Compounds > 5-hydroxy-2-n,n-dipropylaminotetralin
Page last updated: 2024-09-05

5-hydroxy-2-n,n-dipropylaminotetralin and 7-hydroxy-2-n,n-dipropylaminotetralin

5-hydroxy-2-n,n-dipropylaminotetralin has been researched along with 7-hydroxy-2-n,n-dipropylaminotetralin in 12 studies

Compound Research Comparison

Studies
(5-hydroxy-2-n,n-dipropylaminotetralin)		Trials
(5-hydroxy-2-n,n-dipropylaminotetralin)		Recent Studies (post-2010)
(5-hydroxy-2-n,n-dipropylaminotetralin)		Studies
(7-hydroxy-2-n,n-dipropylaminotetralin)		Trials
(7-hydroxy-2-n,n-dipropylaminotetralin)		Recent Studies (post-2010) (7-hydroxy-2-n,n-dipropylaminotetralin)
4203398029

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's3 (25.00)18.2507
2000's1 (8.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freeman, HS; McDermed, JD; McKenzie, GM1
Dijkstra, D; Horn, AS; Mulder, TB; Rollema, H; Tepper, PG; Van der Weide, J1
Batink, H; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B1
Arvidsson, LE; Carlsson, A; Hacksell, U; Hjorth, S; Lindberg, P; Nilsson, JL; Sanchez, D; Wikstrom, H1
Arvidsson, LE; Carlsson, A; Hacksell, U; Hjorth, S; Johansson, A; Lindberg, P; Nilsson, JL; Sanchez, D; Wikström, H1
Boije, M; Carlsson, A; Duncan, JN; Ekman, A; King, LJ; Martin, IJ; Romero, AG; Sonesson, C; Svensson, K; Wikström, H1
Antonio, T; Biswas, S; Brown, DA; Dutta, AK; Mishra, M; Parrington, I; Reith, ME; Zhang, S1
Antonio, T; Dutta, AK; Ghosh, B; Reith, ME1
Antonio, T; Dutta, A; Ghosh, B; Gopishetty, B; Reith, M1
Dyck, LE1
Hacksell, U; Johansson, AM; Malmberg, A; Mohell, N; Nordvall, G1
Audinot, V; Cussac, D; Dubuffet, T; Lavielle, G; Loutz, A; Millan, MJ; Newman-Tancredi, A1

Other Studies

12 other study(ies) available for 5-hydroxy-2-n,n-dipropylaminotetralin and 7-hydroxy-2-n,n-dipropylaminotetralin

ArticleYear
Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:4

    Topics: 2-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dogs; Dopamine; Humans; Naphthols; Rats; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship; Vomiting

1976
Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:11

    Topics: Animals; Benzopyrans; Binding Sites; Brain Chemistry; Cattle; Dopamine; Dopamine Agents; Nitrogen; Oxazines; Protons; Rats; Receptors, Dopamine

1988
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Pressure; Brain; Cell Membrane; Clonidine; Kinetics; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vasoconstriction

1984
8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Molecular Conformation; Naphthalenes; Rats; Receptors, Serotonin; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes

1981
Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:8

    Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; In Vitro Techniques; Motor Activity; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin

1982
Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo.
    Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Behavior, Animal; Biological Availability; Biotransformation; Chemical Phenomena; Chemistry, Physical; Hydrocarbons, Fluorinated; Injections, Intravenous; Ligands; Liver; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes

1993
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.
    Bioorganic & medicinal chemistry, 2009, Jun-01, Volume: 17, Issue:11

    Topics: Animals; Cell Line; Heterocyclic Compounds; Inhibitory Concentration 50; Molecular Structure; Piperazine; Piperazines; Protein Binding; Receptors, Dopamine D3; Tetrahydronaphthalenes

2009
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto
    Journal of medicinal chemistry, 2010, Mar-11, Volume: 53, Issue:5

    Topics: Animals; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iron Chelating Agents; Locomotion; Magnetic Resonance Spectroscopy; Male; Neuroprotective Agents; Oxyquinoline; Parkinson Disease; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Tetrahydronaphthalenes

2010
Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.
    Bioorganic & medicinal chemistry, 2010, Aug-01, Volume: 18, Issue:15

    Topics: Binding Sites; Biphenyl Compounds; Cell Line; Humans; Hydrophobic and Hydrophilic Interactions; Piperazine; Piperazines; Receptors, Dopamine D2; Receptors, Dopamine D3; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes

2010
Release of radiolabeled dopamine, p-tyramine, and m-tyramine from rat striatal slices by some aminotetralins.
    Neurochemical research, 1981, Volume: 6, Issue:4

    Topics: 2-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Caudate Nucleus; Dopamine; In Vitro Techniques; Isomerism; Male; Naphthalenes; Rats; Tetrahydronaphthalenes; Tyramine

1981
Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors.
    Molecular pharmacology, 1994, Volume: 46, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Computer Graphics; Humans; Methylation; Mice; Models, Molecular; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Tetrahydronaphthalenes

1994
Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonist.
    Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Pyrroles; Pyrrolidines; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Sulpiride; Tetrahydronaphthalenes; Transfection

1999