5-ht-moduline and cyanopindolol

5-ht-moduline has been researched along with cyanopindolol* in 2 studies

Other Studies

2 other study(ies) available for 5-ht-moduline and cyanopindolol

Article	Year
5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus. Neuroscience letters, 1999, May-14, Volume: 266, Issue:3 In vivo chronoamperometry was used to determine the effects of locally applied antagonists of the serotonin-1B (5-HT1B) receptor (cyanopindolol, 5-HT-moduline and methiothepin) on the clearance of 5-HT in the CA3 region of the dorsal hippocampus and the corpus callosum (a brain region devoid of serotonin transporters and 5-HT1B receptors) of the rat. When 5-HT was pressure ejected into these regions, reproducible signals were detected. In the CA3 region, local application of 5-HT1B antagonists decreased the rate of clearance of the serotonin signal comparably to the selective 5-HT uptake inhibitor (SSRI), fluvoxamine. By contrast, in the corpus callosum, none of the drugs altered the 5-HT signal. One interpretation of these data is that 5-HT1B receptors can modulate the activity of the 5-HT transporter. Topics: Analysis of Variance; Animals; Corpus Callosum; Hippocampus; Male; Metabolic Clearance Rate; Methiothepin; Neuropeptides; Oligopeptides; Pindolol; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists	1999
A new peptide, 5-HT-moduline, isolated and purified from mammalian brain specifically interacts with 5-HT1B/1D receptors. Behavioural brain research, 1996, Volume: 73, Issue:1-2 5-HT-Moduline (Leu-Ser-Ala-Leu) is a new endogenous peptide purified from rat brain which interacts specifically with 5-HT1B/1D receptors. The binding interaction of 5-HT-Moduline with 5-HT1B/1D receptors appeared to be a non-competitive process, since the Bmax value of [125I] cyanopindolol binding on rat brain cortical membranes was decreased without modification of the Kd. This interaction was conserved on NIH 3T3 cells expressing the 5-HT1B receptor (IC50 = 10(-11)M) suggesting that the binding site for 5-HT-Moduline is localized on the 5-HT1B receptor protein. The observed interaction may lead to functional alterations of 5-HT1B/1D receptors known to play an important role in regulating the release of 5-HT from serotonergic nerve terminals (autoreceptors) as well as the release of other neurotransmitters (heteroreceptors). Topics: Amino Acid Sequence; Animals; Binding Sites; Brain Chemistry; Cell Line; Cerebral Cortex; Chromatography, High Pressure Liquid; In Vitro Techniques; Membranes; Mice; Molecular Sequence Data; Neuropeptides; Oligopeptides; Pindolol; Rats; Receptors, Serotonin	1996

Article

Year

5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus.

Neuroscience letters, 1999, May-14, Volume: 266, Issue:3

In vivo chronoamperometry was used to determine the effects of locally applied antagonists of the serotonin-1B (5-HT1B) receptor (cyanopindolol, 5-HT-moduline and methiothepin) on the clearance of 5-HT in the CA3 region of the dorsal hippocampus and the corpus callosum (a brain region devoid of serotonin transporters and 5-HT1B receptors) of the rat. When 5-HT was pressure ejected into these regions, reproducible signals were detected. In the CA3 region, local application of 5-HT1B antagonists decreased the rate of clearance of the serotonin signal comparably to the selective 5-HT uptake inhibitor (SSRI), fluvoxamine. By contrast, in the corpus callosum, none of the drugs altered the 5-HT signal. One interpretation of these data is that 5-HT1B receptors can modulate the activity of the 5-HT transporter.

Topics: Analysis of Variance; Animals; Corpus Callosum; Hippocampus; Male; Metabolic Clearance Rate; Methiothepin; Neuropeptides; Oligopeptides; Pindolol; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists

1999

A new peptide, 5-HT-moduline, isolated and purified from mammalian brain specifically interacts with 5-HT1B/1D receptors.

Behavioural brain research, 1996, Volume: 73, Issue:1-2

5-HT-Moduline (Leu-Ser-Ala-Leu) is a new endogenous peptide purified from rat brain which interacts specifically with 5-HT1B/1D receptors. The binding interaction of 5-HT-Moduline with 5-HT1B/1D receptors appeared to be a non-competitive process, since the Bmax value of [125I] cyanopindolol binding on rat brain cortical membranes was decreased without modification of the Kd. This interaction was conserved on NIH 3T3 cells expressing the 5-HT1B receptor (IC50 = 10(-11)M) suggesting that the binding site for 5-HT-Moduline is localized on the 5-HT1B receptor protein. The observed interaction may lead to functional alterations of 5-HT1B/1D receptors known to play an important role in regulating the release of 5-HT from serotonergic nerve terminals (autoreceptors) as well as the release of other neurotransmitters (heteroreceptors).

Topics: Amino Acid Sequence; Animals; Binding Sites; Brain Chemistry; Cell Line; Cerebral Cortex; Chromatography, High Pressure Liquid; In Vitro Techniques; Membranes; Mice; Molecular Sequence Data; Neuropeptides; Oligopeptides; Pindolol; Rats; Receptors, Serotonin

1996