5-fluorowillardiine has been researched along with kainic acid in 7 studies
| Studies (5-fluorowillardiine) | Trials (5-fluorowillardiine) | Recent Studies (post-2010) (5-fluorowillardiine) | Studies (kainic acid) | Trials (kainic acid) | Recent Studies (post-2010) (kainic acid) |
|---|---|---|---|---|---|
| 29 | 0 | 8 | 9,540 | 3 | 1,775 |
| Protein | Taxonomy | 5-fluorowillardiine (IC50) | kainic acid (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 4 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 0.0126 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bleakman, D; Deverill, M; Hoo, K; Jane, DE; Kamboj, R; Mandelzys, A | 1 |
| Butini, S; Campiani, G; Christensen, JK; Coccone, SS; De Angelis, M; Fiorini, I; Gemma, S; Guarino, E; Morelli, E; Novellino, E; Pickering, DS; Schousboe, A; Trotta, F | 1 |
| England, PM; Fleming, JJ | 1 |
| Butterworth, RF; Michalak, A | 1 |
| Henley, JM; Olivera, S; Rodriguez-Ithurralde, D | 1 |
| Hesp, BR; Kerr, DS; Mullaney, I; Wrightson, T | 1 |
| Chebli, M; Eibl, C; Plested, A; Salazar, H | 1 |
7 other study(ies) available for 5-fluorowillardiine and kainic acid
| Article | Year |
|---|---|
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Topics: Alanine; Cell Line; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Triazines; Uracil | 1997 |
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Topics: Animals; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Humans; Ligands; Molecular Structure; Oocytes; Pyrimidinones; Rats; Receptors, Glutamate; Spodoptera; Structure-Activity Relationship; Thiophenes; Xenopus laevis | 2008 |
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Topics: Allosteric Regulation; Animals; Binding Sites; Ligands; Receptors, AMPA | 2010 |
Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure.
Topics: Alanine; Animals; Binding Sites; Brain; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Hepatic Encephalopathy; Hippocampus; Kainic Acid; Male; Pyrimidines; Rats; Rats, Sprague-Dawley | 1997 |
Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain.
Topics: Acetylcholinesterase; Aging; Alanine; Animals; Autoradiography; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Binding, Competitive; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Pyrimidines; Rats; Rats, Wistar; Receptors, AMPA; Solubility; Tritium | 2001 |
Kainate receptor agonists and antagonists mediate tolerance to kainic acid and reduce high-affinity GTPase activity in young, but not aged, rat hippocampus.
Topics: Action Potentials; Age Factors; Alanine; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GTP Phosphohydrolases; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid | 2004 |
Mechanism of partial agonism in AMPA-type glutamate receptors.
Topics: Alanine; Animals; Cross-Linking Reagents; Crystallography, X-Ray; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Kainic Acid; Models, Molecular; Protein Conformation; Protein Domains; Protein Multimerization; Pyrimidines; Rats; Receptors, AMPA; Receptors, Glutamate | 2017 |