5-guanidino-4-nitroimidazole and guanidinohydantoin

5-guanidino-4-nitroimidazole has been researched along with guanidinohydantoin* in 1 studies

Reviews

1 review(s) available for 5-guanidino-4-nitroimidazole and guanidinohydantoin

ArticleYear
Removal of oxidatively generated DNA damage by overlapping repair pathways.
    Free radical biology & medicine, 2017, Volume: 107

    It is generally believed that the mammalian nucleotide excision repair pathway removes DNA helix-distorting bulky DNA lesions, while small non-bulky lesions are repaired by base excision repair (BER). However, recent work demonstrates that the oxidativly generated guanine oxidation products, spiroimininodihydantoin (Sp), 5-guanidinohydantoin (Gh), and certain intrastrand cross-linked lesions, are good substrates of NER and BER pathways that compete with one another in human cell extracts. The oxidation of guanine by peroxynitrite is known to generate 5-guanidino-4-nitroimidazole (NIm) which is structurally similar to Gh, except that the 4-nitro group in NIm is replaced by a keto group in Gh. However, unlike Gh, NIm is an excellent substrate of BER, but not of NER. These and other related results are reviewed and discussed in this article.

    Topics: DNA Damage; DNA Glycosylases; DNA Repair; DNA, B-Form; Guanidines; Humans; Hydantoins; Nitroimidazoles; Oxidation-Reduction; Oxidative Stress; Substrate Specificity

2017