5-fluorowillardiine has been researched along with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid in 9 studies
| Studies (5-fluorowillardiine) | Trials (5-fluorowillardiine) | Recent Studies (post-2010) (5-fluorowillardiine) | Studies (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) | Trials (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) | Recent Studies (post-2010) (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) |
|---|---|---|---|---|---|
| 29 | 0 | 8 | 2,899 | 11 | 609 |
| 29 | 0 | 8 | 24 | 0 | 3 |
| Protein | Taxonomy | 5-fluorowillardiine (IC50) | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.157 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.1765 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.1765 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.1765 | |
| Glutamate receptor 1 | Mus musculus (house mouse) | 0.04 | |
| Glutamate receptor 2 | Mus musculus (house mouse) | 0.04 | |
| Glutamate receptor 1 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 2 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 3 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 4 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 4 | Mus musculus (house mouse) | 0.04 | |
| Glutamate receptor 3 | Mus musculus (house mouse) | 0.04 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Butini, S; Campiani, G; Christensen, JK; Coccone, SS; De Angelis, M; Fiorini, I; Gemma, S; Guarino, E; Morelli, E; Novellino, E; Pickering, DS; Schousboe, A; Trotta, F | 1 |
| England, PM; Fleming, JJ | 1 |
| Beart, PM; Cheung, NS; Larm, JA | 1 |
| Espitia, SA; Hawkinson, JE | 1 |
| Henley, JM; Olivera, S; Rodriguez-Ithurralde, D | 1 |
| Ashworth-Preece, MA; Chen, F; Jarrott, B; Lawrence, AJ | 1 |
| Arai, A; Kessler, M; Rogers, G | 1 |
| Arai, AC; Kessler, M | 1 |
| Bleakman, D; Deverill, M; Hoo, K; Jane, DE; Kamboj, R; Mandelzys, A | 1 |
9 other study(ies) available for 5-fluorowillardiine and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
| Article | Year |
|---|---|
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Topics: Animals; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Humans; Ligands; Molecular Structure; Oocytes; Pyrimidinones; Rats; Receptors, Glutamate; Spodoptera; Structure-Activity Relationship; Thiophenes; Xenopus laevis | 2008 |
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Topics: Allosteric Regulation; Animals; Binding Sites; Ligands; Receptors, AMPA | 2010 |
(S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Mice; Neurons; Pyrimidines; Receptors, Kainic Acid | 1996 |
Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain; Excitatory Amino Acid Agonists; In Vitro Techniques; Ligands; Male; Pyrimidines; Rats; Receptors, AMPA; Stereoisomerism; Thiocyanates | 1997 |
Acetylcholinesterase potentiates [3H]fluorowillardiine and [3H]AMPA binding to rat cortical membranes.
Topics: Acetylcholinesterase; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blotting, Western; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA | 1999 |
Visualisation of AMPA binding sites in the brain stem of normotensive and hypertensive rats.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Stem; Denervation; Hypertension; Male; Neurons, Afferent; Nodose Ganglion; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Solitary Nucleus; Tissue Distribution; Vagus Nerve | 1999 |
The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alternative Splicing; Animals; Antihypertensive Agents; Benzothiadiazines; Binding Sites; Binding, Competitive; Cells, Cultured; Excitatory Amino Acid Agonists; Humans; Kidney; Pyrimidines; Rats; Receptors, AMPA; Tritium | 2000 |
Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Allosteric Site; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Membranes; Peptides, Cyclic; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tritium | 2006 |
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Topics: Alanine; Cell Line; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Triazines; Uracil | 1997 |