5-hydroxybenzimidazole and aminoimidazole-ribotide

5-hydroxybenzimidazole has been researched along with aminoimidazole-ribotide* in 1 studies

Other Studies

1 other study(ies) available for 5-hydroxybenzimidazole and aminoimidazole-ribotide

Article	Year
Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B₁₂ Biosynthesis. Journal of the American Chemical Society, 2015, Aug-26, Volume: 137, Issue:33 Comparative genomics of the bacterial thiamin pyrimidine synthase (thiC) revealed a paralogue of thiC (bzaF) clustered with anaerobic vitamin B12 biosynthetic genes. Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkable conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI). We identify the origin of key product atoms and propose a reaction mechanism. These studies represent the first step in solving a long-standing problem in anaerobic vitamin B12 assembly and reveal an unanticipated intersection of thiamin and vitamin B12 biosynthesis. Topics: Anaerobiosis; Bacterial Proteins; Benzimidazoles; Biocatalysis; Models, Molecular; Protein Conformation; Ribonucleotides; Thiamine; Vitamin B 12	2015

Article

Year

Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B₁₂ Biosynthesis.

Journal of the American Chemical Society, 2015, Aug-26, Volume: 137, Issue:33

Comparative genomics of the bacterial thiamin pyrimidine synthase (thiC) revealed a paralogue of thiC (bzaF) clustered with anaerobic vitamin B12 biosynthetic genes. Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkable conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI). We identify the origin of key product atoms and propose a reaction mechanism. These studies represent the first step in solving a long-standing problem in anaerobic vitamin B12 assembly and reveal an unanticipated intersection of thiamin and vitamin B12 biosynthesis.

Topics: Anaerobiosis; Bacterial Proteins; Benzimidazoles; Biocatalysis; Models, Molecular; Protein Conformation; Ribonucleotides; Thiamine; Vitamin B 12

2015