Reduction; Pentoxyl; Thymidine | 1989 |
Effects of 5-hydroxymethyluracil and 3-aminobenzamide on the repair and toxicity of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Cricetinae; DNA; DNA Repair; HeLa Cells; Pentoxyl; Thymidine; Uracil | 1989 |
Genetic effects of 5-hydroxymethyl-2'-deoxyuridine, a product of ionizing radiation.
Topics: Bacteriophage lambda; DNA, Bacterial; Mutagenicity Tests; Mutation; Salmonella typhimurium; Suppression, Genetic; Thymidine; Virus Activation | 1987 |
Metabolism, incorporation into DNA, and interactions with 1-beta-D-arabinofuranosylcytosine of 5-hydroxymethyl-2'-deoxyuridine in human promyelocytic leukemia cells (HL-60).
Topics: Cell Line; Cell Survival; Cytarabine; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Kinetics; Leukemia, Myeloid, Acute; Thymidine | 1988 |
Mutagenicity of 5-hydroxymethyl-2'-deoxyuridine to Chinese hamster cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Glycosylases; DNA Repair; Mutagenicity Tests; N-Glycosyl Hydrolases; Pentoxyl; Thymidine | 1988 |
Biochemical analysis of toxic effects of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Thymidine | 1986 |
Resistance to toxic effects of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Culture Media; DNA; Drug Resistance; HeLa Cells; Humans; Mutation; Phenotype; Thymidine | 1987 |
Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2'-deoxyuridine analogs in the Ames Salmonella/microsome test.
Topics: Animals; Deoxyuridine; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship; Thymidine | 1986 |
Radioimmunoassay of 5-hydroxymethyl-2'-deoxyuridine.
Topics: Animals; Antibodies; Chromatography, High Pressure Liquid; Cross Reactions; Mice; Mice, Inbred DBA; Rabbits; Radioimmunoassay; Thymidine | 1987 |
Antileukemic activity against L1210 leukemia, pharmacokinetics and hematological side effects of 5-hydroxymethyl-2'-deoxyuridine.
Topics: Animals; Antineoplastic Agents; Blood Cells; Female; Leukemia L1210; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Thymidine | 1987 |
Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes.
Topics: DNA; DNA Damage; Dose-Response Relationship, Radiation; Free Radicals; Humans; Hydroxides; In Vitro Techniques; Iron; Neutrophils; Stereoisomerism; Tetradecanoylphorbol Acetate; Thymidine; Transferrin | 1986 |
In vitro and in vivo studies of a promising antileukemic thymidine analogue, 5-hydroxymethyl-2' deoxyuridine.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Cell Line; Deoxycytidine; Humans; Leukemia; Leukemia L1210; Thymidine | 1986 |
Toxicologic and antitumor studies on 5-hydroxymethyldeoxyuridine.
Topics: Animals; Antineoplastic Agents; Body Weight; Humans; Intestine, Small; Leukemia L1210; Leukemia L5178; Liver; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasm Transplantation; Thymidine | 1985 |
5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells.
Topics: Carbon Radioisotopes; Cell Division; Cell Line; DNA; DNA, Neoplasm; Humans; Kinetics; Leukemia; Lymphoma; Thymidine | 1985 |
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Deoxyribonucleosides; Female; Kinetics; Leukemia L1210; Mice; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Structure-Activity Relationship; Thymidine; Zidovudine | 1980 |
Ionizing radiation and tritium transmutation both cause formation of 5-hydroxymethyl-2'-deoxyuridine in cellular DNA.
Topics: DNA; Female; Gamma Rays; HeLa Cells; Humans; Thymidine; Tritium | 1984 |
7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; DNA; DNA Damage; Female; Guanine; Hydrogen Peroxide; Mice; Mice, Inbred SENCAR; Neutrophils; Oxidation-Reduction; Peroxidase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine | 1995 |
Effects of 5-hydroxymethyl-2'-deoxyuridine and 3-aminobenzamide on chromosome aberrations in cultured human lymphocytes.
Topics: Antineoplastic Agents; Benzamides; Chromosome Aberrations; DNA Repair; Drug Synergism; Humans; Lymphocytes; Mitotic Index; Poly(ADP-ribose) Polymerase Inhibitors; Sister Chromatid Exchange; Thymidine | 1993 |
Inhibition of oxidative stress in HeLa cells by chemopreventive agents.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Anticarcinogenic Agents; Antineoplastic Agents; Caffeic Acids; Catechin; Deoxyguanosine; Diterpenes; DNA, Neoplasm; HeLa Cells; Humans; Hydrogen Peroxide; Hydrolyzable Tannins; Oxidation-Reduction; Phenylethyl Alcohol; Tamoxifen; Tannins; Tetradecanoylphorbol Acetate; Thymidine | 1993 |
Toxicity of camptothecin to Chinese hamster cells containing 5-hydroxymethyl-2'-deoxyuridine in their DNA.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Line; Cricetinae; Cricetulus; DNA Repair; Dose-Response Relationship, Drug; Drug Synergism; Irinotecan; Lung; Naphthoquinones; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; S Phase; Thymidine; Topoisomerase I Inhibitors | 1995 |
DNA base excision repair of 5-hydroxymethyl-2'-deoxyuridine stimulates poly(ADP-ribose) synthesis in Chinese hamster cells.
Topics: Animals; Antineoplastic Agents; Benzamides; Bromodeoxyuridine; Carcinogens; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Repair; Kinetics; Methylnitronitrosoguanidine; NAD; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Thymidine; Time Factors | 1995 |
Analysis of 8-hydroxy-2'-deoxyguanosine in rat urine and liver DNA by stable isotope dilution gas chromatography/mass spectrometry.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Gas Chromatography-Mass Spectrometry; Indicator Dilution Techniques; Liver; Male; Nitrogen Isotopes; Oxygen Isotopes; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Thymidine | 1995 |
Method for the analysis of oxidized nucleosides by gas chromatography/mass spectrometry.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylation; Bacillus subtilis; Bacteriophages; Biological Assay; Catalysis; Deoxyguanosine; DNA, Viral; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Linear Models; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity; Thymidine | 1993 |
Antibody titers to an oxidized thymidine moiety are altered by systemic pharmacotherapy and by ultraviolet B phototherapy.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Cell Survival; Humans; Immune Complex Diseases; Molecular Structure; Oxidation-Reduction; Psoriasis; Thymidine; Titrimetry; Ultraviolet Therapy | 1993 |
Recognition of oxidized DNA bases by sera of patients with inflammatory diseases.
Topics: Adult; Aged; Aging; Antibodies, Antinuclear; Antigens; Autoantibodies; DNA; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Oxidation-Reduction; Serum Albumin, Bovine; Thymidine | 1993 |
Toxicity, single-strand breaks, and 5-hydroxymethyl-2'-deoxyuridine formation in human breast epithelial cells treated with hydrogen peroxide.
Topics: Antioxidants; Breast Neoplasms; Catalase; DNA Damage; Epithelium; Free Radicals; Glutathione Reductase; Humans; Hydrogen Peroxide; Superoxide Dismutase; Thymidine; Tumor Cells, Cultured | 1993 |
Formation of DNA adducts and oxidative DNA damage in rats treated with 1,6-dinitropyrene.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; DNA; DNA Damage; Female; Liver; Oxidation-Reduction; Pyrenes; Rats; Rats, Sprague-Dawley; Thymidine; Urinary Bladder | 1993 |
Structures of base pairs with 5-(hydroxymethyl)-2'-deoxyuridine in DNA determined by NMR spectroscopy.
Topics: Base Composition; DNA; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Protons; Thymidine | 1993 |
Levels of 5-hydroxymethyl-2'-deoxyuridine in DNA from blood as a marker of breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; DNA; DNA Damage; Female; Humans; Middle Aged; Odds Ratio; Pilot Projects; Postmenopause; Reference Values; Regression Analysis; Risk Factors; Smoking; Statistics, Nonparametric; Thymidine | 1996 |
1H NMR studies of the 5-(hydroxymethyl)-2'-deoxyuridine containing TF1 binding site.
Topics: Base Sequence; Binding Sites; DNA; DNA-Binding Proteins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Protons; Temperature; Thymidine; Viral Proteins | 1996 |
Molecular spectrum of mutations induced by 5-hydroxymethyl-2'-deoxyuridine in (CHO)-PL61 cells.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Blotting, Southern; CHO Cells; Cricetinae; DNA; DNA Repair; Escherichia coli Proteins; Gene Expression Regulation; Gentamicins; Hypoxanthine Phosphoribosyltransferase; Kanamycin Kinase; Molecular Sequence Data; Mutagenesis; Mutagenesis, Insertional; Mutagenicity Tests; Pentosyltransferases; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proteins; Sequence Deletion; Thioguanine; Thymidine | 1997 |
Lack of phenotypic alteration of hmUra-DNA glycosylase-deficient hamster cells exposed to DNA-damaging agents.
Topics: Alkylating Agents; Animals; Benzamides; Cell Division; Cell Line; Cell Survival; Cricetinae; DNA Damage; DNA Glycosylases; DNA Repair; Drug Resistance; Gamma Rays; Glycosylation; Mutagenesis; Mutagenicity Tests; Mutagens; N-Glycosyl Hydrolases; Oxidants; Poly Adenosine Diphosphate Ribose; Thymidine; Ultraviolet Rays | 1997 |
Chronic weight cycling increases oxidative DNA damage levels in mammary gland of female rats fed a high-fat diet.
Topics: Animals; DNA Damage; Energy Intake; Female; Mammary Glands, Animal; Oxidation-Reduction; Rats; Rats, Wistar; Thymidine; Weight Gain; Weight Loss | 1997 |
Nuclear magnetic resonance-based model of a TF1/HmU-DNA complex.
Topics: Bacillus subtilis; Bacterial Proteins; Computer Simulation; DNA; DNA-Binding Proteins; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Protein Conformation; Protein Structure, Secondary; Thymidine; Transcription Factors; Viral Proteins | 1997 |
Serum autoantibodies recognizing 5-hydroxymethyl-2'-deoxyuridine, an oxidized DNA base, as biomarkers of cancer risk in women.
Topics: Adult; Age Factors; Aged; Autoantibodies; Biomarkers, Tumor; Breast Neoplasms; Colorectal Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Middle Aged; Smoking; Thymidine | 1998 |
Recruitment for a pilot case control study of oxidative DNA damage and breast cancer risk.
Topics: Antineoplastic Agents; Breast Neoplasms; Case-Control Studies; DNA Damage; Female; Humans; Logistic Models; Middle Aged; Molecular Epidemiology; Oxidants; Patient Selection; Pilot Projects; Risk Factors; Thymidine | 2000 |
Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Cell Cycle; Cell Membrane; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Nucleotidylexotransferase; DNA Repair; Fibroblasts; Fluorescein-5-isothiocyanate; G2 Phase; Genes, p53; HL-60 Cells; Humans; Lung; Mice; Mutation; Pentoxyl; Phosphatidylserines; Thymidine; Tumor Suppressor Protein p53 | 2001 |
Comparison of iron-catalyzed DNA and lipid oxidation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; DNA; Ferric Compounds; Ferrous Compounds; Fluorescent Dyes; Hydrogen Peroxide; Iron; Iron Chelating Agents; Kinetics; Lipid Peroxidation; Lipid Peroxides; Liposomes; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Thymidine | 2001 |
Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers.
Topics: Adult; Aged; Antineoplastic Agents; Autoantibodies; Biomarkers; DNA Damage; Female; Humans; Male; Middle Aged; Oxidative Stress; Sex Factors; Smoking; Thymidine | 2001 |
Association of tocopherols with circulating autoantibody levels against an oxidized DNA nucleoside in humans.
Topics: Adult; Antineoplastic Agents; Autoantibodies; DNA; Enzyme-Linked Immunosorbent Assay; Female; Free Radicals; Humans; Lipid Peroxidation; Male; Malondialdehyde; Micronutrients; Middle Aged; Neoplasms; Thymidine; Tocopherols | 2001 |
Effect of varying dietary fat levels on rat growth and oxidative DNA damage.
Topics: Animals; Biomarkers; Body Weight; Diet; Dietary Fats; DNA Damage; Eating; Energy Intake; Food, Formulated; Mammary Glands, Animal; Oxidation-Reduction; Rats; Rats, Inbred F344; Thymidine; Weight Gain | 2001 |
Effect of varying caloric restriction levels on female rat growth and 5-hydroxymethyl-2'-deoxyuridine in DNA.
Topics: Animals; Body Weight; DNA Damage; Eating; Energy Intake; Erythroblasts; Female; Liver; Mammary Glands, Animal; Oxidative Stress; Rats; Rats, Inbred F344; Thymidine; Time Factors | 2002 |
Antibodies against 5-hydroxymethyl-2'-deoxyuridine are associated with lifestyle factors and GSTM1 genotype: a report from the Malmö Diet and Cancer cohort.
Topics: Age Distribution; Aged; Alcohol Drinking; Autoantibodies; Biomarkers; Body Composition; Cohort Studies; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Diet; Female; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Humans; Life Style; Male; Middle Aged; Neoplasms; Obesity; Prospective Studies; Registries; Risk Factors; Sex Distribution; Smoking; Sweden; Thymidine | 2003 |
Urinary excretion of three nucleic acid oxidation adducts and isoprostane F(2)alpha measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Age Distribution; Aged; Aged, 80 and over; Chromatography, Liquid; Deoxyguanosine; Dinoprost; DNA Adducts; Female; Guanosine; Humans; Male; Mass Spectrometry; Middle Aged; Oxidation-Reduction; Oxidative Stress; Sex Distribution; Smoking; Thymidine | 2003 |
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates.
Topics: Cell Line, Transformed; DNA Helicases; DNA Repair; DNA Repair Enzymes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Genome, Human; Humans; Methyl Methanesulfonate; Poly-ADP-Ribose Binding Proteins; Thymidine | 2007 |
Measurement of the incorporation and repair of exogenous 5-hydroxymethyl-2'-deoxyuridine in human cells in culture using gas chromatography-negative chemical ionization-mass spectrometry.
Topics: Biomarkers; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Repair; Formates; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Peroxide; Hydrolysis; Sensitivity and Specificity; Thymidine; Thymine | 2007 |
Metabolic significance of bisphenol A-induced oxidative stress in rat urine measured by liquid chromatography-mass spectrometry.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzhydryl Compounds; Chromatography, Liquid; Deoxyguanosine; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal; Female; Mass Spectrometry; Metabolomics; Nucleosides; Oxidative Stress; Phenols; Rats; Rats, Sprague-Dawley; Thymidine; Time Factors; Urinalysis | 2009 |
Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine; Adult; Breast Neoplasms; Chromatography, Liquid; Deoxyguanosine; Female; Guanosine; Humans; Mastectomy; Middle Aged; Nucleosides; Oxidative Stress; Postoperative Period; Reactive Oxygen Species; Tandem Mass Spectrometry; Thymidine | 2009 |
Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxyguanosine; Deoxyuridine; DNA Damage; DNA Repair; Gene Expression Regulation; Isotopes; Liver; Oxidation-Reduction; Rats; Rats, Inbred LEC; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Stereoisomerism; Tandem Mass Spectrometry; Thymidine; Time Factors | 2011 |
Recombination phenotypes of the NCI-60 collection of human cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Repair; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Multigene Family; Neoplasms; Phenotype; Recombination, Genetic; Sister Chromatid Exchange; Thymidine | 2011 |
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Topics: Animals; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Floxuridine; Fluorouracil; Gene Knockdown Techniques; Humans; Mice; MutS Homolog 2 Protein; RNA; Thymidine; Thymine DNA Glycosylase; Uracil-DNA Glycosidase; Uridine | 2011 |
Biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: markers of immune response?
Topics: Adult; Autoantibodies; Biomarkers; Cohort Studies; DNA, Viral; Female; Human papillomavirus 16; Humans; Malondialdehyde; Middle Aged; Oxidants; Papillomavirus Infections; Proportional Hazards Models; Reactive Oxygen Species; Thymidine; Uterine Cervical Neoplasms; Young Adult | 2012 |
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Topics: Animals; beta-Galactosidase; Cell Line; DNA Repair; Fibroblasts; Fluorouracil; Gene Targeting; Genetic Predisposition to Disease; Longevity; Mice; Mice, Inbred C57BL; Mice, Knockout; MutS Homolog 2 Protein; Neoplasms, Experimental; Pentoxyl; Thymidine; Uracil-DNA Glycosidase | 2012 |
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Topics: Antitubercular Agents; Humans; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Thymidine; Tuberculosis | 2013 |
Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Cell Line, Tumor; Chromatography, High Pressure Liquid; Deoxycytidine; Dioxygenases; DNA; DNA-Binding Proteins; HEK293 Cells; Humans; Mice; Mixed Function Oxygenases; Oxidation-Reduction; Proto-Oncogene Proteins; Skin; Tandem Mass Spectrometry; Thymidine | 2013 |
Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA.
Topics: Arabidopsis; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxycytidine Monophosphate; DNA, Plant; Epigenesis, Genetic; Fluoresceins; Isotope Labeling; Molecular Structure; Nucleosides; Oxidation-Reduction; Tandem Mass Spectrometry; Thymidine | 2013 |
Thymidine decomposition induced by low-energy electrons and soft X rays under N2 and O2 atmospheres.
Topics: Atmospheric Pressure; Carbon; Deoxyuridine; DNA Damage; Electrons; Glass; Photons; Tandem Mass Spectrometry; Tantalum; Thymidine; X-Rays | 2014 |
Comparison of the absolute level of epigenetic marks 5-methylcytosine, 5-hydroxymethylcytosine, and 5-hydroxymethyluracil between human leukocytes and sperm.
Topics: 5-Methylcytosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Leukocytes; Male; Pentoxyl; Poland; Spectrometry, Mass, Electrospray Ionization; Spermatozoa; Tandem Mass Spectrometry; Thymidine; Up-Regulation | 2014 |
5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification.
Topics: Anticoagulants; Aptamers, Nucleotide; Base Sequence; Circular Dichroism; Fibrinogen; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Binding; Thrombin; Thymidine | 2014 |
Evaluation of anti-HIV-1 mutagenic nucleoside analogues.
Topics: Anti-HIV Agents; Base Pair Mismatch; Base Pairing; Base Sequence; Deoxycytidine; Drug Design; High-Throughput Screening Assays; HIV Reverse Transcriptase; HIV-1; Molecular Sequence Data; Mutagenesis; Mutagens; Nucleic Acid Denaturation; Predictive Value of Tests; Reverse Transcriptase Inhibitors; Reverse Transcription; Thermodynamics; Thymidine; Time Factors | 2015 |
The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2'-deoxyuridine on telomeric G-quadruplex structures.
Topics: Calorimetry, Differential Scanning; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; G-Quadruplexes; Humans; Nucleic Acid Denaturation; Oxidation-Reduction; Telomere; Temperature; Thymidine | 2015 |
Replacement of Thymidine by a Modified Base in the Escherichia coli Genome.
Topics: Base Sequence; DNA, Bacterial; Escherichia coli; Genetic Engineering; Genome, Bacterial; Plasmids; Thymidine | 2016 |
Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops.
Topics: Aptamers, Nucleotide; Drug Discovery; G-Quadruplexes; HIV Infections; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Molecular Docking Simulation; Thymidine | 2018 |
Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein.
Topics: Chromatography, High Pressure Liquid; DNA-Binding Proteins; Leishmania; Protozoan Proteins; Substrate Specificity; Tandem Mass Spectrometry; Thymidine | 2020 |
Targeting the nucleotide salvage factor DNPH1 sensitizes
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; CRISPR-Cas Systems; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; DNA Breaks, Double-Stranded; DNA Replication; DNA, Neoplasm; Drug Resistance, Neoplasm; Genes, BRCA1; Humans; Hydrolysis; N-Glycosyl Hydrolases; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Synthetic Lethal Mutations; Thymidine; Uracil-DNA Glycosidase | 2021 |
XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxyuridine.
Topics: 5-Methylcytosine; Cell Line; Cell Survival; Deoxycytidine; DNA Damage; DNA Demethylation; DNA Replication; Epigenesis, Genetic; Genomic Instability; Humans; Replication Origin; Thymidine; X-ray Repair Cross Complementing Protein 1 | 2022 |
FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2'-deoxycytidine and 5-hydroxymethyl-2'-deoxyuridine.
Topics: Deoxycytidine; DNA Demethylation; DNA Replication; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Humans; Thymidine | 2022 |
UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties.
Topics: DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Thymidine; Ultraviolet Rays | 2023 |
Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Chemical Phenomena; Chemistry; Deoxyuridine; Encephalitis; Herpes Simplex; Nucleosides; Radionuclide Imaging; Rats; Simplexvirus; Structure-Activity Relationship; Thymidylate Synthase; Uridine | 1988 |
Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.
Topics: Animals; Deoxyuridine; Horses; In Vitro Techniques; Models, Biological; Pentosyltransferases; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Thymidine Phosphorylase | 1980 |