Compounds > 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone
Page last updated: 2024-09-04

5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and nobiletin

5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone has been researched along with nobiletin in 5 studies

Compound Research Comparison

Studies
(5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone)		Trials
(5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone)		Recent Studies (post-2010)
(5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone)		Studies
(nobiletin)		Trials
(nobiletin)		Recent Studies (post-2010) (nobiletin)
25094781350

Protein Interaction Comparison

ProteinTaxonomy5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (IC50)nobiletin (IC50)
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.65

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beutler, JA; Boyd, MR; Cardellina, JH; Haemers, A; Hamel, E; Rajan, P; Roitman, JN; Vlietinck, AJ1
Ash, K; Grohmann, K; Manthey, CL; Manthey, JA; Montanari, A1
Dushenkov, S; Ho, CT; Lai, CS; Li, S; Lo, CY; Pan, MH1
Ho, CT; Jin, H; Li, S; Patel, T; Xiao, H; Yang, CS1
Chen, PY; Chiu, SP; Ho, CT; Lai, HC; Lin, MH; Sheu, TT; Wu, MJ; Yen, JH1

Other Studies

5 other study(ies) available for 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and nobiletin

ArticleYear
Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
    Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13

    Topics: Antineoplastic Agents, Phytogenic; Biopolymers; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Flavonoids; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured

1998
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.
    Journal of natural products, 1999, Volume: 62, Issue:3

    Topics: Citrus; Cyclic AMP; Flavonoids; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

1999
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
    Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Chromatography, High Pressure Liquid; Citrus; Flavones; Fruit; HL-60 Cells; Humans; Hydroxylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2007
Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis.
    Molecular nutrition & food research, 2009, Volume: 53, Issue:3

    Topics: Anticarcinogenic Agents; Antioxidants; Apoptosis; Cell Division; Cell Line, Tumor; Citrus sinensis; Flavones; Flavonoids; Fruit; Humans; Hydroxylation; Lung Neoplasms; Structure-Activity Relationship

2009
Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Animals; Cell Shape; Citrus; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Flavones; GAP-43 Protein; Gene Expression Regulation; Models, Biological; Naphthols; Nerve Growth Factors; Neurites; Organophosphates; PC12 Cells; Phosphorylation; Rats; Receptor, trkA; RNA, Messenger; Signal Transduction

2011