5-fluorouridine has been researched along with uridine in 219 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 88 (40.18) | 18.7374 |
| 1990's | 58 (26.48) | 18.2507 |
| 2000's | 34 (15.53) | 29.6817 |
| 2010's | 34 (15.53) | 24.3611 |
| 2020's | 5 (2.28) | 2.80 |
| Authors | Studies |
|---|---|
| Balatsos, NA; Bougiatioti, S; Chatzileontiadou, DS; Gkaragkouni, DN; Kaffesaki, E; Kantsadi, AL; Komiotis, D; Leonidas, DD; Manta, S; Maragozidis, P; Parmenopoulou, V; Skamnaki, VT; Zographos, SE; Zounpoulakis, P | 1 |
| Hong, J; Johnson, ZL; Kwon, DY; Lee, JH; Lee, K; Lee, M; Lee, SY | 1 |
| Chinali, G; Horowitz, J; Ofengand, J | 1 |
| Horowitz, J; Ishaq, M; Moeller, B; Ramberg, ES; Rulf, S | 1 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 4 |
| Lönn, U | 1 |
| Andersen, O; Rønne, M | 1 |
| Herrmann, B; Holstege, A; Keppler, DO | 1 |
| De Leenheer, AP; Gelijkens, CF | 1 |
| Kaiser, II; Young, PA | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Heimer, R; Sartorelli, AC | 3 |
| Ophir, A | 1 |
| Kita, J; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O | 1 |
| Barberi-Heyob, M; Merlin, JL; Webér, B | 1 |
| Fujimoto, S; Kaneko, M; Kikugawa, M; Tamaki, N | 1 |
| Britt, JM; Hopp, RH; Leon, JA; Milam, AH; Mills, RP | 1 |
| Goldenberg, DM; Sharkey, RM; Shih, LB; Xuan, H | 1 |
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| Kitada, S; Lee, DA; Shapourifar-Tehrani, S; Stephenson, TR | 1 |
| Lee, DA; Moore, JJ; Shapourifar-Tehrani, S; Smyth, RJ | 1 |
| Novotný, L; Vachálková, A | 1 |
| Rustum, YM; Zhang, ZG | 1 |
| Dunkelburger, GR; Jampel, HD; Leong, KW; Quigley, HA | 1 |
| De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| Kumar, AM; Nayak, R | 1 |
| Hirose, S; Kito, M; Takeshima, S; Urakami, K; Yoshida, S | 1 |
| Berger, SH; Hakala, MT | 1 |
| Choi, WY; Kim, DJ; Nam, HW; Youn, JH | 1 |
| Nohta, H; Ohkura, Y; Umegae, Y | 1 |
| Fasoli, MO; Kerridge, D; Morris, PG; Torosantucci, A | 1 |
| Chapekar, MS; Glazer, RI; Iigo, M | 1 |
| Fauler, J; Gasser, T; Holstege, A; Keppler, D; Leube, K; Schulz-Holstege, C; Weckbecker, G | 1 |
| Holstege, A; Keppler, D | 2 |
| Anukarahanonta, T; Gerok, W; Holstege, A; Keppler, D; Pausch, J | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY | 1 |
| Hardin, CC; Horowitz, J | 1 |
| Dominski, Z; Kole, R; Shukla, RR; Sierakowska, H | 1 |
| Ho, DH; Kamiya, K; Nakamura, T; Sasaki, K; Tsutani, H; Uchida, M; Yoshimura, T | 1 |
| Desrosiers, R; Tanguay, RM | 1 |
| Arnon, R; Hurwitz, E; Kashi, R; Sela, M; Wilchek, M | 1 |
| Khoobehi, B; Niesman, MR; Oncel, M; Peyman, GA | 1 |
| Akiyama, T; Hoshi, A; Ike, Y; Mori, H; Ozaki, S | 1 |
| Gross, CA; Jin, DJ | 1 |
| Blumenkranz, MS; Cheng, M; Dailey, WA; Hajek, AS; Hartzer, MK; Margherio, AR | 1 |
| Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L | 2 |
| Heath, TD; Lewis, GP; Lopez, NG; Stern, WH | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 2 |
| Blumenkranz, MS; Hajek, AS; Hartzer, MK | 1 |
| Aigner, KR; Danenberg, PV; Link, KH; Peschau, K; Schwemmle, K; Warthona, M | 1 |
| Belt, JA; Noel, LD | 1 |
| Fasoli, M; Kerridge, D | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Matsuzawa, T; Murakami, M | 1 |
| Lin, F; Warren, BS; Williams, WM | 1 |
| Blumenkranz, MS; Hartzer, M; Hernandez, E; Huang, DS | 1 |
| Benz, C; James, TL; Keniry, M; Shafer, RH | 1 |
| Alderfer, JL; Loomis, RE | 1 |
| Brooks, M; Cadman, E; Tseng, A | 1 |
| Christenson, PI; Erichsen, C; Eriksson, G; Jönsson, PE; Stenram, U; Yngner, T | 1 |
| Fauler, J; Gasser, T; Holstege, A; Keppler, D; Weckbecker, G | 1 |
| Franze-Fernández, MT; Iapalucci-Espinoza, S; Medrano, EE; Perrone-Bizzozero, N | 1 |
| Anukarahanonta, T; Holstege, A; Kattermann, R; Keppler, D; Koch, HK; Lesch, R; Yamamoto, M | 1 |
| Anukarahanonta, T; Holstege, A; Keppler, DO | 1 |
| Beck, G; Giesen, EM; Holstege, A; Keppler, DO | 1 |
| Campisi, J; Pardee, AB | 1 |
| Gustavsson, B; Hafström, L | 1 |
| Crawford, EJ; Fowler, JS; Friedkin, M; Gallagher, BM; Goldin, A; Lambrecht, RM; MacGregor, RR; Shiue, CY; Wodinsky, I; Wolf, AP | 1 |
| Fukushima, S; Kubota, Y; Miura, T; Moriyama, M; Ooshima, H; Shiozaki, H; Shuin, T | 1 |
| Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG | 1 |
| Franze-Fernandez, MT; Iapalucci-Espinoza, S | 1 |
| Cadman, E; Grant, S | 1 |
| Ardalan, B; Cooney, D; Lippman, M; Macdonald, J; Schein, P | 1 |
| Buxton, FP; Radford, A | 1 |
| Polak, A | 1 |
| Armstrong, RD; Connolly, KM; Diasio, RB; Kaplan, AM | 1 |
| Abe, Y; Endo, S; Fukuda, H; Ido, T; Ishiwata, K; Kubota, K; Matsuzawa, T; Sato, T; Takahashi, T; Yamada, K; Yoshioka, S | 1 |
| Ido, T; Ishiwata, K; Kawashima, K; Murakami, M; Takahashi, T | 1 |
| Hoshi, A; Iigo, M | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Matsuzawa, T; Monma, M; Takahashi, T; Tsurumi, Y | 1 |
| Gerok, W; Holstege, A; Keppler, D; Pausch, J | 1 |
| Brdar, B; Sorić, J | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Hoshi, A; Kuretani, K; Yoshida, M | 1 |
| Heidelberger, C; Mulkins, MA | 1 |
| Keppler, DO; Weckbecker, G | 1 |
| McCloskey, JA; Nelson, CC; Sethi, SK | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Dźwigaj-Stokłosa, W; Hołuj-Gubała, J; Pawlik, B | 1 |
| Danenberg, PV; Shani, J | 1 |
| Benvenuto, J; Drewinko, B; Freireich, EJ; Ho, DH; Loo, TL; Yang, LY | 1 |
| Glazer, RI; Hartman, KD | 1 |
| Cerna, I; Klubes, P | 1 |
| Hadjiolov, AA; Hadjiolova, KV; Naydenova, ZG | 1 |
| Au, JL; Danhauser, L; Luccioni, C; Rustum, YM | 1 |
| Alderfer, JL; Loomis, RE; Zielinski, TJ | 1 |
| Glazer, RI; Lloyd, LS | 1 |
| Fox, JJ; Halat, MJ; Hollenberg, DH; Matsuda, A; Nisselbaum, JS; Watanabe, KA | 1 |
| Clement, JJ; Faucette, LF; Howard, WS; Johnson, RK; Wodinsky, I | 1 |
| Gmeiner, WH; Pon, RT; Sahasrabudhe, PV | 1 |
| Barberi-Heyob, M; de Bruijn, EA; Dittrich, C; Guillemin, F; Luporsi, E; Merlin, JL; Weber, B | 1 |
| Bahgat, MM; Bandok, B; el-Aswad, M; Niesman, MR; Peyman, GA; Salah-Eldin, M | 1 |
| Imamura, S; Itoh, H; Matsuda, A; Nakagami, K; Sakai, A; Shuto, S | 1 |
| Abdulmalek, S; McCarthy, CM; Montoya, DP | 1 |
| Abraham, R; Aman, N; Darsley, M; Kamireddy, B; Kenten, J; Morris, G; Titmas, R; von Borstel, R | 1 |
| Fujita, K; Matsukawa, A; Oi, S; Shibata, K; Tanaka, T; Taniguchi, M | 1 |
| Inaba, M; Mitsuhashi, J | 1 |
| Chen, TB; Huzak, M; Macura, S; Vuk-Pavlović, S | 1 |
| Jacobson, MR; Patton, JR; Pederson, T | 1 |
| Konishi, T; Ling, L; Maekawa, T; Ozaki, S; Uemura, A; Yamashita, K | 1 |
| Patton, JR | 2 |
| el Kouni, MH; el Kouni, MM; Naguib, FN | 1 |
| Blumenkranz, M; Hartzer, M; Lin, LR; Ward, T | 1 |
| Andersen, AA; Fan, H; McClarty, G | 1 |
| Haba, S; Koga, M; Ozaki, S; Saeki, T; Suzuki, T; Yamamoto, M; Yasusa, T | 1 |
| Adami, M; Fenu, S; Nardelli, D; Nicolini, C; Zolfino, I | 1 |
| Allegra, CJ; Chu, E | 1 |
| Black, AR; Dolnick, BJ; Hsueh, CT; Schindler, K; Winkler, PM | 1 |
| Fushiya, S; Hojo, H; Kikuchi, Y; Kondo, Y; Nozoe, S; Takano, F; Yahagi, N; Yahagi, R | 1 |
| Arpicco, S; Brusa, P; Cattel, L; Coppo, S; Crosasso, P; Dosio, F; Pacchioni, D | 1 |
| Ishida, R; Ito, S; Koda, A; Mori, H; Nagai, H; Nakayama, K | 1 |
| Arpicco, S; Brusa, P; Cattel, L; Crosasso, P; Dosio, F; Pacchioni, D; Schuber, F | 1 |
| Casaroli, R; Corcostegui, B; Fonseca, MJ; García-Arumí, J; Isart, FR; Mateo, C; Pascual, R | 1 |
| Bertino, JR | 1 |
| Dorta, MJ; Fariña, JB; Llabrés, M; Martin, VS; Munguía, O | 1 |
| Inaba, M; Mitsuhashi, J; Naoe, Y | 1 |
| Landis, DM; Loeb, LA | 1 |
| Foster, RE; Lewis, H; Schwendeman, SP; Zhou, T | 1 |
| Au, JL; Gan, Y; Song, D; Wientjes, MG | 1 |
| Arnon, R; Chen, L; Schechter, B; Wilchek, M | 1 |
| Bajzer, Z; Chen, TB; Macura, S; Vuk-Pavlovic, S | 1 |
| Lu, Y; Miller, MJ | 1 |
| Bentires-Alj, M; Bours, V; Fillet, G; Gielen, J; Hellin, AC; Lechanteur, C; Lopez, M; Merville, MP; Princen, F | 1 |
| Adamiak, RW; Bielecki, L; Fischer, A; Gdaniec, Z; Olejniczak, M | 1 |
| Arnold, JR; Fisher, J | 1 |
| Dorta, MJ; Llabrés, M; Munguía, O | 1 |
| Cass, CE; Lang, TT; Selner, M; Young, JD | 1 |
| Li, F; Shi, T | 1 |
| Liu, W; Wan, X; Xiang, Y; Xin, F; Yang, N; Yang, X | 1 |
| Arbós, P; Campanero, MA; Irache, JM | 1 |
| Dorta, MJ; Fariña, JB; Llabrés, M; Munguía, O; Oliva, A | 1 |
| Li, ZH; Terns, MP; Terns, RM; Yu, YT; Zhao, X | 1 |
| Dou, J; Ruan, Q; Wu, W; Zhou, C | 1 |
| CRUZ, O; GRIESBACH, L; GRUNBERG, E; HEIDELBERGER, C; SCHNITZER, RJ | 1 |
| BOLAFFI, JL; CHEONG, L; EIDINOFF, ML; KNOLL, JE; RICH, MA | 1 |
| ERLANDSON, M; HARTMANN, JR; MURPHY, ML; ORIGENES, ML; SITARZ, A | 1 |
| HAHN, RG; MOERTEL, CG; REITEMEIER, RJ | 1 |
| BASCH, RS; KARNOFSKY, DA | 1 |
| Mueller, EG; Spedaliere, CJ | 1 |
| Yu, YT; Zhao, X | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Agarwal, R; Ardalan, B; Patel, M | 1 |
| Ginter, JM; Johnston, MV; Mueller, EG; Spedaliere, CJ | 1 |
| de Bruin, M; Fukushima, M; Peters, GJ; Pinedo, HM; Smid, K; van der Ent, MA | 1 |
| Soni, SD; Srikrishnan, T | 1 |
| Chiang, GH; Lu, LW; Randerath, K; Tseng, WC | 1 |
| Bacher, A; Gerwert, K; Hessling, B; Illarionova, V; Richter, G; Schleicher, E; Weber, S | 1 |
| Brackett, DJ; Do, SV; Gissel, KA; Jupe, ER; Lawrence, BP; Lerner, MR; Liu, Q; Schmittgen, TD; Zakrajsek, BA | 1 |
| Berciano, MT; Casafont, I; Lafarga, M; Navascués, J; Pena, E | 1 |
| Abraham, GA; de Queiroz, AA; Higa, OZ | 1 |
| Hosie, AH; Webb, AJ | 1 |
| Ginter, JM; Greco, TM; Hamilton, CS; Johnston, MV; Mueller, EG; Vizthum, CA | 1 |
| Cricca, S; de Bruin, M; Laan, AC; Peters, GJ; Temmink, OH; Turksma, AW | 1 |
| Deitmer, JW; Ekkehard Neuhaus, H; Flörchinger, M; Kunz, HH; Möhlmann, T; Piecuch, J; Traub, M; Weise-Steinmetz, A | 1 |
| Engelbrecher, A; Häuser, R; Titz, B; Uetz, P | 1 |
| Lou, WY; Wang, H; Wu, H; Zong, MH | 1 |
| Beumer, JH; Doroshow, JH; Egorin, MJ; Lenz, HJ; Newman, EM; Parise, RA; Synold, TW | 1 |
| Cengelli, F; Grzyb, JA; Hanessian, S; Juillerat-Jeanneret, L | 1 |
| Florea-Wang, D; Karpeisky, A; Lönnberg, H; Lönnberg, T; Ora, M; Zinnen, S | 1 |
| Burton, GJ; Cindrova-Davies, T; Ellery, PM; Ferguson-Smith, AC; Jauniaux, E | 1 |
| Banerjee, D; Bertino, JR; Humeniuk, R; Mishra, PJ | 1 |
| Banerjee, D; Bertino, JR; Cheng, YC; Gorlick, R; Humeniuk, R; Kemeny, N; Menon, LG; Mishra, PJ; Pizzorno, G; Rode, W; Sowers, R | 1 |
| Bengoechea, R; Berciano, MT; Casafont, I; Lafarga, M; Tapia, O | 1 |
| Berciano, MT; Casafont, I; Lafarga, M | 1 |
| Bremner, JB; Locke, JM; Pyne, SG; Ranson, M; Vine, KL | 1 |
| Chen, J; McDonald, MK; Miracco, EJ; Mueller, EG; Xie, Y | 1 |
| Goltz, D; Jauch, C; Schott, H; Schott, TC; Schwendener, RA | 1 |
| Miracco, EJ; Mueller, EG | 1 |
| Doseth, B; Kavli, B; Krokan, HE; Pettersen, HS; Slupphaug, G; Svaasand, EK; Vågbø, CB; Visnes, T | 1 |
| Chen, M; Thelen, JJ | 1 |
| Diao, YF; Han, RX; Jin, DI; Lee, MG; Oqani, RK | 1 |
| Baek, IH; Kim, MS; Kwon, KI; Lee, BY | 1 |
| Antonyuk, SV; Kershaw, NM; Samar Hasnain, S; Strange, RW; Wright, GS | 1 |
| Bogdanov, B; Miracco, EJ; Mueller, EG | 1 |
| Andersen, JK; Angeli, S; Bhaumik, D; Klang, I; Lithgow, GJ; Mark, K; Sivapatham, R; Zucker, D | 1 |
| Malecki, E; Rosemeyer, H; Viere, R | 1 |
| Alian, A; Ashley, GW; Czudnochowski, N; Finer-Moore, J; Santi, DV; Stroud, RM | 1 |
| Knies, C; Malecki, E; Rosemeyer, H; Werz, E | 1 |
| Bonaterra, GA; Farhat, A; Kinscherf, R; Malecki, E; Rosemeyer, H; Röthlein, D; Schmitt, J; Wolf, M | 2 |
| Knies, C; Malecki, E; Montilla Martinez, M; Ottenhaus, V; Rosemeyer, H; Werz, E | 1 |
| Andreasen, SØ; Fejerskov, B; Zelikin, AN | 1 |
| Accoceberry, I; Brèthes, D; Dementhon, K; El-Kirat-Chatel, S; Fitton-Ouhabi, V; Gabriel, F; Noël, T; Pujol, S; Sabra, A | 1 |
| Basché, T; Helm, M; Hinze, G; Kellner, S; Kreutz, C; Micura, R; Spenkuch, F | 1 |
| Adjalley, SH; Akabas, MH; Coburn-Flynn, O; Deng, SX; Deniskin, R; Fidock, DA; Frame, IJ; Katz, F; Landry, DW; Moir, RD; Rinderspacher, A; Willis, IM | 1 |
| Archid, R; Bajaeifer, K; Hack, A; Königsrainer, A; Schott, TC; Weinreich, J | 1 |
| Ottenhaus, V; Rosemeyer, H | 1 |
| Ji, ZY; Yan, FL; Yan, JW; Yang, YX; Yin, YY; Zhuang, FF | 1 |
| Mueller, EG; Singh, SK; Veerareddygari, GR | 1 |
| Chen, JL; Disney, MD; Fountain, MA; VanEtten, DM; Yildirim, I | 1 |
| Bian, B; Hong, Y; Hu, N; Ji, Z; Li, R; Liu, Q; Song, Z; Wu, F; Wu, P; Yin, JF | 1 |
| Brancale, A; Ferla, S; McGuigan, C; Slusarczyk, M | 1 |
| Amini, SK | 1 |
| Blinov, N; Hinge, VK; Kovalenko, A; Roy, D; Wishart, DS | 1 |
| Ducho, C; Heib, A; Koppermann, S; Niro, G; Weck, SC | 1 |
| Cabral, JV; Cmarko, D; Jirsova, K; Kereïche, S; Smirnov, E; Studeny, P; Trosan, P | 1 |
| Montesdeoca-Esponda, S; Mordačíková, E; Santana-Rodríguez, JJ; Santana-Viera, S; Škvára, P; Vojs Staňová, A | 1 |
| Kovalenko, A; LeVatte, M; Lipfert, M; Roy, D; Wishart, DS | 1 |
| Callan, B; Callan, JF; Gao, J; Griffith, DM; Logan, KA; Love, M; McHale, AP; McKaig, T; Nesbitt, H; Taylor, M | 1 |
| Abudawood, M; Al-Eidi, H; Alatar, G; Alhaidan, Y; Almuzzaini, B; AlSaud, NA; AlSubait, A; AlTuwaijri, A; AlWadaani, D; Matou-Nasri, S; Najdi, M; Trivilegio, T | 1 |
4 review(s) available for 5-fluorouridine and uridine
| Article | Year |
|---|---|
Encapsulated filtering bleb. A selective review--new deductions.
Topics: Animals; Blister; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Postoperative Complications; Rabbits; Trabeculectomy; Uridine; Wound Healing | 1992 |
Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Culture Media; Drug Evaluation, Preclinical; Fluorouracil; Humans; Tegafur; Thymidine; Uridine | 1980 |
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Neoplasms; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Uridine | 1981 |
Chemotherapy of colorectal cancer: history and new themes.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; History, 20th Century; Humans; Prodrugs; Uridine | 1997 |
3 trial(s) available for 5-fluorouridine and uridine
| Article | Year |
|---|---|
[Evaluation of intraperitoneal chemotherapy in stage IV gastrointestinal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Routes; Female; Gastrointestinal Neoplasms; Humans; Infusions, Parenteral; Injections, Intravenous; Interleukin-2; Male; Middle Aged; Survival Rate; Uridine | 2001 |
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Deoxycytidine; DNA Modification Methylases; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrouridine; Uridine | 2008 |
212 other study(ies) available for 5-fluorouridine and uridine
| Article | Year |
|---|---|
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.
Topics: Animals; Cattle; Crystallography, X-Ray; Drug Design; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Protein Conformation; Pyrimidine Nucleosides; Ribonuclease, Pancreatic; Triazoles | 2012 |
Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Topics: Animals; Bacterial Proteins; Binding Sites; Biological Transport; Crystallography, X-Ray; Deoxycytidine; Female; Gemcitabine; Gene Expression; Humans; Kinetics; Membrane Transport Proteins; Molecular Docking Simulation; Nucleoside Transport Proteins; Oocytes; Protein Binding; Quantitative Structure-Activity Relationship; Recombinant Proteins; Ribavirin; Substrate Specificity; Thermodynamics; Uridine; Vibrio cholerae; Xenopus laevis | 2014 |
Replacement of pseudouridine in transfer RNA by 5-fluorouridine does not affect the ability to stimulate the synthesis of guanosine 5'-triphosphate 3'-diphosphate.
Topics: Escherichia coli; Guanine Nucleotides; Guanosine Tetraphosphate; Kinetics; Phenylalanine; Pseudouridine; Ribonucleosides; Ribosomes; RNA, Transfer; Uridine | 1978 |
Inhibition of transfer RNA function by replacement of uridine and uridine-derived nucleosides with 5-fluorouridine.
Topics: Amino Acyl-tRNA Synthetases; Escherichia coli; Kinetics; Protein Biosynthesis; Ribosomes; RNA, Transfer; RNA, Transfer, Amino Acyl; Uridine | 1978 |
Antitumor activity of alkylesters of 1-beta-D-ribofuranosyl-5-fluorouracil-5'-phosphate against murine lymphoma L5178Y resistant to 1-beta-D-ribofuranosyl-5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Mice; Uracil Nucleotides; Uridine | 1979 |
Differential inhibitory effect of 5-fluorouridine on RNA labelling in dipteran salivary gland cells.
Topics: Diptera; Larva; Protein Biosynthesis; RNA; RNA, Ribosomal; Salivary Glands; Uridine | 1978 |
Effect of 5-fluorouracil and 5-fluorouridine on metaphase chromosome structure in human lymphoid cells.
Topics: Antineoplastic Agents; Cell Cycle; Chromosomes, Human; Fluorouracil; Humans; Lymphocytes; Metaphase; Uridine | 1978 |
Increased formation of nucleotide derivatives of 5-fluorouridine in hepatoma cells treated with inhibitors of pyrimidine synthesis and D-galactosamine.
Topics: Animals; Azauridine; Biological Transport; Female; Galactosamine; Kinetics; Liver Neoplasms, Experimental; Rats; Ribonucleotides; Uridine | 1978 |
Quantification of 5-fluorouridine in human urine by capillary gas-liquid chromatography with a nitrogen-selective detector.
Topics: Chromatography, Gas; Chromatography, Liquid; Humans; Nitrogen; Uridine | 1978 |
Determination of 5-fluorouridine and 5-fluorocytidine in RNA hydrolysates using high-performance ion-exclusion chromatography.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cytidine; RNA; Uridine | 1975 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
RNA-directed actions of 5-fluorouridine in hemin stimulated K-562 erythroleukemia cells.
Topics: Actins; Cell Division; Cell Nucleus; Globins; Hemin; Humans; Leukemia, Erythroblastic, Acute; Ornithine Decarboxylase; Poly A; RNA, Messenger; RNA, Neoplasm; RNA, Ribosomal; RNA, Ribosomal, 18S; RNA, Ribosomal, 28S; Stimulation, Chemical; Transcription, Genetic; Tritium; Tumor Cells, Cultured; Uridine | 1992 |
Novel derivatives of 5-fluorouridine and 5-fluorouracil having potent antitumor and lower immunosuppressive activities.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Cell Division; Fluorouracil; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Organ Size; RNA, Ribosomal; Thymus Gland; Tumor Cells, Cultured; Uridine | 1992 |
Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Phosphates; Potassium; Potassium Compounds; Spectrophotometry, Ultraviolet; Uridine | 1992 |
Role of dihydropyrimidine dehydrogenase in the uridine nucleotide metabolism in the rat liver.
Topics: Age Factors; Animals; Dihydrouracil Dehydrogenase (NADP); Glucocorticoids; In Vitro Techniques; Liver; Oxidoreductases; Rats; Uracil; Uracil Nucleotides; Uridine | 1992 |
Effects of fluorouracil and fluorouridine on protein synthesis in rabbit retina.
Topics: Animals; Autoradiography; Axonal Transport; Conjunctiva; Eye Proteins; Fluorouracil; Photoreceptor Cells; Rabbits; Retina; Retinal Ganglion Cells; Rod Cell Outer Segment; Uridine; Vitreous Body | 1990 |
A fluorouridine-anti-CEA immunoconjugate is therapeutically effective in a human colonic cancer xenograft model.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Cell Survival; Colonic Neoplasms; Dextrans; Drug Carriers; Humans; Immunoglobulin Fc Fragments; Mice; Mice, Nude; Neoplasm Transplantation; Tissue Distribution; Transplantation, Heterologous; Tumor Cells, Cultured; Uridine | 1990 |
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
The effects of the fluorinated pyrimidines FUR, FUdR, FUMP, and FdUMP on human Tenon's fibroblasts.
Topics: Adenosine; Cell Division; Cell Survival; Culture Techniques; Dose-Response Relationship, Drug; Eye; Fibroblasts; Floxuridine; Humans; Trypan Blue; Uracil Nucleotides; Uridine | 1991 |
The effects of 5-fluorouridine, 5-fluorodeoxyuridine, and 5-fluorodeoxyuridine monophosphate on rabbit tenon's capsule fibroblasts in vitro.
Topics: Adenosine; Animals; beta-N-Acetylhexosaminidases; Cell Adhesion; Cell Count; Cell Division; Cell Line; DNA; Fascia; Fibroblasts; Floxuridine; Humans; Rabbits; Uridine | 1991 |
Some electrochemical characteristics of synthetic analogs of nucleic acid components. III. Derivatives of 5-fluorouridine. An attempt to find correlation between some of their characteristics.
Topics: Animals; Leukemia L1210; Nucleic Acids; Polarography; Tegafur; Thioctic Acid; Tumor Cells, Cultured; Uracil Nucleotides; Uridine | 1991 |
Effects of diastereoisomers of 5-formyltetrahydrofolate on cellular growth, sensitivity to 5-fluoro-2'-deoxyuridine, and methylenetetrahydrofolate polyglutamate levels in HCT-8 cells.
Topics: Cell Division; Chromatography, High Pressure Liquid; Cytoplasm; Humans; In Vitro Techniques; Leucovorin; Pteroylpolyglutamic Acids; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine | 1991 |
Glaucoma filtration surgery in monkeys using 5-fluorouridine in polyanhydride disks.
Topics: Animals; Cells, Cultured; Cornea; Decanoic Acids; Disease Models, Animal; Drug Carriers; Fibroblasts; Fistula; Glaucoma; Haplorhini; Humans; Intraocular Pressure; Polyesters; Postoperative Complications; Prognosis; Uridine | 1990 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Thymidine Phosphorylase; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
Glycosidic bond cleavage of 5-fluoro-2'-deoxyuridine and 5-fluorouridine by amino acyl-tRNA synthetases.
Topics: Animals; Chromatography, Thin Layer; Cytoplasm; Floxuridine; Glycoside Hydrolases; Glycosides; Hydrolysis; Liver; Lysine-tRNA Ligase; Rats; Rats, Inbred Strains; Uridine | 1990 |
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
Topics: Chromatography, High Pressure Liquid; Coumarins; Floxuridine; Fluorine; Fluorouracil; Humans; Molecular Structure; Pyrimidines; Tegafur; Umbelliferones; Uridine | 1990 |
Calcium leucovorin and 5-fluorouridine cytotoxicity.
Topics: Fluorodeoxyuridylate; Humans; Leucovorin; RNA, Ribosomal; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1990 |
Effects of pyrimidine salvage inhibitors on uracil incorporation of Toxoplasma gondii.
Topics: Animals; DNA; Folic Acid Antagonists; Methotrexate; Pyrimethamine; Thymidylate Synthase; Toxoplasma; Uracil; Uridine | 1990 |
Determination of pseudouridine in human urine and serum by high-performance liquid chromatography with post-column fluorescence derivatization.
Topics: Chromatography, High Pressure Liquid; Fluorescence; Humans; Pseudouridine; RNA, Ribosomal; Uridine | 1990 |
19F nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of Candida glabrata with specific defects in pyrimidine metabolism.
Topics: Candida; Cells, Cultured; Cytosine Deaminase; Flucytosine; Fluorouracil; Magnetic Resonance Spectroscopy; Nucleoside Deaminases; Pentosyltransferases; Phenotype; RNA, Ribosomal; Uridine; Uridine Kinase | 1990 |
Reductions in gamma-globin mRNA levels restricted to the cytoplasm of 5-fluorouridine treated K-562 human erythroleukemia cells.
Topics: Actins; Cell Line; Cell Nucleus; Cytosol; Globins; Humans; Kinetics; Leukemia, Erythroblastic, Acute; RNA, Messenger; RNA, Ribosomal; Tumor Cells, Cultured; Uridine | 1990 |
Synergistic antitumor effect of fluoropyrimidines and polyinosinic-polycytidylic acid against L1210 leukemia.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Drug Synergism; Fluorouracil; Interferons; Leukemia L1210; Mice; Mice, Inbred Strains; Poly I-C; RNA; Uridine | 1985 |
Uridylate-trapping sugar analogs in combination with inhibitors of uridylate synthesis de novo and 5-fluorouridine.
Topics: Animals; Cells, Cultured; Drug Synergism; Female; Galactose; Glucose; In Vitro Techniques; Liver Neoplasms, Experimental; Pyrimidine Nucleotides; Pyrimidines; Rats; Rats, Inbred Strains; RNA; Uridine; Uridine Monophosphate; Uridine Triphosphate | 1985 |
Effects of D-glucosamine and 6-azauridine on nucleotide contents, 5-fluorouridine uptake, and cytotoxicity in TA3 mammary tumor cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Azauridine; Cytidine Triphosphate; Female; Glucosamine; Guanosine Triphosphate; Mammary Neoplasms, Experimental; Mice; Nucleotides; RNA, Neoplasm; Uridine; Uridine Triphosphate | 1986 |
First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azauridine; Carcinoma, Hepatocellular; Female; Galactosamine; Humans; Liver Neoplasms; Male; Middle Aged; Uridine | 1985 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Messenger; RNA, Ribosomal; Sarcoma 180; Uridine | 1987 |
Mobility of individual 5-fluorouridine residues in 5-fluorouracil-substituted Escherichia coli valine transfer RNA. A 19F nuclear magnetic resonance relaxation study.
Topics: Chemical Phenomena; Chemistry, Physical; Escherichia coli; Fluorouracil; Magnetic Resonance Spectroscopy; RNA, Bacterial; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Val; Uridine | 1987 |
Inhibition of pre-mRNA splicing by 5-fluoro-, 5-chloro-, and 5-bromouridine.
Topics: Antiviral Agents; Bromouracil; DNA; Exons; Floxuridine; Genes; Genetic Complementation Test; Globins; HeLa Cells; Humans; Plasmids; RNA Precursors; RNA Splicing; RNA, Small Nuclear; Templates, Genetic; Transcription, Genetic; Uridine | 1989 |
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia L1210; Mice; Tumor Cells, Cultured; Uridine | 1989 |
Transcriptional inhibitors affecting topoisomerase II induce changes in histone methylation patterns similar to those induced by heat shock.
Topics: Animals; Camptothecin; Cells, Cultured; Dactinomycin; Drosophila melanogaster; Ethidium; Histones; Hot Temperature; In Vitro Techniques; Methylation; Novobiocin; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Uridine | 1989 |
The covalent linking of two nucleotide analogues to antibodies.
Topics: Animals; Antibodies; Cytarabine; Dextrans; Dosage Forms; Leukemia, Experimental; Mice; Uridine | 1985 |
Hyperthermia and temperature-sensitive liposomes: selective delivery of drugs into the eye.
Topics: Animals; Aqueous Humor; Cytarabine; Drug Carriers; Eye; Hot Temperature; Hyperthermia, Induced; Liposomes; Microwaves; Rabbits; Uridine; Vitreous Body | 1989 |
5-Fluorouracil derivative. XVII. Synthesis and antitumor activity of 5'-O-acyl-5-fluorouridines.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Uridine | 1989 |
Characterization of the pleiotropic phenotypes of rifampin-resistant rpoB mutants of Escherichia coli.
Topics: Alleles; Drug Resistance, Microbial; Escherichia coli; Mutation; Phenotype; Rifampin; Uracil; Uridine | 1989 |
RNA polymerase II transcripts as targets for 5-fluorouridine cytotoxicity: antagonism of 5-fluorouridine actions by alpha-amanitin.
Topics: Adenosine; Amanitins; Cell Division; Cell Membrane Permeability; Chromatography, Affinity; Electrophoresis, Agar Gel; Humans; Leukemia, Erythroblastic, Acute; Lysophosphatidylcholines; Nucleic Acid Hybridization; RNA Polymerase II; RNA Precursors; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1989 |
Selection of therapeutic agents for intraocular proliferative disease 3. Effects of fluoropyrimidines on cell-mediated contraction of human fibroblasts.
Topics: Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Fibroblasts; Fluorouracil; Gels; Humans; Sclera; Uridine | 1989 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; Rectal Neoplasms; Uridine | 1986 |
Fluoropyrimidine treatment of ocular cicatricial disease.
Topics: Animals; Cell Division; Cicatrix; Eye Diseases; Fibroblasts; Floxuridine; Fluorouracil; Osmolar Concentration; Rabbits; Skin; Uridine | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eye Neoplasms; Floxuridine; Flucytosine; Fluorouracil; Humans; Uridine | 1987 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Rectal Neoplasms; Uridine | 1987 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Rectal Neoplasms; Time Factors; Tumor Cells, Cultured; Uridine | 1988 |
Isolation and characterization of a mutant of L1210 murine leukemia deficient in nitrobenzylthioinosine-insensitive nucleoside transport.
Topics: Animals; Biological Transport; Carrier Proteins; Cytarabine; Floxuridine; Inosine; Leukemia L1210; Membrane Proteins; Mice; Mutation; Nucleoside Transport Proteins; Nucleosides; Thioinosine; Thymidine; Tubercidin; Tumor Cells, Cultured; Uridine | 1988 |
Biochemical basis for improving chemotherapeutic regimens in liver malignancies.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Drug Synergism; Humans; Kinetics; Liver Neoplasms; Pyrimidines; Uridine; Uridine Triphosphate | 1986 |
Isolation and characterization of fluoropyrimidine-resistant mutants in two Candida species.
Topics: Candida; Candida albicans; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Mutation; Phenotype; Uridine | 1988 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimidines; Radionuclide Imaging; Rats; Thymidine; Tissue Distribution; Tritium; Uridine | 1985 |
Gas-liquid chromatographic analysis of fluoropyrimidine nucleosides and fluorouracil in plasma and urine.
Topics: Animals; Chromatography, Gas; Chromatography, Ion Exchange; Dogs; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kidney; Kinetics; Uridine | 1985 |
Uptake and clearance of 5-fluorouridine following subconjunctival and intravitreal injection.
Topics: Animals; Anterior Chamber; Conjunctiva; Injections; Rabbits; Uridine; Vitreous Body | 1988 |
Noninvasive spectroscopic analysis of fluoropyrimidine metabolism in cultured tumor cells.
Topics: Animals; Cells, Cultured; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Magnetic Resonance Spectroscopy; Mice; Monitoring, Physiologic; Neoplasms; Sarcoma 180; Uridine | 1986 |
Halogenated nucleic acids: effects of 5-fluorouracil on the conformation and properties of a polyribonucleotide and its constituents.
Topics: Fluorouracil; Molecular Conformation; Nucleic Acid Conformation; Poly U; Polydeoxyribonucleotides; Uracil Nucleotides; Uridine | 1986 |
Modulation of fluoropyrimidine metabolism by chlorpromazine.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cell Survival; Chlorpromazine; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Mice; Sarcoma, Experimental; Tritium; Uridine | 1986 |
Effects of administration routes on the uptake of uridine and 5-fluorouridine into an adenocarcinoma transplanted to rat liver.
Topics: Adenocarcinoma; Animals; Catheterization; Female; Femoral Vein; Hepatic Artery; Liver Neoplasms, Experimental; Peritoneal Cavity; Portal Vein; Rats; Rats, Inbred Strains; RNA, Neoplasm; Tissue Distribution; Uridine | 1986 |
Potentiation of antimetabolite action by uridylate trapping.
Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Galactose; Glucose; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Pyrimidines; Rats; Rats, Inbred Strains; Uracil Nucleotides; Uridine | 1985 |
Fluoropyrimidine-mediated changes in small nuclear RNA.
Topics: Animals; Cell Line; Cell Survival; Cytidine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Mice; Nucleic Acid Conformation; RNA, Small Nuclear; Sarcoma 180; Time Factors; Uridine | 1986 |
Transcription of ribosomal RNA is differentially controlled in resting and growing BALB/c 3T3 cells.
Topics: Adenosine; Animals; Blood; Cell Division; Cells, Cultured; Cycloheximide; Fibroblasts; Kinetics; Mice; Mice, Inbred BALB C; Pactamycin; RNA Polymerase I; RNA, Ribosomal; Toyocamycin; Transcription, Genetic; Uridine | 1985 |
Preventive effects of 5-fluorouridine and uridine on d-galactosamine-induced liver injury.
Topics: Animals; Cell Nucleolus; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Rats; RNA; Uridine; Uridine Diphosphate; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars; Uridine Triphosphate | 1981 |
Selective enhancement of 5-fluorouridine uptake and action in rat hepatomas in vivo following pretreatment with D-galactosamine and 6-azauridine or N-(phosphonacetyl)-L-aspartate.
Topics: Animals; Aspartic Acid; Azauridine; DNA, Neoplasm; Drug Therapy, Combination; Female; Galactosamine; Liver; Liver Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Rats; RNA, Neoplasm; Stimulation, Chemical; Uracil Nucleotides; Uridine | 1980 |
Inhibition of tyrosine aminotransferase induction by UTP deficiency and its reversal by 5-fluorouridine in cultured hepatoma cells.
Topics: Animals; Azauridine; Cells, Cultured; Dexamethasone; Enzyme Induction; Galactosamine; Liver Neoplasms, Experimental; Tyrosine Transaminase; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1981 |
Cellular mutations and drug resistance probed by herpes simplex virus.
Topics: Animals; Bleomycin; Carcinoma, Squamous Cell; Chlorocebus aethiops; Drug Resistance; Fibroblasts; Fluorescent Antibody Technique; Fluorouracil; Humans; Methotrexate; Mice; Mutation; Simplexvirus; Thioguanine; Uridine | 1981 |
Adjuvant and palliative treatment of colorectal cancer with fluorinated pyrimidines. A pharmacological and clinical review.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Prognosis; Pyrimidines; Rectal Neoplasms; Uridine | 1981 |
18F-5-Fluorouridine, a new probe for measuring the proliferation of tissue in vivo.
Topics: Animals; Cell Division; Dactinomycin; Female; Fluorine; Isotope Labeling; Mice; Neoplasms, Experimental; Phenylhydrazines; Radioisotopes; RNA; Uridine | 1982 |
Combination chemotherapy for metastatic urinary bladder cancer with 5-FU, vincristine, bleomycin, cyclophosphamide, mitomycin, and methotrexate.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Transitional Cell; Cyclophosphamide; Female; Humans; Male; Methotrexate; Middle Aged; Mitomycins; Uridine; Urinary Bladder Neoplasms; Vincristine | 1984 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues.
Topics: Animals; Azaguanine; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricetinae; Floxuridine; Kidney; Ribosomal Proteins; RNA, Ribosomal; Toyocamycin; Transcription, Genetic; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.
Topics: Breast Neoplasms; Cell-Free System; Cytosol; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Phosphorylation; Uridine | 1981 |
Nitrogen metabolite repression of fluoropyrimidine resistance and pyrimidine uptake in Neurospora crassa.
Topics: Ammonia; Biological Transport; Drug Resistance, Microbial; Fluorouracil; Mutation; Neurospora; Neurospora crassa; Nitrogen; Pyrimidines; Temperature; Uracil; Uridine | 1982 |
Mode of action of 5-fluorocytosine and 5-fluorouracil in dematiaceous fungi.
Topics: Cytosine; Drug Resistance, Microbial; Floxuridine; Flucytosine; Fluorouracil; Mitosporic Fungi; RNA, Fungal; RNA, Ribosomal; Species Specificity; Uridine | 1983 |
Decreased immunosuppression associated with antitumor activity of 5-deoxy-5-fluorouridine compared to 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Survival; Female; Floxuridine; Fluorouracil; Immunosuppression Therapy; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrans; Thioglycolates; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.
Topics: Animals; Bile; Floxuridine; Fluorine; Fluorouracil; Radioisotopes; Rats; Rats, Inbred Strains; Uridine | 1984 |
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Floxuridine; Fluorouracil; Guanosine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleosides; Uridine | 1984 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Rats; Uridine | 1984 |
[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)].
Topics: Antineoplastic Agents; Asialoglycoproteins; Azo Compounds; Carcinoma, Hepatocellular; Cell Membrane Permeability; Doxorubicin; Drug Therapy, Combination; Enzyme Activation; Fluorouracil; Glycoproteins; Humans; Injections, Intra-Arterial; Liver Neoplasms; NADH, NADPH Oxidoreductases; Nitroreductases; Pyrimidine Nucleotides; Uridine | 1981 |
Production of plasminogen activator by synchronized normal and Rous sarcoma virus-transformed chicken fibroblasts in culture.
Topics: Animals; Avian Sarcoma Viruses; Cell Cycle; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Kinetics; Plasminogen Activators; RNA, Ribosomal; Uridine | 1982 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine | 1980 |
Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Floxuridine; Leukemia L5178; Leukemia, Experimental; Male; Mice; Uridine | 1980 |
Mechanism of cytotoxicity of 5-fluorouracil: distinction between the irreversible cytotoxic effect of 5-fluorouridine and the reversible cytotoxic effect of 5-fluoro-2'-deoxyuridine on murine lymphoma L5178Y cells in culture.
Topics: Animals; Cell Division; Cell Line; Floxuridine; Fluorouracil; Leukemia, Experimental; Mice; Uridine | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidylate Synthase; Uridine | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Uridine | 1980 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Mutation; Phenotype; Selection, Genetic; Uridine | 1982 |
Substrate properties of 5-fluorouridine diphospho sugars detected in hepatoma cells.
Topics: Animals; Female; Kinetics; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Stereoisomerism; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1984 |
Dehalogenation reactions in fast atom bombardment mass spectrometry.
Topics: Bromouracil; Halogens; Idoxuridine; Mass Spectrometry; Nucleosides; Structure-Activity Relationship; Uridine | 1984 |
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1984 |
[Induction of resistance of yeast-like fungi to synthetic antifungal agents].
Topics: Antifungal Agents; Candida; Clotrimazole; Culture Techniques; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Miconazole; Uridine | 1983 |
Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized.
Topics: Animals; Cell Compartmentation; Cell Nucleus; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytosol; Fluorouracil; Leukemia L1210; Mice; RNA, Neoplasm; Sepharose; Uracil Nucleotides; Uridine | 1984 |
In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine.
Topics: Cell Line; Centrifugation, Density Gradient; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Humans; Protein Biosynthesis; RNA, Messenger; Uridine | 1983 |
Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil.
Topics: Animals; Bone Marrow; Deoxyuridine; Drug Therapy, Combination; Fluorouracil; Infusions, Parenteral; Injections, Intraperitoneal; Leukemia L1210; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Uridine | 1983 |
Inhibition of ribosomal RNA maturation in Friend erythroleukemia cells by 5-fluorouridine and toyocamycin.
Topics: Animals; Cell Line; Cell Nucleus; Cytoplasm; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Ribonucleosides; RNA, Neoplasm; RNA, Ribosomal; Toyocamycin; Uridine | 1981 |
Fluorinated nucleic acid constituents: a carbon-13 nuclear magnetic resonance study of adenosine, cytidine, uridine, and their fluorinated analogues.
Topics: Adenosine; Chemical Phenomena; Chemistry; Cytidine; Magnetic Resonance Spectroscopy; Uridine | 1982 |
Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture.
Topics: Cell Nucleus; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Neoplasms, Experimental; RNA, Neoplasm; Uridine | 1982 |
Nucleosides. 114. 5'-O-Glucuronides of 5-fluorouridine and 5-fluorocytidine. Masked precursors of anticancer nucleosides.
Topics: Antineoplastic Agents; Cells, Cultured; Cytidine; Glucuronates; Neoplasms, Experimental; Uridine | 1981 |
Influence of pyrazofurin on the toxicity and antitumor activity of fluorinated pyrimidines in vivo.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Drug Interactions; Drug Therapy, Combination; Female; Fluorouracil; Hematopoietic Stem Cells; Male; Mice; Neoplasms, Experimental; Pyrazoles; Ribonucleosides; Ribose; Uridine | 1980 |
Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.
Topics: Base Sequence; Binding Sites; Circular Dichroism; DNA; Drug Stability; Floxuridine; Molecular Sequence Data; Nucleic Acid Conformation; RNA; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics; Uridine | 1995 |
Evaluation of plasma 5-fluorouracil nucleoside levels in patients with metastatic breast cancer: relationships with toxicities.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Uridine | 1995 |
Evaluation of toxicity and efficacy of a combination of antineoplastic agents in the prevention of PVR.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cells, Cultured; Disease Models, Animal; Drug Carriers; Drug Evaluation; Fibroblasts; Liposomes; Rabbits; Retina; Retinal Detachment; Retinal Neovascularization; RNA, Ribosomal; Uridine; Vitreoretinopathy, Proliferative | 1994 |
Nucleosides and nucleotides--CXXXVII. Antitumor phospholipids with 5-fluorouridine as a cytotoxic polar-head: synthesis of 5'-phosphatidyl-5-fluorouridines by phospholipase D-catalyzed transphosphatidylation.
Topics: Animals; Antineoplastic Agents; Fibrosarcoma; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Neoplasm Transplantation; Phosphatidic Acids; Phospholipase D; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine | 1995 |
Incorporation of 5-fluorouracil into RNA by Mycobacterium avium complex strain LM1.
Topics: Biotransformation; Cytidine; Drug Resistance, Microbial; Fluorouracil; Mycobacterium avium Complex; RNA, Bacterial; Uracil; Uridine | 1993 |
Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibody Specificity; beta-Galactosidase; Galactose; Humans; Immunoconjugates; Immunoenzyme Techniques; Prodrugs; Tumor Cells, Cultured; Uridine | 1994 |
Synthesis of 5-fluorouridine 5'-diphosphate galactose from 5-fluorouridine by chemical phosphorylation and microbial uridylyl transfer.
Topics: Candida; Galactose; Indicators and Reagents; Magnetic Resonance Spectroscopy; Oligosaccharides; Phosphorylation; Uridine; Uridine Diphosphate Glucose | 1994 |
Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells.
Topics: Cell Cycle; Cell Survival; Colorectal Neoplasms; DNA, Neoplasm; DNA, Ribosomal; Dose-Response Relationship, Drug; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1994 |
Somatostatin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids.
Topics: Adenocarcinoma; Amino Acid Sequence; Cell Cycle; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorine; Fluorouracil; G1 Phase; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Octreotide; Receptors, Somatostatin; Resting Phase, Cell Cycle; RNA, Ribosomal; S Phase; Tumor Cells, Cultured; Uridine | 1994 |
Pseudouridine formation in U2 small nuclear RNA.
Topics: Animals; Base Sequence; Cell-Free System; HeLa Cells; Humans; Molecular Sequence Data; Pseudouridine; Rats; RNA Processing, Post-Transcriptional; RNA, Small Nuclear; Uridine | 1994 |
Enzyme aided regio-selective acylation and deacylation of nucleosides.
Topics: Acylation; Catalysis; Floxuridine; Hydrolysis; Lipase; Nucleosides; Uridine | 1993 |
In vitro splicing of pre-messenger RNA with extracts from 5-fluorouridine-treated cells.
Topics: HeLa Cells; Humans; In Vitro Techniques; Ribonucleoproteins, Small Nuclear; RNA Splicing; RNA, Messenger; Spliceosomes; Uridine | 1994 |
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Liver; Mice; Placenta; Species Specificity; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 1993 |
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Incidence; Injections; Rabbits; Retinal Detachment; Retinal Diseases; RNA, Ribosomal; Uridine; Vitreous Body | 1993 |
Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine.
Topics: HeLa Cells; Humans; Ribonucleoproteins; RNA Splicing; RNA, Small Nuclear; Uridine | 1993 |
Diversity in nucleotide acquisition by antigenically similar Chlamydia psittaci of avian origin.
Topics: Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Bacterial Typing Techniques; Base Sequence; Biological Transport; Birds; Chlamydophila psittaci; DNA, Bacterial; Genes, Bacterial; Host-Parasite Interactions; Molecular Sequence Data; Nucleotides; Purines; Pyrimidines; Species Specificity; Sulfisoxazole; Uridine | 1993 |
Synthesis and properties of 5-fluorouracil oligonucleotides.
Topics: Antimetabolites, Antineoplastic; Floxuridine; Molecular Structure; Oligonucleotides; Uridine | 1995 |
Potentiometric alternating biosensing system for in continuum toxicity tests on cell population.
Topics: Animals; Antineoplastic Agents; Biosensing Techniques; Cell Count; CHO Cells; Cisplatin; Cricetinae; Electrophysiology; HeLa Cells; Humans; Hydrogen-Ion Concentration; Methotrexate; Potentiometry; Toxicity Tests; Uridine | 1996 |
The role of thymidylate synthase in cellular regulation.
Topics: Antineoplastic Agents; Blotting, Southern; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyuridylate; Gene Expression Regulation, Neoplastic; Humans; Polymerase Chain Reaction; Precipitin Tests; Protein Biosynthesis; RNA-Binding Proteins; RNA, Messenger; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured; Uridine; Uridine Monophosphate | 1996 |
rTS gene expression is associated with altered cell sensitivity to thymidylate synthase inhibitors.
Topics: Alternative Splicing; Amino Acid Sequence; Antineoplastic Agents; Blotting, Northern; Chromosomes, Human, Pair 18; Conserved Sequence; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Phylogeny; Precipitin Tests; RNA, Antisense; RNA, Messenger; Sequence Homology, Amino Acid; Thymidylate Synthase; Transfection; Trifluridine; Tumor Cells, Cultured; Uridine | 1996 |
The culture fluid of Isaira japonica yasuda augments anti-sheep red blood cell antibody response in mice.
Topics: Adjuvants, Immunologic; Animals; Antibodies; Antibody Formation; Cell Count; Cells, Cultured; Culture Media; Erythrocytes; Fungi; Immunization; Lymphocytes; Male; Mice; Mice, Inbred Strains; Organ Size; Sheep; Spleen; Uridine | 1996 |
In vitro and in vivo antitumor activity of immunoconjugates prepared by linking 5-fluorouridine to antiadenocarcinoma monoclonal antibody.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Colorectal Neoplasms; Drug Stability; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunotoxins; Lethal Dose 50; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Protein Synthesis Inhibitors; Tumor Cells, Cultured; Uridine | 1997 |
Irreversible cytotoxic effect of a novel lowly immunosuppressive antitumor fluorouridine derivative, UK-21.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; Flow Cytometry; Floxuridine; Fluorouracil; Glycine; Humans; Immunosuppressive Agents; KB Cells; Neoplastic Stem Cells; Thymidine; Uridine | 1997 |
Antitumoral activity of liposomes and immunoliposomes containing 5-fluorouridine prodrugs.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Calorimetry, Differential Scanning; Colorectal Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Humans; Liposomes; Mice; Neoplasm Transplantation; Prodrugs; Tumor Cells, Cultured; Uridine | 1997 |
Pharmacokinetics and retinal toxicity of intravitreal liposome-encapsulated 5-fluorouridine.
Topics: Animals; Dose-Response Relationship, Drug; Drug Carriers; Electroretinography; Half-Life; Injections; Liposomes; Rabbits; Reproducibility of Results; Retina; Uridine; Vitreoretinopathy, Proliferative; Vitreous Body | 1997 |
Stability indicating high performance liquid chromatography methods for 5-fluorouridine in aqueous solution.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Magnetic Resonance Spectroscopy; Solutions; Spectrophotometry, Ultraviolet; Uridine | 1997 |
Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells.
Topics: Antimetabolites, Antineoplastic; Cell Count; Colorectal Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Intracellular Fluid; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1998 |
Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases.
Topics: Amino Acid Sequence; Binding Sites; Cell Survival; Deoxyuracil Nucleotides; Drug Resistance; Enzyme Inhibitors; Escherichia coli; Humans; Kinetics; Molecular Sequence Data; Mutagenesis; Mutation; Protein Binding; Sequence Analysis, DNA; Tetrahydrofolates; Thymidylate Synthase; Uridine | 1998 |
Development of a multiple-drug delivery implant for intraocular management of proliferative vitreoretinopathy.
Topics: Chromatography, High Pressure Liquid; Drug Implants; Eye; Humans; Microscopy, Electron, Scanning; Molecular Weight; Particle Size; Polymers; Recombinant Proteins; Tissue Plasminogen Activator; Triamcinolone; Uridine; Vitreoretinopathy, Proliferative | 1998 |
Bladder tissue pharmacokinetics and antitumor effect of intravesical 5-fluorouridine.
Topics: Administration, Intravesical; Animals; Antibiotics, Antineoplastic; Biological Availability; Dogs; Female; Fluorouracil; Humans; Male; Metabolic Clearance Rate; Uridine; Urinary Bladder; Urinary Bladder Neoplasms | 1997 |
Organ selective delivery using a tissue-directed streptavidin--biotin system: targeting 5-fluorouridine via TNP-streptavidin.
Topics: Animals; Binding Sites; Biotin; Cattle; Dextrans; Liver; Mice; Organ Specificity; Ovalbumin; Serum Albumin, Bovine; Spleen; Streptavidin; Time Factors; Uridine | 1999 |
Differences in metabolism of 5-fluorouracil and 5-fluorouridine and regulation by glucosamine in human colon cancer multicell tumor spheroids.
Topics: Body Fluid Compartments; Colonic Neoplasms; Fluorouracil; Glucosamine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Biological; Nonlinear Dynamics; Phosphates; Spheroids, Cellular; Uridine | 1999 |
Syntheses and studies of multiwarhead siderophore-5-fluorouridine conjugates.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Biological Transport, Active; Candida albicans; Drug Delivery Systems; Drug Design; Drug Resistance, Microbial; Escherichia coli; Iron; Magnetic Resonance Spectroscopy; Siderophores; Uridine | 1999 |
Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma; Colorectal Neoplasms; Cytosine Deaminase; Disease Models, Animal; Feasibility Studies; Flucytosine; Genetic Therapy; Humans; Male; Neoplasm Transplantation; Nucleoside Deaminases; Peritoneal Neoplasms; Rats; Tumor Cells, Cultured; Uridine | 2000 |
Does 29-mer RNA hairpin of the HIV-1 TAR RNA sequence bind magnesium? 19F-NMR and modelling studies.
Topics: Base Sequence; Calcium; Computer Simulation; Fluorine; HIV-1; Magnesium; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; RNA, Viral; Uridine | 1999 |
Structural equilibria in RNA as revealed by 19F NMR.
Topics: Fluorine; Hydrogen-Ion Concentration; Ions; Kinetics; Magnesium Chloride; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Phosphates; RNA; Sodium Chloride; Temperature; Thermodynamics; Ultraviolet Rays; Uridine | 2000 |
Kinetic model for 5-fluorouridine degradation. Catalytic effect of 5-fluorouracil.
Topics: Algorithms; Catalysis; Fluorouracil; Hydrolysis; Kinetics; Models, Chemical; Uridine | 2000 |
Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells.
Topics: Biological Transport; Cell Division; DNA, Complementary; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Equilibrative Nucleoside Transporter 1; Floxuridine; Gene Transfer Techniques; Halogens; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Molecular Sequence Data; Purine Nucleosides; Pyrimidine Nucleosides; RNA, Messenger; Sodium; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine | 2001 |
[Superselective arterial embolization for hemorrhage from malignant gestational trophoblastic tumor].
Topics: Antineoplastic Agents; Combined Modality Therapy; Embolization, Therapeutic; Female; Hemorrhage; Humans; Pregnancy; Treatment Outcome; Trophoblastic Neoplasms; Uridine | 2002 |
RP-LC determination of 5-fluorouridine in nanoparticulate formulations.
Topics: Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Fluorouracil; Reproducibility of Results; Solutions; Uridine | 2002 |
In-vitro release of fluoropyrimidines from PLGA film implants.
Topics: Absorbable Implants; Analysis of Variance; Chromatography, High Pressure Liquid; Drug Carriers; Drug Implants; Fluorouracil; Humans; Polyglactin 910; Uridine | 2002 |
An H/ACA guide RNA directs U2 pseudouridylation at two different sites in the branchpoint recognition region in Xenopus oocytes.
Topics: Animals; Base Sequence; Cell Nucleus Structures; Female; Molecular Sequence Data; Oocytes; Ribonucleoproteins, Small Nucleolar; RNA; RNA, Small Nuclear; RNA, Small Nucleolar; Uridine; Xenopus | 2002 |
[Studies on biotransformation of 5-FUR].
Topics: Biotransformation; Enterobacter aerogenes; Hydrogen-Ion Concentration; Temperature; Uridine | 2002 |
Fluorinated pyrimidines. VI. Effects of 5-fluorouridine and 5-fluoro-2'-deoxyuridine on transplanted tumors.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Neoplasms, Experimental; Pyrimidines; Uridine | 1958 |
Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uridine | 1958 |
EFFECTS OF 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) AND 5-FLUOROURACIL (NSC-19893) ON CHILDHOOD LEUKEMIA.
Topics: Bone Marrow Examination; Child; Floxuridine; Fluorouracil; Leukemia; Leukopenia; Melena; Nausea; Toxicology; Uridine; Vomiting | 1964 |
COMPARISON OF 5-FLUOROURACIL (NSC-19893) AND 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) IN TREATMENT OF PATIENTS WITH ADVANCED ADENOCARCINOMA OF COLON OR RECTUM.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Deoxyuridine; Drug Therapy; Fluorouracil; Humans; Nucleosides; Palliative Care; Rectal Neoplasms; Rectum; Toxicology; Uridine | 1965 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
Not all pseudouridine synthases are potently inhibited by RNA containing 5-fluorouridine.
Topics: Escherichia coli; Hydro-Lyases; Intramolecular Lyases; Intramolecular Transferases; RNA; Uridine | 2004 |
Pseudouridines in and near the branch site recognition region of U2 snRNA are required for snRNP biogenesis and pre-mRNA splicing in Xenopus oocytes.
Topics: Animals; Female; Oocytes; Pseudouridine; Ribonucleoproteins, Small Nuclear; RNA Precursors; RNA Splicing; RNA, Messenger; RNA, Small Nuclear; Spliceosomes; Uridine; Xenopus | 2004 |
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Irinotecan; Nucleic Acids; Organoplatinum Compounds; Oxaliplatin; Uridine | 2004 |
The pseudouridine synthases: revisiting a mechanism that seemed settled.
Topics: Escherichia coli; Hydro-Lyases; Hydrolysis; Pseudouridine; RNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uridine | 2004 |
Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha.
Topics: Catalysis; Cell Line, Tumor; Cytokines; DNA Damage; HT29 Cells; Humans; Interferon-alpha; Interferons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thymidine Phosphorylase; Time Factors; Up-Regulation; Uridine | 2004 |
Crystal structure and conformation of 5-fluorouridine: conformational preferences for 5-fluorinated pyranosides.
Topics: Antineoplastic Agents; Crystallography, X-Ray; HeLa Cells; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Pyrimidines; Structure-Activity Relationship; Uridine | 2004 |
Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA.
Topics: Animals; Base Composition; Chromatography, Thin Layer; Liver; Male; Mice; Nucleosides; RNA, Transfer; Uridine | 1976 |
Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy.
Topics: Bacillus subtilis; Catalysis; Deoxyribodipyrimidine Photo-Lyase; DNA Damage; DNA Repair; Enzyme Activation; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Light; Mutation; Photochemistry; Spectroscopy, Fourier Transform Infrared; Thymine; Uridine | 2005 |
Diverse gene expression pattern during 5-fluorouridine-induced apoptosis.
Topics: Analysis of Variance; Apoptosis; Cell Survival; Cluster Analysis; Colorectal Neoplasms; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Microscopy, Electron; Necrosis; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Thymidine; Time Factors; Up-Regulation; Uridine | 2005 |
Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5'-fluorouridine into nascent RNA.
Topics: Animals; Biological Assay; Cell Nucleolus; Cell Nucleus; Dactinomycin; DNA Repair; Euchromatin; Gene Expression; Gene Silencing; Histones; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Neurons, Afferent; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staining and Labeling; Transcription, Genetic; Transcriptional Activation; Trigeminal Ganglion; Uridine | 2006 |
Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films.
Topics: Animals; Cross-Linking Reagents; Delayed-Action Preparations; Diffusion; Drug Carriers; Elasticity; Gamma Rays; Materials Testing; Membranes, Artificial; Polyvinyls; Rats; Rats, Wistar; Uridine | 2006 |
A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans.
Topics: Adenosine; Adenosine Triphosphatases; ATP-Binding Cassette Transporters; Bacterial Proteins; Carbohydrate Metabolism; Cytidine; Drug Resistance, Bacterial; Humans; Mutation; Ribonucleosides; Streptococcal Infections; Streptococcus mutans; Uridine | 2006 |
Mechanistic investigations of the pseudouridine synthase RluA using RNA containing 5-fluorouridine.
Topics: Escherichia coli; Escherichia coli Proteins; Hot Temperature; Hydro-Lyases; Models, Molecular; Nucleic Acid Conformation; Pseudouridine; RNA; Uridine | 2006 |
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Floxuridine; Humans; Kinetics; Pyrimidines; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 2007 |
The fluorouridine insensitive 1 (fur1) mutant is defective in equilibrative nucleoside transporter 3 (ENT3), and thus represents an important pyrimidine nucleoside uptake system in Arabidopsis thaliana.
Topics: Animals; Arabidopsis; Biological Transport; Electrophysiology; Equilibrative Nucleoside Transport Proteins; Female; Gene Expression Regulation, Plant; Mutagenesis, Site-Directed; Oocytes; Uridine; Xenopus | 2007 |
The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
Topics: Azacitidine; Bromodeoxyuridine; Decitabine; Deoxyuridine; DNA Damage; Escherichia coli; Escherichia coli Proteins; Fluorouracil; Models, Biological; Molecular Structure; Mutation; N-Glycosyl Hydrolases; Nucleotidases; Orotic Acid; Substrate Specificity; Thymidine Monophosphate; Uridine | 2007 |
Novel and highly regioselective route for synthesis of 5-fluorouridine lipophilic ester derivatives by lipozyme TL IM.
Topics: Acylation; Ascomycota; Catalysis; Enzymes, Immobilized; Esters; Fungal Proteins; Kinetics; Lipase; Substrate Specificity; Uridine | 2007 |
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs.
Topics: Antineoplastic Agents; Cross-Linking Reagents; Doxorubicin; Drug Carriers; Ferrosoferric Oxide; Humans; Melanoma; Metal Nanoparticles; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine | 2008 |
Bisphosphonate derivatives of nucleoside antimetabolites: hydrolytic stability and hydroxyapatite adsorption of 5'-beta,gamma-methylene and 5'-beta,gamma-(1-hydroxyethylidene) triphosphates of 5-fluorouridine and ara-cytidine.
Topics: Adsorption; Animals; Calcium; Cytidine; Diphosphonates; Humans; Hydrolysis; Kinetics; Magnesium; Mice; Nucleosides; Uridine | 2008 |
Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta.
Topics: Alpha-Amanitin; Cell Nucleus; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Histones; Humans; Immunohistochemistry; In Vitro Techniques; Microscopy, Electron, Transmission; Pregnancy; RNA Polymerase II; Transcription, Genetic; Tritium; Trophoblasts; Uridine | 2009 |
Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Epigenomics; Fluorouracil; Gene Expression Regulation, Neoplastic; Gene Order; Humans; Mice; Mice, Nude; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Promoter Regions, Genetic; RNA Stability; Uridine; Xenograft Model Antitumor Assays | 2009 |
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Topics: Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; Nucleoside-Phosphate Kinase; RNA Interference; Uridine | 2009 |
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.
Topics: Animals; Cell Nucleus; Chromatin; DNA-Binding Proteins; Immunohistochemistry; Male; Neurons; Rats; Rats, Sprague-Dawley; RNA Processing, Post-Transcriptional; RNA, Messenger; Telomere; Transcription, Genetic; Uridine | 2009 |
Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons.
Topics: Adaptor Proteins, Signal Transducing; Animals; Boronic Acids; Bortezomib; Cell Nucleus; Ganglia, Spinal; Gene Expression Regulation; Male; Microscopy, Electron, Transmission; Poly(A)-Binding Protein II; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensory Receptor Cells; Time Factors; Ubiquitin; Uridine | 2010 |
Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro.
Topics: Cell Line, Tumor; Humans; Neoplasms; Plasminogen Activator Inhibitor 2; Uridine; Urokinase-Type Plasminogen Activator | 2010 |
The handling of the mechanistic probe 5-fluorouridine by the pseudouridine synthase TruA and its consistency with the handling of the same probe by the pseudouridine synthases TruB and RluA.
Topics: Aspartic Acid; Escherichia coli Proteins; Esters; Hydrolysis; Intramolecular Transferases; Molecular Probes; Nucleosides; RNA; Uridine | 2011 |
N⁴-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine-new drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate).
Topics: Alendronate; Animals; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Bone and Bones; Bone Density Conservation Agents; Cell Line, Tumor; Cytidine; Diphosphonates; Drug Screening Assays, Antitumor; Durapatite; Fluorouracil; Humans; Macrophages; Mice; Pamidronate; Uridine; Zidovudine | 2011 |
The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another.
Topics: Intramolecular Transferases; Molecular Structure; Quantum Theory; RNA; Stereoisomerism; Uridine | 2011 |
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Topics: Animals; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Floxuridine; Fluorouracil; Gene Knockdown Techniques; Humans; Mice; MutS Homolog 2 Protein; RNA; Thymidine; Thymine DNA Glycosylase; Uracil-DNA Glycosidase; Uridine | 2011 |
Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biomass; Cellulose; Fluorouracil; Isoenzymes; Light; Lignin; Mutagenesis, Insertional; Orotic Acid; Pentosyltransferases; Phenotype; Plant Leaves; Plants, Genetically Modified; Plastids; Recombinant Fusion Proteins; Seeds; Starch; Uracil; Uridine; Uridine Kinase | 2011 |
Halogenated nucleotide labeling of nascent RNAs reveals dynamic transcription in growing pig oocytes.
Topics: Animals; Chromatin Assembly and Disassembly; Female; Fluorescence; Gene Expression Regulation, Developmental; Immunohistochemistry; Microscopy, Confocal; Oocytes; RNA; Staining and Labeling; Swine; Transcription, Genetic; Uridine | 2013 |
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Topics: Administration, Oral; Algorithms; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Floxuridine; Fluorouracil; Indicators and Reagents; Mass Spectrometry; Tandem Mass Spectrometry; Uridine | 2013 |
Ligand binding and aggregation of pathogenic SOD1.
Topics: Apoproteins; Dopamine; Enzyme Stability; Epinephrine; Guanidine; Humans; Isoproterenol; Ligands; Models, Molecular; Mutant Proteins; Mutation; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Protein Unfolding; Recombinant Proteins; Scattering, Small Angle; Superoxide Dismutase; Superoxide Dismutase-1; Uridine; X-Ray Diffraction | 2013 |
Unexpected linear ion trap collision-induced dissociation and Fourier transform ion cyclotron resonance infrared multi-photon dissociation fragmentation of a hydrated C-glycoside of 5-fluorouridine formed by the action of the pseudouridine synthases RluA
Topics: Glycosides; Hydro-Lyases; Intramolecular Transferases; Molecular Structure; Monosaccharides; Pseudouridine; RNA; Spectroscopy, Fourier Transform Infrared; Uridine | 2011 |
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Fertility; Forkhead Transcription Factors; Heat-Shock Proteins; Homeostasis; Stress, Physiological; Transcription Factors; Uridine | 2013 |
Immobilization of 5-fluorouridine on chitosan.
Topics: Chitosan; Hydrogen-Ion Concentration; Levulinic Acids; Prenylation; Spectrophotometry, Ultraviolet; Uridine | 2013 |
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Topics: Apoenzymes; Arginine; Catalytic Domain; Escherichia coli Proteins; Intramolecular Transferases; Models, Molecular; Nucleic Acid Conformation; Protein Conformation; RNA, Ribosomal, 23S; Substrate Specificity; Tyrosine; Uridine; Water | 2014 |
Mitsunobu reactions of 5-fluorouridine with the terpenols phytol and nerol: DNA building blocks for a biomimetic lipophilization of nucleic acids.
Topics: Acyclic Monoterpenes; Biocompatible Materials; DNA; Isomerism; Lipid Bilayers; Oligonucleotides; Phytol; Terpenes; Uridine | 2013 |
Synthesis of 5-fluorouridine nucleolipid derivatives and their cytostatic/cytotoxic activities on human HT-29 colon carcinoma cells.
Topics: Antineoplastic Agents; Cell Survival; Colonic Neoplasms; HT29 Cells; Humans; Microscopy, Confocal; Uridine | 2013 |
Nucleolipids of the cancerostatic 5-fluorouridine: synthesis, adherence to oligonucleotides, and incorporation in artificial lipid bilayers.
Topics: Lipid Bilayers; Lipids; Molecular Conformation; Oligonucleotides; Uridine | 2014 |
Biocatalytic polymer thin films: optimization of the multilayered architecture towards in situ synthesis of anti-proliferative drugs.
Topics: Animals; beta-Galactosidase; Catalysis; Cell Line; Cell Proliferation; Delayed-Action Preparations; Enzymes, Immobilized; Membranes, Artificial; Mice; Polyamines; Polystyrenes; Prostheses and Implants; Tissue Engineering; Uridine | 2014 |
Cytostatic/cytotoxic effects of 5-fluorouridine nucleolipids on colon, hepatocellular, and renal carcinoma cells: in vitro identification of a potential cytotoxic multi-anticancer drug.
Topics: Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Cell Survival; Hep G2 Cells; HT29 Cells; Humans; RNA, Messenger; Tumor Suppressor Protein p53; Uridine | 2014 |
Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole.
Topics: Antifungal Agents; Azoles; Biological Transport; Candida; Crosses, Genetic; Drug Antagonism; Drug Resistance, Fungal; Flucytosine; Fluorouracil; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Microbial Sensitivity Tests; Nucleobase Transport Proteins; Nucleotide Transport Proteins; Sterol 14-Demethylase; Uracil; Uridine | 2014 |
Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.
Topics: Artifacts; Chromatography, Liquid; Fluorescent Dyes; Intramolecular Transferases; Protein Binding; RNA, Transfer; Spectrometry, Fluorescence; Tandem Mass Spectrometry; Uridine | 2014 |
Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.
Topics: Adenosine; Antimalarials; Axenic Culture; Biological Transport; Gene Deletion; Gene Expression; Genetic Complementation Test; High-Throughput Screening Assays; Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins; Nucleoside Transport Proteins; Plasmodium falciparum; Protozoan Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Small Molecule Libraries; Structure-Activity Relationship; Trophozoites; Uridine | 2015 |
Growth and Chemosensitivity of Gastric Adenocarcinoma and Non-Malignant Cell Lines in Response to Novel Anti-Cancer Drug Combinations.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Growth Inhibitors; Humans; Stomach Neoplasms; Uridine | 2014 |
Mitsunobu alkylation of cancerostatic 5-fluorouridine with (2E)-10-hydroxydec-2-enoic acid, a fatty acid from royal jelly with multiple biological activities.
Topics: Alkylation; Anticarcinogenic Agents; Fatty Acids; Fatty Acids, Monounsaturated; Succinimides; Uridine | 2015 |
Synthesis and antitumor activity evaluation of lamiridosin A derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Iridoids; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Uridine | 2016 |
The Pseudouridine Synthases Proceed through a Glycal Intermediate.
Topics: Anions; Chemistry, Organic; Crystallization; Intramolecular Transferases; Kinetics; Nucleic Acid Conformation; Polysaccharides; Protein Isoforms; Protons; Pseudouridine; RNA; Uridine | 2016 |
Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.
Topics: 3' Untranslated Regions; Base Pairing; Energy Transfer; Exons; Humans; Huntingtin Protein; Huntington Disease; Hydrogen Bonding; Models, Molecular; Molecular Dynamics Simulation; Mutation; Myotonic Dystrophy; Myotonin-Protein Kinase; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Nucleotide Motifs; RNA Folding; RNA, Messenger; Trinucleotide Repeat Expansion; Uridine | 2017 |
Strengthening Gastric Cancer Therapy by Trastuzumab-Conjugated Nanoparticles with Simultaneous Encapsulation of Anti-MiR-21 and 5-Fluorouridine.
Topics: Animals; Antagomirs; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Nanoparticles; Polyesters; Receptor, ErbB-2; Stomach Neoplasms; Trastuzumab; Uridine | 2017 |
Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides.
Topics: Antineoplastic Agents; Antiviral Agents; Binding Sites; Cell Line, Tumor; Cell Survival; Chikungunya virus; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Nerve Tissue Proteins; Phosphoramides; Prodrugs; Protein Structure, Tertiary; Structure-Activity Relationship; Uridine; Virus Internalization | 2018 |
Relative Populations of Some Tautomeric Forms of 2'-Deoxyguanosine-5-Fluorouridine Mismatch.
Topics: Deoxyguanosine; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Dynamics Simulation; Quantum Theory; Uridine | 2018 |
The role of hydration effects in 5-fluorouridine binding to SOD1: insight from a new 3D-RISM-KH based protocol for including structural water in docking simulations.
Topics: Binding Sites; Humans; Models, Theoretical; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Conformation; Quantum Theory; Solvents; Superoxide Dismutase-1; Uridine; Water | 2019 |
Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Models, Molecular; Molecular Structure; Nucleosides; Structure-Activity Relationship; Thymidine; Transferases; Transferases (Other Substituted Phosphate Groups); Uridine | 2019 |
Discontinuous transcription of ribosomal DNA in human cells.
Topics: Aged; Cadaver; Cell Nucleolus; Cold Temperature; DNA, Ribosomal; Epithelial Cells; HeLa Cells; Humans; Kinetics; Limbus Corneae; Middle Aged; Ribosomes; RNA, Ribosomal; Software; Transcription, Genetic; Transfection; Uridine; Uridine Triphosphate | 2020 |
Determination of 5-fluorocytosine, 5-fluorouracil, and 5-fluorouridine in hospital wastewater by liquid chromatography-mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Flucytosine; Fluorouracil; Hospitals; Molecular Structure; Solid Phase Extraction; Tandem Mass Spectrometry; Uridine; Wastewater; Water Pollutants, Chemical | 2020 |
Cloning and high-level expression of monomeric human superoxide dismutase 1 (SOD1) and its interaction with pyrimidine analogs.
Topics: Amyotrophic Lateral Sclerosis; Base Sequence; Bromouracil; Cloning, Molecular; Drug Evaluation, Preclinical; Escherichia coli; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Folding; Proton Magnetic Resonance Spectroscopy; Superoxide Dismutase-1; Trifluridine; Tryptophan; Uridine | 2021 |
A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Mice; Microbubbles; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome; Uridine | 2021 |
Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling.
Topics: Apoptosis; Cell Line; Humans; Leukemia, Myeloid, Acute; MicroRNAs; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Recurrence; Stem Cells; Uridine | 2022 |