5-fluorouridine has been researched along with fluorouracil in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (58.24) | 18.7374 |
| 1990's | 22 (24.18) | 18.2507 |
| 2000's | 8 (8.79) | 29.6817 |
| 2010's | 6 (6.59) | 24.3611 |
| 2020's | 2 (2.20) | 2.80 |
| Authors | Studies |
|---|---|
| An, SH; Bernacki, RJ; Bobek, M; De Clercq, E; Skrincosky, D | 1 |
| Balzarini, J; Bentrude, WG; Béres, J; De Clercq, E; Kálmán, A; Párkányi, L | 1 |
| Ajmera, S; Danenberg, PV | 1 |
| Kim, SH; Rosowsky, A; Trites, D; Wick, M | 1 |
| Drabikowska, AK; Felczak, K; Kulikowski, T; Shugar, D; Vilpo, JA | 1 |
| Balzarini, J; Komiotis, D; Liekens, S; Manta, S; Tsoukala, E; Tzioumaki, N; Vande Voorde, J | 1 |
| Andersen, O; Rønne, M | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Ophir, A | 1 |
| Kita, J; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O | 1 |
| Barberi-Heyob, M; Merlin, JL; Webér, B | 1 |
| Britt, JM; Hopp, RH; Leon, JA; Milam, AH; Mills, RP | 1 |
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| Hirose, S; Kito, M; Takeshima, S; Urakami, K; Yoshida, S | 1 |
| Fasoli, MO; Kerridge, D; Morris, PG; Torosantucci, A | 1 |
| Chapekar, MS; Glazer, RI; Iigo, M | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY | 1 |
| Hardin, CC; Horowitz, J | 1 |
| Ho, DH; Kamiya, K; Nakamura, T; Sasaki, K; Tsutani, H; Uchida, M; Yoshimura, T | 1 |
| Blumenkranz, MS; Cheng, M; Dailey, WA; Hajek, AS; Hartzer, MK; Margherio, AR | 1 |
| Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L | 2 |
| Heath, TD; Lewis, GP; Lopez, NG; Stern, WH | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 1 |
| Blumenkranz, MS; Hajek, AS; Hartzer, MK | 1 |
| Aigner, KR; Danenberg, PV; Link, KH; Peschau, K; Schwemmle, K; Warthona, M | 1 |
| Fasoli, M; Kerridge, D | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Matsuzawa, T; Murakami, M | 1 |
| Lin, F; Warren, BS; Williams, WM | 1 |
| Benz, C; James, TL; Keniry, M; Shafer, RH | 1 |
| Alderfer, JL; Loomis, RE | 1 |
| Brooks, M; Cadman, E; Tseng, A | 1 |
| Campisi, J; Pardee, AB | 1 |
| Gustavsson, B; Hafström, L | 1 |
| Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG | 1 |
| Cadman, E; Grant, S | 1 |
| Ardalan, B; Cooney, D; Lippman, M; Macdonald, J; Schein, P | 1 |
| Buxton, FP; Radford, A | 1 |
| Polak, A | 1 |
| Armstrong, RD; Connolly, KM; Diasio, RB; Kaplan, AM | 1 |
| Abe, Y; Endo, S; Fukuda, H; Ido, T; Ishiwata, K; Kubota, K; Matsuzawa, T; Sato, T; Takahashi, T; Yamada, K; Yoshioka, S | 1 |
| Ido, T; Ishiwata, K; Kawashima, K; Murakami, M; Takahashi, T | 1 |
| Hoshi, A; Iigo, M | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Matsuzawa, T; Monma, M; Takahashi, T; Tsurumi, Y | 1 |
| Gerok, W; Holstege, A; Keppler, D; Pausch, J | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 2 |
| Hoshi, A; Kuretani, K; Yoshida, M | 1 |
| Heidelberger, C; Mulkins, MA | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Dźwigaj-Stokłosa, W; Hołuj-Gubała, J; Pawlik, B | 1 |
| Danenberg, PV; Shani, J | 1 |
| Benvenuto, J; Drewinko, B; Freireich, EJ; Ho, DH; Loo, TL; Yang, LY | 1 |
| Glazer, RI; Hartman, KD | 1 |
| Cerna, I; Klubes, P | 1 |
| Au, JL; Danhauser, L; Luccioni, C; Rustum, YM | 1 |
| Glazer, RI; Lloyd, LS | 1 |
| Clement, JJ; Faucette, LF; Howard, WS; Johnson, RK; Wodinsky, I | 1 |
| Barberi-Heyob, M; de Bruijn, EA; Dittrich, C; Guillemin, F; Luporsi, E; Merlin, JL; Weber, B | 1 |
| Abdulmalek, S; McCarthy, CM; Montoya, DP | 1 |
| Inaba, M; Mitsuhashi, J | 1 |
| Chen, TB; Huzak, M; Macura, S; Vuk-Pavlović, S | 1 |
| el Kouni, MH; el Kouni, MM; Naguib, FN | 1 |
| Blumenkranz, M; Hartzer, M; Lin, LR; Ward, T | 1 |
| Ishida, R; Ito, S; Koda, A; Mori, H; Nagai, H; Nakayama, K | 1 |
| Bertino, JR | 1 |
| Inaba, M; Mitsuhashi, J; Naoe, Y | 1 |
| Au, JL; Gan, Y; Song, D; Wientjes, MG | 1 |
| Bajzer, Z; Chen, TB; Macura, S; Vuk-Pavlovic, S | 1 |
| Dorta, MJ; Llabrés, M; Munguía, O | 1 |
| Arbós, P; Campanero, MA; Irache, JM | 1 |
| Dorta, MJ; Fariña, JB; Llabrés, M; Munguía, O; Oliva, A | 1 |
| BOLAFFI, JL; CHEONG, L; EIDINOFF, ML; KNOLL, JE; RICH, MA | 1 |
| ERLANDSON, M; HARTMANN, JR; MURPHY, ML; ORIGENES, ML; SITARZ, A | 1 |
| HAHN, RG; MOERTEL, CG; REITEMEIER, RJ | 1 |
| BASCH, RS; KARNOFSKY, DA | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Agarwal, R; Ardalan, B; Patel, M | 1 |
| Engelbrecher, A; Häuser, R; Titz, B; Uetz, P | 1 |
| Beumer, JH; Doroshow, JH; Egorin, MJ; Lenz, HJ; Newman, EM; Parise, RA; Synold, TW | 1 |
| Banerjee, D; Bertino, JR; Humeniuk, R; Mishra, PJ | 1 |
| Goltz, D; Jauch, C; Schott, H; Schott, TC; Schwendener, RA | 1 |
| Doseth, B; Kavli, B; Krokan, HE; Pettersen, HS; Slupphaug, G; Svaasand, EK; Vågbø, CB; Visnes, T | 1 |
| Chen, M; Thelen, JJ | 1 |
| Baek, IH; Kim, MS; Kwon, KI; Lee, BY | 1 |
| Accoceberry, I; Brèthes, D; Dementhon, K; El-Kirat-Chatel, S; Fitton-Ouhabi, V; Gabriel, F; Noël, T; Pujol, S; Sabra, A | 1 |
| Montesdeoca-Esponda, S; Mordačíková, E; Santana-Rodríguez, JJ; Santana-Viera, S; Škvára, P; Vojs Staňová, A | 1 |
| Callan, B; Callan, JF; Gao, J; Griffith, DM; Logan, KA; Love, M; McHale, AP; McKaig, T; Nesbitt, H; Taylor, M | 1 |
4 review(s) available for 5-fluorouridine and fluorouracil
| Article | Year |
|---|---|
Encapsulated filtering bleb. A selective review--new deductions.
Topics: Animals; Blister; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Postoperative Complications; Rabbits; Trabeculectomy; Uridine; Wound Healing | 1992 |
Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Culture Media; Drug Evaluation, Preclinical; Fluorouracil; Humans; Tegafur; Thymidine; Uridine | 1980 |
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Neoplasms; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Uridine | 1981 |
Chemotherapy of colorectal cancer: history and new themes.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; History, 20th Century; Humans; Prodrugs; Uridine | 1997 |
2 trial(s) available for 5-fluorouridine and fluorouracil
| Article | Year |
|---|---|
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Deoxycytidine; DNA Modification Methylases; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrouridine; Uridine | 2008 |
85 other study(ies) available for 5-fluorouridine and fluorouracil
| Article | Year |
|---|---|
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Topics: Animals; Arabinonucleosides; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Female; Fluorine; Humans; Kinetics; Leukemia L1210; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Conformation; Neoplasms, Experimental; Nucleotides; Sarcoma, Experimental; Tumor Cells, Cultured; Uracil; Viruses | 1989 |
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Humans; Leukemia L1210; Mice; Molecular Conformation; Nucleotides, Cyclic; Protein Kinases; Rabbits; Simplexvirus; Structure-Activity Relationship; Uracil Nucleotides; Uridine Monophosphate; Vaccinia virus; X-Ray Diffraction | 1986 |
Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Leukemia L1210; Mice; Mice, Inbred DBA; Uridine | 1982 |
Synthesis and in vivo antitumor activity of potential 5-fluorouracil prodrugs.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Leukemia P388; Male; Mice | 1982 |
6-Substituted and 5,6-disubstituted derivatives of uridine: stereoselective synthesis, interaction with uridine phosphorylase, and in vitro antitumor activity.
Topics: Antineoplastic Agents; Humans; Molecular Conformation; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 1996 |
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Enzyme Inhibitors; Fluorouracil; Humans; Inhibitory Concentration 50; Mice; Nucleosides; Substrate Specificity; Thymidylate Synthase; Uridine Phosphorylase; Viruses | 2011 |
Effect of 5-fluorouracil and 5-fluorouridine on metaphase chromosome structure in human lymphoid cells.
Topics: Antineoplastic Agents; Cell Cycle; Chromosomes, Human; Fluorouracil; Humans; Lymphocytes; Metaphase; Uridine | 1978 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
Novel derivatives of 5-fluorouridine and 5-fluorouracil having potent antitumor and lower immunosuppressive activities.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Cell Division; Fluorouracil; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Organ Size; RNA, Ribosomal; Thymus Gland; Tumor Cells, Cultured; Uridine | 1992 |
Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Phosphates; Potassium; Potassium Compounds; Spectrophotometry, Ultraviolet; Uridine | 1992 |
Effects of fluorouracil and fluorouridine on protein synthesis in rabbit retina.
Topics: Animals; Autoradiography; Axonal Transport; Conjunctiva; Eye Proteins; Fluorouracil; Photoreceptor Cells; Rabbits; Retina; Retinal Ganglion Cells; Rod Cell Outer Segment; Uridine; Vitreous Body | 1990 |
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Thymidine Phosphorylase; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
Topics: Chromatography, High Pressure Liquid; Coumarins; Floxuridine; Fluorine; Fluorouracil; Humans; Molecular Structure; Pyrimidines; Tegafur; Umbelliferones; Uridine | 1990 |
19F nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of Candida glabrata with specific defects in pyrimidine metabolism.
Topics: Candida; Cells, Cultured; Cytosine Deaminase; Flucytosine; Fluorouracil; Magnetic Resonance Spectroscopy; Nucleoside Deaminases; Pentosyltransferases; Phenotype; RNA, Ribosomal; Uridine; Uridine Kinase | 1990 |
Synergistic antitumor effect of fluoropyrimidines and polyinosinic-polycytidylic acid against L1210 leukemia.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Drug Synergism; Fluorouracil; Interferons; Leukemia L1210; Mice; Mice, Inbred Strains; Poly I-C; RNA; Uridine | 1985 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Messenger; RNA, Ribosomal; Sarcoma 180; Uridine | 1987 |
Mobility of individual 5-fluorouridine residues in 5-fluorouracil-substituted Escherichia coli valine transfer RNA. A 19F nuclear magnetic resonance relaxation study.
Topics: Chemical Phenomena; Chemistry, Physical; Escherichia coli; Fluorouracil; Magnetic Resonance Spectroscopy; RNA, Bacterial; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Val; Uridine | 1987 |
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia L1210; Mice; Tumor Cells, Cultured; Uridine | 1989 |
Selection of therapeutic agents for intraocular proliferative disease 3. Effects of fluoropyrimidines on cell-mediated contraction of human fibroblasts.
Topics: Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Fibroblasts; Fluorouracil; Gels; Humans; Sclera; Uridine | 1989 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; Rectal Neoplasms; Uridine | 1986 |
Fluoropyrimidine treatment of ocular cicatricial disease.
Topics: Animals; Cell Division; Cicatrix; Eye Diseases; Fibroblasts; Floxuridine; Fluorouracil; Osmolar Concentration; Rabbits; Skin; Uridine | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eye Neoplasms; Floxuridine; Flucytosine; Fluorouracil; Humans; Uridine | 1987 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Rectal Neoplasms; Uridine | 1987 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Rectal Neoplasms; Time Factors; Tumor Cells, Cultured; Uridine | 1988 |
Isolation and characterization of fluoropyrimidine-resistant mutants in two Candida species.
Topics: Candida; Candida albicans; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Mutation; Phenotype; Uridine | 1988 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimidines; Radionuclide Imaging; Rats; Thymidine; Tissue Distribution; Tritium; Uridine | 1985 |
Gas-liquid chromatographic analysis of fluoropyrimidine nucleosides and fluorouracil in plasma and urine.
Topics: Animals; Chromatography, Gas; Chromatography, Ion Exchange; Dogs; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kidney; Kinetics; Uridine | 1985 |
Noninvasive spectroscopic analysis of fluoropyrimidine metabolism in cultured tumor cells.
Topics: Animals; Cells, Cultured; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Magnetic Resonance Spectroscopy; Mice; Monitoring, Physiologic; Neoplasms; Sarcoma 180; Uridine | 1986 |
Halogenated nucleic acids: effects of 5-fluorouracil on the conformation and properties of a polyribonucleotide and its constituents.
Topics: Fluorouracil; Molecular Conformation; Nucleic Acid Conformation; Poly U; Polydeoxyribonucleotides; Uracil Nucleotides; Uridine | 1986 |
Modulation of fluoropyrimidine metabolism by chlorpromazine.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cell Survival; Chlorpromazine; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Mice; Sarcoma, Experimental; Tritium; Uridine | 1986 |
Cellular mutations and drug resistance probed by herpes simplex virus.
Topics: Animals; Bleomycin; Carcinoma, Squamous Cell; Chlorocebus aethiops; Drug Resistance; Fibroblasts; Fluorescent Antibody Technique; Fluorouracil; Humans; Methotrexate; Mice; Mutation; Simplexvirus; Thioguanine; Uridine | 1981 |
Adjuvant and palliative treatment of colorectal cancer with fluorinated pyrimidines. A pharmacological and clinical review.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Prognosis; Pyrimidines; Rectal Neoplasms; Uridine | 1981 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.
Topics: Breast Neoplasms; Cell-Free System; Cytosol; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Phosphorylation; Uridine | 1981 |
Nitrogen metabolite repression of fluoropyrimidine resistance and pyrimidine uptake in Neurospora crassa.
Topics: Ammonia; Biological Transport; Drug Resistance, Microbial; Fluorouracil; Mutation; Neurospora; Neurospora crassa; Nitrogen; Pyrimidines; Temperature; Uracil; Uridine | 1982 |
Mode of action of 5-fluorocytosine and 5-fluorouracil in dematiaceous fungi.
Topics: Cytosine; Drug Resistance, Microbial; Floxuridine; Flucytosine; Fluorouracil; Mitosporic Fungi; RNA, Fungal; RNA, Ribosomal; Species Specificity; Uridine | 1983 |
Decreased immunosuppression associated with antitumor activity of 5-deoxy-5-fluorouridine compared to 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Survival; Female; Floxuridine; Fluorouracil; Immunosuppression Therapy; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrans; Thioglycolates; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.
Topics: Animals; Bile; Floxuridine; Fluorine; Fluorouracil; Radioisotopes; Rats; Rats, Inbred Strains; Uridine | 1984 |
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Floxuridine; Fluorouracil; Guanosine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleosides; Uridine | 1984 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Rats; Uridine | 1984 |
[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)].
Topics: Antineoplastic Agents; Asialoglycoproteins; Azo Compounds; Carcinoma, Hepatocellular; Cell Membrane Permeability; Doxorubicin; Drug Therapy, Combination; Enzyme Activation; Fluorouracil; Glycoproteins; Humans; Injections, Intra-Arterial; Liver Neoplasms; NADH, NADPH Oxidoreductases; Nitroreductases; Pyrimidine Nucleotides; Uridine | 1981 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine | 1980 |
Mechanism of cytotoxicity of 5-fluorouracil: distinction between the irreversible cytotoxic effect of 5-fluorouridine and the reversible cytotoxic effect of 5-fluoro-2'-deoxyuridine on murine lymphoma L5178Y cells in culture.
Topics: Animals; Cell Division; Cell Line; Floxuridine; Fluorouracil; Leukemia, Experimental; Mice; Uridine | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidylate Synthase; Uridine | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Uridine | 1980 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Mutation; Phenotype; Selection, Genetic; Uridine | 1982 |
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1984 |
[Induction of resistance of yeast-like fungi to synthetic antifungal agents].
Topics: Antifungal Agents; Candida; Clotrimazole; Culture Techniques; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Miconazole; Uridine | 1983 |
Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized.
Topics: Animals; Cell Compartmentation; Cell Nucleus; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytosol; Fluorouracil; Leukemia L1210; Mice; RNA, Neoplasm; Sepharose; Uracil Nucleotides; Uridine | 1984 |
In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine.
Topics: Cell Line; Centrifugation, Density Gradient; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Humans; Protein Biosynthesis; RNA, Messenger; Uridine | 1983 |
Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil.
Topics: Animals; Bone Marrow; Deoxyuridine; Drug Therapy, Combination; Fluorouracil; Infusions, Parenteral; Injections, Intraperitoneal; Leukemia L1210; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Uridine | 1983 |
Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture.
Topics: Cell Nucleus; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Neoplasms, Experimental; RNA, Neoplasm; Uridine | 1982 |
Influence of pyrazofurin on the toxicity and antitumor activity of fluorinated pyrimidines in vivo.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Drug Interactions; Drug Therapy, Combination; Female; Fluorouracil; Hematopoietic Stem Cells; Male; Mice; Neoplasms, Experimental; Pyrazoles; Ribonucleosides; Ribose; Uridine | 1980 |
Evaluation of plasma 5-fluorouracil nucleoside levels in patients with metastatic breast cancer: relationships with toxicities.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Uridine | 1995 |
Incorporation of 5-fluorouracil into RNA by Mycobacterium avium complex strain LM1.
Topics: Biotransformation; Cytidine; Drug Resistance, Microbial; Fluorouracil; Mycobacterium avium Complex; RNA, Bacterial; Uracil; Uridine | 1993 |
Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells.
Topics: Cell Cycle; Cell Survival; Colorectal Neoplasms; DNA, Neoplasm; DNA, Ribosomal; Dose-Response Relationship, Drug; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1994 |
Somatostatin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids.
Topics: Adenocarcinoma; Amino Acid Sequence; Cell Cycle; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorine; Fluorouracil; G1 Phase; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Octreotide; Receptors, Somatostatin; Resting Phase, Cell Cycle; RNA, Ribosomal; S Phase; Tumor Cells, Cultured; Uridine | 1994 |
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Liver; Mice; Placenta; Species Specificity; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 1993 |
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Incidence; Injections; Rabbits; Retinal Detachment; Retinal Diseases; RNA, Ribosomal; Uridine; Vitreous Body | 1993 |
Irreversible cytotoxic effect of a novel lowly immunosuppressive antitumor fluorouridine derivative, UK-21.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; Flow Cytometry; Floxuridine; Fluorouracil; Glycine; Humans; Immunosuppressive Agents; KB Cells; Neoplastic Stem Cells; Thymidine; Uridine | 1997 |
Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells.
Topics: Antimetabolites, Antineoplastic; Cell Count; Colorectal Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Intracellular Fluid; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1998 |
Bladder tissue pharmacokinetics and antitumor effect of intravesical 5-fluorouridine.
Topics: Administration, Intravesical; Animals; Antibiotics, Antineoplastic; Biological Availability; Dogs; Female; Fluorouracil; Humans; Male; Metabolic Clearance Rate; Uridine; Urinary Bladder; Urinary Bladder Neoplasms | 1997 |
Differences in metabolism of 5-fluorouracil and 5-fluorouridine and regulation by glucosamine in human colon cancer multicell tumor spheroids.
Topics: Body Fluid Compartments; Colonic Neoplasms; Fluorouracil; Glucosamine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Biological; Nonlinear Dynamics; Phosphates; Spheroids, Cellular; Uridine | 1999 |
Kinetic model for 5-fluorouridine degradation. Catalytic effect of 5-fluorouracil.
Topics: Algorithms; Catalysis; Fluorouracil; Hydrolysis; Kinetics; Models, Chemical; Uridine | 2000 |
RP-LC determination of 5-fluorouridine in nanoparticulate formulations.
Topics: Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Fluorouracil; Reproducibility of Results; Solutions; Uridine | 2002 |
In-vitro release of fluoropyrimidines from PLGA film implants.
Topics: Absorbable Implants; Analysis of Variance; Chromatography, High Pressure Liquid; Drug Carriers; Drug Implants; Fluorouracil; Humans; Polyglactin 910; Uridine | 2002 |
Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uridine | 1958 |
EFFECTS OF 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) AND 5-FLUOROURACIL (NSC-19893) ON CHILDHOOD LEUKEMIA.
Topics: Bone Marrow Examination; Child; Floxuridine; Fluorouracil; Leukemia; Leukopenia; Melena; Nausea; Toxicology; Uridine; Vomiting | 1964 |
COMPARISON OF 5-FLUOROURACIL (NSC-19893) AND 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) IN TREATMENT OF PATIENTS WITH ADVANCED ADENOCARCINOMA OF COLON OR RECTUM.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Deoxyuridine; Drug Therapy; Fluorouracil; Humans; Nucleosides; Palliative Care; Rectal Neoplasms; Rectum; Toxicology; Uridine | 1965 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Irinotecan; Nucleic Acids; Organoplatinum Compounds; Oxaliplatin; Uridine | 2004 |
The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
Topics: Azacitidine; Bromodeoxyuridine; Decitabine; Deoxyuridine; DNA Damage; Escherichia coli; Escherichia coli Proteins; Fluorouracil; Models, Biological; Molecular Structure; Mutation; N-Glycosyl Hydrolases; Nucleotidases; Orotic Acid; Substrate Specificity; Thymidine Monophosphate; Uridine | 2007 |
Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Epigenomics; Fluorouracil; Gene Expression Regulation, Neoplastic; Gene Order; Humans; Mice; Mice, Nude; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Promoter Regions, Genetic; RNA Stability; Uridine; Xenograft Model Antitumor Assays | 2009 |
N⁴-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine-new drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate).
Topics: Alendronate; Animals; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Bone and Bones; Bone Density Conservation Agents; Cell Line, Tumor; Cytidine; Diphosphonates; Drug Screening Assays, Antitumor; Durapatite; Fluorouracil; Humans; Macrophages; Mice; Pamidronate; Uridine; Zidovudine | 2011 |
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Topics: Animals; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Floxuridine; Fluorouracil; Gene Knockdown Techniques; Humans; Mice; MutS Homolog 2 Protein; RNA; Thymidine; Thymine DNA Glycosylase; Uracil-DNA Glycosidase; Uridine | 2011 |
Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biomass; Cellulose; Fluorouracil; Isoenzymes; Light; Lignin; Mutagenesis, Insertional; Orotic Acid; Pentosyltransferases; Phenotype; Plant Leaves; Plants, Genetically Modified; Plastids; Recombinant Fusion Proteins; Seeds; Starch; Uracil; Uridine; Uridine Kinase | 2011 |
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Topics: Administration, Oral; Algorithms; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Floxuridine; Fluorouracil; Indicators and Reagents; Mass Spectrometry; Tandem Mass Spectrometry; Uridine | 2013 |
Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole.
Topics: Antifungal Agents; Azoles; Biological Transport; Candida; Crosses, Genetic; Drug Antagonism; Drug Resistance, Fungal; Flucytosine; Fluorouracil; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Microbial Sensitivity Tests; Nucleobase Transport Proteins; Nucleotide Transport Proteins; Sterol 14-Demethylase; Uracil; Uridine | 2014 |
Determination of 5-fluorocytosine, 5-fluorouracil, and 5-fluorouridine in hospital wastewater by liquid chromatography-mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Flucytosine; Fluorouracil; Hospitals; Molecular Structure; Solid Phase Extraction; Tandem Mass Spectrometry; Uridine; Wastewater; Water Pollutants, Chemical | 2020 |
A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Mice; Microbubbles; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome; Uridine | 2021 |