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5-hydroxyflavone and 7-hydroxyflavone

5-hydroxyflavone has been researched along with 7-hydroxyflavone in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (27.27)18.2507
2000's6 (27.27)29.6817
2010's8 (36.36)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Constantinou, A; Mehta, R; Moon, R; Rao, K; Runyan, C; Vaughan, A1
Ares, JJ; Ems, BL; Kakodkar, SV; Kelm, GR; Kershaw, WC; Murray, PD; O'Brien, LM; Outt, PE; Randall, JL; Weisshaar, PS1
Jacobson, KA; Ji, XD; Melman, N1
Jacobson, KA; Moro, S; Sanders, LH; van Rhee, AM1
Albasini, A; Antolini, L; Bose, P; Costantino, L; Del Corso, A; Gamberini, MC; Iannone, A; Mura, U; Rastelli, G; Staffieri, M; Vinson, JA1
Dekermendjian, K; Kahnberg, P; Liljefors, T; Nielsen, M; Sterner, O; Witt, MR1
Chi, YS; Dao, TT; Kim, HP; Kim, J; Kim, S; Park, H1
Brun, R; Lack, G; Perozzo, R; Rüedi, P; Scapozza, L; Tasdemir, D1
Cavaleiro, JA; Fernandes, E; Gomes, A; Lima, JL; Pinto, DC; Santos, CM; Silva, AM1
Akamatsu, M; Hosoda, A; Hotta, Y; Ishimoto, Y; Nishizaki, Y; Tamura, H; Yoshikawa, H1
Amić, D; Lucić, B1
Ataide Martins, JP; Borges de Melo, E; Castro Ferreira, MM; Friozi, MC; Marinho Jorge, TC1
Chan, CB; France, S; He, K; Huang, J; Jang, SW; Jia, Y; Liu, X; Luo, HR; Phun, LH; Pradoldej, S; Xiao, G; Ye, K1
Fernandes, E; Freitas, M; Porto, G; Ribeiro, D; Silva, AM; Tomé, SM1
Cabrita, EJ; Fernandes, E; Freitas, M; Marques, MM; Porto, G; Ribeiro, D; Silva, AM; Tomé, SM1
Govil, G; Joshi, A; Joshi, UJ; Sinha, R; Srivastava, S1
Cahlikova, L; Chlebek, J; Havrankova, J; Hofman, J; Hostalkova, A; Lundova, T; Musilek, K; Novotna, E; Wsol, V; Zemanova, L1
Dutour, R; Poirier, D1
Fernandes, E; Fernandes, PA; Freitas, M; Oliveira, A; Proença, C; Ramos, MJ; Ribeiro, D; Silva, AMS; Sousa, JLC1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Mosca, F; Pacifici, GM; Pietrabissa, A; Spisni, R; Vietri, M1
Chao, PD; Hou, YC; Kuo, SC; Shia, CS; Tsai, SY1

Reviews

1 review(s) available for 5-hydroxyflavone and 7-hydroxyflavone

ArticleYear
Inhibitors of cytochrome P450 (CYP) 1B1.
    European journal of medicinal chemistry, 2017, Jul-28, Volume: 135

    Topics: Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship

2017

Other Studies

21 other study(ies) available for 5-hydroxyflavone and 7-hydroxyflavone

ArticleYear
Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships.
    Journal of natural products, 1995, Volume: 58, Issue:2

    Topics: DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Electrophoresis, Agar Gel; Flavonoids; Hydroxylation; Plasmids; Protein Conformation; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1995
Synthesis and biological evaluation of substituted flavones as gastroprotective agents.
    Journal of medicinal chemistry, 1995, Dec-08, Volume: 38, Issue:25

    Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Flavonoids; Indomethacin; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Oxidoreductases; Rats; Rats, Sprague-Dawley; Stomach Diseases; Structure-Activity Relationship

1995
Interactions of flavonoids and other phytochemicals with adenosine receptors.
    Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3

    Topics: Animals; Cell Line; CHO Cells; Cricetinae; Flavonoids; Humans; Magnetic Resonance Spectroscopy; Plants; Protein Binding; Radioligand Assay; Rats; Receptors, Purinergic P1

1996
Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model.
    Journal of medicinal chemistry, 1998, Jan-01, Volume: 41, Issue:1

    Topics: Binding Sites; Computer Simulation; Flavonoids; Kinetics; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Regression Analysis; Reproducibility of Results; Static Electricity; Structure-Activity Relationship

1998
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.
    Journal of medicinal chemistry, 1999, Jun-03, Volume: 42, Issue:11

    Topics: Aldehyde Reductase; Animals; Antioxidants; Benzopyrans; Cattle; Enzyme Inhibitors; Humans; Kidney; Lens, Crystalline; Lipoproteins, LDL; Lipoproteins, VLDL; Models, Molecular; Oxidation-Reduction; Structure-Activity Relationship

1999
Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex.
    Journal of medicinal chemistry, 1999, Oct-21, Volume: 42, Issue:21

    Topics: Animals; Binding Sites; Brain; Flavonoids; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Reproducibility of Results; Structure-Activity Relationship

1999
Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives.
    Bioorganic & medicinal chemistry letters, 2004, Mar-08, Volume: 14, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalysis; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Flavonoids; Isoenzymes; Mice; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Prostaglandins

2004
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
    Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11

    Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; Alcohol Oxidoreductases; Animals; Antimalarials; Catechin; Cells, Cultured; Chloroquine; Drug Resistance; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acids; Flavones; Flavonoids; Humans; Hydro-Lyases; Kinetics; Luteolin; Phenols; Plasmodium falciparum; Polyphenols; Structure-Activity Relationship

2006
2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.
    Bioorganic & medicinal chemistry, 2007, Sep-15, Volume: 15, Issue:18

    Topics: Antioxidants; Chromones; Free Radical Scavengers; Free Radicals; Reactive Nitrogen Species; Reactive Oxygen Species; Styrenes

2007
Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.
    Bioorganic & medicinal chemistry letters, 2009, Aug-15, Volume: 19, Issue:16

    Topics: Androgen Receptor Antagonists; Androgens; Cell Line, Tumor; Flavonoids; Genes, Reporter; Humans; Receptors, Androgen; Receptors, Glucocorticoid; Structure-Activity Relationship

2009
Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Flavonoids; Free Radical Scavengers; Models, Biological; Quantitative Structure-Activity Relationship; Quantum Theory; Software; Thermodynamics

2010
Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:10

    Topics: Algorithms; Antimutagenic Agents; Flavonoids; Fluorenes; Least-Squares Analysis; Models, Biological; Models, Molecular; Mutagens; Quantitative Structure-Activity Relationship; Salmonella typhimurium

2010
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
    Journal of medicinal chemistry, 2010, Dec-09, Volume: 53, Issue:23

    Topics: Animals; Antidepressive Agents; Apoptosis; Flavones; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship

2010
Modulation of human neutrophils' oxidative burst by flavonoids.
    European journal of medicinal chemistry, 2013, Volume: 67

    Topics: Flavonoids; Humans; Luminescent Measurements; Molecular Structure; Neutrophils; Oxidation-Reduction

2013
Inhibition of LOX by flavonoids: a structure-activity relationship study.
    European journal of medicinal chemistry, 2014, Jan-24, Volume: 72

    Topics: Dose-Response Relationship, Drug; Flavonoids; Glycine max; Humans; Leukotriene B4; Lipoxygenase; Molecular Structure; Neutrophils; Structure-Activity Relationship

2014
Localization and interaction of hydroxyflavones with lipid bilayer model membranes: a study using DSC and multinuclear NMR.
    European journal of medicinal chemistry, 2014, Jun-10, Volume: 80

    Topics: Biphenyl Compounds; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Flavones; Free Radical Scavengers; Humans; Hydroxides; Lipid Bilayers; Magnetic Resonance Spectroscopy; Picrates; Structure-Activity Relationship

2014
Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment.
    Journal of natural products, 2015, Nov-25, Volume: 78, Issue:11

    Topics: Aldehyde Reductase; Aldo-Keto Reductases; Apigenin; Daunorubicin; Enzyme Inhibitors; Flavones; Flavonoids; HCT116 Cells; Humans; Luteolin; Molecular Conformation; Molecular Structure; Neoplasms

2015
Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.
    Journal of natural products, 2020, 05-22, Volume: 83, Issue:5

    Topics: Drug Design; Enzyme Inhibitors; Flavonoids; Fructose; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Liver; Molecular Structure

2020
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
7-OH-flavone is sulfated in the human liver and duodenum, whereas 5-OH-flavone and 3-OH-flavone are potent inhibitors of SULT1A1 activity and 7-OH-flavone sulfation rate.
    Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Arylsulfotransferase; Duodenum; Enzyme Inhibitors; Female; Flavonoids; Humans; In Vitro Techniques; Kinetics; Liver; Male; Middle Aged; Substrate Specificity; Sulfates; Sulfotransferases

2002
Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.
    Journal of agricultural and food chemistry, 2009, Jan-14, Volume: 57, Issue:1

    Topics: Animals; Flavonoids; Flavonols; Glucuronides; Hemolysis; Male; Rats; Rats, Sprague-Dawley; Sulfates

2009