Page last updated: 2024-09-04

5-fluorouridine 5'-phosphate and fluorouracil

5-fluorouridine 5'-phosphate has been researched along with fluorouracil in 12 studies

Compound Research Comparison

Studies
(5-fluorouridine 5'-phosphate)
Trials
(5-fluorouridine 5'-phosphate)
Recent Studies (post-2010)
(5-fluorouridine 5'-phosphate)
Studies
(fluorouracil)
Trials
(fluorouracil)
Recent Studies (post-2010) (fluorouracil)
240245,5629,30714,663

Protein Interaction Comparison

ProteinTaxonomy5-fluorouridine 5'-phosphate (IC50)fluorouracil (IC50)
Epidermal growth factor receptorHomo sapiens (human)0.32
Thymidylate synthaseMus musculus (house mouse)1.58
AromataseHomo sapiens (human)0.63

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19908 (66.67)18.7374
1990's4 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hoshi, A; Kuretani, K; Yoshida, M1
Laurensse, EJ; Peters, GJ; Pinedo, HM; van Groeningen, CJ1
Martin, DS; Sawyer, RC; Stolfi, RL1
Handschumacher, RE; Hyde, CM; Moir, RD; Schwartz, PM; Turek, PJ1
Alderfer, JL; Loomis, RE1
Danenberg, PV; Heidelberger, C; Moran, RG1
Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG1
Danenberg, PV; Shani, J1
Fukushima, M; Shimamoto, Y; Shirasaka, T1
Ghoshal, K; Jacob, ST1
Hamada, H; Inaba, M; Sadata, A; Sawada, H1
Benz, C; Cadman, E; Heimer, R; O'Shaughnessy, J1

Reviews

1 review(s) available for 5-fluorouridine 5'-phosphate and fluorouracil

ArticleYear
Fluorinated pyrimidines and their nucleosides.
    Advances in enzymology and related areas of molecular biology, 1983, Volume: 54

    Topics: Animals; Enzyme Activation; Fluorouracil; Humans; Neoplasms; Pyrimidines; RNA; Thymidylate Synthase; Transcription, Genetic; Uracil Nucleotides; Uridine Triphosphate

1983

Other Studies

11 other study(ies) available for 5-fluorouridine 5'-phosphate and fluorouracil

ArticleYear
Mode of action of 5-fluorouridine 5'-phosphate in vivo and in vitro.
    Chemical & pharmaceutical bulletin, 1978, Volume: 26, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Cytarabine; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Mice; Nucleic Acid Precursors; Uracil Nucleotides

1978
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa.
    Cancer, 1991, Nov-01, Volume: 68, Issue:9

    Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Middle Aged; Orotate Phosphoribosyltransferase; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Pyrimidine Phosphorylases; Rectal Neoplasms; Ribosemonophosphates; Uracil Nucleotides; Uridine Triphosphate

1991
Effect of L-histidinol on the metabolism of 5-fluorouracil in the BALB/c x DBA/8 F1 murine tumor system.
    Cancer research, 1988, Dec-01, Volume: 48, Issue:23

    Topics: Animals; DNA, Neoplasm; Fluorouracil; Histidinol; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms, Experimental; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Uracil Nucleotides

1988
Role of uridine phosphorylase in the anabolism of 5-fluorouracil.
    Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19

    Topics: Animals; Bone Marrow; Colonic Neoplasms; Diphosphates; Female; Fluorouracil; Kinetics; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Orotate Phosphoribosyltransferase; Pentosyltransferases; Peritoneal Neoplasms; Rats; Uracil Nucleotides; Uridine Kinase; Uridine Phosphorylase

1985
Halogenated nucleic acids: effects of 5-fluorouracil on the conformation and properties of a polyribonucleotide and its constituents.
    Biopolymers, 1986, Volume: 25, Issue:4

    Topics: Fluorouracil; Molecular Conformation; Nucleic Acid Conformation; Poly U; Polydeoxyribonucleotides; Uracil Nucleotides; Uridine

1986
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
    Journal of chromatography, 1982, Mar-12, Volume: 228

    Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine

1982
Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized.
    Biochemical and biophysical research communications, 1984, Jul-18, Volume: 122, Issue:1

    Topics: Animals; Cell Compartmentation; Cell Nucleus; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytosol; Fluorouracil; Leukemia L1210; Mice; RNA, Neoplasm; Sepharose; Uracil Nucleotides; Uridine

1984
Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats.
    Cancer research, 1993, Sep-01, Volume: 53, Issue:17

    Topics: Administration, Oral; Animals; Digestive System; Fluorouracil; Infusions, Intravenous; Liver; Male; Oxonic Acid; Phosphorylation; Rats; RNA; Sarcoma, Yoshida; Uracil Nucleotides

1993
Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil.
    Cancer research, 1994, Feb-01, Volume: 54, Issue:3

    Topics: Animals; Base Sequence; Cell Division; Cell Nucleus; DNA, Ribosomal; Fluorouracil; Lymphoma, Non-Hodgkin; Mice; Molecular Sequence Data; RNA Precursors; RNA, Neoplasm; RNA, Ribosomal; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Uracil Nucleotides; Uridine Triphosphate

1994
Circumvention of 5-fluorouracil resistance in human stomach cancer cells by uracil phosphoribosyltransferase gene transduction.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:3

    Topics: Adenoviridae; Cytosol; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Escherichia coli; Fluorouracil; Genes, Reporter; Genetic Therapy; Genetic Vectors; Humans; Inhibitory Concentration 50; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Recombinant Proteins; Stomach Neoplasms; Transduction, Genetic; Transfection; Tumor Cells, Cultured; Uracil Nucleotides

1999
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity.
    Biochemical pharmacology, 1981, Sep-01, Volume: 30, Issue:17

    Topics: Alanine; Animals; Azaserine; Cell Line, Tumor; Cell Survival; Diazooxonorleucine; Dose-Response Relationship, Drug; Fluorouracil; Methotrexate; Nucleic Acid Synthesis Inhibitors; Purines; Thioinosine; Thionucleotides; Uracil Nucleotides

1981