Compounds > 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

Page last updated: 2024-09-04

5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and 3,3',4',5,6,7,8-heptamethoxyflavone

5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone has been researched along with 3,3',4',5,6,7,8-heptamethoxyflavone in 8 studies

Compound Research Comparison

Studies (5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone)	Trials (5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone)	Recent Studies (post-2010) (5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone)	Studies (3,3',4',5,6,7,8-heptamethoxyflavone)	Trials (3,3',4',5,6,7,8-heptamethoxyflavone)	Recent Studies (post-2010) (3,3',4',5,6,7,8-heptamethoxyflavone)
25	0	9	36	0	16

Protein Interaction Comparison

Protein	Taxonomy	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (IC50)	3,3',4',5,6,7,8-heptamethoxyflavone (IC50)
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)		1.5

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (37.50)	18.2507
2000's	3 (37.50)	29.6817
2010's	2 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
De Meyer, N; Haemers, A; Mishra, L; Pandey, HK; Pieters, LA; Vanden Berghe, DA; Vlietinck, AJ	1
Beutler, JA; Boyd, MR; Cardellina, JH; Haemers, A; Hamel, E; Rajan, P; Roitman, JN; Vlietinck, AJ	1
Ash, K; Grohmann, K; Manthey, CL; Manthey, JA; Montanari, A	1
Dushenkov, S; Ho, CT; Lai, CS; Li, S; Lo, CY; Pan, MH	1
Ho, CT; Jin, H; Li, S; Patel, T; Xiao, H; Yang, CS	1
Dushenkov, S; Ho, CT; Li, S; Rawson, NE; Sergeev, IN	1
Fu, SH; Ho, CT; Kou, MC; Li, S; Weng, CY; Wu, MJ; Yen, JH	1
Chen, YF; Ho, CT; Lee, PS; Pan, MH; Wang, Y	1

Other Studies

8 other study(ies) available for 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and 3,3',4',5,6,7,8-heptamethoxyflavone

Article	Year
4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. Journal of medicinal chemistry, 1991, Volume: 34, Issue:2 Topics: Animals; Antiviral Agents; Chemical Phenomena; Chemistry; Culture Techniques; Flavonoids; Humans; Male; Microbial Sensitivity Tests; Mutagenicity Tests; Poliovirus; Rats; Rats, Inbred Strains; Rhinovirus; Salmonella typhimurium; Structure-Activity Relationship	1991
Structure-activity requirements for flavone cytotoxicity and binding to tubulin. Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13 Topics: Antineoplastic Agents, Phytogenic; Biopolymers; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Flavonoids; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	1998
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes. Journal of natural products, 1999, Volume: 62, Issue:3 Topics: Citrus; Cyclic AMP; Flavonoids; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha	1999
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10 Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Chromatography, High Pressure Liquid; Citrus; Flavones; Fruit; HL-60 Cells; Humans; Hydroxylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet	2007
Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Molecular nutrition & food research, 2009, Volume: 53, Issue:3 Topics: Anticarcinogenic Agents; Antioxidants; Apoptosis; Cell Division; Cell Line, Tumor; Citrus sinensis; Flavones; Flavonoids; Fruit; Humans; Hydroxylation; Lung Neoplasms; Structure-Activity Relationship	2009
Polymethoxyflavones activate Ca2+-dependent apoptotic targets in adipocytes. Journal of agricultural and food chemistry, 2009, Jul-08, Volume: 57, Issue:13 Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Calcium; Citrus sinensis; Flavones; Flavonoids; Fruit; Luteolin; Mice	2009
Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and 3,5,6,7,8,3',4'-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor. Food & function, 2013, Apr-25, Volume: 4, Issue:4 Topics: Biological Transport; Cell Line; Citrus; Flavones; Flavonoids; Gene Expression; Humans; Lipoproteins, LDL; Liver; Macrophages; Plant Extracts; Receptors, LDL; Receptors, Scavenger	2013
Suppression of Adipogenesis by 5-Hydroxy-3,6,7,8,3',4'-Hexamethoxyflavone from Orange Peel in 3T3-L1 Cells. Journal of medicinal food, 2016, Volume: 19, Issue:9 Topics: 3T3-L1 Cells; Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Protein-alpha; Citrus; Flavones; Flavonoids; Fruit; Lipid Metabolism; Mice; Obesity; Phytotherapy; Plant Extracts; PPAR gamma; Protein Kinases; Signal Transduction; Sirtuin 1	2016